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Subplate pioneers and the formation of descending connections from cerebral cortex
The adult cerebral cortex extends axons to a variety of subcortical targets, including the thalamus and superior colliculus. These descending projections are pioneered during development by the axons of a transient population of subplate neurons (McConnell et al., 1989). We show here that the descen...
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| Published in: | The Journal of neuroscience 1994-04, Vol.14 (4), p.1892-1907 |
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| Language: | English |
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| container_end_page | 1907 |
| container_issue | 4 |
| container_start_page | 1892 |
| container_title | The Journal of neuroscience |
| container_volume | 14 |
| creator | McConnell, SK Ghosh, A Shatz, CJ |
| description | The adult cerebral cortex extends axons to a variety of subcortical targets, including the thalamus and superior colliculus. These descending projections are pioneered during development by the axons of a transient population of subplate neurons (McConnell et al., 1989). We show here that the descending axons of cortical plate neurons appear to be delayed significantly in their outgrowth, compared with those of subplate neurons. To assess the possible role of subplate neurons in the formation of these pathways, subplate neurons were ablated during the embryonic period. In all cases, an axon pathway formed from visual cortex through the internal capsule and into the thalamus. In half of all cases, however, cortical axons failed to invade their normal subcortical targets. In the other half, targets were innervated normally. Subplate neurons are therefore likely to provide important cues that aid the process by which cortical axons grow toward, select, and invade their subcortical targets. |
| doi_str_mv | 10.1523/jneurosci.14-04-01892.1994 |
| format | article |
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These descending projections are pioneered during development by the axons of a transient population of subplate neurons (McConnell et al., 1989). We show here that the descending axons of cortical plate neurons appear to be delayed significantly in their outgrowth, compared with those of subplate neurons. To assess the possible role of subplate neurons in the formation of these pathways, subplate neurons were ablated during the embryonic period. In all cases, an axon pathway formed from visual cortex through the internal capsule and into the thalamus. In half of all cases, however, cortical axons failed to invade their normal subcortical targets. In the other half, targets were innervated normally. 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These descending projections are pioneered during development by the axons of a transient population of subplate neurons (McConnell et al., 1989). We show here that the descending axons of cortical plate neurons appear to be delayed significantly in their outgrowth, compared with those of subplate neurons. To assess the possible role of subplate neurons in the formation of these pathways, subplate neurons were ablated during the embryonic period. In all cases, an axon pathway formed from visual cortex through the internal capsule and into the thalamus. In half of all cases, however, cortical axons failed to invade their normal subcortical targets. In the other half, targets were innervated normally. Subplate neurons are therefore likely to provide important cues that aid the process by which cortical axons grow toward, select, and invade their subcortical targets.</description><subject>Afferent Pathways - anatomy & histology</subject><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Axonal Transport</subject><subject>Axons - physiology</subject><subject>Axons - ultrastructure</subject><subject>Carbocyanines</subject><subject>Cats</subject><subject>Cerebral Cortex - anatomy & histology</subject><subject>Cerebral Cortex - physiology</subject><subject>Efferent Pathways - anatomy & histology</subject><subject>Efferent Pathways - physiology</subject><subject>Fetus</subject><subject>Fluorescent Dyes</subject><subject>Mammalia</subject><subject>Models, Neurological</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Temporal Lobe - anatomy & histology</subject><subject>Temporal Lobe - physiology</subject><subject>Thalamus - anatomy & histology</subject><subject>Thalamus - physiology</subject><subject>Visual Cortex - anatomy & histology</subject><subject>Visual Cortex - physiology</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqFkV9rFDEUxYModa1-BCH44NusuTOZzI4PgixtrZQWWvsc8udmN2VmsiYzrv32zdil6lPhQiDn3B_ncgj5AGwJdVl9uhtwiiEZvwResDywassltC1_QRbZ0RYlZ_CSLFjZsELwhr8mb1K6Y4w1DJojctTUUIoKFuT6ZtK7To1Idz4MiDFRNVg6bpG6EHs15l8aHLWYDA7WDxtqwjCgmYVEXQw9NRhRR9VlJY74-y155VSX8N3hPSa3pyc_1t-Ki6uz8_XXi8IIJsYCXQktGmGZUAKgAiFqzZWumUGNBphC6wCrlVMKQRttXKldK1bC2srqpjomXx65u0n3aHO8MYeQu-h7Fe9lUF7-rwx-KzfhlxR100AJGfDxAIjh54RplL3PV3adGjBMSTaCVy20zxuhFsDFH-PnR6PJ9aSI7ikNMDlXJ79fntxeX92szyVwyfLM1cm5urz8_t97nlYPXf1NsfWb7d5HlKlXXZfdIPf7feZxOdOqB_ZUqH0</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>McConnell, SK</creator><creator>Ghosh, A</creator><creator>Shatz, CJ</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940401</creationdate><title>Subplate pioneers and the formation of descending connections from cerebral cortex</title><author>McConnell, SK ; Ghosh, A ; Shatz, CJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-ef219ec6d06a61131665b4ab50cebec10aedf1e38faae1bcbcf2bf9686dd3db73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Afferent Pathways - anatomy & histology</topic><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Axonal Transport</topic><topic>Axons - physiology</topic><topic>Axons - ultrastructure</topic><topic>Carbocyanines</topic><topic>Cats</topic><topic>Cerebral Cortex - anatomy & histology</topic><topic>Cerebral Cortex - physiology</topic><topic>Efferent Pathways - anatomy & histology</topic><topic>Efferent Pathways - physiology</topic><topic>Fetus</topic><topic>Fluorescent Dyes</topic><topic>Mammalia</topic><topic>Models, Neurological</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Temporal Lobe - anatomy & histology</topic><topic>Temporal Lobe - physiology</topic><topic>Thalamus - anatomy & histology</topic><topic>Thalamus - physiology</topic><topic>Visual Cortex - anatomy & histology</topic><topic>Visual Cortex - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McConnell, SK</creatorcontrib><creatorcontrib>Ghosh, A</creatorcontrib><creatorcontrib>Shatz, CJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McConnell, SK</au><au>Ghosh, A</au><au>Shatz, CJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subplate pioneers and the formation of descending connections from cerebral cortex</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>14</volume><issue>4</issue><spage>1892</spage><epage>1907</epage><pages>1892-1907</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The adult cerebral cortex extends axons to a variety of subcortical targets, including the thalamus and superior colliculus. These descending projections are pioneered during development by the axons of a transient population of subplate neurons (McConnell et al., 1989). We show here that the descending axons of cortical plate neurons appear to be delayed significantly in their outgrowth, compared with those of subplate neurons. To assess the possible role of subplate neurons in the formation of these pathways, subplate neurons were ablated during the embryonic period. In all cases, an axon pathway formed from visual cortex through the internal capsule and into the thalamus. In half of all cases, however, cortical axons failed to invade their normal subcortical targets. In the other half, targets were innervated normally. Subplate neurons are therefore likely to provide important cues that aid the process by which cortical axons grow toward, select, and invade their subcortical targets.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>7512631</pmid><doi>10.1523/jneurosci.14-04-01892.1994</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of neuroscience, 1994-04, Vol.14 (4), p.1892-1907 |
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| language | eng |
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| source | PubMed Central |
| subjects | Afferent Pathways - anatomy & histology Afferent Pathways - physiology Animals Animals, Newborn Axonal Transport Axons - physiology Axons - ultrastructure Carbocyanines Cats Cerebral Cortex - anatomy & histology Cerebral Cortex - physiology Efferent Pathways - anatomy & histology Efferent Pathways - physiology Fetus Fluorescent Dyes Mammalia Models, Neurological Neurons - cytology Neurons - physiology Temporal Lobe - anatomy & histology Temporal Lobe - physiology Thalamus - anatomy & histology Thalamus - physiology Visual Cortex - anatomy & histology Visual Cortex - physiology |
| title | Subplate pioneers and the formation of descending connections from cerebral cortex |
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