Modulation of miR‐29 expression by alpha‐fetoprotein is linked to the hepatocellular carcinoma epigenome

Globally, hepatocellular carcinoma (HCC) accounts for 70%‐85% of primary liver cancers and ranks as the second leading cause of male cancer death. Serum alpha‐fetoprotein (AFP), normally highly expressed in the liver only during fetal development, is reactivated in 60% of HCC tumors and associated w...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 2014-09, Vol.60 (3), p.872-883
Main Authors: Parpart, Sonya, Roessler, Stephanie, Dong, Fei, Rao, Vinay, Takai, Atsushi, Ji, Junfang, Qin, Lun‐Xiu, Ye, Qing‐Hai, Jia, Hu‐Liang, Tang, Zhao‐You, Wang, Xin Wei
Format: Article
Language:English
Subjects:
Adult
alpha-Fetoproteins - biosynthesis
alpha-Fetoproteins - genetics
Animals
Carcinoma, Hepatocellular - enzymology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - mortality
Cell Line, Tumor
Cohort Studies
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Down-Regulation - genetics
Epigenomics
Female
Gene expression
Gene Expression Regulation, Neoplastic
Hepatology
Humans
Liver cancer
Liver Neoplasms - enzymology
Liver Neoplasms - genetics
Liver Neoplasms - mortality
Liver Neoplasms, Experimental - enzymology
Liver Neoplasms, Experimental - genetics
Liver Neoplasms, Experimental - mortality
Male
Medical prognosis
Mice
Mice, Nude
MicroRNAs - antagonists & inhibitors
MicroRNAs - biosynthesis
MicroRNAs - genetics
Middle Aged
Tumors
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Summary:Globally, hepatocellular carcinoma (HCC) accounts for 70%‐85% of primary liver cancers and ranks as the second leading cause of male cancer death. Serum alpha‐fetoprotein (AFP), normally highly expressed in the liver only during fetal development, is reactivated in 60% of HCC tumors and associated with poor patient outcome. We hypothesize that AFP+ and AFP− tumors differ biologically. Multivariable analysis in 237 HCC cases demonstrates that AFP level predicts poor survival independent of tumor stage (P 
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.27200