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Mortality reduction with physical activity in patients with and without cardiovascular disease
Abstract Aims Physical activity has been shown to reduce mortality in a dose-response fashion. Current guidelines recommend 500–1000 metabolic equivalent task (MET)-min per week of regular physical activity. This study aimed to compare the impact of leisure-time physical activity on mortality in pri...
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| Published in: | European heart journal 2019-11, Vol.40 (43), p.3547-3555 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 3555 |
| container_issue | 43 |
| container_start_page | 3547 |
| container_title | European heart journal |
| container_volume | 40 |
| creator | Jeong, Sang-Woo Kim, Sun-Hwa Kang, Si-Hyuck Kim, Hee-Jun Yoon, Chang-Hwan Youn, Tae-Jin Chae, In-Ho |
| description | Abstract
Aims
Physical activity has been shown to reduce mortality in a dose-response fashion. Current guidelines recommend 500–1000 metabolic equivalent task (MET)-min per week of regular physical activity. This study aimed to compare the impact of leisure-time physical activity on mortality in primary versus secondary cardiovascular prevention.
Methods and results
This study included a total of 131 558 and 310 240 subjects with and without cardiovascular disease (CVD), respectively, from a population-based cohort. Leisure-time physical activity was measured by self-report questionnaires. The study subjects were followed-up for a median of 5.9 years, and the main study outcome was all-cause mortality. There was an inverse relationship between the physical activity level and the mortality risk in both groups. The benefit in the secondary prevention group was shown to be greater than that in the primary prevention group: every 500 MET-min/week increase in physical activity resulted in a 14% and 7% risk reduction in mortality in the secondary and primary prevention groups, respectively (interaction P < 0.001). In addition, while individuals without CVD benefited the most between 1 and 500 MET-min/week of physical activity, the benefit in those with CVD continued above 500 − 1000 MET-min/week. The adjusted mortality risk of individuals with CVD who performed a high level of physical activity (≥1000 MET-min/week) was shown to be comparable to or lower than that of their counterparts without CVD.
Conclusion
Individuals with CVD may benefit from physical activity to a greater extent than do healthy subjects without CVD. |
| doi_str_mv | 10.1093/eurheartj/ehz564 |
| format | article |
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Aims
Physical activity has been shown to reduce mortality in a dose-response fashion. Current guidelines recommend 500–1000 metabolic equivalent task (MET)-min per week of regular physical activity. This study aimed to compare the impact of leisure-time physical activity on mortality in primary versus secondary cardiovascular prevention.
Methods and results
This study included a total of 131 558 and 310 240 subjects with and without cardiovascular disease (CVD), respectively, from a population-based cohort. Leisure-time physical activity was measured by self-report questionnaires. The study subjects were followed-up for a median of 5.9 years, and the main study outcome was all-cause mortality. There was an inverse relationship between the physical activity level and the mortality risk in both groups. The benefit in the secondary prevention group was shown to be greater than that in the primary prevention group: every 500 MET-min/week increase in physical activity resulted in a 14% and 7% risk reduction in mortality in the secondary and primary prevention groups, respectively (interaction P < 0.001). In addition, while individuals without CVD benefited the most between 1 and 500 MET-min/week of physical activity, the benefit in those with CVD continued above 500 − 1000 MET-min/week. The adjusted mortality risk of individuals with CVD who performed a high level of physical activity (≥1000 MET-min/week) was shown to be comparable to or lower than that of their counterparts without CVD.
Conclusion
Individuals with CVD may benefit from physical activity to a greater extent than do healthy subjects without CVD.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehz564</identifier><identifier>PMID: 31504416</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Fast Track Clinical Research</subject><ispartof>European heart journal, 2019-11, Vol.40 (43), p.3547-3555</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-fed4cb80334d7d14ca73b0189b05527faf8484bddbf7e4c7fb0d93c455ff301a3</citedby><cites>FETCH-LOGICAL-c432t-fed4cb80334d7d14ca73b0189b05527faf8484bddbf7e4c7fb0d93c455ff301a3</cites><orcidid>0000-0001-6305-4442 ; 0000-0003-4755-6367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,1591,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31504416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Sun-Hwa</creatorcontrib><creatorcontrib>Kang, Si-Hyuck</creatorcontrib><creatorcontrib>Kim, Hee-Jun</creatorcontrib><creatorcontrib>Yoon, Chang-Hwan</creatorcontrib><creatorcontrib>Youn, Tae-Jin</creatorcontrib><creatorcontrib>Chae, In-Ho</creatorcontrib><title>Mortality reduction with physical activity in patients with and without cardiovascular disease</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Abstract
Aims
Physical activity has been shown to reduce mortality in a dose-response fashion. Current guidelines recommend 500–1000 metabolic equivalent task (MET)-min per week of regular physical activity. This study aimed to compare the impact of leisure-time physical activity on mortality in primary versus secondary cardiovascular prevention.
Methods and results
This study included a total of 131 558 and 310 240 subjects with and without cardiovascular disease (CVD), respectively, from a population-based cohort. Leisure-time physical activity was measured by self-report questionnaires. The study subjects were followed-up for a median of 5.9 years, and the main study outcome was all-cause mortality. There was an inverse relationship between the physical activity level and the mortality risk in both groups. The benefit in the secondary prevention group was shown to be greater than that in the primary prevention group: every 500 MET-min/week increase in physical activity resulted in a 14% and 7% risk reduction in mortality in the secondary and primary prevention groups, respectively (interaction P < 0.001). In addition, while individuals without CVD benefited the most between 1 and 500 MET-min/week of physical activity, the benefit in those with CVD continued above 500 − 1000 MET-min/week. The adjusted mortality risk of individuals with CVD who performed a high level of physical activity (≥1000 MET-min/week) was shown to be comparable to or lower than that of their counterparts without CVD.
Conclusion
Individuals with CVD may benefit from physical activity to a greater extent than do healthy subjects without CVD.</description><subject>Fast Track Clinical Research</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkc1v1DAQxS1UxG4Ld05VjpVQqB1_xLkgVavSIhVxAYkT1sQfjatsHGxn0fLXN0vKCk49zWjmN2-e9BB6S_B7ght6aafYWYj54dJ2v7lgL9Ca8KoqG8H4CVpj0vBSCPl9hU5TesAYS0HEK7SihGPGiFijH59DzND7vC-iNZPOPgzFL5-7Yuz2yWvoC5iHuwPgh2KE7O2Q04LAYP40YcqFhmh82EHSUw-xMD5ZSPY1eumgT_bNUz1D3z5ef93clndfbj5tru5KzWiVS2cN063ElDJTG8I01LTFRDYt5ryqHTjJJGuNaV1tma5di01DNePcOYoJ0DP0YdEdp3ZrjZ49RujVGP0W4l4F8Or_zeA7dR92SkjOCZWzwMWTQAw_J5uy2vqkbd_DYMOUVFVJWRMpZDOjeEF1DClF645vCFaHWNQxFrXEMp-c_2vvePA3hxl4twBhGp-XewR8B6Aw</recordid><startdate>20191114</startdate><enddate>20191114</enddate><creator>Jeong, Sang-Woo</creator><creator>Kim, Sun-Hwa</creator><creator>Kang, Si-Hyuck</creator><creator>Kim, Hee-Jun</creator><creator>Yoon, Chang-Hwan</creator><creator>Youn, Tae-Jin</creator><creator>Chae, In-Ho</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6305-4442</orcidid><orcidid>https://orcid.org/0000-0003-4755-6367</orcidid></search><sort><creationdate>20191114</creationdate><title>Mortality reduction with physical activity in patients with and without cardiovascular disease</title><author>Jeong, Sang-Woo ; Kim, Sun-Hwa ; Kang, Si-Hyuck ; Kim, Hee-Jun ; Yoon, Chang-Hwan ; Youn, Tae-Jin ; Chae, In-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-fed4cb80334d7d14ca73b0189b05527faf8484bddbf7e4c7fb0d93c455ff301a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Fast Track Clinical Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Sun-Hwa</creatorcontrib><creatorcontrib>Kang, Si-Hyuck</creatorcontrib><creatorcontrib>Kim, Hee-Jun</creatorcontrib><creatorcontrib>Yoon, Chang-Hwan</creatorcontrib><creatorcontrib>Youn, Tae-Jin</creatorcontrib><creatorcontrib>Chae, In-Ho</creatorcontrib><collection>Open Access: Oxford University Press Open Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Sang-Woo</au><au>Kim, Sun-Hwa</au><au>Kang, Si-Hyuck</au><au>Kim, Hee-Jun</au><au>Yoon, Chang-Hwan</au><au>Youn, Tae-Jin</au><au>Chae, In-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality reduction with physical activity in patients with and without cardiovascular disease</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2019-11-14</date><risdate>2019</risdate><volume>40</volume><issue>43</issue><spage>3547</spage><epage>3555</epage><pages>3547-3555</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract
Aims
Physical activity has been shown to reduce mortality in a dose-response fashion. Current guidelines recommend 500–1000 metabolic equivalent task (MET)-min per week of regular physical activity. This study aimed to compare the impact of leisure-time physical activity on mortality in primary versus secondary cardiovascular prevention.
Methods and results
This study included a total of 131 558 and 310 240 subjects with and without cardiovascular disease (CVD), respectively, from a population-based cohort. Leisure-time physical activity was measured by self-report questionnaires. The study subjects were followed-up for a median of 5.9 years, and the main study outcome was all-cause mortality. There was an inverse relationship between the physical activity level and the mortality risk in both groups. The benefit in the secondary prevention group was shown to be greater than that in the primary prevention group: every 500 MET-min/week increase in physical activity resulted in a 14% and 7% risk reduction in mortality in the secondary and primary prevention groups, respectively (interaction P < 0.001). In addition, while individuals without CVD benefited the most between 1 and 500 MET-min/week of physical activity, the benefit in those with CVD continued above 500 − 1000 MET-min/week. The adjusted mortality risk of individuals with CVD who performed a high level of physical activity (≥1000 MET-min/week) was shown to be comparable to or lower than that of their counterparts without CVD.
Conclusion
Individuals with CVD may benefit from physical activity to a greater extent than do healthy subjects without CVD.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31504416</pmid><doi>10.1093/eurheartj/ehz564</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6305-4442</orcidid><orcidid>https://orcid.org/0000-0003-4755-6367</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal, 2019-11, Vol.40 (43), p.3547-3555 |
| issn | 0195-668X 1522-9645 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6855138 |
| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Fast Track Clinical Research |
| title | Mortality reduction with physical activity in patients with and without cardiovascular disease |
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