Sickle cell trait is not associated with chronic kidney disease in adult Congolese patients: a clinic-based, cross-sectional study

Summary Objective The aim of this study was to evaluate the determinants of chronic kidney disease (CKD) with special emphasis on sickle cell trait (SCT). Methods Three hundred and fifty-nine patients (171 men and 188 women), aged 18 years or older, with reduced kidney function (eGFR < 90 ml/min/...

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Published in:Cardiovascular Journal of Africa 2015-05, Vol.26 (3), p.125-129
Main Authors: Mukendi, K, Lepira, F B, Sumaili KE, Nseka, M N, Kayembe, P K
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Cardiovascular Topics
Cross-sectional studies
Kidney diseases
Sickle cell disease
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container_title Cardiovascular Journal of Africa
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creator Mukendi, K
Lepira, F B
Sumaili KE
Nseka, M N
Kayembe, P K
description Summary Objective The aim of this study was to evaluate the determinants of chronic kidney disease (CKD) with special emphasis on sickle cell trait (SCT). Methods Three hundred and fifty-nine patients (171 men and 188 women), aged 18 years or older, with reduced kidney function (eGFR < 90 ml/min/1.73 m2) and seen at secondary and tertiary healthcare in Kinshasa were consecutively recruited in this cross-sectional study. Serum creatinine and haemoglobin electrophoresis were performed in each patient. CKD was defined as < 60 ml/min/1.73 m2. Logistic regression analysis was used to assess determinants of CKD with a special emphasis on SCT. A p-value < 0.05 defined the level of statistical significance. Results SCT was present in 19% of the study population; its frequency was 21 and 18% (p > 0.05) in patients with and without CKD, respectively. In multivariate analysis, sickle cell trait was not significantly (OR: 0.38; 95% CI: 0.559–1.839; p = 0.235) associated with CKD; the main determinants were dipstick proteinuria (OR: 1.86; 95% CI: 1.094–3.168; p = 0.02), the metabolic syndrome (OR: 1.69; 95% CI: 1.033–2.965; p = 0.03), haemoblobin ≥ 12 g/dl (OR: 0.36; 95% CI: 0.210–0.625; p = 0.001), and personal history of hypertension (OR: 2.16; 95% CI: 1.202–3.892; p = 0.01) and of diabetes mellitus (OR: 2.35; 95% CI: 1.150–4.454; p = 0.001). Conclusion SCT was not an independent determinant of CKD in the present case series. Traditional risk factors emerged as the main determinants of CKD.
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Methods Three hundred and fifty-nine patients (171 men and 188 women), aged 18 years or older, with reduced kidney function (eGFR &lt; 90 ml/min/1.73 m2) and seen at secondary and tertiary healthcare in Kinshasa were consecutively recruited in this cross-sectional study. Serum creatinine and haemoglobin electrophoresis were performed in each patient. CKD was defined as &lt; 60 ml/min/1.73 m2. Logistic regression analysis was used to assess determinants of CKD with a special emphasis on SCT. A p-value &lt; 0.05 defined the level of statistical significance. Results SCT was present in 19% of the study population; its frequency was 21 and 18% (p &gt; 0.05) in patients with and without CKD, respectively. In multivariate analysis, sickle cell trait was not significantly (OR: 0.38; 95% CI: 0.559–1.839; p = 0.235) associated with CKD; the main determinants were dipstick proteinuria (OR: 1.86; 95% CI: 1.094–3.168; p = 0.02), the metabolic syndrome (OR: 1.69; 95% CI: 1.033–2.965; p = 0.03), haemoblobin ≥ 12 g/dl (OR: 0.36; 95% CI: 0.210–0.625; p = 0.001), and personal history of hypertension (OR: 2.16; 95% CI: 1.202–3.892; p = 0.01) and of diabetes mellitus (OR: 2.35; 95% CI: 1.150–4.454; p = 0.001). Conclusion SCT was not an independent determinant of CKD in the present case series. Traditional risk factors emerged as the main determinants of CKD.</description><identifier>ISSN: 1995-1892</identifier><identifier>EISSN: 1680-0745</identifier><identifier>DOI: 10.5830/CVJA-2014-076</identifier><identifier>PMID: 26592908</identifier><language>eng</language><publisher>Durbanville: Clinics Cardive Publishing</publisher><subject>Cardiovascular Topics ; Cross-sectional studies ; Kidney diseases ; Sickle cell disease</subject><ispartof>Cardiovascular Journal of Africa, 2015-05, Vol.26 (3), p.125-129</ispartof><rights>Copyright © 2010 Clinics Cardive Publishing. This work is licensed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2010 Clinics Cardive Publishing 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538907/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538907/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids></links><search><creatorcontrib>Mukendi, K</creatorcontrib><creatorcontrib>Lepira, F B</creatorcontrib><creatorcontrib>Sumaili KE</creatorcontrib><creatorcontrib>Nseka, M N</creatorcontrib><creatorcontrib>Kayembe, P K</creatorcontrib><title>Sickle cell trait is not associated with chronic kidney disease in adult Congolese patients: a clinic-based, cross-sectional study</title><title>Cardiovascular Journal of Africa</title><description>Summary Objective The aim of this study was to evaluate the determinants of chronic kidney disease (CKD) with special emphasis on sickle cell trait (SCT). Methods Three hundred and fifty-nine patients (171 men and 188 women), aged 18 years or older, with reduced kidney function (eGFR &lt; 90 ml/min/1.73 m2) and seen at secondary and tertiary healthcare in Kinshasa were consecutively recruited in this cross-sectional study. Serum creatinine and haemoglobin electrophoresis were performed in each patient. CKD was defined as &lt; 60 ml/min/1.73 m2. Logistic regression analysis was used to assess determinants of CKD with a special emphasis on SCT. A p-value &lt; 0.05 defined the level of statistical significance. Results SCT was present in 19% of the study population; its frequency was 21 and 18% (p &gt; 0.05) in patients with and without CKD, respectively. In multivariate analysis, sickle cell trait was not significantly (OR: 0.38; 95% CI: 0.559–1.839; p = 0.235) associated with CKD; the main determinants were dipstick proteinuria (OR: 1.86; 95% CI: 1.094–3.168; p = 0.02), the metabolic syndrome (OR: 1.69; 95% CI: 1.033–2.965; p = 0.03), haemoblobin ≥ 12 g/dl (OR: 0.36; 95% CI: 0.210–0.625; p = 0.001), and personal history of hypertension (OR: 2.16; 95% CI: 1.202–3.892; p = 0.01) and of diabetes mellitus (OR: 2.35; 95% CI: 1.150–4.454; p = 0.001). Conclusion SCT was not an independent determinant of CKD in the present case series. 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Methods Three hundred and fifty-nine patients (171 men and 188 women), aged 18 years or older, with reduced kidney function (eGFR &lt; 90 ml/min/1.73 m2) and seen at secondary and tertiary healthcare in Kinshasa were consecutively recruited in this cross-sectional study. Serum creatinine and haemoglobin electrophoresis were performed in each patient. CKD was defined as &lt; 60 ml/min/1.73 m2. Logistic regression analysis was used to assess determinants of CKD with a special emphasis on SCT. A p-value &lt; 0.05 defined the level of statistical significance. Results SCT was present in 19% of the study population; its frequency was 21 and 18% (p &gt; 0.05) in patients with and without CKD, respectively. In multivariate analysis, sickle cell trait was not significantly (OR: 0.38; 95% CI: 0.559–1.839; p = 0.235) associated with CKD; the main determinants were dipstick proteinuria (OR: 1.86; 95% CI: 1.094–3.168; p = 0.02), the metabolic syndrome (OR: 1.69; 95% CI: 1.033–2.965; p = 0.03), haemoblobin ≥ 12 g/dl (OR: 0.36; 95% CI: 0.210–0.625; p = 0.001), and personal history of hypertension (OR: 2.16; 95% CI: 1.202–3.892; p = 0.01) and of diabetes mellitus (OR: 2.35; 95% CI: 1.150–4.454; p = 0.001). Conclusion SCT was not an independent determinant of CKD in the present case series. Traditional risk factors emerged as the main determinants of CKD.</abstract><cop>Durbanville</cop><pub>Clinics Cardive Publishing</pub><pmid>26592908</pmid><doi>10.5830/CVJA-2014-076</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Cardiovascular Topics
Cross-sectional studies
Kidney diseases
Sickle cell disease
title Sickle cell trait is not associated with chronic kidney disease in adult Congolese patients: a clinic-based, cross-sectional study
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