Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration

Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age-matched controls. Main up-regulated c...

Full description

Saved in:
Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2017-03, Vol.9 (3), p.823-851
Main Authors: Andrés-Benito, Pol, Moreno, Jesús, Aso, Ester, Povedano, Mónica, Ferrer, Isidro
Format: Article
Language:English
Subjects:
Adult
Aged
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - pathology
Female
Frontal Lobe - metabolism
Frontal Lobe - pathology
Frontotemporal Lobar Degeneration - genetics
Frontotemporal Lobar Degeneration - metabolism
Frontotemporal Lobar Degeneration - pathology
Gene Expression Regulation
Humans
Male
Middle Aged
Research Paper
Spinal Cord - metabolism
Spinal Cord - pathology
Transcriptome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3
cites cdi_FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3
container_end_page 851
container_issue 3
container_start_page 823
container_title Aging (Albany, NY.)
container_volume 9
creator Andrés-Benito, Pol
Moreno, Jesús
Aso, Ester
Povedano, Mónica
Ferrer, Isidro
description Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age-matched controls. Main up-regulated clusters in the anterior horn are related to inflammation and apoptosis; down-regulated clusters are linked to axoneme structures and protein synthesis. In contrast, up-regulated gene clusters in frontal cortex area 8 involve neurotransmission, synaptic proteins and vesicle trafficking, whereas main down-regulated genes cluster into oligodendrocyte function and myelin-related proteins. RT-qPCR validates the expression of 58 of 66 assessed genes from different clusters. The present results: a. reveal regional differences in de-regulated gene expression between the anterior horn of the spinal cord and frontal cortex area 8 in the same individuals suffering from sALS; b. validate and extend our knowledge about the complexity of the inflammatory response in the anterior horn of the spinal cord; and c. identify for the first time extensive gene up-regulation of neurotransmission and synaptic-related genes, together with significant down-regulation of oligodendrocyte- and myelin-related genes, as important contributors to the pathogenesis of frontal cortex alterations in the sALS/frontotemporal lobar degeneration spectrum complex at stages with no apparent cognitive impairment.
doi_str_mv 10.18632/aging.101195
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5391234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1876497734</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3</originalsourceid><addsrcrecordid>eNpVkUtv1TAQhS0EoqWwZIu8ZEHaOH6zQKoqHpUqsWnXluNMco0SO9i-iP4g_ie-uaUqK1szn8-Z8UHoLWnPiRK0u7CTD9M5aQnR_Bk6JZrxhnGlnz-5n6BXOf9oW8E5Ey_RSac6RYXkp-jP5XIfS4rrzjs82wLJzji7GVLMPn_AEwTAAySY9rXrY8A-4LIDbENlfUx4F1PAcdyKefWhvncxDRUY8JhiKMdCgd_YJrBYfcR-WWfvNrl80NuwWGBZ48F-jr1N1fTgnTbqNXox2jnDm4fzDN19-Xx79a25-f71-urypnGM09IQCa6F3jk28HZgou7YCa2konbomNK9Ula2VI6Udm4ksrdCWymI7oC0CkZ6hj4dddd9v8DgIJQ6kFmTX2y6N9F6838n-J2Z4i_DqSYdZVXg_YNAij_3kItZfHYwzzZA3GdDlBRMS7mhzRF19atzgvHRhrRmi9Zs0ZpjtJV_93S2R_pflvQvD22lQQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1876497734</pqid></control><display><type>article</type><title>Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration</title><source>PubMed (Medline)</source><creator>Andrés-Benito, Pol ; Moreno, Jesús ; Aso, Ester ; Povedano, Mónica ; Ferrer, Isidro</creator><creatorcontrib>Andrés-Benito, Pol ; Moreno, Jesús ; Aso, Ester ; Povedano, Mónica ; Ferrer, Isidro</creatorcontrib><description>Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age-matched controls. Main up-regulated clusters in the anterior horn are related to inflammation and apoptosis; down-regulated clusters are linked to axoneme structures and protein synthesis. In contrast, up-regulated gene clusters in frontal cortex area 8 involve neurotransmission, synaptic proteins and vesicle trafficking, whereas main down-regulated genes cluster into oligodendrocyte function and myelin-related proteins. RT-qPCR validates the expression of 58 of 66 assessed genes from different clusters. The present results: a. reveal regional differences in de-regulated gene expression between the anterior horn of the spinal cord and frontal cortex area 8 in the same individuals suffering from sALS; b. validate and extend our knowledge about the complexity of the inflammatory response in the anterior horn of the spinal cord; and c. identify for the first time extensive gene up-regulation of neurotransmission and synaptic-related genes, together with significant down-regulation of oligodendrocyte- and myelin-related genes, as important contributors to the pathogenesis of frontal cortex alterations in the sALS/frontotemporal lobar degeneration spectrum complex at stages with no apparent cognitive impairment.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.101195</identifier><identifier>PMID: 28283675</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Adult ; Aged ; Amyotrophic Lateral Sclerosis - genetics ; Amyotrophic Lateral Sclerosis - metabolism ; Amyotrophic Lateral Sclerosis - pathology ; Female ; Frontal Lobe - metabolism ; Frontal Lobe - pathology ; Frontotemporal Lobar Degeneration - genetics ; Frontotemporal Lobar Degeneration - metabolism ; Frontotemporal Lobar Degeneration - pathology ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Research Paper ; Spinal Cord - metabolism ; Spinal Cord - pathology ; Transcriptome</subject><ispartof>Aging (Albany, NY.), 2017-03, Vol.9 (3), p.823-851</ispartof><rights>Copyright: © 2017 Andrés-Benito et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3</citedby><cites>FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391234/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391234/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28283675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrés-Benito, Pol</creatorcontrib><creatorcontrib>Moreno, Jesús</creatorcontrib><creatorcontrib>Aso, Ester</creatorcontrib><creatorcontrib>Povedano, Mónica</creatorcontrib><creatorcontrib>Ferrer, Isidro</creatorcontrib><title>Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age-matched controls. Main up-regulated clusters in the anterior horn are related to inflammation and apoptosis; down-regulated clusters are linked to axoneme structures and protein synthesis. In contrast, up-regulated gene clusters in frontal cortex area 8 involve neurotransmission, synaptic proteins and vesicle trafficking, whereas main down-regulated genes cluster into oligodendrocyte function and myelin-related proteins. RT-qPCR validates the expression of 58 of 66 assessed genes from different clusters. The present results: a. reveal regional differences in de-regulated gene expression between the anterior horn of the spinal cord and frontal cortex area 8 in the same individuals suffering from sALS; b. validate and extend our knowledge about the complexity of the inflammatory response in the anterior horn of the spinal cord; and c. identify for the first time extensive gene up-regulation of neurotransmission and synaptic-related genes, together with significant down-regulation of oligodendrocyte- and myelin-related genes, as important contributors to the pathogenesis of frontal cortex alterations in the sALS/frontotemporal lobar degeneration spectrum complex at stages with no apparent cognitive impairment.</description><subject>Adult</subject><subject>Aged</subject><subject>Amyotrophic Lateral Sclerosis - genetics</subject><subject>Amyotrophic Lateral Sclerosis - metabolism</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Female</subject><subject>Frontal Lobe - metabolism</subject><subject>Frontal Lobe - pathology</subject><subject>Frontotemporal Lobar Degeneration - genetics</subject><subject>Frontotemporal Lobar Degeneration - metabolism</subject><subject>Frontotemporal Lobar Degeneration - pathology</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Research Paper</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - pathology</subject><subject>Transcriptome</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkUtv1TAQhS0EoqWwZIu8ZEHaOH6zQKoqHpUqsWnXluNMco0SO9i-iP4g_ie-uaUqK1szn8-Z8UHoLWnPiRK0u7CTD9M5aQnR_Bk6JZrxhnGlnz-5n6BXOf9oW8E5Ey_RSac6RYXkp-jP5XIfS4rrzjs82wLJzji7GVLMPn_AEwTAAySY9rXrY8A-4LIDbENlfUx4F1PAcdyKefWhvncxDRUY8JhiKMdCgd_YJrBYfcR-WWfvNrl80NuwWGBZ48F-jr1N1fTgnTbqNXox2jnDm4fzDN19-Xx79a25-f71-urypnGM09IQCa6F3jk28HZgou7YCa2konbomNK9Ula2VI6Udm4ksrdCWymI7oC0CkZ6hj4dddd9v8DgIJQ6kFmTX2y6N9F6838n-J2Z4i_DqSYdZVXg_YNAij_3kItZfHYwzzZA3GdDlBRMS7mhzRF19atzgvHRhrRmi9Zs0ZpjtJV_93S2R_pflvQvD22lQQ</recordid><startdate>20170309</startdate><enddate>20170309</enddate><creator>Andrés-Benito, Pol</creator><creator>Moreno, Jesús</creator><creator>Aso, Ester</creator><creator>Povedano, Mónica</creator><creator>Ferrer, Isidro</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170309</creationdate><title>Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration</title><author>Andrés-Benito, Pol ; Moreno, Jesús ; Aso, Ester ; Povedano, Mónica ; Ferrer, Isidro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amyotrophic Lateral Sclerosis - genetics</topic><topic>Amyotrophic Lateral Sclerosis - metabolism</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Female</topic><topic>Frontal Lobe - metabolism</topic><topic>Frontal Lobe - pathology</topic><topic>Frontotemporal Lobar Degeneration - genetics</topic><topic>Frontotemporal Lobar Degeneration - metabolism</topic><topic>Frontotemporal Lobar Degeneration - pathology</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Research Paper</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - pathology</topic><topic>Transcriptome</topic><toplevel>online_resources</toplevel><creatorcontrib>Andrés-Benito, Pol</creatorcontrib><creatorcontrib>Moreno, Jesús</creatorcontrib><creatorcontrib>Aso, Ester</creatorcontrib><creatorcontrib>Povedano, Mónica</creatorcontrib><creatorcontrib>Ferrer, Isidro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrés-Benito, Pol</au><au>Moreno, Jesús</au><au>Aso, Ester</au><au>Povedano, Mónica</au><au>Ferrer, Isidro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2017-03-09</date><risdate>2017</risdate><volume>9</volume><issue>3</issue><spage>823</spage><epage>851</epage><pages>823-851</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age-matched controls. Main up-regulated clusters in the anterior horn are related to inflammation and apoptosis; down-regulated clusters are linked to axoneme structures and protein synthesis. In contrast, up-regulated gene clusters in frontal cortex area 8 involve neurotransmission, synaptic proteins and vesicle trafficking, whereas main down-regulated genes cluster into oligodendrocyte function and myelin-related proteins. RT-qPCR validates the expression of 58 of 66 assessed genes from different clusters. The present results: a. reveal regional differences in de-regulated gene expression between the anterior horn of the spinal cord and frontal cortex area 8 in the same individuals suffering from sALS; b. validate and extend our knowledge about the complexity of the inflammatory response in the anterior horn of the spinal cord; and c. identify for the first time extensive gene up-regulation of neurotransmission and synaptic-related genes, together with significant down-regulation of oligodendrocyte- and myelin-related genes, as important contributors to the pathogenesis of frontal cortex alterations in the sALS/frontotemporal lobar degeneration spectrum complex at stages with no apparent cognitive impairment.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28283675</pmid><doi>10.18632/aging.101195</doi><tpages>29</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1945-4589
ispartof Aging (Albany, NY.), 2017-03, Vol.9 (3), p.823-851
issn 1945-4589
1945-4589
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5391234
source PubMed (Medline)
subjects Adult
Aged
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - pathology
Female
Frontal Lobe - metabolism
Frontal Lobe - pathology
Frontotemporal Lobar Degeneration - genetics
Frontotemporal Lobar Degeneration - metabolism
Frontotemporal Lobar Degeneration - pathology
Gene Expression Regulation
Humans
Male
Middle Aged
Research Paper
Spinal Cord - metabolism
Spinal Cord - pathology
Transcriptome
title Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T21%3A27%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Amyotrophic%20lateral%20sclerosis,%20gene%20deregulation%20in%20the%20anterior%20horn%20of%20the%20spinal%20cord%20and%20frontal%20cortex%20area%208:%20implications%20in%20frontotemporal%20lobar%20degeneration&rft.jtitle=Aging%20(Albany,%20NY.)&rft.au=Andr%C3%A9s-Benito,%20Pol&rft.date=2017-03-09&rft.volume=9&rft.issue=3&rft.spage=823&rft.epage=851&rft.pages=823-851&rft.issn=1945-4589&rft.eissn=1945-4589&rft_id=info:doi/10.18632/aging.101195&rft_dat=%3Cproquest_pubme%3E1876497734%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c453t-17ec0ebcc4d50d468362698783ad2489b88a7037f332cf17ba69a76192e108ef3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1876497734&rft_id=info:pmid/28283675&rfr_iscdi=true