Transcriptional Regulation in Prostate Cancer

Prostate cancer development involves corruption of the normal prostate transcriptional network, following deregulated expression or mutation of key transcription factors. Here, we provide an overview of the transcription factors that are important in normal prostate homeostasis (NKX3-1, p63, androge...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2018-11, Vol.8 (11), p.a030437
Main Authors: Labbé, David P, Brown, Myles
Format: Article
Language:English
Subjects:
Androgens - genetics
Genes, Neoplasm - genetics
Hepatocyte Nuclear Factor 3-alpha - genetics
Humans
Male
Prostatic Neoplasms - genetics
Prostatic Neoplasms, Castration-Resistant - genetics
Proto-Oncogene Proteins c-myc - genetics
Receptors, Androgen - genetics
Signal Transduction - genetics
Transcription, Genetic - genetics
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Summary:Prostate cancer development involves corruption of the normal prostate transcriptional network, following deregulated expression or mutation of key transcription factors. Here, we provide an overview of the transcription factors that are important in normal prostate homeostasis (NKX3-1, p63, androgen receptor [AR]), primary prostate cancer (ETS family members, c-MYC), castration-resistant prostate cancer (AR, FOXA1), and AR-independent castration-resistant neuroendocrine prostate cancer (RB1, p53, N-MYC). We use functional (in vitro and in vivo) as well as clinical data to discuss evidence that unveils their roles in the initiation and progression of prostate cancer, with an emphasis on results of chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq).
ISSN:2157-1422
2157-1422
2472-5412
DOI:10.1101/cshperspect.a030437