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The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy
Survivors of childhood brain tumors (BTs) treated with CNS-directed therapy show changes in cerebral white matter that are related to neurocognitive late effects. We examined the association between white matter volume and working memory ability in survivors treated with conformal radiation therapy...
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| Published in: | Journal of neuro-oncology 2014-08, Vol.119 (1), p.197-205 |
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| container_title | Journal of neuro-oncology |
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| creator | Jacola, Lisa M. Ashford, Jason M. Reddick, Wilburn E. Glass, John O. Ogg, Robert J. Merchant, Thomas E. Conklin, Heather M. |
| description | Survivors of childhood brain tumors (BTs) treated with CNS-directed therapy show changes in cerebral white matter that are related to neurocognitive late effects. We examined the association between white matter volume and working memory ability in survivors treated with conformal radiation therapy (CRT). Fifty survivors (25 males, age at assessment = 13.14 ± 2.88, age at CRT = 7.41 ± 3.41 years) completed Digit Span from the Wechsler Intelligence Scales for Children, 4th Edition and experimental Self-Ordered Search (SOS) tasks as measures of working memory. Caregiver ratings were obtained using the Behavior Rating Inventory of Executive Function. MRI exams were acquired on a 1.5 T scanner. Volumes of normal appearing white matter (NAWM) were quantified using a well-validated automated segmentation and classification program. Correlational analyses demonstrated that NAWM volumes were significantly larger in males and participants with tumors located in the infratentorial space. Correlations between NAWM volume and Digit Span Backward were distributed across anterior and posterior regions, with evidence for greater right hemisphere involvement (
r
= .32–.34,
p
≤ .05). Correlations between NAWM volume with Digit Span Backward (
r
= .44–.52;
p
≤ .05) and NAWM volume with SOS-Object Total (
r
= .45–.52,
p
≤ .05) were of greater magnitude in females. No relationship was found between NAWM volume and caregiver report. Working memory performance in survivors of pediatric BTs treated with CRT are related to regionally specific NAWM volume. Developmental differences in cerebral myelination may explain findings of greater risk for neurocognitive late effects in female survivors. Future studies are needed to better isolate vulnerable white matter pathways, thus facilitating the development of neuroprotective interventions. |
| doi_str_mv | 10.1007/s11060-014-1476-4 |
| format | article |
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r
= .32–.34,
p
≤ .05). Correlations between NAWM volume with Digit Span Backward (
r
= .44–.52;
p
≤ .05) and NAWM volume with SOS-Object Total (
r
= .45–.52,
p
≤ .05) were of greater magnitude in females. No relationship was found between NAWM volume and caregiver report. Working memory performance in survivors of pediatric BTs treated with CRT are related to regionally specific NAWM volume. Developmental differences in cerebral myelination may explain findings of greater risk for neurocognitive late effects in female survivors. Future studies are needed to better isolate vulnerable white matter pathways, thus facilitating the development of neuroprotective interventions.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-014-1476-4</identifier><identifier>PMID: 24847967</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Brain - pathology ; Brain - radiation effects ; Brain Neoplasms - pathology ; Brain Neoplasms - psychology ; Brain Neoplasms - radiotherapy ; Child ; Child, Preschool ; Clinical Study ; Cranial Irradiation ; Craniopharyngioma - pathology ; Craniopharyngioma - psychology ; Craniopharyngioma - radiotherapy ; Executive Function - physiology ; Female ; Glioma - pathology ; Glioma - psychology ; Glioma - radiotherapy ; Humans ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Memory, Short-Term - physiology ; Neurology ; Neuropsychological Tests ; Oncology ; Pituitary Neoplasms - pathology ; Pituitary Neoplasms - psychology ; Pituitary Neoplasms - radiotherapy ; Survivors ; White Matter - pathology ; White Matter - radiation effects</subject><ispartof>Journal of neuro-oncology, 2014-08, Vol.119 (1), p.197-205</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-8b2469fed4df8cb90d4bf9a5c0cda9f250dd78651311f4428a891e55e994a3743</citedby><cites>FETCH-LOGICAL-c536t-8b2469fed4df8cb90d4bf9a5c0cda9f250dd78651311f4428a891e55e994a3743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,783,787,888,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24847967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacola, Lisa M.</creatorcontrib><creatorcontrib>Ashford, Jason M.</creatorcontrib><creatorcontrib>Reddick, Wilburn E.</creatorcontrib><creatorcontrib>Glass, John O.</creatorcontrib><creatorcontrib>Ogg, Robert J.</creatorcontrib><creatorcontrib>Merchant, Thomas E.</creatorcontrib><creatorcontrib>Conklin, Heather M.</creatorcontrib><title>The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Survivors of childhood brain tumors (BTs) treated with CNS-directed therapy show changes in cerebral white matter that are related to neurocognitive late effects. We examined the association between white matter volume and working memory ability in survivors treated with conformal radiation therapy (CRT). Fifty survivors (25 males, age at assessment = 13.14 ± 2.88, age at CRT = 7.41 ± 3.41 years) completed Digit Span from the Wechsler Intelligence Scales for Children, 4th Edition and experimental Self-Ordered Search (SOS) tasks as measures of working memory. Caregiver ratings were obtained using the Behavior Rating Inventory of Executive Function. MRI exams were acquired on a 1.5 T scanner. Volumes of normal appearing white matter (NAWM) were quantified using a well-validated automated segmentation and classification program. Correlational analyses demonstrated that NAWM volumes were significantly larger in males and participants with tumors located in the infratentorial space. Correlations between NAWM volume and Digit Span Backward were distributed across anterior and posterior regions, with evidence for greater right hemisphere involvement (
r
= .32–.34,
p
≤ .05). Correlations between NAWM volume with Digit Span Backward (
r
= .44–.52;
p
≤ .05) and NAWM volume with SOS-Object Total (
r
= .45–.52,
p
≤ .05) were of greater magnitude in females. No relationship was found between NAWM volume and caregiver report. Working memory performance in survivors of pediatric BTs treated with CRT are related to regionally specific NAWM volume. Developmental differences in cerebral myelination may explain findings of greater risk for neurocognitive late effects in female survivors. Future studies are needed to better isolate vulnerable white matter pathways, thus facilitating the development of neuroprotective interventions.</description><subject>Adolescent</subject><subject>Brain - pathology</subject><subject>Brain - radiation effects</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - psychology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Study</subject><subject>Cranial Irradiation</subject><subject>Craniopharyngioma - pathology</subject><subject>Craniopharyngioma - psychology</subject><subject>Craniopharyngioma - radiotherapy</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Glioma - pathology</subject><subject>Glioma - psychology</subject><subject>Glioma - radiotherapy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory, Short-Term - physiology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Oncology</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Pituitary Neoplasms - psychology</subject><subject>Pituitary Neoplasms - radiotherapy</subject><subject>Survivors</subject><subject>White Matter - pathology</subject><subject>White Matter - radiation effects</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNks2KFDEUhQtRnHb0AdxIwI2b0qTyV7URZBh_YMDNCO5CKrnVlbEqaZNUN_0mPq4pexxGQXCVxfnuyT2XU1XPCX5NMJZvEiFY4BoTVhMmRc0eVBvCJa0llfRhtcFEyJp37OtZ9SSlG4wxk5Q8rs4a1jLZCbmpflyPgCJMOrvg0-h2qId8APDoEOI357dohjnEI9LeIgMR-qgndBhdBjTrnCGifZiWGZDzKC1x7_YhJhQGZEY32TEEi8pIEfMyr0qOoDNYdHB5RCb4IcS5OEZt3a8dUB4h6t3xafVo0FOCZ7fvefXl_eX1xcf66vOHTxfvrmrDqch12zdMdANYZofW9B22rB86zQ02VndDw7G1shWcUEIGxppWtx0BzqHrmKaS0fPq7cl3t_QzWAM-l4RqF92s41EF7dSfinej2oa9YoRSikUxeHVrEMP3BVJWs0sGpkl7CEtShAtMKGsJ_w-UU4I5421BX_6F3oQl-nKJlWq4kMW2UOREmRhSijDc7U2wWiuiThVRpSJqrYhaA7-4H_hu4ncnCtCcgFQkv4V47-t_uv4EjzbLOQ</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Jacola, Lisa M.</creator><creator>Ashford, Jason M.</creator><creator>Reddick, Wilburn E.</creator><creator>Glass, John O.</creator><creator>Ogg, Robert J.</creator><creator>Merchant, Thomas E.</creator><creator>Conklin, Heather M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140801</creationdate><title>The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy</title><author>Jacola, Lisa M. ; 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We examined the association between white matter volume and working memory ability in survivors treated with conformal radiation therapy (CRT). Fifty survivors (25 males, age at assessment = 13.14 ± 2.88, age at CRT = 7.41 ± 3.41 years) completed Digit Span from the Wechsler Intelligence Scales for Children, 4th Edition and experimental Self-Ordered Search (SOS) tasks as measures of working memory. Caregiver ratings were obtained using the Behavior Rating Inventory of Executive Function. MRI exams were acquired on a 1.5 T scanner. Volumes of normal appearing white matter (NAWM) were quantified using a well-validated automated segmentation and classification program. Correlational analyses demonstrated that NAWM volumes were significantly larger in males and participants with tumors located in the infratentorial space. Correlations between NAWM volume and Digit Span Backward were distributed across anterior and posterior regions, with evidence for greater right hemisphere involvement (
r
= .32–.34,
p
≤ .05). Correlations between NAWM volume with Digit Span Backward (
r
= .44–.52;
p
≤ .05) and NAWM volume with SOS-Object Total (
r
= .45–.52,
p
≤ .05) were of greater magnitude in females. No relationship was found between NAWM volume and caregiver report. Working memory performance in survivors of pediatric BTs treated with CRT are related to regionally specific NAWM volume. Developmental differences in cerebral myelination may explain findings of greater risk for neurocognitive late effects in female survivors. Future studies are needed to better isolate vulnerable white matter pathways, thus facilitating the development of neuroprotective interventions.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24847967</pmid><doi>10.1007/s11060-014-1476-4</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0167-594X 1573-7373 |
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| subjects | Adolescent Brain - pathology Brain - radiation effects Brain Neoplasms - pathology Brain Neoplasms - psychology Brain Neoplasms - radiotherapy Child Child, Preschool Clinical Study Cranial Irradiation Craniopharyngioma - pathology Craniopharyngioma - psychology Craniopharyngioma - radiotherapy Executive Function - physiology Female Glioma - pathology Glioma - psychology Glioma - radiotherapy Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Memory, Short-Term - physiology Neurology Neuropsychological Tests Oncology Pituitary Neoplasms - pathology Pituitary Neoplasms - psychology Pituitary Neoplasms - radiotherapy Survivors White Matter - pathology White Matter - radiation effects |
| title | The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy |
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