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Pharmacological analyses of learning and memory in zebrafish (Danio rerio)
Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro stud...
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| Published in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2015-12, Vol.139 (0), p.103-111 |
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| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 139 |
| creator | Bailey, Jordan M. Oliveri, Anthony N. Levin, Edward D. |
| description | Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro studies and traditional mammalian models. Zebrafish offer great advantages of economy compared to their rodent counterparts, their complex brains and behavioral repertoire offer great translational potential relative to in vitro models. The development and validation of a variety of tests to measure behavior, including cognition, in zebrafish have set the stage for the use of this animal for behavioral pharmacology studies. This has led to research into the basic mechanisms of cognitive function as well as screening for potential cognition-improving drug therapies, among other lines of research. As with all models, zebrafish have limitations, which span pharmacokinetic challenges to difficulties quantifying behavior. The use, efficacy and limitations associated with a zebrafish model of cognitive function are discussed in this review, within the context of behavioral pharmacology.
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•Zebrafish can be used to assess neurobehavioral processes of learning and memory.•Zebrafish provide a complementary model for screening the cognitive effects of drugs.•Zebrafish can be used to help characterize neural systems underlying cognitive function. |
| doi_str_mv | 10.1016/j.pbb.2015.03.006 |
| format | article |
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•Zebrafish can be used to assess neurobehavioral processes of learning and memory.•Zebrafish provide a complementary model for screening the cognitive effects of drugs.•Zebrafish can be used to help characterize neural systems underlying cognitive function.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/j.pbb.2015.03.006</identifier><identifier>PMID: 25792292</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Cognition - drug effects ; Cognition - physiology ; Danio rerio ; Executive Function - drug effects ; Executive Function - physiology ; Learning ; Learning - drug effects ; Learning - physiology ; Memory ; Memory - drug effects ; Memory - physiology ; Models, Animal ; Pharmacology ; Psychotropic Drugs - pharmacology ; Zebrafish ; Zebrafish - physiology</subject><ispartof>Pharmacology, biochemistry and behavior, 2015-12, Vol.139 (0), p.103-111</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-e12028d6d6ae490065bec183256210bf2137cbbfb0ebf21d5a8fdc7a6dbb39fc3</citedby><cites>FETCH-LOGICAL-c532t-e12028d6d6ae490065bec183256210bf2137cbbfb0ebf21d5a8fdc7a6dbb39fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25792292$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bailey, Jordan M.</creatorcontrib><creatorcontrib>Oliveri, Anthony N.</creatorcontrib><creatorcontrib>Levin, Edward D.</creatorcontrib><title>Pharmacological analyses of learning and memory in zebrafish (Danio rerio)</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro studies and traditional mammalian models. Zebrafish offer great advantages of economy compared to their rodent counterparts, their complex brains and behavioral repertoire offer great translational potential relative to in vitro models. The development and validation of a variety of tests to measure behavior, including cognition, in zebrafish have set the stage for the use of this animal for behavioral pharmacology studies. This has led to research into the basic mechanisms of cognitive function as well as screening for potential cognition-improving drug therapies, among other lines of research. As with all models, zebrafish have limitations, which span pharmacokinetic challenges to difficulties quantifying behavior. The use, efficacy and limitations associated with a zebrafish model of cognitive function are discussed in this review, within the context of behavioral pharmacology.
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•Zebrafish can be used to assess neurobehavioral processes of learning and memory.•Zebrafish provide a complementary model for screening the cognitive effects of drugs.•Zebrafish can be used to help characterize neural systems underlying cognitive function.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Cognition - drug effects</subject><subject>Cognition - physiology</subject><subject>Danio rerio</subject><subject>Executive Function - drug effects</subject><subject>Executive Function - physiology</subject><subject>Learning</subject><subject>Learning - drug effects</subject><subject>Learning - physiology</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Models, Animal</subject><subject>Pharmacology</subject><subject>Psychotropic Drugs - pharmacology</subject><subject>Zebrafish</subject><subject>Zebrafish - physiology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkU1PGzEQhq0KVALtD-il2iM97DK243VWSEiIAqVCag_t2fLHbOJo1w52gpT-ehwFUHtBPY1m5plXM_MS8olCQ4G2Z8tmZUzDgIoGeAPQviMTOpO8FlTKAzIB6GjNQcgjcpzzEgCmrJXvyRETsmOsYxPy_edCp1HbOMS5t3qodNDDNmOuYl8NqFPwYV6KrhpxjGlb-VD9QZN07_OiOv2qg49VwuTjlw_ksNdDxo_P8YT8vrn-dfWtvv9xe3d1eV9bwdm6RsqAzVzrWo3TriwtDFo640y0jILpGeXSGtMbwF3ihJ71zkrdOmN411t-Qi72uquNGdFZDOukB7VKftRpq6L26t9O8As1j49qKiSXUhSB02eBFB82mNdq9NniMOiAcZMVlS3jctpR-R-oKD_tOGMFpXvUpphzwv51IwpqZ5daqmKX2tmlgKtyeZn5_PcprxMv_hTgfA9geeijx6Sy9RgsOp_QrpWL_g35J3jZppU</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Bailey, Jordan M.</creator><creator>Oliveri, Anthony N.</creator><creator>Levin, Edward D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Pharmacological analyses of learning and memory in zebrafish (Danio rerio)</title><author>Bailey, Jordan M. ; Oliveri, Anthony N. ; Levin, Edward D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-e12028d6d6ae490065bec183256210bf2137cbbfb0ebf21d5a8fdc7a6dbb39fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Cognition - drug effects</topic><topic>Cognition - physiology</topic><topic>Danio rerio</topic><topic>Executive Function - drug effects</topic><topic>Executive Function - physiology</topic><topic>Learning</topic><topic>Learning - drug effects</topic><topic>Learning - physiology</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Models, Animal</topic><topic>Pharmacology</topic><topic>Psychotropic Drugs - pharmacology</topic><topic>Zebrafish</topic><topic>Zebrafish - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bailey, Jordan M.</creatorcontrib><creatorcontrib>Oliveri, Anthony N.</creatorcontrib><creatorcontrib>Levin, Edward D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bailey, Jordan M.</au><au>Oliveri, Anthony N.</au><au>Levin, Edward D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological analyses of learning and memory in zebrafish (Danio rerio)</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>139</volume><issue>0</issue><spage>103</spage><epage>111</epage><pages>103-111</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-2</notes><notes>ObjectType-Feature-2</notes><abstract>Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro studies and traditional mammalian models. Zebrafish offer great advantages of economy compared to their rodent counterparts, their complex brains and behavioral repertoire offer great translational potential relative to in vitro models. The development and validation of a variety of tests to measure behavior, including cognition, in zebrafish have set the stage for the use of this animal for behavioral pharmacology studies. This has led to research into the basic mechanisms of cognitive function as well as screening for potential cognition-improving drug therapies, among other lines of research. As with all models, zebrafish have limitations, which span pharmacokinetic challenges to difficulties quantifying behavior. The use, efficacy and limitations associated with a zebrafish model of cognitive function are discussed in this review, within the context of behavioral pharmacology.
[Display omitted]
•Zebrafish can be used to assess neurobehavioral processes of learning and memory.•Zebrafish provide a complementary model for screening the cognitive effects of drugs.•Zebrafish can be used to help characterize neural systems underlying cognitive function.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25792292</pmid><doi>10.1016/j.pbb.2015.03.006</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 2015-12, Vol.139 (0), p.103-111 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Animals Behavior, Animal - drug effects Behavior, Animal - physiology Cognition - drug effects Cognition - physiology Danio rerio Executive Function - drug effects Executive Function - physiology Learning Learning - drug effects Learning - physiology Memory Memory - drug effects Memory - physiology Models, Animal Pharmacology Psychotropic Drugs - pharmacology Zebrafish Zebrafish - physiology |
| title | Pharmacological analyses of learning and memory in zebrafish (Danio rerio) |
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