Relationships between hydration biomarkers and total fluid intake in pregnant and lactating women

Introduction Previous research established significant relationships between total fluid intake (TFI) and urinary biomarkers of the hydration process in free-living males and females; however, the nature of this relationship is not known for pregnant (PREG) and lactating (LACT) women. Purpose To det...

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Bibliographic Details
Published in:European journal of nutrition 2017-09, Vol.56 (6), p.2161-2170
Main Authors: McKenzie, Amy L., Perrier, Erica T., Guelinckx, Isabelle, Kavouras, Stavros A., Aerni, Giselle, Lee, Elaine C., Volek, Jeff S., Maresh, Carl M., Armstrong, Lawrence E.
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomarkers - urine
Body Mass Index
Breast Feeding
Breastfeeding & lactation
Chemistry
Chemistry and Materials Science
Color
Dehydration - diagnosis
Dehydration - urine
Drinking
Female
Fluid intake
Gestation
Gravity
Hematocrit
Hematology
Humans
Hydration
Lactation
Male
Nutrition
Organism Hydration Status
Original Contribution
Postpartum
Pregnancy
Soy products
Urine
Water-Electrolyte Balance
Womens health
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Summary:Introduction Previous research established significant relationships between total fluid intake (TFI) and urinary biomarkers of the hydration process in free-living males and females; however, the nature of this relationship is not known for pregnant (PREG) and lactating (LACT) women. Purpose To determine the relationship between urinary and hematological hydration biomarkers with TFI in PREG and LACT. Methods Eighteen PREG/LACT (age: 31 ± 3 years, pre-pregnancy BMI: 24.26 ± 5.85 kg m −2 ) collected 24-h urine samples, recorded TFI, and provided a blood sample at 5 time points (15 ± 2, 26 ± 1, 37 ± 1 weeks gestation, 3 ± 1 and 9 ± 1 weeks postpartum during lactation); 18 pair-matched non-pregnant (NP), non-lactating (NL) women (age: 29 ± 4 years, BMI: 24.1 ± 3.7 kg m −2 ) provided samples at similar time intervals. Twenty-four-hour urine volume ( U VOL ), osmolality ( U OSM ), specific gravity ( U SG ), and color ( U COL ) were measured. Hematocrit, serum osmolality ( S OSM ), and serum total protein ( S TP ) were measured in blood. Results Significant relationships were present between TFI and urinary biomarkers in all women ( P   0.05). Conclusion Urinary biomarkers of hydration, but not hematological biomarkers, have a strong relationship with TFI in PREG, LACT, NP, and NL women. These data suggest that urinary biomarkers of hydration reflect TFI during pregnancy and breast-feeding.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-016-1256-3