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Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry
Background Ischemic heart disease is a growing health problem in Latin America. We aimed to analyze risk factors, acute management, and short‐term outcome of Mexicans with ST‐elevation myocardial infarction (STEMI). Hypothesis Modifiable risk factors are associated with the occurrence of STEMI in Me...
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Published in: | Clinical cardiology (Mahwah, N.J.) N.J.), 2013-05, Vol.36 (5), p.241-248 |
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description | Background
Ischemic heart disease is a growing health problem in Latin America. We aimed to analyze risk factors, acute management, and short‐term outcome of Mexicans with ST‐elevation myocardial infarction (STEMI).
Hypothesis
Modifiable risk factors are associated with the occurrence of STEMI in Mexicans, and potentially preventable acute complications are responsible for most short‐term deaths.
Methods
Among 8600 patients enrolled in Registro Nacional de los Síndromes Coronarios Agudos II (RENASICA II) with a suspected acute coronary syndrome, we analyzed 4555 patients (56%; age 21–100 y) with confirmed STEMI who presented within 24 hours from symptoms' onset.
Results
Smoking (66%), hypertension (50%), and diabetes (43%) were the main risk factors. Most patients (74%) presented with Killip class I (class IV in 4%). Anterior‐located STEMI occurred in 56% of cases, and posterior‐inferior in 40% of cases. Significant Q waves were present in 43%, right bundle branch block in 7%, left bundle branch block in 5%, first‐degree atrioventricular block in 2%, and high‐degree atrioventricular block in 2%. A total of 1685 (37%) patients received fibrinolytic therapy (streptokinase, 82%; alteplase, 17%; tenecteplase, 1%), with 31% of patients receiving therapy in 6 hours. Thirty percent of patients received either percutaneous coronary intervention or coronary artery bypass grafting during hospitalization. Major adverse cardiovascular events were recurrent ischemia (12%), reinfarction (4%), cardiogenic shock (4%), and stroke (1%). The main predictors of 30‐day mortality (10%) in multivariate analysis were age ≥65 years (odds ratio [OR]: 2.47, 95% confidence interval [CI]: 1.94‐3.13), Killip class IV (OR: 10.60, 95% CI: 6.09‐18.40), and cardiogenic shock (OR: 18.76, 95% CI: 10.60‐33.20).
Conclusions
Largely modifiable risk factors and preventable short‐term complications are responsible for most STEMI cases and outcomes in this Mexican population. |
doi_str_mv | 10.1002/clc.22107 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6649652</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2968283621</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4437-7106cbf1e6d5f605c974e9508b89df59f0c8aadfdb0c1fb6af26c2851bd643d3</originalsourceid><addsrcrecordid>eNp1kcFuEzEURS0EoqGw4AeQJVZITGt7PJ4xC6QoStuREiqlkVhaHo_duEzGU9tTyI5P4Bv6aXwJDikVLFg96b3z7r3SBeA1RicYIXKqOnVCCEblEzDBPCdZVeblUzBBmKGMk4ofgRch3CQUVSR_Do5ITjmlrJyA-5UNX-CZVNH58B6uN9rLQY_RKjgdBu-k2ui0l30L6_7n9x8XLgw2yg5ejlG5rQ7Q9nCpv1kl-wA_27iBV-vEzTt9J6N1PZyqMWq43DklfWvTZ90b6dX-9mHvB1fzT9OrejaFdQ2XY5esdR-1hyt9bUP0u5fgmZFd0K8e5jFYn83Xs4tscXme3haZojQvsxIjphqDNWsLw1CheEk1L1DVVLw1BTdIVVK2pm2QwqZh0hCmSFXgpmU0b_Nj8PEgO4zNVrf7EF52YvB2K_1OOGnFv5febsS1uxOMUc4KkgTePgh4dzvqEMWNG32fIgucFwhXhOY4Ue8OlPIuBK_NowNGYt-mSG2K320m9s3fkR7JP_Ul4PQAfLWd3v1fScwWs4PkL_C7rcY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1350182431</pqid></control><display><type>article</type><title>Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry</title><source>PubMed Central</source><creator>Juárez‐Herrera, Úrsulo ; Jerjes‐Sánchez, Carlos</creator><creatorcontrib>Juárez‐Herrera, Úrsulo ; Jerjes‐Sánchez, Carlos ; RENASICA II Investigators ; and The RENASICA II Investigators</creatorcontrib><description>Background
Ischemic heart disease is a growing health problem in Latin America. We aimed to analyze risk factors, acute management, and short‐term outcome of Mexicans with ST‐elevation myocardial infarction (STEMI).
Hypothesis
Modifiable risk factors are associated with the occurrence of STEMI in Mexicans, and potentially preventable acute complications are responsible for most short‐term deaths.
Methods
Among 8600 patients enrolled in Registro Nacional de los Síndromes Coronarios Agudos II (RENASICA II) with a suspected acute coronary syndrome, we analyzed 4555 patients (56%; age 21–100 y) with confirmed STEMI who presented within 24 hours from symptoms' onset.
Results
Smoking (66%), hypertension (50%), and diabetes (43%) were the main risk factors. Most patients (74%) presented with Killip class I (class IV in 4%). Anterior‐located STEMI occurred in 56% of cases, and posterior‐inferior in 40% of cases. Significant Q waves were present in 43%, right bundle branch block in 7%, left bundle branch block in 5%, first‐degree atrioventricular block in 2%, and high‐degree atrioventricular block in 2%. A total of 1685 (37%) patients received fibrinolytic therapy (streptokinase, 82%; alteplase, 17%; tenecteplase, 1%), with 31% of patients receiving therapy in <2 hours, 36% in 2–4 hours, 19% in 4–6 hours, and 15% in >6 hours. Thirty percent of patients received either percutaneous coronary intervention or coronary artery bypass grafting during hospitalization. Major adverse cardiovascular events were recurrent ischemia (12%), reinfarction (4%), cardiogenic shock (4%), and stroke (1%). The main predictors of 30‐day mortality (10%) in multivariate analysis were age ≥65 years (odds ratio [OR]: 2.47, 95% confidence interval [CI]: 1.94‐3.13), Killip class IV (OR: 10.60, 95% CI: 6.09‐18.40), and cardiogenic shock (OR: 18.76, 95% CI: 10.60‐33.20).
Conclusions
Largely modifiable risk factors and preventable short‐term complications are responsible for most STEMI cases and outcomes in this Mexican population.</description><identifier>ISSN: 0160-9289</identifier><identifier>EISSN: 1932-8737</identifier><identifier>DOI: 10.1002/clc.22107</identifier><identifier>PMID: 23494467</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Acute coronary syndromes ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anterior Wall Myocardial Infarction - diagnosis ; Anterior Wall Myocardial Infarction - mortality ; Anterior Wall Myocardial Infarction - therapy ; Cardiovascular disease ; Confidence intervals ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - mortality ; Female ; Heart attacks ; Heart Block - mortality ; Heart Block - therapy ; Hospital Mortality ; Hospitalization ; Humans ; Inferior Wall Myocardial Infarction - diagnosis ; Inferior Wall Myocardial Infarction - mortality ; Inferior Wall Myocardial Infarction - therapy ; Logistic Models ; Male ; Mexico - epidemiology ; Middle Aged ; Mortality ; Multivariate Analysis ; Odds Ratio ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - mortality ; Quality and Outcomes ; Recurrence ; Registries ; Risk Factors ; Shock, Cardiogenic - mortality ; Shock, Cardiogenic - therapy ; Stroke - mortality ; Stroke - therapy ; Thrombolytic Therapy - adverse effects ; Thrombolytic Therapy - mortality ; Time Factors ; Treatment Outcome ; Young Adult</subject><ispartof>Clinical cardiology (Mahwah, N.J.), 2013-05, Vol.36 (5), p.241-248</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4437-7106cbf1e6d5f605c974e9508b89df59f0c8aadfdb0c1fb6af26c2851bd643d3</citedby><cites>FETCH-LOGICAL-c4437-7106cbf1e6d5f605c974e9508b89df59f0c8aadfdb0c1fb6af26c2851bd643d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649652/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649652/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23494467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juárez‐Herrera, Úrsulo</creatorcontrib><creatorcontrib>Jerjes‐Sánchez, Carlos</creatorcontrib><creatorcontrib>RENASICA II Investigators</creatorcontrib><creatorcontrib>and The RENASICA II Investigators</creatorcontrib><title>Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry</title><title>Clinical cardiology (Mahwah, N.J.)</title><addtitle>Clin Cardiol</addtitle><description>Background
Ischemic heart disease is a growing health problem in Latin America. We aimed to analyze risk factors, acute management, and short‐term outcome of Mexicans with ST‐elevation myocardial infarction (STEMI).
Hypothesis
Modifiable risk factors are associated with the occurrence of STEMI in Mexicans, and potentially preventable acute complications are responsible for most short‐term deaths.
Methods
Among 8600 patients enrolled in Registro Nacional de los Síndromes Coronarios Agudos II (RENASICA II) with a suspected acute coronary syndrome, we analyzed 4555 patients (56%; age 21–100 y) with confirmed STEMI who presented within 24 hours from symptoms' onset.
Results
Smoking (66%), hypertension (50%), and diabetes (43%) were the main risk factors. Most patients (74%) presented with Killip class I (class IV in 4%). Anterior‐located STEMI occurred in 56% of cases, and posterior‐inferior in 40% of cases. Significant Q waves were present in 43%, right bundle branch block in 7%, left bundle branch block in 5%, first‐degree atrioventricular block in 2%, and high‐degree atrioventricular block in 2%. A total of 1685 (37%) patients received fibrinolytic therapy (streptokinase, 82%; alteplase, 17%; tenecteplase, 1%), with 31% of patients receiving therapy in <2 hours, 36% in 2–4 hours, 19% in 4–6 hours, and 15% in >6 hours. Thirty percent of patients received either percutaneous coronary intervention or coronary artery bypass grafting during hospitalization. Major adverse cardiovascular events were recurrent ischemia (12%), reinfarction (4%), cardiogenic shock (4%), and stroke (1%). The main predictors of 30‐day mortality (10%) in multivariate analysis were age ≥65 years (odds ratio [OR]: 2.47, 95% confidence interval [CI]: 1.94‐3.13), Killip class IV (OR: 10.60, 95% CI: 6.09‐18.40), and cardiogenic shock (OR: 18.76, 95% CI: 10.60‐33.20).
Conclusions
Largely modifiable risk factors and preventable short‐term complications are responsible for most STEMI cases and outcomes in this Mexican population.</description><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anterior Wall Myocardial Infarction - diagnosis</subject><subject>Anterior Wall Myocardial Infarction - mortality</subject><subject>Anterior Wall Myocardial Infarction - therapy</subject><subject>Cardiovascular disease</subject><subject>Confidence intervals</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Bypass - mortality</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Heart Block - mortality</subject><subject>Heart Block - therapy</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Inferior Wall Myocardial Infarction - diagnosis</subject><subject>Inferior Wall Myocardial Infarction - mortality</subject><subject>Inferior Wall Myocardial Infarction - therapy</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - mortality</subject><subject>Quality and Outcomes</subject><subject>Recurrence</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Shock, Cardiogenic - mortality</subject><subject>Shock, Cardiogenic - therapy</subject><subject>Stroke - mortality</subject><subject>Stroke - therapy</subject><subject>Thrombolytic Therapy - adverse effects</subject><subject>Thrombolytic Therapy - mortality</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0160-9289</issn><issn>1932-8737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kcFuEzEURS0EoqGw4AeQJVZITGt7PJ4xC6QoStuREiqlkVhaHo_duEzGU9tTyI5P4Bv6aXwJDikVLFg96b3z7r3SBeA1RicYIXKqOnVCCEblEzDBPCdZVeblUzBBmKGMk4ofgRch3CQUVSR_Do5ITjmlrJyA-5UNX-CZVNH58B6uN9rLQY_RKjgdBu-k2ui0l30L6_7n9x8XLgw2yg5ejlG5rQ7Q9nCpv1kl-wA_27iBV-vEzTt9J6N1PZyqMWq43DklfWvTZ90b6dX-9mHvB1fzT9OrejaFdQ2XY5esdR-1hyt9bUP0u5fgmZFd0K8e5jFYn83Xs4tscXme3haZojQvsxIjphqDNWsLw1CheEk1L1DVVLw1BTdIVVK2pm2QwqZh0hCmSFXgpmU0b_Nj8PEgO4zNVrf7EF52YvB2K_1OOGnFv5febsS1uxOMUc4KkgTePgh4dzvqEMWNG32fIgucFwhXhOY4Ue8OlPIuBK_NowNGYt-mSG2K320m9s3fkR7JP_Ul4PQAfLWd3v1fScwWs4PkL_C7rcY</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Juárez‐Herrera, Úrsulo</creator><creator>Jerjes‐Sánchez, Carlos</creator><general>Wiley Periodicals, Inc</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201305</creationdate><title>Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry</title><author>Juárez‐Herrera, Úrsulo ; Jerjes‐Sánchez, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4437-7106cbf1e6d5f605c974e9508b89df59f0c8aadfdb0c1fb6af26c2851bd643d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute coronary syndromes</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anterior Wall Myocardial Infarction - diagnosis</topic><topic>Anterior Wall Myocardial Infarction - mortality</topic><topic>Anterior Wall Myocardial Infarction - therapy</topic><topic>Cardiovascular disease</topic><topic>Confidence intervals</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Bypass - mortality</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Heart Block - mortality</topic><topic>Heart Block - therapy</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Inferior Wall Myocardial Infarction - diagnosis</topic><topic>Inferior Wall Myocardial Infarction - mortality</topic><topic>Inferior Wall Myocardial Infarction - therapy</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mexico - epidemiology</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Quality and Outcomes</topic><topic>Recurrence</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Shock, Cardiogenic - mortality</topic><topic>Shock, Cardiogenic - therapy</topic><topic>Stroke - mortality</topic><topic>Stroke - therapy</topic><topic>Thrombolytic Therapy - adverse effects</topic><topic>Thrombolytic Therapy - mortality</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juárez‐Herrera, Úrsulo</creatorcontrib><creatorcontrib>Jerjes‐Sánchez, Carlos</creatorcontrib><creatorcontrib>RENASICA II Investigators</creatorcontrib><creatorcontrib>and The RENASICA II Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juárez‐Herrera, Úrsulo</au><au>Jerjes‐Sánchez, Carlos</au><aucorp>RENASICA II Investigators</aucorp><aucorp>and The RENASICA II Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry</atitle><jtitle>Clinical cardiology (Mahwah, N.J.)</jtitle><addtitle>Clin Cardiol</addtitle><date>2013-05</date><risdate>2013</risdate><volume>36</volume><issue>5</issue><spage>241</spage><epage>248</epage><pages>241-248</pages><issn>0160-9289</issn><eissn>1932-8737</eissn><notes>The authors have no funding, financial relationships, or conflicts of interest to disclose.</notes><abstract>Background
Ischemic heart disease is a growing health problem in Latin America. We aimed to analyze risk factors, acute management, and short‐term outcome of Mexicans with ST‐elevation myocardial infarction (STEMI).
Hypothesis
Modifiable risk factors are associated with the occurrence of STEMI in Mexicans, and potentially preventable acute complications are responsible for most short‐term deaths.
Methods
Among 8600 patients enrolled in Registro Nacional de los Síndromes Coronarios Agudos II (RENASICA II) with a suspected acute coronary syndrome, we analyzed 4555 patients (56%; age 21–100 y) with confirmed STEMI who presented within 24 hours from symptoms' onset.
Results
Smoking (66%), hypertension (50%), and diabetes (43%) were the main risk factors. Most patients (74%) presented with Killip class I (class IV in 4%). Anterior‐located STEMI occurred in 56% of cases, and posterior‐inferior in 40% of cases. Significant Q waves were present in 43%, right bundle branch block in 7%, left bundle branch block in 5%, first‐degree atrioventricular block in 2%, and high‐degree atrioventricular block in 2%. A total of 1685 (37%) patients received fibrinolytic therapy (streptokinase, 82%; alteplase, 17%; tenecteplase, 1%), with 31% of patients receiving therapy in <2 hours, 36% in 2–4 hours, 19% in 4–6 hours, and 15% in >6 hours. Thirty percent of patients received either percutaneous coronary intervention or coronary artery bypass grafting during hospitalization. Major adverse cardiovascular events were recurrent ischemia (12%), reinfarction (4%), cardiogenic shock (4%), and stroke (1%). The main predictors of 30‐day mortality (10%) in multivariate analysis were age ≥65 years (odds ratio [OR]: 2.47, 95% confidence interval [CI]: 1.94‐3.13), Killip class IV (OR: 10.60, 95% CI: 6.09‐18.40), and cardiogenic shock (OR: 18.76, 95% CI: 10.60‐33.20).
Conclusions
Largely modifiable risk factors and preventable short‐term complications are responsible for most STEMI cases and outcomes in this Mexican population.</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><pmid>23494467</pmid><doi>10.1002/clc.22107</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acute coronary syndromes Adult Age Factors Aged Aged, 80 and over Anterior Wall Myocardial Infarction - diagnosis Anterior Wall Myocardial Infarction - mortality Anterior Wall Myocardial Infarction - therapy Cardiovascular disease Confidence intervals Coronary Artery Bypass - adverse effects Coronary Artery Bypass - mortality Female Heart attacks Heart Block - mortality Heart Block - therapy Hospital Mortality Hospitalization Humans Inferior Wall Myocardial Infarction - diagnosis Inferior Wall Myocardial Infarction - mortality Inferior Wall Myocardial Infarction - therapy Logistic Models Male Mexico - epidemiology Middle Aged Mortality Multivariate Analysis Odds Ratio Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - mortality Quality and Outcomes Recurrence Registries Risk Factors Shock, Cardiogenic - mortality Shock, Cardiogenic - therapy Stroke - mortality Stroke - therapy Thrombolytic Therapy - adverse effects Thrombolytic Therapy - mortality Time Factors Treatment Outcome Young Adult |
title | Risk Factors, Therapeutic Approaches, and In‐Hospital Outcomes in Mexicans With ST‐Elevation Acute Myocardial Infarction: The RENASICA II Multicenter Registry |
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