The Effect of Everolimus on Refractory Hypoglycemia in a Patient with Inoperable Metastatic Insulinoma Evaluated by Continuous Glucose Monitoring

An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated....

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Bibliographic Details
Published in:Internal Medicine 2018/09/01, Vol.57(17), pp.2527-2531
Main Authors: Yanagiya, Shingo, Cho, Kyu Yong, Nakamura, Akinobu, Nomoto, Hiroshi, Kawamoto, Yasuyuki, Kawakubo, Kazumichi, Komatsu, Yoshito, Mitsuhashi, Tomoko, Miyoshi, Hideaki, Atsumi, Tatsuya
Format: Article
Language:English
Subjects:
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Blood Glucose - drug effects
Blood Glucose Self-Monitoring
Case Report
continuous glucose monitoring
everolimus
Everolimus - therapeutic use
Female
Glucose
Glucose monitoring
Hematologic Tests
Humans
Hypoglycemia
Hypoglycemia - drug therapy
Insulinoma
Insulinoma - drug therapy
Insulinoma - pathology
Internal medicine
Metastases
Metastasis
Neoplasm Metastasis
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - pathology
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Description
Summary:An 84-year-old Japanese woman with metastatic insulinoma suffered from frequent hypoglycemic events. Continuous glucose monitoring (CGM) confirmed severe and frequent symptomatic/asymptomatic hypoglycemia. After the initiation of everolimus treatment, the hypoglycemic events were rapidly eliminated. CGM revealed that her blood glucose levels were maintained without hypoglycemia throughout the day. Furthermore, everolimus reduced the duration of time above the upper limit (>180 mg/dL) along with the standard deviation and mean amplitude of glycemic excursions. This case shows the potential effects of everolimus on hypoglycemia and glycemic control in a patient with inoperable metastatic insulinoma evaluated by CGM.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0126-17