Loading…
Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models
To determine whether oral administration of CGMCC313-2 ( CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model. Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration...
Saved in:
| Published in: | World journal of gastroenterology : WJG 2017-03, Vol.23 (12), p.2149-2158 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803 |
| container_end_page | 2158 |
| container_issue | 12 |
| container_start_page | 2149 |
| container_title | World journal of gastroenterology : WJG |
| container_volume | 23 |
| creator | Liu, Meng-Yun Yang, Zhen-Yu Dai, Wen-Kui Huang, Jian-Qiong Li, Yin-Hu Zhang, Juan Qiu, Chuang-Zhao Wei, Chun Zhou, Qian Sun, Xin Feng, Xin Li, Dong-Fang Wang, He-Ping Zheng, Yue-Jie |
| description | To determine whether oral administration of
CGMCC313-2 (
CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model.
Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration of
CGMCC313-2 during or after allergen sensitization, histopathologic changes in the lung and intestine were evaluated by hematoxylin and eosin (HE) staining. In the allergic asthma mouse model, we evaluated the proportion of lung-infiltrating inflammatory cells. OVA-specific IgE and IgG1 levels in serum and cytokine levels in bronchoalveolar lavage fluid (BALF) were also assessed. In the food allergy mouse model, the levels of total IgE and cytokines in serum were measured.
Oral administration of
CGMCC313-2 during or after allergen sensitization suppressed allergic inflammation in lung and intestinal tissues, while the proportion of infiltrating inflammatory cells was significantly decreased in the BALF of allergic asthma mice. Moreover,
CGMCC313-2 decreased the serum levels of total IgE in food allergy mice, and reductions in IgE and IgG1 were also observed in OVA-induced allergic asthma mice. The expression of interleukin-4 (IL-4) and IL-13 in both serum and BALF was suppressed following the administration of
CGMCC313-2, while an effect on serum IL-10 levels was not observed.
CGMCC313-2 inhibits the secretion of allergen-induced IgE, IL-4 and IL-13, and attenuates allergic inflammation. |
| doi_str_mv | 10.3748/wjg.v23.i12.2149 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5374126</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1887420848</sourcerecordid><originalsourceid>FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803</originalsourceid><addsrcrecordid>eNpVkc1uFSEcxYnR2Nvq3pVh6WaufM3AbEx0oq1JjS50TRg-bmkYqMDc5j6ML-GD-Exy09rUDZD8zzlw-AHwCqMt5Uy8vb3ebfeEbj0mW4LZ-ARsCMFjRwRDT8EGI8S7kRJ-Ak5LuUaIUNqT5-DkOO8xIxvw61tO1erq9xZa59oJJgc_eOdNmpWuNvt1gT46FasvcDr_Mk0U047AFGHaqzCvi4-dj2bV1kDl8606QFXq1aKgigb--d2FlpN2Ic1reCT1sdpSfVQBupSaNQSbdwe4pLXYthobygvwzKlQ7Mv7_Qz8-PTx-3TRXX49_zy9v-x0a1I7Mc6jpogMhjCCle31bDDHymhmhRm0mlX7lsGZnjDMER9tTxlnGs8D5lwgegbe3eXerPNijbaxZhXkTfaLygeZlJf_T6K_kru0l33DgMnQAt7cB-T0c2295OKLtiGoaFsfiYXgjCDBRJOiO6nOqZRs3cM1GMkjVdmoykZVNqrySLVZXj9-3oPhH0b6F7T3o4Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1887420848</pqid></control><display><type>article</type><title>Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models</title><source>PubMed Central</source><creator>Liu, Meng-Yun ; Yang, Zhen-Yu ; Dai, Wen-Kui ; Huang, Jian-Qiong ; Li, Yin-Hu ; Zhang, Juan ; Qiu, Chuang-Zhao ; Wei, Chun ; Zhou, Qian ; Sun, Xin ; Feng, Xin ; Li, Dong-Fang ; Wang, He-Ping ; Zheng, Yue-Jie</creator><creatorcontrib>Liu, Meng-Yun ; Yang, Zhen-Yu ; Dai, Wen-Kui ; Huang, Jian-Qiong ; Li, Yin-Hu ; Zhang, Juan ; Qiu, Chuang-Zhao ; Wei, Chun ; Zhou, Qian ; Sun, Xin ; Feng, Xin ; Li, Dong-Fang ; Wang, He-Ping ; Zheng, Yue-Jie</creatorcontrib><description>To determine whether oral administration of
CGMCC313-2 (
CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model.
Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration of
CGMCC313-2 during or after allergen sensitization, histopathologic changes in the lung and intestine were evaluated by hematoxylin and eosin (HE) staining. In the allergic asthma mouse model, we evaluated the proportion of lung-infiltrating inflammatory cells. OVA-specific IgE and IgG1 levels in serum and cytokine levels in bronchoalveolar lavage fluid (BALF) were also assessed. In the food allergy mouse model, the levels of total IgE and cytokines in serum were measured.
Oral administration of
CGMCC313-2 during or after allergen sensitization suppressed allergic inflammation in lung and intestinal tissues, while the proportion of infiltrating inflammatory cells was significantly decreased in the BALF of allergic asthma mice. Moreover,
CGMCC313-2 decreased the serum levels of total IgE in food allergy mice, and reductions in IgE and IgG1 were also observed in OVA-induced allergic asthma mice. The expression of interleukin-4 (IL-4) and IL-13 in both serum and BALF was suppressed following the administration of
CGMCC313-2, while an effect on serum IL-10 levels was not observed.
CGMCC313-2 inhibits the secretion of allergen-induced IgE, IL-4 and IL-13, and attenuates allergic inflammation.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v23.i12.2149</identifier><identifier>PMID: 28405142</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Allergens - chemistry ; Animals ; Asthma - chemically induced ; Basic Study ; Bifidobacterium longum subspecies infantis ; Bronchoalveolar Lavage Fluid ; Cytokines - blood ; Disease Models, Animal ; Food Hypersensitivity - prevention & control ; Food Hypersensitivity - therapy ; Immunoglobulin E - blood ; Immunoglobulin G - blood ; Inflammation ; Interleukin-13 - blood ; Interleukin-4 - blood ; Intestines - immunology ; Lactoglobulins - chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Ovalbumin - chemistry ; Probiotics</subject><ispartof>World journal of gastroenterology : WJG, 2017-03, Vol.23 (12), p.2149-2158</ispartof><rights>The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803</citedby><cites>FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374126/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374126/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28405142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Meng-Yun</creatorcontrib><creatorcontrib>Yang, Zhen-Yu</creatorcontrib><creatorcontrib>Dai, Wen-Kui</creatorcontrib><creatorcontrib>Huang, Jian-Qiong</creatorcontrib><creatorcontrib>Li, Yin-Hu</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Qiu, Chuang-Zhao</creatorcontrib><creatorcontrib>Wei, Chun</creatorcontrib><creatorcontrib>Zhou, Qian</creatorcontrib><creatorcontrib>Sun, Xin</creatorcontrib><creatorcontrib>Feng, Xin</creatorcontrib><creatorcontrib>Li, Dong-Fang</creatorcontrib><creatorcontrib>Wang, He-Ping</creatorcontrib><creatorcontrib>Zheng, Yue-Jie</creatorcontrib><title>Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To determine whether oral administration of
CGMCC313-2 (
CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model.
Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration of
CGMCC313-2 during or after allergen sensitization, histopathologic changes in the lung and intestine were evaluated by hematoxylin and eosin (HE) staining. In the allergic asthma mouse model, we evaluated the proportion of lung-infiltrating inflammatory cells. OVA-specific IgE and IgG1 levels in serum and cytokine levels in bronchoalveolar lavage fluid (BALF) were also assessed. In the food allergy mouse model, the levels of total IgE and cytokines in serum were measured.
Oral administration of
CGMCC313-2 during or after allergen sensitization suppressed allergic inflammation in lung and intestinal tissues, while the proportion of infiltrating inflammatory cells was significantly decreased in the BALF of allergic asthma mice. Moreover,
CGMCC313-2 decreased the serum levels of total IgE in food allergy mice, and reductions in IgE and IgG1 were also observed in OVA-induced allergic asthma mice. The expression of interleukin-4 (IL-4) and IL-13 in both serum and BALF was suppressed following the administration of
CGMCC313-2, while an effect on serum IL-10 levels was not observed.
CGMCC313-2 inhibits the secretion of allergen-induced IgE, IL-4 and IL-13, and attenuates allergic inflammation.</description><subject>Allergens - chemistry</subject><subject>Animals</subject><subject>Asthma - chemically induced</subject><subject>Basic Study</subject><subject>Bifidobacterium longum subspecies infantis</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Cytokines - blood</subject><subject>Disease Models, Animal</subject><subject>Food Hypersensitivity - prevention & control</subject><subject>Food Hypersensitivity - therapy</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Inflammation</subject><subject>Interleukin-13 - blood</subject><subject>Interleukin-4 - blood</subject><subject>Intestines - immunology</subject><subject>Lactoglobulins - chemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Ovalbumin - chemistry</subject><subject>Probiotics</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpVkc1uFSEcxYnR2Nvq3pVh6WaufM3AbEx0oq1JjS50TRg-bmkYqMDc5j6ML-GD-Exy09rUDZD8zzlw-AHwCqMt5Uy8vb3ebfeEbj0mW4LZ-ARsCMFjRwRDT8EGI8S7kRJ-Ak5LuUaIUNqT5-DkOO8xIxvw61tO1erq9xZa59oJJgc_eOdNmpWuNvt1gT46FasvcDr_Mk0U047AFGHaqzCvi4-dj2bV1kDl8606QFXq1aKgigb--d2FlpN2Ic1reCT1sdpSfVQBupSaNQSbdwe4pLXYthobygvwzKlQ7Mv7_Qz8-PTx-3TRXX49_zy9v-x0a1I7Mc6jpogMhjCCle31bDDHymhmhRm0mlX7lsGZnjDMER9tTxlnGs8D5lwgegbe3eXerPNijbaxZhXkTfaLygeZlJf_T6K_kru0l33DgMnQAt7cB-T0c2295OKLtiGoaFsfiYXgjCDBRJOiO6nOqZRs3cM1GMkjVdmoykZVNqrySLVZXj9-3oPhH0b6F7T3o4Q</recordid><startdate>20170328</startdate><enddate>20170328</enddate><creator>Liu, Meng-Yun</creator><creator>Yang, Zhen-Yu</creator><creator>Dai, Wen-Kui</creator><creator>Huang, Jian-Qiong</creator><creator>Li, Yin-Hu</creator><creator>Zhang, Juan</creator><creator>Qiu, Chuang-Zhao</creator><creator>Wei, Chun</creator><creator>Zhou, Qian</creator><creator>Sun, Xin</creator><creator>Feng, Xin</creator><creator>Li, Dong-Fang</creator><creator>Wang, He-Ping</creator><creator>Zheng, Yue-Jie</creator><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170328</creationdate><title>Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models</title><author>Liu, Meng-Yun ; Yang, Zhen-Yu ; Dai, Wen-Kui ; Huang, Jian-Qiong ; Li, Yin-Hu ; Zhang, Juan ; Qiu, Chuang-Zhao ; Wei, Chun ; Zhou, Qian ; Sun, Xin ; Feng, Xin ; Li, Dong-Fang ; Wang, He-Ping ; Zheng, Yue-Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Allergens - chemistry</topic><topic>Animals</topic><topic>Asthma - chemically induced</topic><topic>Basic Study</topic><topic>Bifidobacterium longum subspecies infantis</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Cytokines - blood</topic><topic>Disease Models, Animal</topic><topic>Food Hypersensitivity - prevention & control</topic><topic>Food Hypersensitivity - therapy</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Inflammation</topic><topic>Interleukin-13 - blood</topic><topic>Interleukin-4 - blood</topic><topic>Intestines - immunology</topic><topic>Lactoglobulins - chemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Ovalbumin - chemistry</topic><topic>Probiotics</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Meng-Yun</creatorcontrib><creatorcontrib>Yang, Zhen-Yu</creatorcontrib><creatorcontrib>Dai, Wen-Kui</creatorcontrib><creatorcontrib>Huang, Jian-Qiong</creatorcontrib><creatorcontrib>Li, Yin-Hu</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Qiu, Chuang-Zhao</creatorcontrib><creatorcontrib>Wei, Chun</creatorcontrib><creatorcontrib>Zhou, Qian</creatorcontrib><creatorcontrib>Sun, Xin</creatorcontrib><creatorcontrib>Feng, Xin</creatorcontrib><creatorcontrib>Li, Dong-Fang</creatorcontrib><creatorcontrib>Wang, He-Ping</creatorcontrib><creatorcontrib>Zheng, Yue-Jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Meng-Yun</au><au>Yang, Zhen-Yu</au><au>Dai, Wen-Kui</au><au>Huang, Jian-Qiong</au><au>Li, Yin-Hu</au><au>Zhang, Juan</au><au>Qiu, Chuang-Zhao</au><au>Wei, Chun</au><au>Zhou, Qian</au><au>Sun, Xin</au><au>Feng, Xin</au><au>Li, Dong-Fang</au><au>Wang, He-Ping</au><au>Zheng, Yue-Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2017-03-28</date><risdate>2017</risdate><volume>23</volume><issue>12</issue><spage>2149</spage><epage>2158</epage><pages>2149-2158</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Telephone: +86-755-83936101 Fax: +86-755-83009800</notes><notes>Supported by Basic Science Research Program funded by The Innovation of Science and Technology Commission of Shenzhen Municipality, China, No. JCYJ20120828092009036; Shenzhen Science and Technology Project, No. JCYJ20150403100317067.</notes><notes>Correspondence to: Dr. Yue-Jie Zheng, Director, Department of Respiratory, Shenzhen Children’s Hospital, No. 7019 Yitian Road, Shenzhen 518026, China. shine1990@sina.com</notes><notes>Author contributions: Zheng YJ designed the study; Liu MY, Yang ZY and Li YH interpreted the data and wrote the manuscript; Qiu CZ, Zhou Q and Feng X conducted the bioinformatics analysis; Li DF, Huang JQ, Zhang J, Wang HP, Wei C and Sun X contributed to the study design and animal experiments; Liu MY, Yang ZY and Dai WK contributed to this work equally.</notes><abstract>To determine whether oral administration of
CGMCC313-2 (
CGMCC313-2) inhibits allergen-induced airway inflammation and food allergies in a mouse model.
Ovalbumin (OVA)-induced allergic asthma and β-lactoglobulin-induced food allergy mouse models were used in this study. Following oral administration of
CGMCC313-2 during or after allergen sensitization, histopathologic changes in the lung and intestine were evaluated by hematoxylin and eosin (HE) staining. In the allergic asthma mouse model, we evaluated the proportion of lung-infiltrating inflammatory cells. OVA-specific IgE and IgG1 levels in serum and cytokine levels in bronchoalveolar lavage fluid (BALF) were also assessed. In the food allergy mouse model, the levels of total IgE and cytokines in serum were measured.
Oral administration of
CGMCC313-2 during or after allergen sensitization suppressed allergic inflammation in lung and intestinal tissues, while the proportion of infiltrating inflammatory cells was significantly decreased in the BALF of allergic asthma mice. Moreover,
CGMCC313-2 decreased the serum levels of total IgE in food allergy mice, and reductions in IgE and IgG1 were also observed in OVA-induced allergic asthma mice. The expression of interleukin-4 (IL-4) and IL-13 in both serum and BALF was suppressed following the administration of
CGMCC313-2, while an effect on serum IL-10 levels was not observed.
CGMCC313-2 inhibits the secretion of allergen-induced IgE, IL-4 and IL-13, and attenuates allergic inflammation.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>28405142</pmid><doi>10.3748/wjg.v23.i12.2149</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2017-03, Vol.23 (12), p.2149-2158 |
| issn | 1007-9327 2219-2840 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5374126 |
| source | PubMed Central |
| subjects | Allergens - chemistry Animals Asthma - chemically induced Basic Study Bifidobacterium longum subspecies infantis Bronchoalveolar Lavage Fluid Cytokines - blood Disease Models, Animal Food Hypersensitivity - prevention & control Food Hypersensitivity - therapy Immunoglobulin E - blood Immunoglobulin G - blood Inflammation Interleukin-13 - blood Interleukin-4 - blood Intestines - immunology Lactoglobulins - chemistry Male Mice Mice, Inbred BALB C Ovalbumin - chemistry Probiotics |
| title | Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T06%3A39%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20Bifidobacterium%20infantis%20CGMCC313-2%20on%20ovalbumin-induced%20airway%20asthma%20and%20%CE%B2-lactoglobulin-induced%20intestinal%20food%20allergy%20mouse%20models&rft.jtitle=World%20journal%20of%20gastroenterology%20:%20WJG&rft.au=Liu,%20Meng-Yun&rft.date=2017-03-28&rft.volume=23&rft.issue=12&rft.spage=2149&rft.epage=2158&rft.pages=2149-2158&rft.issn=1007-9327&rft.eissn=2219-2840&rft_id=info:doi/10.3748/wjg.v23.i12.2149&rft_dat=%3Cproquest_pubme%3E1887420848%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c284t-89b9c3026d2421ae5cbd171adc4e8d6caba2216fd52417079e53474c1b6177803%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1887420848&rft_id=info:pmid/28405142&rfr_iscdi=true |