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Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer
BACKGROUND Substance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer. METHODS This was an observational cohort s...
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| Published in: | Cancer 2014-11, Vol.120 (21), p.3338-3345 |
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| container_end_page | 3345 |
| container_issue | 21 |
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| container_title | Cancer |
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| creator | Chhatre, Sumedha Metzger, David S. Malkowicz, S. Bruce Woody, George Jayadevappa, Ravishankar |
| description | BACKGROUND
Substance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer.
METHODS
This was an observational cohort study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data from 2000 to 2009. Among men who were diagnosed with advanced prostate cancer between 2001 and 2004, we identified those who had a claim for substance use disorder in the year before cancer diagnosis, 1 year after cancer diagnosis, and an additional 4 years after diagnosis. The outcomes investigated were use of health services, costs, and mortality.
RESULTS
The prevalence of substance use disorder was 10.6%. The category drug psychoses and related had greater odds of inpatient hospitalizations (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9‐2.8), outpatient hospital visits (OR, 2.6; 95% CI, 1.9‐3.6), and emergency room visits (OR, 1.7; 95% CI, 1.2‐2.4). Substance use disorder in the follow‐up phase was associated with greater odds of inpatient hospitalizations (OR, 2.0; 95% CI, 1.8‐2.2), outpatient hospital visits (OR, 2.0; 95% CI, 1.7‐2.4), and emergency room visits (OR, 1.7; 95% CI, 1.5‐2.1). Compared with men who did not have substance use disorder, those in the category drug psychoses and related had 70% higher costs, and those who had substance use disorder during the follow‐up phase had 60% higher costs. The hazard of all‐cause mortality was highest for patients in the drug psychoses and related category (hazard ratio, 1.3; 95% CI, 1.1‐1.7) and the substance use disorder in treatment phase category (hazard ratio, 1.5; 95% CI, 1.3‐1.7).
CONCLUSIONS
The intersection of advanced prostate cancer and substance use disorder may adversely affect outcomes. Incorporating substance use screening and treatments into prostate cancer care guidelines and coordination of care is desirable. Cancer 2014;120:3338–3345. © 2014 American Cancer Society.
The intersection of advanced prostate cancer and substance use disorder appears to adversely affect outcomes. Thus, incorporating substance use screening and treatments into prostate cancer care guidelines and care coordination is desirable. |
| doi_str_mv | 10.1002/cncr.28861 |
| format | article |
| fullrecord | <record><control><sourceid>wiley_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4205195</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CNCR28861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5201-4b289dc7610ec0924b6c78599238065a159d15140aac37a09d442a07f303fe4b3</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMotlY3PoBk40YYPbnNTDaCFG8gCl7AXcgkmTbSzpRkqrjzEXxGn8TUet24Opd85__Jj9A2gX0CQA9MY8I-LcucrKA-AVlkQDhdRX0AKDPB2X0PbcT4kMaCCraOelQAp0zmfaRu5lXsdGMcnkeHrY9tsC5g3Vjsu4hdXTuTatvgdt6Zduoi9g2eugY_-W6MtX1cHNu3l9ckM3J4FtrUdA6bxT5sorVaT6Lb-qwDdHdyfDs8yy6uTs-HRxeZERRIxitaSmuKnIAzICmvclOUQkrKSsiFJkJaIggHrQ0rNEjLOdVQ1AxY7XjFBuhwqTubV1NnjWu6oCdqFvxUh2fVaq_-vjR-rEbto-IUBJEiCewtBUz6QAyu_r4loBYxq0XM6iPmBO_8dvtGv3JNwO4noKPRkzqkMHz84UrJGeM8cWTJPfmJe_7HUg0vh9dL83fNE5do</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer</title><source>Wiley</source><source>EZB Electronic Journals Library</source><creator>Chhatre, Sumedha ; Metzger, David S. ; Malkowicz, S. Bruce ; Woody, George ; Jayadevappa, Ravishankar</creator><creatorcontrib>Chhatre, Sumedha ; Metzger, David S. ; Malkowicz, S. Bruce ; Woody, George ; Jayadevappa, Ravishankar</creatorcontrib><description>BACKGROUND
Substance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer.
METHODS
This was an observational cohort study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data from 2000 to 2009. Among men who were diagnosed with advanced prostate cancer between 2001 and 2004, we identified those who had a claim for substance use disorder in the year before cancer diagnosis, 1 year after cancer diagnosis, and an additional 4 years after diagnosis. The outcomes investigated were use of health services, costs, and mortality.
RESULTS
The prevalence of substance use disorder was 10.6%. The category drug psychoses and related had greater odds of inpatient hospitalizations (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9‐2.8), outpatient hospital visits (OR, 2.6; 95% CI, 1.9‐3.6), and emergency room visits (OR, 1.7; 95% CI, 1.2‐2.4). Substance use disorder in the follow‐up phase was associated with greater odds of inpatient hospitalizations (OR, 2.0; 95% CI, 1.8‐2.2), outpatient hospital visits (OR, 2.0; 95% CI, 1.7‐2.4), and emergency room visits (OR, 1.7; 95% CI, 1.5‐2.1). Compared with men who did not have substance use disorder, those in the category drug psychoses and related had 70% higher costs, and those who had substance use disorder during the follow‐up phase had 60% higher costs. The hazard of all‐cause mortality was highest for patients in the drug psychoses and related category (hazard ratio, 1.3; 95% CI, 1.1‐1.7) and the substance use disorder in treatment phase category (hazard ratio, 1.5; 95% CI, 1.3‐1.7).
CONCLUSIONS
The intersection of advanced prostate cancer and substance use disorder may adversely affect outcomes. Incorporating substance use screening and treatments into prostate cancer care guidelines and coordination of care is desirable. Cancer 2014;120:3338–3345. © 2014 American Cancer Society.
The intersection of advanced prostate cancer and substance use disorder appears to adversely affect outcomes. Thus, incorporating substance use screening and treatments into prostate cancer care guidelines and care coordination is desirable.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.28861</identifier><identifier>PMID: 25042396</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>advanced prostate cancer ; Aged ; Aged, 80 and over ; Biological and medical sciences ; health services ; Humans ; Insurance Claim Review ; Male ; Medical sciences ; Medicare elderly ; mortality ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Staging ; Nephrology. Urinary tract diseases ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; substance use disorder ; Substance-Related Disorders - classification ; Substance-Related Disorders - complications ; Substance-Related Disorders - pathology ; Treatment Outcome ; Tumors ; Tumors of the urinary system ; United States ; Urinary tract. Prostate gland</subject><ispartof>Cancer, 2014-11, Vol.120 (21), p.3338-3345</ispartof><rights>2014 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>2014 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5201-4b289dc7610ec0924b6c78599238065a159d15140aac37a09d442a07f303fe4b3</citedby><cites>FETCH-LOGICAL-c5201-4b289dc7610ec0924b6c78599238065a159d15140aac37a09d442a07f303fe4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.28861$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.28861$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28943344$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25042396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chhatre, Sumedha</creatorcontrib><creatorcontrib>Metzger, David S.</creatorcontrib><creatorcontrib>Malkowicz, S. Bruce</creatorcontrib><creatorcontrib>Woody, George</creatorcontrib><creatorcontrib>Jayadevappa, Ravishankar</creatorcontrib><title>Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Substance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer.
METHODS
This was an observational cohort study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data from 2000 to 2009. Among men who were diagnosed with advanced prostate cancer between 2001 and 2004, we identified those who had a claim for substance use disorder in the year before cancer diagnosis, 1 year after cancer diagnosis, and an additional 4 years after diagnosis. The outcomes investigated were use of health services, costs, and mortality.
RESULTS
The prevalence of substance use disorder was 10.6%. The category drug psychoses and related had greater odds of inpatient hospitalizations (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9‐2.8), outpatient hospital visits (OR, 2.6; 95% CI, 1.9‐3.6), and emergency room visits (OR, 1.7; 95% CI, 1.2‐2.4). Substance use disorder in the follow‐up phase was associated with greater odds of inpatient hospitalizations (OR, 2.0; 95% CI, 1.8‐2.2), outpatient hospital visits (OR, 2.0; 95% CI, 1.7‐2.4), and emergency room visits (OR, 1.7; 95% CI, 1.5‐2.1). Compared with men who did not have substance use disorder, those in the category drug psychoses and related had 70% higher costs, and those who had substance use disorder during the follow‐up phase had 60% higher costs. The hazard of all‐cause mortality was highest for patients in the drug psychoses and related category (hazard ratio, 1.3; 95% CI, 1.1‐1.7) and the substance use disorder in treatment phase category (hazard ratio, 1.5; 95% CI, 1.3‐1.7).
CONCLUSIONS
The intersection of advanced prostate cancer and substance use disorder may adversely affect outcomes. Incorporating substance use screening and treatments into prostate cancer care guidelines and coordination of care is desirable. Cancer 2014;120:3338–3345. © 2014 American Cancer Society.
The intersection of advanced prostate cancer and substance use disorder appears to adversely affect outcomes. Thus, incorporating substance use screening and treatments into prostate cancer care guidelines and care coordination is desirable.</description><subject>advanced prostate cancer</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>health services</subject><subject>Humans</subject><subject>Insurance Claim Review</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicare elderly</subject><subject>mortality</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Staging</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>substance use disorder</subject><subject>Substance-Related Disorders - classification</subject><subject>Substance-Related Disorders - complications</subject><subject>Substance-Related Disorders - pathology</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>United States</subject><subject>Urinary tract. Prostate gland</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMotlY3PoBk40YYPbnNTDaCFG8gCl7AXcgkmTbSzpRkqrjzEXxGn8TUet24Opd85__Jj9A2gX0CQA9MY8I-LcucrKA-AVlkQDhdRX0AKDPB2X0PbcT4kMaCCraOelQAp0zmfaRu5lXsdGMcnkeHrY9tsC5g3Vjsu4hdXTuTatvgdt6Zduoi9g2eugY_-W6MtX1cHNu3l9ckM3J4FtrUdA6bxT5sorVaT6Lb-qwDdHdyfDs8yy6uTs-HRxeZERRIxitaSmuKnIAzICmvclOUQkrKSsiFJkJaIggHrQ0rNEjLOdVQ1AxY7XjFBuhwqTubV1NnjWu6oCdqFvxUh2fVaq_-vjR-rEbto-IUBJEiCewtBUz6QAyu_r4loBYxq0XM6iPmBO_8dvtGv3JNwO4noKPRkzqkMHz84UrJGeM8cWTJPfmJe_7HUg0vh9dL83fNE5do</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Chhatre, Sumedha</creator><creator>Metzger, David S.</creator><creator>Malkowicz, S. Bruce</creator><creator>Woody, George</creator><creator>Jayadevappa, Ravishankar</creator><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer</title><author>Chhatre, Sumedha ; Metzger, David S. ; Malkowicz, S. Bruce ; Woody, George ; Jayadevappa, Ravishankar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5201-4b289dc7610ec0924b6c78599238065a159d15140aac37a09d442a07f303fe4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>advanced prostate cancer</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>health services</topic><topic>Humans</topic><topic>Insurance Claim Review</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicare elderly</topic><topic>mortality</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Staging</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>substance use disorder</topic><topic>Substance-Related Disorders - classification</topic><topic>Substance-Related Disorders - complications</topic><topic>Substance-Related Disorders - pathology</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>United States</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chhatre, Sumedha</creatorcontrib><creatorcontrib>Metzger, David S.</creatorcontrib><creatorcontrib>Malkowicz, S. Bruce</creatorcontrib><creatorcontrib>Woody, George</creatorcontrib><creatorcontrib>Jayadevappa, Ravishankar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chhatre, Sumedha</au><au>Metzger, David S.</au><au>Malkowicz, S. Bruce</au><au>Woody, George</au><au>Jayadevappa, Ravishankar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>120</volume><issue>21</issue><spage>3338</spage><epage>3345</epage><pages>3338-3345</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Substance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer.
METHODS
This was an observational cohort study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data from 2000 to 2009. Among men who were diagnosed with advanced prostate cancer between 2001 and 2004, we identified those who had a claim for substance use disorder in the year before cancer diagnosis, 1 year after cancer diagnosis, and an additional 4 years after diagnosis. The outcomes investigated were use of health services, costs, and mortality.
RESULTS
The prevalence of substance use disorder was 10.6%. The category drug psychoses and related had greater odds of inpatient hospitalizations (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.9‐2.8), outpatient hospital visits (OR, 2.6; 95% CI, 1.9‐3.6), and emergency room visits (OR, 1.7; 95% CI, 1.2‐2.4). Substance use disorder in the follow‐up phase was associated with greater odds of inpatient hospitalizations (OR, 2.0; 95% CI, 1.8‐2.2), outpatient hospital visits (OR, 2.0; 95% CI, 1.7‐2.4), and emergency room visits (OR, 1.7; 95% CI, 1.5‐2.1). Compared with men who did not have substance use disorder, those in the category drug psychoses and related had 70% higher costs, and those who had substance use disorder during the follow‐up phase had 60% higher costs. The hazard of all‐cause mortality was highest for patients in the drug psychoses and related category (hazard ratio, 1.3; 95% CI, 1.1‐1.7) and the substance use disorder in treatment phase category (hazard ratio, 1.5; 95% CI, 1.3‐1.7).
CONCLUSIONS
The intersection of advanced prostate cancer and substance use disorder may adversely affect outcomes. Incorporating substance use screening and treatments into prostate cancer care guidelines and coordination of care is desirable. Cancer 2014;120:3338–3345. © 2014 American Cancer Society.
The intersection of advanced prostate cancer and substance use disorder appears to adversely affect outcomes. Thus, incorporating substance use screening and treatments into prostate cancer care guidelines and care coordination is desirable.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>25042396</pmid><doi>10.1002/cncr.28861</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | advanced prostate cancer Aged Aged, 80 and over Biological and medical sciences health services Humans Insurance Claim Review Male Medical sciences Medicare elderly mortality Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Staging Nephrology. Urinary tract diseases Prostatic Neoplasms - complications Prostatic Neoplasms - drug therapy Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology substance use disorder Substance-Related Disorders - classification Substance-Related Disorders - complications Substance-Related Disorders - pathology Treatment Outcome Tumors Tumors of the urinary system United States Urinary tract. Prostate gland |
| title | Substance use disorder and its effects on outcomes in men with advanced‐stage prostate cancer |
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