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Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients
Purpose Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein li...
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| Published in: | Lung 2020-02, Vol.198 (1), p.173-179 |
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| container_end_page | 179 |
| container_issue | 1 |
| container_start_page | 173 |
| container_title | Lung |
| container_volume | 198 |
| creator | Horváth, P. Lázár, Z. Gálffy, G. Puskás, R. Kunos, L. Losonczy, Gy Mészáros, M. Tárnoki, Á. D. Tárnoki, D. L. Bikov, A. |
| description | Purpose
Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea.
Methods
Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea–hypopnea index ≥ 5/h.
Results
PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8–40.8 ng/ml) and patients with OSA (19.6/8.4–56.8,
p
= 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4–56.8 ng/ml) compared to mild OSA patients (14.1/8.5–35.3 ng/ml,
p
= 0.006) and controls (
p
= 0.03).
Conclusions
P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA. |
| doi_str_mv | 10.1007/s00408-019-00299-0 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7012996</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A614362639</galeid><sourcerecordid>A614362639</sourcerecordid><originalsourceid>FETCH-LOGICAL-c582t-be4d77ed5bf9d1654fc533cd7955b272b5871dfdd101cfc6499448826dc5c6983</originalsourceid><addsrcrecordid>eNp9km9r2zAQxs3YWLNuX2AvhmFQ9sadZFmW_WYQwtYNAi10ey1k6eyoKFIm2YF--13mriQQhkB_7n73HJyeLHtPyTUlRHxOhFSkKQhtC0LKFvcX2YJWrCyo4ORltiCsokWJ0EX2JqUHQqioKX-dXTDatIK3bJH1Kxv15NRo_ZDfFffgQOM9v3GPOuxiGAEfazsob3KaH_YjaA17cCnH222XxjhhcA_5vQPY5cudB5XfoTD4Mb3NXvXKJXj3dF5mv759_bn6Xqxvb36slutC86Yciw4qIwQY3vWtoTWves0Z00a0nHelKDveCGp6Yyihutd11bZV1TRlbTTXdduwy-zLrLubui0Yjb2jcnIX7VbFRxmUlacZbzdyCHspCMUJ1ijw6Ukght8TpFFubdLgnPIQpiRLxlhNaSUOvT7O6KAcSOv7gIr6gMtljd9QlzVrkSrOUAN4wPbBQ28xfMJfn-FxGdhafbbg6qhgA8qNmxTcNNrg0ylYzqCOIaUI_fNYKJEHQ8nZUBINJf8aShIs-nA80OeSfw5CgM1AwpQfIMqHMEWPn_w_2T8FidSm</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2333611478</pqid></control><display><type>article</type><title>Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients</title><source>Springer Link</source><creator>Horváth, P. ; Lázár, Z. ; Gálffy, G. ; Puskás, R. ; Kunos, L. ; Losonczy, Gy ; Mészáros, M. ; Tárnoki, Á. D. ; Tárnoki, D. L. ; Bikov, A.</creator><creatorcontrib>Horváth, P. ; Lázár, Z. ; Gálffy, G. ; Puskás, R. ; Kunos, L. ; Losonczy, Gy ; Mészáros, M. ; Tárnoki, Á. D. ; Tárnoki, D. L. ; Bikov, A.</creatorcontrib><description>Purpose
Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea.
Methods
Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea–hypopnea index ≥ 5/h.
Results
PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8–40.8 ng/ml) and patients with OSA (19.6/8.4–56.8,
p
= 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4–56.8 ng/ml) compared to mild OSA patients (14.1/8.5–35.3 ng/ml,
p
= 0.006) and controls (
p
= 0.03).
Conclusions
P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-019-00299-0</identifier><identifier>PMID: 31897593</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Diagnosis ; Glycoproteins ; Health aspects ; Medicine ; Medicine & Public Health ; Obesity ; Physiological aspects ; Pneumology/Respiratory System ; Sleep ; Sleep apnea syndromes</subject><ispartof>Lung, 2020-02, Vol.198 (1), p.173-179</ispartof><rights>The Author(s) 2019</rights><rights>COPYRIGHT 2020 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-be4d77ed5bf9d1654fc533cd7955b272b5871dfdd101cfc6499448826dc5c6983</citedby><cites>FETCH-LOGICAL-c582t-be4d77ed5bf9d1654fc533cd7955b272b5871dfdd101cfc6499448826dc5c6983</cites><orcidid>0000-0001-9966-5747</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31897593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horváth, P.</creatorcontrib><creatorcontrib>Lázár, Z.</creatorcontrib><creatorcontrib>Gálffy, G.</creatorcontrib><creatorcontrib>Puskás, R.</creatorcontrib><creatorcontrib>Kunos, L.</creatorcontrib><creatorcontrib>Losonczy, Gy</creatorcontrib><creatorcontrib>Mészáros, M.</creatorcontrib><creatorcontrib>Tárnoki, Á. D.</creatorcontrib><creatorcontrib>Tárnoki, D. L.</creatorcontrib><creatorcontrib>Bikov, A.</creatorcontrib><title>Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Purpose
Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea.
Methods
Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea–hypopnea index ≥ 5/h.
Results
PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8–40.8 ng/ml) and patients with OSA (19.6/8.4–56.8,
p
= 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4–56.8 ng/ml) compared to mild OSA patients (14.1/8.5–35.3 ng/ml,
p
= 0.006) and controls (
p
= 0.03).
Conclusions
P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA.</description><subject>Diagnosis</subject><subject>Glycoproteins</subject><subject>Health aspects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Pneumology/Respiratory System</subject><subject>Sleep</subject><subject>Sleep apnea syndromes</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9km9r2zAQxs3YWLNuX2AvhmFQ9sadZFmW_WYQwtYNAi10ey1k6eyoKFIm2YF--13mriQQhkB_7n73HJyeLHtPyTUlRHxOhFSkKQhtC0LKFvcX2YJWrCyo4ORltiCsokWJ0EX2JqUHQqioKX-dXTDatIK3bJH1Kxv15NRo_ZDfFffgQOM9v3GPOuxiGAEfazsob3KaH_YjaA17cCnH222XxjhhcA_5vQPY5cudB5XfoTD4Mb3NXvXKJXj3dF5mv759_bn6Xqxvb36slutC86Yciw4qIwQY3vWtoTWves0Z00a0nHelKDveCGp6Yyihutd11bZV1TRlbTTXdduwy-zLrLubui0Yjb2jcnIX7VbFRxmUlacZbzdyCHspCMUJ1ijw6Ukght8TpFFubdLgnPIQpiRLxlhNaSUOvT7O6KAcSOv7gIr6gMtljd9QlzVrkSrOUAN4wPbBQ28xfMJfn-FxGdhafbbg6qhgA8qNmxTcNNrg0ylYzqCOIaUI_fNYKJEHQ8nZUBINJf8aShIs-nA80OeSfw5CgM1AwpQfIMqHMEWPn_w_2T8FidSm</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Horváth, P.</creator><creator>Lázár, Z.</creator><creator>Gálffy, G.</creator><creator>Puskás, R.</creator><creator>Kunos, L.</creator><creator>Losonczy, Gy</creator><creator>Mészáros, M.</creator><creator>Tárnoki, Á. D.</creator><creator>Tárnoki, D. L.</creator><creator>Bikov, A.</creator><general>Springer US</general><general>Springer</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9966-5747</orcidid></search><sort><creationdate>20200201</creationdate><title>Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients</title><author>Horváth, P. ; Lázár, Z. ; Gálffy, G. ; Puskás, R. ; Kunos, L. ; Losonczy, Gy ; Mészáros, M. ; Tárnoki, Á. D. ; Tárnoki, D. L. ; Bikov, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-be4d77ed5bf9d1654fc533cd7955b272b5871dfdd101cfc6499448826dc5c6983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Diagnosis</topic><topic>Glycoproteins</topic><topic>Health aspects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Physiological aspects</topic><topic>Pneumology/Respiratory System</topic><topic>Sleep</topic><topic>Sleep apnea syndromes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horváth, P.</creatorcontrib><creatorcontrib>Lázár, Z.</creatorcontrib><creatorcontrib>Gálffy, G.</creatorcontrib><creatorcontrib>Puskás, R.</creatorcontrib><creatorcontrib>Kunos, L.</creatorcontrib><creatorcontrib>Losonczy, Gy</creatorcontrib><creatorcontrib>Mészáros, M.</creatorcontrib><creatorcontrib>Tárnoki, Á. D.</creatorcontrib><creatorcontrib>Tárnoki, D. L.</creatorcontrib><creatorcontrib>Bikov, A.</creatorcontrib><collection>Springer Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horváth, P.</au><au>Lázár, Z.</au><au>Gálffy, G.</au><au>Puskás, R.</au><au>Kunos, L.</au><au>Losonczy, Gy</au><au>Mészáros, M.</au><au>Tárnoki, Á. D.</au><au>Tárnoki, D. L.</au><au>Bikov, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>198</volume><issue>1</issue><spage>173</spage><epage>179</epage><pages>173-179</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Purpose
Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea.
Methods
Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea–hypopnea index ≥ 5/h.
Results
PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8–40.8 ng/ml) and patients with OSA (19.6/8.4–56.8,
p
= 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4–56.8 ng/ml) compared to mild OSA patients (14.1/8.5–35.3 ng/ml,
p
= 0.006) and controls (
p
= 0.03).
Conclusions
P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31897593</pmid><doi>10.1007/s00408-019-00299-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9966-5747</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0341-2040 |
| ispartof | Lung, 2020-02, Vol.198 (1), p.173-179 |
| issn | 0341-2040 1432-1750 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7012996 |
| source | Springer Link |
| subjects | Diagnosis Glycoproteins Health aspects Medicine Medicine & Public Health Obesity Physiological aspects Pneumology/Respiratory System Sleep Sleep apnea syndromes |
| title | Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients |
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