Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication

It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (d...

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Bibliographic Details
Published in:Theranostics 2014-01, Vol.4 (4), p.399-411
Main Authors: Wan, Zhihui, Mao, Huajian, Guo, Miao, Li, Yanli, Zhu, Aijun, Yang, Hong, He, Hui, Shen, Junkang, Zhou, Lijuan, Jiang, Zhen, Ge, Cuicui, Chen, Xiaoyuan, Yang, Xiangliang, Liu, Gang, Chen, Huabing
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Cell Line - drug effects
Combined Modality Therapy
Diagnostic Imaging - methods
Doxorubicin - pharmacology
Female
Fluorescence
Humans
Hyperthermia, Induced - methods
Indocyanine Green - chemistry
Lysosomes - drug effects
Mice
Mice, Inbred BALB C
Micelles
Neoplasms, Experimental - therapy
Phototherapy - methods
Rabbits
Research Paper
Singlet Oxygen - therapeutic use
Tissue Distribution
Xenograft Model Antitumor Assays
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Summary:It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability and enhanced cellular uptake via clathrin-mediated endocytosis. I/D-Micelles exhibit the multiple functionalities including near-infrared fluorescence (NIRF), hyperthermia and intracellular singlet oxygen from indocyanine green, and simultaneous cytotoxicity from doxorubicin. Upon photoirradiation, I/D-Micelles can induce NIRF imaging, acute photothermal therapy via hyperthermia and simultaneous synergistic chemotherapy via singlet oxygen-triggered disruption of lysosomal membranes, eventually leading to enhanced NIRF imaging and superior tumor eradication without any re-growth. Our results suggest that the hierarchical micelles can act as a superior theranostic platform for cancer imaging and multimodal synergistic therapy.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.8171