Preoperative ultrasound-guided carbon nanoparticles localization for metastatic lymph nodes in papillary thyroid carcinoma during reoperation: A retrospective cohort study

Due to the damaged anatomical structure and a large amount of fibrous and scar tissues in the surgical field, reoperation of papillary thyroid carcinoma is difficult. This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety o...

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Published in:Medicine (Baltimore) 2017-03, Vol.96 (10), p.e6285
Main Authors: Zhao, Wan-Jun, Luo, Han, Zhou, Yi-Mei, Gou, Ze-Hui, Wang, Bin, Zhu, Jing-Qiang
Format: Article
Language:English
Subjects:
Adult
Carbon
Carcinoma - diagnostic imaging
Carcinoma, Papillary
Female
Humans
Lymph Nodes - diagnostic imaging
Lymphatic Metastasis
Male
Middle Aged
Nanoparticles
Observational Study
Reoperation
Retrospective Studies
Thyroid Cancer, Papillary
Thyroid Neoplasms - diagnostic imaging
Ultrasonography, Interventional
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cited_by cdi_FETCH-LOGICAL-c290t-69b49769b4d51d40bd24c16155dc6485c57b284a700dd45d9937958c47634273
cites cdi_FETCH-LOGICAL-c290t-69b49769b4d51d40bd24c16155dc6485c57b284a700dd45d9937958c47634273
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container_issue 10
container_start_page e6285
container_title Medicine (Baltimore)
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creator Zhao, Wan-Jun
Luo, Han
Zhou, Yi-Mei
Gou, Ze-Hui
Wang, Bin
Zhu, Jing-Qiang
description Due to the damaged anatomical structure and a large amount of fibrous and scar tissues in the surgical field, reoperation of papillary thyroid carcinoma is difficult. This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety of the preoperative ultrasound-guided carbon nanoparticles (CNs) localization. This retrospective cohort study enrolled 52 patients who were diagnosed with lymph node metastasis by histopathology and underwent reoperation from October 2015 to February 2016. The modified radical neck dissection or selective neck node dissection was performed. A total of 26 patients underwent preoperative ultrasound-guided CNs injection, and other 26 patients did not. Tolerance, the result of injection, the number of resected metastatic lymph nodes, and postoperative complications were recorded and analyzed. In CNs group, 102 suspicious nonpalpable lesions in 26 patients were injected with CNs, and 99 of the 102 lesions were successfully identified by surgeon in the reoperation. The positive rate of resected lymph nodes in total, in the central compartment, and in the lateral compartment were 31.6%, 31.2%, and 32.8%, respectively, which was significantly higher than that in the control group (P 
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This study introduces a new method of locating metastatic lymph nodes during reoperation and evaluates the effectiveness and safety of the preoperative ultrasound-guided carbon nanoparticles (CNs) localization. This retrospective cohort study enrolled 52 patients who were diagnosed with lymph node metastasis by histopathology and underwent reoperation from October 2015 to February 2016. The modified radical neck dissection or selective neck node dissection was performed. A total of 26 patients underwent preoperative ultrasound-guided CNs injection, and other 26 patients did not. Tolerance, the result of injection, the number of resected metastatic lymph nodes, and postoperative complications were recorded and analyzed. In CNs group, 102 suspicious nonpalpable lesions in 26 patients were injected with CNs, and 99 of the 102 lesions were successfully identified by surgeon in the reoperation. The positive rate of resected lymph nodes in total, in the central compartment, and in the lateral compartment were 31.6%, 31.2%, and 32.8%, respectively, which was significantly higher than that in the control group (P &lt; 0.001, P &lt; 0.001, and P = 0.041). In addition, the positive rates of levels III, IV, and V in the CNs group were 35.6%, 21.9%, and 30.5%, respectively, which was significantly higher than that in the control group (P &lt; 0.001, P = 0.005, and P = 0.01). In additional, in the CNs group, the rate of temporary hypoparathyroidism was significantly lower compared with the control group (0% vs 26.9%, P = 0.021). 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The positive rate of resected lymph nodes in total, in the central compartment, and in the lateral compartment were 31.6%, 31.2%, and 32.8%, respectively, which was significantly higher than that in the control group (P &lt; 0.001, P &lt; 0.001, and P = 0.041). In addition, the positive rates of levels III, IV, and V in the CNs group were 35.6%, 21.9%, and 30.5%, respectively, which was significantly higher than that in the control group (P &lt; 0.001, P = 0.005, and P = 0.01). In additional, in the CNs group, the rate of temporary hypoparathyroidism was significantly lower compared with the control group (0% vs 26.9%, P = 0.021). 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The positive rate of resected lymph nodes in total, in the central compartment, and in the lateral compartment were 31.6%, 31.2%, and 32.8%, respectively, which was significantly higher than that in the control group (P &lt; 0.001, P &lt; 0.001, and P = 0.041). In addition, the positive rates of levels III, IV, and V in the CNs group were 35.6%, 21.9%, and 30.5%, respectively, which was significantly higher than that in the control group (P &lt; 0.001, P = 0.005, and P = 0.01). In additional, in the CNs group, the rate of temporary hypoparathyroidism was significantly lower compared with the control group (0% vs 26.9%, P = 0.021). Preoperative ultrasound-guided CNs injection is a safe and effective method for localization of the metastatic lymph nodes during reoperation.</abstract><cop>United States</cop><pub>Wolters Kluwer Health</pub><pmid>28272249</pmid><doi>10.1097/MD.0000000000006285</doi><oa>free_for_read</oa></addata></record>
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subjects Adult
Carbon
Carcinoma - diagnostic imaging
Carcinoma, Papillary
Female
Humans
Lymph Nodes - diagnostic imaging
Lymphatic Metastasis
Male
Middle Aged
Nanoparticles
Observational Study
Reoperation
Retrospective Studies
Thyroid Cancer, Papillary
Thyroid Neoplasms - diagnostic imaging
Ultrasonography, Interventional
title Preoperative ultrasound-guided carbon nanoparticles localization for metastatic lymph nodes in papillary thyroid carcinoma during reoperation: A retrospective cohort study
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