Candidate gene analysis in pathogenesis of surgically and non-surgically treated necrotizing enterocolitis in preterm infants

Necrotizing enterocolitis (NEC) is one of the most severe and unpredictable complications of prematurity. There are two possible mechanisms involved in the pathogenesis of NEC: individual inflammatory response and impaired blood flow in mesenteric vessels with secondary ischemia of the intestine. Th...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2018-02, Vol.439 (1-2), p.53-63
Main Authors: Szpecht, Dawid, Neumann-Klimasińska, Natalia, Błaszczyński, Michał, Seremak-Mrozikiewicz, Agnieszka, Kurzawińska, Grażyna, Cygan, Dorothy, Szymankiewicz, Marta, Drews, Krzysztof, Gadzinowski, Janusz
Format: Article
Language:English
Subjects:
Abnormalities
Alleles
Arteries
Biochemistry
Biomedical and Life Sciences
Blood flow
Blood vessels
Cardiology
Children
Complications
Enterocolitis
Enterocolitis, Necrotizing - epidemiology
Enterocolitis, Necrotizing - genetics
Enterocolitis, Necrotizing - surgery
Female
Gastrointestinal diseases
Gene flow
Gene polymorphism
Genes
Genetic polymorphisms
Genotypes
Gestation
Humans
Infant, Newborn
Infant, Newborn, Diseases - epidemiology
Infant, Newborn, Diseases - genetics
Infant, Newborn, Diseases - surgery
Infant, Premature
Infants
Inflammation
Inflammatory response
Interleukin 1
Interleukin 1 receptor antagonist
Interleukin 1 receptors
Interleukin 6
Interleukins
Intestine
Ischemia
Life Sciences
Male
Medical Biochemistry
Necrosis
Necrotizing enterocolitis
Neonates
Oncology
Pathogenesis
Polymorphism
Polymorphism, Genetic
Population (statistical)
Population studies
Pregnancy complications
Premature babies
Premature infants
Prevalence
Statistical analysis
Steroid hormones
Steroids
Surgery
Tumor necrosis factor
Tumor necrosis factor-α
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Summary:Necrotizing enterocolitis (NEC) is one of the most severe and unpredictable complications of prematurity. There are two possible mechanisms involved in the pathogenesis of NEC: individual inflammatory response and impaired blood flow in mesenteric vessels with secondary ischemia of the intestine. The aim of this study was to evaluate the possible relationship between polymorphisms: Il-1β 3953C > T , Il-6 − 174G > C and − 596G > A , TNFα − 308G > A , and 86 bp variable number tandem repeat polymorphism of interleukin-1 receptor antagonist ( Il-1RN VNTR 86 bp ) and three polymorphisms that may participate in arteries tension regulation and in consequence in intestine blood flow impairment: eNOS ( 894G > T and − 786T > C ) and END-1 ( 5665G > T ) and NEC in 100 infants born from singleton pregnancy, before 32 + 0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities. In study population, 22 (22%) newborns developed NEC. Surgery-requiring NEC was present in 7 children. Statistical analysis showed 20-fold higher prevalence of NEC in infants with the genotype TT [OR 20 (3.71–208.7); p  = 0.0004] of eNOS 894G > T gene polymorphism. There was a higher prevalence of allele C carriers of eNOS 786T > C in patients with surgery-requiring NEC [OR 4.881 (1.33–21.99); p  = 0.013]. Our investigation did not confirm any significant prevalence for NEC development in another studied genotypes/alleles. This study confirms the significant role of polymorphisms that play role in intestine blood flow. Identifying gene variants that increase the risk for NEC development may be useful in screening infants with inherent vulnerability and creating strategies for individualized care.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-017-3135-5