Loading…
Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas
Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients af...
Saved in:
Published in: | Oncotarget 2018-12, Vol.9 (99), p.37291-37304 |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03 |
---|---|
cites | cdi_FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03 |
container_end_page | 37304 |
container_issue | 99 |
container_start_page | 37291 |
container_title | Oncotarget |
container_volume | 9 |
creator | Soares, Ciro Melo de Lima Morais, Thayná Carlos, Roman Mariano, Fernanda Viviane Altemani, Albina Freire de Carvalho, Maria Goretti Corrêa, Marcelo Brum Dias Dos Reis, Rodrigo Ribas Amorim, Luciana Schultz Paes de Almeida, Oslei Jorge, Jacks |
description | Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (
< .0001), oral (
< .0001), and sinonasal (
= .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (
= .041) and sinonasal (
< .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas. |
doi_str_mv | 10.18632/oncotarget.26458 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6324666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179378626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03</originalsourceid><addsrcrecordid>eNpVUctOHDEQtKKggIAPyAX5yCEL49fM-IKEEHlISOFAzlaP17trmHFP3LPA_n2cXSDEF3erqqvLLsY-i-pMtLWS55g8TpCXYTqTtTbtB3YgrLYzaYz6-K7eZ8dE91U5RjettJ_YvqrqUjbVAXu4XSGNK8ybHqYw55cPk-DhecyBKGLikTgQoY9b9ClOKz4iZj5mXCakAsfE_XqCFHBNXzhm6DmkOaeYMAGVbgg9JByAjtjeAnoKxy_3Ifv19fru6vvs5ue3H1eXNzOvhG5nyne1sLKzRiplwRTL2ggQnQ-dbEBKIby30JgKBOhOtnbhO21M02mrTKjUIbvY6Y7rbghzH9JUXLkxxwHyxiFE9z-S4sot8dGVX9V1XReB0xeBjL_XgSY3RPKh73evdFI0VjVtLf9SxY7qMxLlsHhbIyq3zcn9y8ltcyozJ-_9vU28pqL-AHEik-8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179378626</pqid></control><display><type>article</type><title>Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas</title><source>PubMed Central</source><creator>Soares, Ciro ; Melo de Lima Morais, Thayná ; Carlos, Roman ; Mariano, Fernanda Viviane ; Altemani, Albina ; Freire de Carvalho, Maria Goretti ; Corrêa, Marcelo Brum ; Dias Dos Reis, Rodrigo Ribas ; Amorim, Luciana Schultz ; Paes de Almeida, Oslei ; Jorge, Jacks</creator><creatorcontrib>Soares, Ciro ; Melo de Lima Morais, Thayná ; Carlos, Roman ; Mariano, Fernanda Viviane ; Altemani, Albina ; Freire de Carvalho, Maria Goretti ; Corrêa, Marcelo Brum ; Dias Dos Reis, Rodrigo Ribas ; Amorim, Luciana Schultz ; Paes de Almeida, Oslei ; Jorge, Jacks</creatorcontrib><description>Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (
< .0001), oral (
< .0001), and sinonasal (
= .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (
= .041) and sinonasal (
< .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.26458</identifier><identifier>PMID: 30647870</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Research Paper</subject><ispartof>Oncotarget, 2018-12, Vol.9 (99), p.37291-37304</ispartof><rights>Copyright: © 2018 Soares et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03</citedby><cites>FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30647870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soares, Ciro</creatorcontrib><creatorcontrib>Melo de Lima Morais, Thayná</creatorcontrib><creatorcontrib>Carlos, Roman</creatorcontrib><creatorcontrib>Mariano, Fernanda Viviane</creatorcontrib><creatorcontrib>Altemani, Albina</creatorcontrib><creatorcontrib>Freire de Carvalho, Maria Goretti</creatorcontrib><creatorcontrib>Corrêa, Marcelo Brum</creatorcontrib><creatorcontrib>Dias Dos Reis, Rodrigo Ribas</creatorcontrib><creatorcontrib>Amorim, Luciana Schultz</creatorcontrib><creatorcontrib>Paes de Almeida, Oslei</creatorcontrib><creatorcontrib>Jorge, Jacks</creatorcontrib><title>Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (
< .0001), oral (
< .0001), and sinonasal (
= .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (
= .041) and sinonasal (
< .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.</description><subject>Research Paper</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpVUctOHDEQtKKggIAPyAX5yCEL49fM-IKEEHlISOFAzlaP17trmHFP3LPA_n2cXSDEF3erqqvLLsY-i-pMtLWS55g8TpCXYTqTtTbtB3YgrLYzaYz6-K7eZ8dE91U5RjettJ_YvqrqUjbVAXu4XSGNK8ybHqYw55cPk-DhecyBKGLikTgQoY9b9ClOKz4iZj5mXCakAsfE_XqCFHBNXzhm6DmkOaeYMAGVbgg9JByAjtjeAnoKxy_3Ifv19fru6vvs5ue3H1eXNzOvhG5nyne1sLKzRiplwRTL2ggQnQ-dbEBKIby30JgKBOhOtnbhO21M02mrTKjUIbvY6Y7rbghzH9JUXLkxxwHyxiFE9z-S4sot8dGVX9V1XReB0xeBjL_XgSY3RPKh73evdFI0VjVtLf9SxY7qMxLlsHhbIyq3zcn9y8ltcyozJ-_9vU28pqL-AHEik-8</recordid><startdate>20181218</startdate><enddate>20181218</enddate><creator>Soares, Ciro</creator><creator>Melo de Lima Morais, Thayná</creator><creator>Carlos, Roman</creator><creator>Mariano, Fernanda Viviane</creator><creator>Altemani, Albina</creator><creator>Freire de Carvalho, Maria Goretti</creator><creator>Corrêa, Marcelo Brum</creator><creator>Dias Dos Reis, Rodrigo Ribas</creator><creator>Amorim, Luciana Schultz</creator><creator>Paes de Almeida, Oslei</creator><creator>Jorge, Jacks</creator><general>Impact Journals LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181218</creationdate><title>Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas</title><author>Soares, Ciro ; Melo de Lima Morais, Thayná ; Carlos, Roman ; Mariano, Fernanda Viviane ; Altemani, Albina ; Freire de Carvalho, Maria Goretti ; Corrêa, Marcelo Brum ; Dias Dos Reis, Rodrigo Ribas ; Amorim, Luciana Schultz ; Paes de Almeida, Oslei ; Jorge, Jacks</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Research Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Soares, Ciro</creatorcontrib><creatorcontrib>Melo de Lima Morais, Thayná</creatorcontrib><creatorcontrib>Carlos, Roman</creatorcontrib><creatorcontrib>Mariano, Fernanda Viviane</creatorcontrib><creatorcontrib>Altemani, Albina</creatorcontrib><creatorcontrib>Freire de Carvalho, Maria Goretti</creatorcontrib><creatorcontrib>Corrêa, Marcelo Brum</creatorcontrib><creatorcontrib>Dias Dos Reis, Rodrigo Ribas</creatorcontrib><creatorcontrib>Amorim, Luciana Schultz</creatorcontrib><creatorcontrib>Paes de Almeida, Oslei</creatorcontrib><creatorcontrib>Jorge, Jacks</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soares, Ciro</au><au>Melo de Lima Morais, Thayná</au><au>Carlos, Roman</au><au>Mariano, Fernanda Viviane</au><au>Altemani, Albina</au><au>Freire de Carvalho, Maria Goretti</au><au>Corrêa, Marcelo Brum</au><au>Dias Dos Reis, Rodrigo Ribas</au><au>Amorim, Luciana Schultz</au><au>Paes de Almeida, Oslei</au><au>Jorge, Jacks</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2018-12-18</date><risdate>2018</risdate><volume>9</volume><issue>99</issue><spage>37291</spage><epage>37304</epage><pages>37291-37304</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (
< .0001), oral (
< .0001), and sinonasal (
= .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (
= .041) and sinonasal (
< .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>30647870</pmid><doi>10.18632/oncotarget.26458</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1949-2553 |
ispartof | Oncotarget, 2018-12, Vol.9 (99), p.37291-37304 |
issn | 1949-2553 1949-2553 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6324666 |
source | PubMed Central |
subjects | Research Paper |
title | Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T18%3A33%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phosphorylated%20Akt1%20expression%20is%20associated%20with%20poor%20prognosis%20in%20cutaneous,%20oral%20and%20sinonasal%20melanomas&rft.jtitle=Oncotarget&rft.au=Soares,%20Ciro&rft.date=2018-12-18&rft.volume=9&rft.issue=99&rft.spage=37291&rft.epage=37304&rft.pages=37291-37304&rft.issn=1949-2553&rft.eissn=1949-2553&rft_id=info:doi/10.18632/oncotarget.26458&rft_dat=%3Cproquest_pubme%3E2179378626%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3148-3cb6192b952339a5829451a1bceb27a2211cc9a750a1a4b289fcb4557b4935e03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2179378626&rft_id=info:pmid/30647870&rfr_iscdi=true |