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The hot patient: acute drug-induced hyperthermia
Drugs can cause dysregulation of the hypothalamic–pituitary–adrenal axis which can result in a rise in core temperature. This type of hyperthermia is unresponsive to antipyretics and can be complicated by rhabdomyolysis, multi-organ failure and disseminated intravascular coagulation. Organic causes...
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Published in: | Australian prescriber 2019-02, Vol.42 (1), p.24-28 |
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container_title | Australian prescriber |
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description | Drugs can cause dysregulation of the hypothalamic–pituitary–adrenal axis which can result in a rise in core temperature. This type of hyperthermia is unresponsive to antipyretics and can be complicated by rhabdomyolysis, multi-organ failure and disseminated intravascular coagulation. Organic causes of fever such as infection must be ruled out. Syndromes associated with drug-induced fever include neuroleptic malignant syndrome and anticholinergic, sympathomimetic and serotonin toxicity. The class of offending drugs, as well as the temporal relationship to starting or stopping them, assists in differentiating between neuroleptic malignant syndrome and serotonin toxicity. Immediate inpatient management is needed. The mainstay of management is stopping the drug, and supportive care often in the intensive care unit. |
doi_str_mv | 10.18773/austprescr.2019.006 |
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This type of hyperthermia is unresponsive to antipyretics and can be complicated by rhabdomyolysis, multi-organ failure and disseminated intravascular coagulation. Organic causes of fever such as infection must be ruled out. Syndromes associated with drug-induced fever include neuroleptic malignant syndrome and anticholinergic, sympathomimetic and serotonin toxicity. The class of offending drugs, as well as the temporal relationship to starting or stopping them, assists in differentiating between neuroleptic malignant syndrome and serotonin toxicity. Immediate inpatient management is needed. 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This type of hyperthermia is unresponsive to antipyretics and can be complicated by rhabdomyolysis, multi-organ failure and disseminated intravascular coagulation. Organic causes of fever such as infection must be ruled out. Syndromes associated with drug-induced fever include neuroleptic malignant syndrome and anticholinergic, sympathomimetic and serotonin toxicity. The class of offending drugs, as well as the temporal relationship to starting or stopping them, assists in differentiating between neuroleptic malignant syndrome and serotonin toxicity. Immediate inpatient management is needed. The mainstay of management is stopping the drug, and supportive care often in the intensive care unit.</description><subject>Acidosis</subject><subject>Amphetamines</subject><subject>Blood pressure</subject><subject>Cardiac arrhythmia</subject><subject>Catatonia</subject><subject>Coma</subject><subject>Delirium</subject><subject>Dopamine</subject><subject>Drug withdrawal</subject><subject>Drugs</subject><subject>Ecstasy</subject><subject>Electrolytes</subject><subject>Fever</subject><subject>Heat</subject><subject>Hyperkalemia</subject><subject>Hypertension</subject><subject>Hyperthermia</subject><subject>Metabolism</subject><subject>Methamphetamine</subject><subject>Nervous system</subject><subject>Psychosis</subject><subject>Psychotropic drugs</subject><subject>Rhabdomyolysis</subject><subject>Serotonin</subject><subject>Tetanus</subject><issn>0312-8008</issn><issn>1839-3942</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkE1Lw0AQhhdRbK3-A5GA59TZTHaz8SBI8QsKXnoP-zFpUtokbjZC_30jVtHTwDsvzzwMY9cc5lxlGd7poQ-dp976eQI8nwPIEzblCvMY8zQ5ZVNAnsQKQE3YRd9vABIQQp6zCUImRQ5yymBVUVS1Iep0qKkJ95G2Q6DI-WEd140bLLmo2nfkQ0V-V-tLdlbqbU9Xxzljq-en1eI1Xr6_vC0el7FNUYY4E3lJwpWcslQRJiYnME6UtuSpRQCr3ZjmyK2hzDgiJ0ggOsNNSirBGXv4xnaD2ZGzo5rX26Lz9U77fdHquvi_aeqqWLefhcQMJMcRcHsE-PZjoD4Um3bwzahcJFJxDgj41br5e-aX__MgPAAlLWvy</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Jamshidi, Nazila</creator><creator>Dawson, Andrew</creator><general>Therapeutic Guidelines Limited</general><general>NPS MedicineWise</general><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>201902</creationdate><title>The hot patient: acute drug-induced hyperthermia</title><author>Jamshidi, Nazila ; 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This type of hyperthermia is unresponsive to antipyretics and can be complicated by rhabdomyolysis, multi-organ failure and disseminated intravascular coagulation. Organic causes of fever such as infection must be ruled out. Syndromes associated with drug-induced fever include neuroleptic malignant syndrome and anticholinergic, sympathomimetic and serotonin toxicity. The class of offending drugs, as well as the temporal relationship to starting or stopping them, assists in differentiating between neuroleptic malignant syndrome and serotonin toxicity. Immediate inpatient management is needed. The mainstay of management is stopping the drug, and supportive care often in the intensive care unit.</abstract><cop>Australia</cop><pub>Therapeutic Guidelines Limited</pub><pmid>30765906</pmid><doi>10.18773/austprescr.2019.006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acidosis Amphetamines Blood pressure Cardiac arrhythmia Catatonia Coma Delirium Dopamine Drug withdrawal Drugs Ecstasy Electrolytes Fever Heat Hyperkalemia Hypertension Hyperthermia Metabolism Methamphetamine Nervous system Psychosis Psychotropic drugs Rhabdomyolysis Serotonin Tetanus |
title | The hot patient: acute drug-induced hyperthermia |
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