Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?

To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue sa...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2007-11, Vol.13 (41), p.5476-5480
Main Authors: Tascilar, Oge, Cakmak, Güldeniz Karadeniz, Tekin, Ishak Ozel, Emre, Ali-Ugur, Ucan, Bulent Hamdi, Irkorucu, Oktay, Karakaya, Kemal, Gül, Mesut, Engin, Hüseyin Bülent, Comert, Mustafa
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Cell Differentiation
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Feasibility Studies
Female
Flow Cytometry - methods
Humans
Male
Middle Aged
Neoplasm Staging
Neural Cell Adhesion Molecules - analysis
Predictive Value of Tests
Prognosis
Rapid Communication
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c423t-24158c31fdd01a93c47834a365583a8f221114b5b1327e38c7ca855ec1944b343
cites
container_end_page 5480
container_issue 41
container_start_page 5476
container_title World journal of gastroenterology : WJG
container_volume 13
creator Tascilar, Oge
Cakmak, Güldeniz Karadeniz
Tekin, Ishak Ozel
Emre, Ali-Ugur
Ucan, Bulent Hamdi
Irkorucu, Oktay
Karakaya, Kemal
Gül, Mesut
Engin, Hüseyin Bülent
Comert, Mustafa
description To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up. As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.
doi_str_mv 10.3748/wjg.v13.i41.5476
format article
fullrecord <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4171282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>wjg200741008</wanfj_id><sourcerecordid>wjg200741008</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-24158c31fdd01a93c47834a365583a8f221114b5b1327e38c7ca855ec1944b343</originalsourceid><addsrcrecordid>eNpVkc1v1DAQxS1ERbcLd07IB8Qti8d21g4HEKooIFXtpZwtxzvZepXYwU5a-O9x2BUfF1vyzDzPez9CXgLbCCX128fDfvMAYuMlbGqptk_IinNoKq4le0pWwJiqGsHVObnI-cAYF6Lmz8g5qIYp3sCKjDc4J9tTh31P7e4es4-BDrFHN_dYgWYUf4wJ8-93m6mlY4r7EPPkHXXJT5iWig_UxT4mdNOiZpPzIQ72He3QZt_2SGOiIU4fnpOzzvYZX5zuNfl29enu8kt1ffv56-XH68pJLqaKS6i1E9DtdgxsI5xUWkgrtnWthdVdsQkg27qFYg-FdspZXdfooJGyFVKsyfuj7ji3A-4chqn4NGPyg00_TbTe_F8J_t7s44ORoIBrXgReHwUebehs2JtDnFMoK5uSOi_JyhKvLm1vTv-k-H3GPJnB5yVNGzDO2Wy1KKGXY03YsdGlmHPC7s8uwMxCc9E1haYpNM1Cs4y8-tfD34ETPvELRqGdAQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68333583</pqid></control><display><type>article</type><title>Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?</title><source>NCBI_PubMed Central（免费）</source><creator>Tascilar, Oge ; Cakmak, Güldeniz Karadeniz ; Tekin, Ishak Ozel ; Emre, Ali-Ugur ; Ucan, Bulent Hamdi ; Irkorucu, Oktay ; Karakaya, Kemal ; Gül, Mesut ; Engin, Hüseyin Bülent ; Comert, Mustafa</creator><creatorcontrib>Tascilar, Oge ; Cakmak, Güldeniz Karadeniz ; Tekin, Ishak Ozel ; Emre, Ali-Ugur ; Ucan, Bulent Hamdi ; Irkorucu, Oktay ; Karakaya, Kemal ; Gül, Mesut ; Engin, Hüseyin Bülent ; Comert, Mustafa</creatorcontrib><description>To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up. As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v13.i41.5476</identifier><identifier>PMID: 17907291</identifier><language>eng</language><publisher>United States: Department of Surgery, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey%Department of Immunology, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey%Department of Medical Oncology, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Cell Differentiation ; Colorectal Neoplasms - chemistry ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - therapy ; Feasibility Studies ; Female ; Flow Cytometry - methods ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Neural Cell Adhesion Molecules - analysis ; Predictive Value of Tests ; Prognosis ; Rapid Communication</subject><ispartof>World journal of gastroenterology : WJG, 2007-11, Vol.13 (41), p.5476-5480</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2007 Baishideng Publishing Group Inc. All rights reserved. 2007</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-24158c31fdd01a93c47834a365583a8f221114b5b1327e38c7ca855ec1944b343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171282/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171282/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17907291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tascilar, Oge</creatorcontrib><creatorcontrib>Cakmak, Güldeniz Karadeniz</creatorcontrib><creatorcontrib>Tekin, Ishak Ozel</creatorcontrib><creatorcontrib>Emre, Ali-Ugur</creatorcontrib><creatorcontrib>Ucan, Bulent Hamdi</creatorcontrib><creatorcontrib>Irkorucu, Oktay</creatorcontrib><creatorcontrib>Karakaya, Kemal</creatorcontrib><creatorcontrib>Gül, Mesut</creatorcontrib><creatorcontrib>Engin, Hüseyin Bülent</creatorcontrib><creatorcontrib>Comert, Mustafa</creatorcontrib><title>Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up. As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cell Differentiation</subject><subject>Colorectal Neoplasms - chemistry</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Flow Cytometry - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neural Cell Adhesion Molecules - analysis</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Rapid Communication</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpVkc1v1DAQxS1ERbcLd07IB8Qti8d21g4HEKooIFXtpZwtxzvZepXYwU5a-O9x2BUfF1vyzDzPez9CXgLbCCX128fDfvMAYuMlbGqptk_IinNoKq4le0pWwJiqGsHVObnI-cAYF6Lmz8g5qIYp3sCKjDc4J9tTh31P7e4es4-BDrFHN_dYgWYUf4wJ8-93m6mlY4r7EPPkHXXJT5iWig_UxT4mdNOiZpPzIQ72He3QZt_2SGOiIU4fnpOzzvYZX5zuNfl29enu8kt1ffv56-XH68pJLqaKS6i1E9DtdgxsI5xUWkgrtnWthdVdsQkg27qFYg-FdspZXdfooJGyFVKsyfuj7ji3A-4chqn4NGPyg00_TbTe_F8J_t7s44ORoIBrXgReHwUebehs2JtDnFMoK5uSOi_JyhKvLm1vTv-k-H3GPJnB5yVNGzDO2Wy1KKGXY03YsdGlmHPC7s8uwMxCc9E1haYpNM1Cs4y8-tfD34ETPvELRqGdAQ</recordid><startdate>20071107</startdate><enddate>20071107</enddate><creator>Tascilar, Oge</creator><creator>Cakmak, Güldeniz Karadeniz</creator><creator>Tekin, Ishak Ozel</creator><creator>Emre, Ali-Ugur</creator><creator>Ucan, Bulent Hamdi</creator><creator>Irkorucu, Oktay</creator><creator>Karakaya, Kemal</creator><creator>Gül, Mesut</creator><creator>Engin, Hüseyin Bülent</creator><creator>Comert, Mustafa</creator><general>Department of Surgery, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey%Department of Immunology, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey%Department of Medical Oncology, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey</general><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20071107</creationdate><title>Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?</title><author>Tascilar, Oge ; Cakmak, Güldeniz Karadeniz ; Tekin, Ishak Ozel ; Emre, Ali-Ugur ; Ucan, Bulent Hamdi ; Irkorucu, Oktay ; Karakaya, Kemal ; Gül, Mesut ; Engin, Hüseyin Bülent ; Comert, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-24158c31fdd01a93c47834a365583a8f221114b5b1327e38c7ca855ec1944b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cell Differentiation</topic><topic>Colorectal Neoplasms - chemistry</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - therapy</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Flow Cytometry - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neural Cell Adhesion Molecules - analysis</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Rapid Communication</topic><toplevel>online_resources</toplevel><creatorcontrib>Tascilar, Oge</creatorcontrib><creatorcontrib>Cakmak, Güldeniz Karadeniz</creatorcontrib><creatorcontrib>Tekin, Ishak Ozel</creatorcontrib><creatorcontrib>Emre, Ali-Ugur</creatorcontrib><creatorcontrib>Ucan, Bulent Hamdi</creatorcontrib><creatorcontrib>Irkorucu, Oktay</creatorcontrib><creatorcontrib>Karakaya, Kemal</creatorcontrib><creatorcontrib>Gül, Mesut</creatorcontrib><creatorcontrib>Engin, Hüseyin Bülent</creatorcontrib><creatorcontrib>Comert, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>中國數字化期刊數據庫</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tascilar, Oge</au><au>Cakmak, Güldeniz Karadeniz</au><au>Tekin, Ishak Ozel</au><au>Emre, Ali-Ugur</au><au>Ucan, Bulent Hamdi</au><au>Irkorucu, Oktay</au><au>Karakaya, Kemal</au><au>Gül, Mesut</au><au>Engin, Hüseyin Bülent</au><au>Comert, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2007-11-07</date><risdate>2007</risdate><volume>13</volume><issue>41</issue><spage>5476</spage><epage>5480</epage><pages>5476-5480</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Undefined-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>Telephone: +90-372-2610169 Fax: +90-372-2610155</notes><notes>Author contributions: All authors contributed equally to the work.</notes><notes>Correspondence to: Dr. Güldeniz Karadeniz Cakmak, Zonguldak Karaelmas Universitesi, Arastirma ve Uygulama Hastanesi Bashekimligi, Kozlu-Zonguldak 67600, Turkey. gkkaradeniz@yahoo.com</notes><abstract>To evaluate the frequency of neural cell adhesion molecule (NCAM)-180 expression in fresh tumor tissue samples and to discuss the prognostic value of NCAM-180 in routine clinical practice. Twenty-six patients (16 men, 10 women) with colorectal cancer were included in the study. Fresh tumor tissue samples and macroscopically healthy proximal margins of each specimen were subjected to flow-cytometric analysis for NCAM-180 expression. Flow-cytometric analysis determined NCAM-180 expression in whole tissue samples of macroscopically healthy colorectal tissues. However, NCAM-180 expression was positive in only one case (3.84%) with well-differentiated Stage II disease who experienced no active disease at 30 mon follow-up. As a consequence of the limited number of cases in our series, it might not be possible to make a generalisation, nevertheless the routine use of NCAM-180 expression as a prognostic marker for colorectal carcinoma seems to be unfeasible and not cost-effective in clinical practice due to its very low incidence.</abstract><cop>United States</cop><pub>Department of Surgery, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey%Department of Immunology, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey%Department of Medical Oncology, Zonguldak Karaelmas University, The School of Medicine, Kozlu-Zonguldak 67600, Turkey</pub><pmid>17907291</pmid><doi>10.3748/wjg.v13.i41.5476</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1007-9327
ispartof World journal of gastroenterology : WJG, 2007-11, Vol.13 (41), p.5476-5480
issn 1007-9327
2219-2840
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4171282
source NCBI_PubMed Central（免费）
subjects Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Cell Differentiation
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Feasibility Studies
Female
Flow Cytometry - methods
Humans
Male
Middle Aged
Neoplasm Staging
Neural Cell Adhesion Molecules - analysis
Predictive Value of Tests
Prognosis
Rapid Communication
title Neural cell adhesion molecule-180 expression as a prognostic criterion in colorectal carcinoma: feasible or not?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T02%3A30%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neural%20cell%20adhesion%20molecule-180%20expression%20as%20a%20prognostic%20criterion%20in%20colorectal%20carcinoma:%20feasible%20or%20not?&rft.jtitle=World%20journal%20of%20gastroenterology%20:%20WJG&rft.au=Tascilar,%20Oge&rft.date=2007-11-07&rft.volume=13&rft.issue=41&rft.spage=5476&rft.epage=5480&rft.pages=5476-5480&rft.issn=1007-9327&rft.eissn=2219-2840&rft_id=info:doi/10.3748/wjg.v13.i41.5476&rft_dat=%3Cwanfang_jour_pubme%3Ewjg200741008%3C/wanfang_jour_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c423t-24158c31fdd01a93c47834a365583a8f221114b5b1327e38c7ca855ec1944b343%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=68333583&rft_id=info:pmid/17907291&rft_wanfj_id=wjg200741008&rfr_iscdi=true