Loading…
Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity
The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA...
Saved in:
| Published in: | Neurobiology of aging 2018-10, Vol.70, p.217-232 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63 |
| container_end_page | 232 |
| container_issue | |
| container_start_page | 217 |
| container_title | Neurobiology of aging |
| container_volume | 70 |
| creator | Hernandez, Abbi R. Reasor, Jordan E. Truckenbrod, Leah M. Campos, Keila T. Federico, Quinten P. Fertal, Kaeli E. Lubke, Katelyn N. Johnson, Sarah A. Clark, Benjamin J. Maurer, Andrew. P. Burke, Sara N. |
| description | The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA1 of young and aged rats by labeling expression of the immediate-early gene Arc. The proportion of cells expressing Arc was quantified at baseline and after a behavior that requires these regions. In addition, PER and CA1 projection neurons to PFC were identified with retrograde labeling. Within CA1, no age-related differences in neuronal activity were observed in the entire neuron population or within CA1 pyramidal cells that project to PFC. Although behavior was comparable across age groups, behaviorally driven Arc expression was higher in the deep layers of both PER and PFC and lower in the superficial layers of these regions. Moreover, age-related changes in activity levels were most evident within PER cells that project to PFC. These data suggest that the PER-PFC circuit is particularly vulnerable in advanced age. |
| doi_str_mv | 10.1016/j.neurobiolaging.2018.06.028 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6829909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0197458018302331</els_id><sourcerecordid>2074123048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63</originalsourceid><addsrcrecordid>eNqNkUGLFDEQhYMo7uzqX5A-ePDSbSWd7k5ABFndVVjwoueQTipjhu5kTDID--_NMOvi3jylIK9evaqPkLcUOgp0fL_rAh5SnH1c9NaHbceAig7GDph4RjZ0GERLuZyekw1QObV8EHBBLnPeAcDEp_EluegBeip7uiH42eccjdfzgg06h6bkJrpG26MOBm2jt9jE0OwTuhRD0UtjYire1EIH26xofS0LrvuYarHEufqEjOvJUJvij77cvyIvnF4yvn54r8jPmy8_rr-2d99vv11_umsNl0NpmevZ1FtJueYzSEYRORoHgxDGDL0dBxCUT8Dp7Di3I1DKwQlWd3bU4thfkY9n3_1hrskMhlJDqX3yq073Kmqvnv4E_0tt41GNgkkJshq8ezBI8fcBc1GrzwaXRQeMh6xYvSBlPXBRpR_OUpNizvU8j2MoqBMptVNPSakTKQWjqqRq-5t_oz42_0VTBTdnAdaDHT0mlY3HExOfKiVlo_-_SX8AhRavqg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2074123048</pqid></control><display><type>article</type><title>Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity</title><source>Elsevier</source><creator>Hernandez, Abbi R. ; Reasor, Jordan E. ; Truckenbrod, Leah M. ; Campos, Keila T. ; Federico, Quinten P. ; Fertal, Kaeli E. ; Lubke, Katelyn N. ; Johnson, Sarah A. ; Clark, Benjamin J. ; Maurer, Andrew. P. ; Burke, Sara N.</creator><creatorcontrib>Hernandez, Abbi R. ; Reasor, Jordan E. ; Truckenbrod, Leah M. ; Campos, Keila T. ; Federico, Quinten P. ; Fertal, Kaeli E. ; Lubke, Katelyn N. ; Johnson, Sarah A. ; Clark, Benjamin J. ; Maurer, Andrew. P. ; Burke, Sara N.</creatorcontrib><description>The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA1 of young and aged rats by labeling expression of the immediate-early gene Arc. The proportion of cells expressing Arc was quantified at baseline and after a behavior that requires these regions. In addition, PER and CA1 projection neurons to PFC were identified with retrograde labeling. Within CA1, no age-related differences in neuronal activity were observed in the entire neuron population or within CA1 pyramidal cells that project to PFC. Although behavior was comparable across age groups, behaviorally driven Arc expression was higher in the deep layers of both PER and PFC and lower in the superficial layers of these regions. Moreover, age-related changes in activity levels were most evident within PER cells that project to PFC. These data suggest that the PER-PFC circuit is particularly vulnerable in advanced age.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/j.neurobiolaging.2018.06.028</identifier><identifier>PMID: 30031931</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging - physiology ; Animals ; Arc ; Association Learning - physiology ; Behavior, Animal ; CA1 ; CA1 Region, Hippocampal - physiology ; Cognition ; Cytoskeletal Proteins - metabolism ; Infralimbic cortex ; Male ; Nerve Tissue Proteins - metabolism ; Neural Pathways - physiology ; Neurons - physiology ; Perirhinal Cortex - physiology ; Prefrontal Cortex - physiology ; Prelimbic cortex ; Rats, Inbred F344 ; Temporal Lobe - physiology</subject><ispartof>Neurobiology of aging, 2018-10, Vol.70, p.217-232</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63</citedby><cites>FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30031931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernandez, Abbi R.</creatorcontrib><creatorcontrib>Reasor, Jordan E.</creatorcontrib><creatorcontrib>Truckenbrod, Leah M.</creatorcontrib><creatorcontrib>Campos, Keila T.</creatorcontrib><creatorcontrib>Federico, Quinten P.</creatorcontrib><creatorcontrib>Fertal, Kaeli E.</creatorcontrib><creatorcontrib>Lubke, Katelyn N.</creatorcontrib><creatorcontrib>Johnson, Sarah A.</creatorcontrib><creatorcontrib>Clark, Benjamin J.</creatorcontrib><creatorcontrib>Maurer, Andrew. P.</creatorcontrib><creatorcontrib>Burke, Sara N.</creatorcontrib><title>Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA1 of young and aged rats by labeling expression of the immediate-early gene Arc. The proportion of cells expressing Arc was quantified at baseline and after a behavior that requires these regions. In addition, PER and CA1 projection neurons to PFC were identified with retrograde labeling. Within CA1, no age-related differences in neuronal activity were observed in the entire neuron population or within CA1 pyramidal cells that project to PFC. Although behavior was comparable across age groups, behaviorally driven Arc expression was higher in the deep layers of both PER and PFC and lower in the superficial layers of these regions. Moreover, age-related changes in activity levels were most evident within PER cells that project to PFC. These data suggest that the PER-PFC circuit is particularly vulnerable in advanced age.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Arc</subject><subject>Association Learning - physiology</subject><subject>Behavior, Animal</subject><subject>CA1</subject><subject>CA1 Region, Hippocampal - physiology</subject><subject>Cognition</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Infralimbic cortex</subject><subject>Male</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neural Pathways - physiology</subject><subject>Neurons - physiology</subject><subject>Perirhinal Cortex - physiology</subject><subject>Prefrontal Cortex - physiology</subject><subject>Prelimbic cortex</subject><subject>Rats, Inbred F344</subject><subject>Temporal Lobe - physiology</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkUGLFDEQhYMo7uzqX5A-ePDSbSWd7k5ABFndVVjwoueQTipjhu5kTDID--_NMOvi3jylIK9evaqPkLcUOgp0fL_rAh5SnH1c9NaHbceAig7GDph4RjZ0GERLuZyekw1QObV8EHBBLnPeAcDEp_EluegBeip7uiH42eccjdfzgg06h6bkJrpG26MOBm2jt9jE0OwTuhRD0UtjYire1EIH26xofS0LrvuYarHEufqEjOvJUJvij77cvyIvnF4yvn54r8jPmy8_rr-2d99vv11_umsNl0NpmevZ1FtJueYzSEYRORoHgxDGDL0dBxCUT8Dp7Di3I1DKwQlWd3bU4thfkY9n3_1hrskMhlJDqX3yq073Kmqvnv4E_0tt41GNgkkJshq8ezBI8fcBc1GrzwaXRQeMh6xYvSBlPXBRpR_OUpNizvU8j2MoqBMptVNPSakTKQWjqqRq-5t_oz42_0VTBTdnAdaDHT0mlY3HExOfKiVlo_-_SX8AhRavqg</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Hernandez, Abbi R.</creator><creator>Reasor, Jordan E.</creator><creator>Truckenbrod, Leah M.</creator><creator>Campos, Keila T.</creator><creator>Federico, Quinten P.</creator><creator>Fertal, Kaeli E.</creator><creator>Lubke, Katelyn N.</creator><creator>Johnson, Sarah A.</creator><creator>Clark, Benjamin J.</creator><creator>Maurer, Andrew. P.</creator><creator>Burke, Sara N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181001</creationdate><title>Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity</title><author>Hernandez, Abbi R. ; Reasor, Jordan E. ; Truckenbrod, Leah M. ; Campos, Keila T. ; Federico, Quinten P. ; Fertal, Kaeli E. ; Lubke, Katelyn N. ; Johnson, Sarah A. ; Clark, Benjamin J. ; Maurer, Andrew. P. ; Burke, Sara N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Arc</topic><topic>Association Learning - physiology</topic><topic>Behavior, Animal</topic><topic>CA1</topic><topic>CA1 Region, Hippocampal - physiology</topic><topic>Cognition</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Infralimbic cortex</topic><topic>Male</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neural Pathways - physiology</topic><topic>Neurons - physiology</topic><topic>Perirhinal Cortex - physiology</topic><topic>Prefrontal Cortex - physiology</topic><topic>Prelimbic cortex</topic><topic>Rats, Inbred F344</topic><topic>Temporal Lobe - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernandez, Abbi R.</creatorcontrib><creatorcontrib>Reasor, Jordan E.</creatorcontrib><creatorcontrib>Truckenbrod, Leah M.</creatorcontrib><creatorcontrib>Campos, Keila T.</creatorcontrib><creatorcontrib>Federico, Quinten P.</creatorcontrib><creatorcontrib>Fertal, Kaeli E.</creatorcontrib><creatorcontrib>Lubke, Katelyn N.</creatorcontrib><creatorcontrib>Johnson, Sarah A.</creatorcontrib><creatorcontrib>Clark, Benjamin J.</creatorcontrib><creatorcontrib>Maurer, Andrew. P.</creatorcontrib><creatorcontrib>Burke, Sara N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernandez, Abbi R.</au><au>Reasor, Jordan E.</au><au>Truckenbrod, Leah M.</au><au>Campos, Keila T.</au><au>Federico, Quinten P.</au><au>Fertal, Kaeli E.</au><au>Lubke, Katelyn N.</au><au>Johnson, Sarah A.</au><au>Clark, Benjamin J.</au><au>Maurer, Andrew. P.</au><au>Burke, Sara N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>70</volume><spage>217</spage><epage>232</epage><pages>217-232</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhinal cortex (PER), and hippocampal subregion CA1 of young and aged rats by labeling expression of the immediate-early gene Arc. The proportion of cells expressing Arc was quantified at baseline and after a behavior that requires these regions. In addition, PER and CA1 projection neurons to PFC were identified with retrograde labeling. Within CA1, no age-related differences in neuronal activity were observed in the entire neuron population or within CA1 pyramidal cells that project to PFC. Although behavior was comparable across age groups, behaviorally driven Arc expression was higher in the deep layers of both PER and PFC and lower in the superficial layers of these regions. Moreover, age-related changes in activity levels were most evident within PER cells that project to PFC. These data suggest that the PER-PFC circuit is particularly vulnerable in advanced age.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30031931</pmid><doi>10.1016/j.neurobiolaging.2018.06.028</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-4580 |
| ispartof | Neurobiology of aging, 2018-10, Vol.70, p.217-232 |
| issn | 0197-4580 1558-1497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6829909 |
| source | Elsevier |
| subjects | Aging - physiology Animals Arc Association Learning - physiology Behavior, Animal CA1 CA1 Region, Hippocampal - physiology Cognition Cytoskeletal Proteins - metabolism Infralimbic cortex Male Nerve Tissue Proteins - metabolism Neural Pathways - physiology Neurons - physiology Perirhinal Cortex - physiology Prefrontal Cortex - physiology Prelimbic cortex Rats, Inbred F344 Temporal Lobe - physiology |
| title | Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-29T03%3A24%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dissociable%20effects%20of%20advanced%20age%20on%20prefrontal%20cortical%20and%20medial%20temporal%20lobe%20ensemble%20activity&rft.jtitle=Neurobiology%20of%20aging&rft.au=Hernandez,%20Abbi%20R.&rft.date=2018-10-01&rft.volume=70&rft.spage=217&rft.epage=232&rft.pages=217-232&rft.issn=0197-4580&rft.eissn=1558-1497&rft_id=info:doi/10.1016/j.neurobiolaging.2018.06.028&rft_dat=%3Cproquest_pubme%3E2074123048%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c495t-2f3273d914a4b0921ee4ecf0588cc53d6508147041bf44d601140f82155f1de63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2074123048&rft_id=info:pmid/30031931&rfr_iscdi=true |