Primary Isolated Lacrimal Gland Amyloidosis: A Case Report and Review of the Literature

We report a case of a 42-year-old woman who presented with a one-year history of a painless right orbital mass and right upper lid ptosis. Magnetic resonance imaging (MRI) revealed a superotemporal right orbital mass involving the lacrimal gland, and subsequent tissue biopsy and histopathologic eval...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2019-11, Vol.11 (11), p.e6258
Main Authors: Evans, William, Thompson, Barrett, Dryden, Stephen C, Awh, Caroline, Fowler, Brian
Format: Article
Language:English
Subjects:
Amyloidosis
Case reports
Family medical history
Hematology
Immunoglobulins
Light
Microscopy
NMR
Nuclear magnetic resonance
Ophthalmology
Patients
Radiation therapy
Stains & staining
Urine
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Summary:We report a case of a 42-year-old woman who presented with a one-year history of a painless right orbital mass and right upper lid ptosis. Magnetic resonance imaging (MRI) revealed a superotemporal right orbital mass involving the lacrimal gland, and subsequent tissue biopsy and histopathologic evaluation was consistent with amyloidosis. An otherwise negative workup by hematology/oncology confirmed a diagnosis of primary isolated lacrimal gland amyloidosis. To the best of our knowledge, this is the first documented case of isolated lacrimal gland amyloidosis without immunoglobulin (Ig) light chain restriction on in situ hybridization testing with a report of MRI findings. In addition, this is the second reported case of the disease without Ig light chain restriction on immunohistochemistry staining, and it is the third case with reported MRI results.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.6258