GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke

BACKGROUND AND PURPOSE—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might im...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2017-05, Vol.48 (5), p.1147-1153
Main Authors: Fernández-Cadenas, Israel, Mendióroz, Maite, Giralt, Dolors, Nafria, Cristina, Garcia, Elena, Carrera, Caty, Gallego-Fabrega, Cristina, Domingues-Montanari, Sophie, Delgado, Pilar, Ribó, Marc, Castellanos, Mar, Martínez, Sergi, Freijo, Marimar, Jiménez-Conde, Jordi, Rubiera, Marta, Alvarez-Sabín, José, Molina, Carlos A, Font, Maria Angels, Grau Olivares, Marta, Palomeras, Ernest, Perez de la Ossa, Natalia, Martinez-Zabaleta, Maite, Masjuan, Jaime, Moniche, Francisco, Canovas, David, Piñana, Carlos, Purroy, Francisco, Cocho, Dolores, Navas, Inma, Tejero, Carlos, Aymerich, Nuria, Cullell, Natalia, Muiño, Elena, Serena, Joaquín, Rubio, Francisco, Davalos, Antoni, Roquer, Jaume, Arenillas, Juan Francisco, Martí-Fábregas, Joan, Keene, Keith, Chen, Wei-Min, Worrall, Bradford, Sale, Michele, Arboix, Adrià, Krupinski, Jerzy, Montaner, Joan
Format: Article
Language:English
Subjects:
Aged
Brain Ischemia - diagnosis
Brain Ischemia - genetics
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - genetics
Cohort Studies
Female
Genotype
Humans
Ischemic Attack, Transient - diagnosis
Ischemic Attack, Transient - genetics
Male
North America
Polymorphism, Single Nucleotide
Prognosis
Recurrence
Risk
Scotland
Spain
Stroke - diagnosis
Stroke - genetics
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c3602-e502e9dcce440b9963faa13e49c4edf69f117c0cbf5288058e51bce6ecf943823
container_end_page 1153
container_issue 5
container_start_page 1147
container_title Stroke (1970)
container_volume 48
creator Fernández-Cadenas, Israel
Mendióroz, Maite
Giralt, Dolors
Nafria, Cristina
Garcia, Elena
Carrera, Caty
Gallego-Fabrega, Cristina
Domingues-Montanari, Sophie
Delgado, Pilar
Ribó, Marc
Castellanos, Mar
Martínez, Sergi
Freijo, Marimar
Jiménez-Conde, Jordi
Rubiera, Marta
Alvarez-Sabín, José
Molina, Carlos A
Font, Maria Angels
Grau Olivares, Marta
Palomeras, Ernest
Perez de la Ossa, Natalia
Martinez-Zabaleta, Maite
Masjuan, Jaime
Moniche, Francisco
Canovas, David
Piñana, Carlos
Purroy, Francisco
Cocho, Dolores
Navas, Inma
Tejero, Carlos
Aymerich, Nuria
Cullell, Natalia
Muiño, Elena
Serena, Joaquín
Rubio, Francisco
Davalos, Antoni
Roquer, Jaume
Arenillas, Juan Francisco
Martí-Fábregas, Joan
Keene, Keith
Chen, Wei-Min
Worrall, Bradford
Sale, Michele
Arboix, Adrià
Krupinski, Jerzy
Montaner, Joan
description BACKGROUND AND PURPOSE—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS—We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. RESULTS—The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). CONCLUSIONS—The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.
doi_str_mv 10.1161/STROKEAHA.116.014322
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5473776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1888683882</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3602-e502e9dcce440b9963faa13e49c4edf69f117c0cbf5288058e51bce6ecf943823</originalsourceid><addsrcrecordid>eNp9kU9vGjEQxa2qVUPSfoOq8jE9bOp_a-weKiFESZRIVEB6tYwZhw3LmtreRsmn71IISi49WeN57zejeQh9ouSCUkm_zubTyfVocDnYlReECs7YG9SjJROFkEy9RT1CuC6Y0PoEnaZ0TwhhXJXv0QlTglImRQ89jaej4WSGf8ZwDy7j8zE0IT9uq-YOT8G1MULjAE-rtMbB41mOYQ1fvuH5CvBtgt1f54BcuYRz6DCwrDpM7tq_bHJtbeNLzsBniAfKB_TO2zrBx8N7hm5_jObDy-JmMr4aDm4KxyVhBZSEgV46B0KQhdaSe2spB6GdgKWX2lPad8QtfMmUIqWCki4cSHBeC64YP0Pf99xtu9jA0kGTo63NNlYbGx9NsJV53WmqlbkLf0wp-rzflx3g_ACI4XcLKZtNlRzUtW0gtMlQpZRUXP2bJfZSF0NKEfxxDCVmF5s5xrYrzT62zvb55YpH03NOnUDtBQ-h7i6Y1nX7ANGswNZ59X_2X6Unp5w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1888683882</pqid></control><display><type>article</type><title>GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke</title><source>Alma/SFX Local Collection</source><creator>Fernández-Cadenas, Israel ; Mendióroz, Maite ; Giralt, Dolors ; Nafria, Cristina ; Garcia, Elena ; Carrera, Caty ; Gallego-Fabrega, Cristina ; Domingues-Montanari, Sophie ; Delgado, Pilar ; Ribó, Marc ; Castellanos, Mar ; Martínez, Sergi ; Freijo, Marimar ; Jiménez-Conde, Jordi ; Rubiera, Marta ; Alvarez-Sabín, José ; Molina, Carlos A ; Font, Maria Angels ; Grau Olivares, Marta ; Palomeras, Ernest ; Perez de la Ossa, Natalia ; Martinez-Zabaleta, Maite ; Masjuan, Jaime ; Moniche, Francisco ; Canovas, David ; Piñana, Carlos ; Purroy, Francisco ; Cocho, Dolores ; Navas, Inma ; Tejero, Carlos ; Aymerich, Nuria ; Cullell, Natalia ; Muiño, Elena ; Serena, Joaquín ; Rubio, Francisco ; Davalos, Antoni ; Roquer, Jaume ; Arenillas, Juan Francisco ; Martí-Fábregas, Joan ; Keene, Keith ; Chen, Wei-Min ; Worrall, Bradford ; Sale, Michele ; Arboix, Adrià ; Krupinski, Jerzy ; Montaner, Joan</creator><creatorcontrib>Fernández-Cadenas, Israel ; Mendióroz, Maite ; Giralt, Dolors ; Nafria, Cristina ; Garcia, Elena ; Carrera, Caty ; Gallego-Fabrega, Cristina ; Domingues-Montanari, Sophie ; Delgado, Pilar ; Ribó, Marc ; Castellanos, Mar ; Martínez, Sergi ; Freijo, Marimar ; Jiménez-Conde, Jordi ; Rubiera, Marta ; Alvarez-Sabín, José ; Molina, Carlos A ; Font, Maria Angels ; Grau Olivares, Marta ; Palomeras, Ernest ; Perez de la Ossa, Natalia ; Martinez-Zabaleta, Maite ; Masjuan, Jaime ; Moniche, Francisco ; Canovas, David ; Piñana, Carlos ; Purroy, Francisco ; Cocho, Dolores ; Navas, Inma ; Tejero, Carlos ; Aymerich, Nuria ; Cullell, Natalia ; Muiño, Elena ; Serena, Joaquín ; Rubio, Francisco ; Davalos, Antoni ; Roquer, Jaume ; Arenillas, Juan Francisco ; Martí-Fábregas, Joan ; Keene, Keith ; Chen, Wei-Min ; Worrall, Bradford ; Sale, Michele ; Arboix, Adrià ; Krupinski, Jerzy ; Montaner, Joan ; GRECOS Study Group</creatorcontrib><description>BACKGROUND AND PURPOSE—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS—We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. RESULTS—The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). CONCLUSIONS—The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.116.014322</identifier><identifier>PMID: 28411264</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Aged ; Brain Ischemia - diagnosis ; Brain Ischemia - genetics ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - genetics ; Cohort Studies ; Female ; Genotype ; Humans ; Ischemic Attack, Transient - diagnosis ; Ischemic Attack, Transient - genetics ; Male ; North America ; Polymorphism, Single Nucleotide ; Prognosis ; Recurrence ; Risk ; Scotland ; Spain ; Stroke - diagnosis ; Stroke - genetics</subject><ispartof>Stroke (1970), 2017-05, Vol.48 (5), p.1147-1153</ispartof><rights>2017 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3602-e502e9dcce440b9963faa13e49c4edf69f117c0cbf5288058e51bce6ecf943823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28411264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Cadenas, Israel</creatorcontrib><creatorcontrib>Mendióroz, Maite</creatorcontrib><creatorcontrib>Giralt, Dolors</creatorcontrib><creatorcontrib>Nafria, Cristina</creatorcontrib><creatorcontrib>Garcia, Elena</creatorcontrib><creatorcontrib>Carrera, Caty</creatorcontrib><creatorcontrib>Gallego-Fabrega, Cristina</creatorcontrib><creatorcontrib>Domingues-Montanari, Sophie</creatorcontrib><creatorcontrib>Delgado, Pilar</creatorcontrib><creatorcontrib>Ribó, Marc</creatorcontrib><creatorcontrib>Castellanos, Mar</creatorcontrib><creatorcontrib>Martínez, Sergi</creatorcontrib><creatorcontrib>Freijo, Marimar</creatorcontrib><creatorcontrib>Jiménez-Conde, Jordi</creatorcontrib><creatorcontrib>Rubiera, Marta</creatorcontrib><creatorcontrib>Alvarez-Sabín, José</creatorcontrib><creatorcontrib>Molina, Carlos A</creatorcontrib><creatorcontrib>Font, Maria Angels</creatorcontrib><creatorcontrib>Grau Olivares, Marta</creatorcontrib><creatorcontrib>Palomeras, Ernest</creatorcontrib><creatorcontrib>Perez de la Ossa, Natalia</creatorcontrib><creatorcontrib>Martinez-Zabaleta, Maite</creatorcontrib><creatorcontrib>Masjuan, Jaime</creatorcontrib><creatorcontrib>Moniche, Francisco</creatorcontrib><creatorcontrib>Canovas, David</creatorcontrib><creatorcontrib>Piñana, Carlos</creatorcontrib><creatorcontrib>Purroy, Francisco</creatorcontrib><creatorcontrib>Cocho, Dolores</creatorcontrib><creatorcontrib>Navas, Inma</creatorcontrib><creatorcontrib>Tejero, Carlos</creatorcontrib><creatorcontrib>Aymerich, Nuria</creatorcontrib><creatorcontrib>Cullell, Natalia</creatorcontrib><creatorcontrib>Muiño, Elena</creatorcontrib><creatorcontrib>Serena, Joaquín</creatorcontrib><creatorcontrib>Rubio, Francisco</creatorcontrib><creatorcontrib>Davalos, Antoni</creatorcontrib><creatorcontrib>Roquer, Jaume</creatorcontrib><creatorcontrib>Arenillas, Juan Francisco</creatorcontrib><creatorcontrib>Martí-Fábregas, Joan</creatorcontrib><creatorcontrib>Keene, Keith</creatorcontrib><creatorcontrib>Chen, Wei-Min</creatorcontrib><creatorcontrib>Worrall, Bradford</creatorcontrib><creatorcontrib>Sale, Michele</creatorcontrib><creatorcontrib>Arboix, Adrià</creatorcontrib><creatorcontrib>Krupinski, Jerzy</creatorcontrib><creatorcontrib>Montaner, Joan</creatorcontrib><creatorcontrib>GRECOS Study Group</creatorcontrib><title>GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS—We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. RESULTS—The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). CONCLUSIONS—The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.</description><subject>Aged</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - genetics</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - diagnosis</subject><subject>Ischemic Attack, Transient - genetics</subject><subject>Male</subject><subject>North America</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Risk</subject><subject>Scotland</subject><subject>Spain</subject><subject>Stroke - diagnosis</subject><subject>Stroke - genetics</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kU9vGjEQxa2qVUPSfoOq8jE9bOp_a-weKiFESZRIVEB6tYwZhw3LmtreRsmn71IISi49WeN57zejeQh9ouSCUkm_zubTyfVocDnYlReECs7YG9SjJROFkEy9RT1CuC6Y0PoEnaZ0TwhhXJXv0QlTglImRQ89jaej4WSGf8ZwDy7j8zE0IT9uq-YOT8G1MULjAE-rtMbB41mOYQ1fvuH5CvBtgt1f54BcuYRz6DCwrDpM7tq_bHJtbeNLzsBniAfKB_TO2zrBx8N7hm5_jObDy-JmMr4aDm4KxyVhBZSEgV46B0KQhdaSe2spB6GdgKWX2lPad8QtfMmUIqWCki4cSHBeC64YP0Pf99xtu9jA0kGTo63NNlYbGx9NsJV53WmqlbkLf0wp-rzflx3g_ACI4XcLKZtNlRzUtW0gtMlQpZRUXP2bJfZSF0NKEfxxDCVmF5s5xrYrzT62zvb55YpH03NOnUDtBQ-h7i6Y1nX7ANGswNZ59X_2X6Unp5w</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Fernández-Cadenas, Israel</creator><creator>Mendióroz, Maite</creator><creator>Giralt, Dolors</creator><creator>Nafria, Cristina</creator><creator>Garcia, Elena</creator><creator>Carrera, Caty</creator><creator>Gallego-Fabrega, Cristina</creator><creator>Domingues-Montanari, Sophie</creator><creator>Delgado, Pilar</creator><creator>Ribó, Marc</creator><creator>Castellanos, Mar</creator><creator>Martínez, Sergi</creator><creator>Freijo, Marimar</creator><creator>Jiménez-Conde, Jordi</creator><creator>Rubiera, Marta</creator><creator>Alvarez-Sabín, José</creator><creator>Molina, Carlos A</creator><creator>Font, Maria Angels</creator><creator>Grau Olivares, Marta</creator><creator>Palomeras, Ernest</creator><creator>Perez de la Ossa, Natalia</creator><creator>Martinez-Zabaleta, Maite</creator><creator>Masjuan, Jaime</creator><creator>Moniche, Francisco</creator><creator>Canovas, David</creator><creator>Piñana, Carlos</creator><creator>Purroy, Francisco</creator><creator>Cocho, Dolores</creator><creator>Navas, Inma</creator><creator>Tejero, Carlos</creator><creator>Aymerich, Nuria</creator><creator>Cullell, Natalia</creator><creator>Muiño, Elena</creator><creator>Serena, Joaquín</creator><creator>Rubio, Francisco</creator><creator>Davalos, Antoni</creator><creator>Roquer, Jaume</creator><creator>Arenillas, Juan Francisco</creator><creator>Martí-Fábregas, Joan</creator><creator>Keene, Keith</creator><creator>Chen, Wei-Min</creator><creator>Worrall, Bradford</creator><creator>Sale, Michele</creator><creator>Arboix, Adrià</creator><creator>Krupinski, Jerzy</creator><creator>Montaner, Joan</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170501</creationdate><title>GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke</title><author>Fernández-Cadenas, Israel ; Mendióroz, Maite ; Giralt, Dolors ; Nafria, Cristina ; Garcia, Elena ; Carrera, Caty ; Gallego-Fabrega, Cristina ; Domingues-Montanari, Sophie ; Delgado, Pilar ; Ribó, Marc ; Castellanos, Mar ; Martínez, Sergi ; Freijo, Marimar ; Jiménez-Conde, Jordi ; Rubiera, Marta ; Alvarez-Sabín, José ; Molina, Carlos A ; Font, Maria Angels ; Grau Olivares, Marta ; Palomeras, Ernest ; Perez de la Ossa, Natalia ; Martinez-Zabaleta, Maite ; Masjuan, Jaime ; Moniche, Francisco ; Canovas, David ; Piñana, Carlos ; Purroy, Francisco ; Cocho, Dolores ; Navas, Inma ; Tejero, Carlos ; Aymerich, Nuria ; Cullell, Natalia ; Muiño, Elena ; Serena, Joaquín ; Rubio, Francisco ; Davalos, Antoni ; Roquer, Jaume ; Arenillas, Juan Francisco ; Martí-Fábregas, Joan ; Keene, Keith ; Chen, Wei-Min ; Worrall, Bradford ; Sale, Michele ; Arboix, Adrià ; Krupinski, Jerzy ; Montaner, Joan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3602-e502e9dcce440b9963faa13e49c4edf69f117c0cbf5288058e51bce6ecf943823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - genetics</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - diagnosis</topic><topic>Ischemic Attack, Transient - genetics</topic><topic>Male</topic><topic>North America</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Risk</topic><topic>Scotland</topic><topic>Spain</topic><topic>Stroke - diagnosis</topic><topic>Stroke - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Cadenas, Israel</creatorcontrib><creatorcontrib>Mendióroz, Maite</creatorcontrib><creatorcontrib>Giralt, Dolors</creatorcontrib><creatorcontrib>Nafria, Cristina</creatorcontrib><creatorcontrib>Garcia, Elena</creatorcontrib><creatorcontrib>Carrera, Caty</creatorcontrib><creatorcontrib>Gallego-Fabrega, Cristina</creatorcontrib><creatorcontrib>Domingues-Montanari, Sophie</creatorcontrib><creatorcontrib>Delgado, Pilar</creatorcontrib><creatorcontrib>Ribó, Marc</creatorcontrib><creatorcontrib>Castellanos, Mar</creatorcontrib><creatorcontrib>Martínez, Sergi</creatorcontrib><creatorcontrib>Freijo, Marimar</creatorcontrib><creatorcontrib>Jiménez-Conde, Jordi</creatorcontrib><creatorcontrib>Rubiera, Marta</creatorcontrib><creatorcontrib>Alvarez-Sabín, José</creatorcontrib><creatorcontrib>Molina, Carlos A</creatorcontrib><creatorcontrib>Font, Maria Angels</creatorcontrib><creatorcontrib>Grau Olivares, Marta</creatorcontrib><creatorcontrib>Palomeras, Ernest</creatorcontrib><creatorcontrib>Perez de la Ossa, Natalia</creatorcontrib><creatorcontrib>Martinez-Zabaleta, Maite</creatorcontrib><creatorcontrib>Masjuan, Jaime</creatorcontrib><creatorcontrib>Moniche, Francisco</creatorcontrib><creatorcontrib>Canovas, David</creatorcontrib><creatorcontrib>Piñana, Carlos</creatorcontrib><creatorcontrib>Purroy, Francisco</creatorcontrib><creatorcontrib>Cocho, Dolores</creatorcontrib><creatorcontrib>Navas, Inma</creatorcontrib><creatorcontrib>Tejero, Carlos</creatorcontrib><creatorcontrib>Aymerich, Nuria</creatorcontrib><creatorcontrib>Cullell, Natalia</creatorcontrib><creatorcontrib>Muiño, Elena</creatorcontrib><creatorcontrib>Serena, Joaquín</creatorcontrib><creatorcontrib>Rubio, Francisco</creatorcontrib><creatorcontrib>Davalos, Antoni</creatorcontrib><creatorcontrib>Roquer, Jaume</creatorcontrib><creatorcontrib>Arenillas, Juan Francisco</creatorcontrib><creatorcontrib>Martí-Fábregas, Joan</creatorcontrib><creatorcontrib>Keene, Keith</creatorcontrib><creatorcontrib>Chen, Wei-Min</creatorcontrib><creatorcontrib>Worrall, Bradford</creatorcontrib><creatorcontrib>Sale, Michele</creatorcontrib><creatorcontrib>Arboix, Adrià</creatorcontrib><creatorcontrib>Krupinski, Jerzy</creatorcontrib><creatorcontrib>Montaner, Joan</creatorcontrib><creatorcontrib>GRECOS Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Cadenas, Israel</au><au>Mendióroz, Maite</au><au>Giralt, Dolors</au><au>Nafria, Cristina</au><au>Garcia, Elena</au><au>Carrera, Caty</au><au>Gallego-Fabrega, Cristina</au><au>Domingues-Montanari, Sophie</au><au>Delgado, Pilar</au><au>Ribó, Marc</au><au>Castellanos, Mar</au><au>Martínez, Sergi</au><au>Freijo, Marimar</au><au>Jiménez-Conde, Jordi</au><au>Rubiera, Marta</au><au>Alvarez-Sabín, José</au><au>Molina, Carlos A</au><au>Font, Maria Angels</au><au>Grau Olivares, Marta</au><au>Palomeras, Ernest</au><au>Perez de la Ossa, Natalia</au><au>Martinez-Zabaleta, Maite</au><au>Masjuan, Jaime</au><au>Moniche, Francisco</au><au>Canovas, David</au><au>Piñana, Carlos</au><au>Purroy, Francisco</au><au>Cocho, Dolores</au><au>Navas, Inma</au><au>Tejero, Carlos</au><au>Aymerich, Nuria</au><au>Cullell, Natalia</au><au>Muiño, Elena</au><au>Serena, Joaquín</au><au>Rubio, Francisco</au><au>Davalos, Antoni</au><au>Roquer, Jaume</au><au>Arenillas, Juan Francisco</au><au>Martí-Fábregas, Joan</au><au>Keene, Keith</au><au>Chen, Wei-Min</au><au>Worrall, Bradford</au><au>Sale, Michele</au><au>Arboix, Adrià</au><au>Krupinski, Jerzy</au><au>Montaner, Joan</au><aucorp>GRECOS Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>48</volume><issue>5</issue><spage>1147</spage><epage>1153</epage><pages>1147-1153</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>These authors contributed equally.</notes><abstract>BACKGROUND AND PURPOSE—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. METHODS—We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. RESULTS—The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). CONCLUSIONS—The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>28411264</pmid><doi>10.1161/STROKEAHA.116.014322</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0039-2499
ispartof Stroke (1970), 2017-05, Vol.48 (5), p.1147-1153
issn 0039-2499
1524-4628
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5473776
source Alma/SFX Local Collection
subjects Aged
Brain Ischemia - diagnosis
Brain Ischemia - genetics
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - genetics
Cohort Studies
Female
Genotype
Humans
Ischemic Attack, Transient - diagnosis
Ischemic Attack, Transient - genetics
Male
North America
Polymorphism, Single Nucleotide
Prognosis
Recurrence
Risk
Scotland
Spain
Stroke - diagnosis
Stroke - genetics
title GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T11%3A38%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GRECOS%20Project%20(Genotyping%20Recurrence%20Risk%20of%20Stroke):%20The%20Use%20of%20Genetics%20to%20Predict%20the%20Vascular%20Recurrence%20After%20Stroke&rft.jtitle=Stroke%20(1970)&rft.au=Fern%C3%A1ndez-Cadenas,%20Israel&rft.aucorp=GRECOS%20Study%20Group&rft.date=2017-05-01&rft.volume=48&rft.issue=5&rft.spage=1147&rft.epage=1153&rft.pages=1147-1153&rft.issn=0039-2499&rft.eissn=1524-4628&rft_id=info:doi/10.1161/STROKEAHA.116.014322&rft_dat=%3Cproquest_pubme%3E1888683882%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3602-e502e9dcce440b9963faa13e49c4edf69f117c0cbf5288058e51bce6ecf943823%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1888683882&rft_id=info:pmid/28411264&rfr_iscdi=true