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Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma
We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, lq24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression l...
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Published in: | Cell research 2014-02, Vol.24 (2), p.204-217 |
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container_title | Cell research |
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creator | Jia, Deshui Jing, Ying Zhang, Zhenfeng Liu, Li Ding, Jie Zhao, Fangyu Ge, Chao Wang, Qifeng Chen, Taoyang Yao, Ming Li, Jinjun Gu, Jianren He, Xianghuo |
description | We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, lq24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic metastasis of the HCC specimens. MPZL1 can significantly enhance the migratory and metastatic potential of the HCC cells. Moreover, we found that one of the mechanisms by which MPZL1 promotes HCC cell migration is by inducing the phosphorylation and activation of the pro-metastatic protein, cortactin. Additionally, we found that Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression. Taken together, these findings suggest that MPZL1 is a novel pro-metastatic gene targeted by a recurrent region of copy number amplification at lq24.1-24.2 in HCC. |
doi_str_mv | 10.1038/cr.2013.158 |
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In the present study, we found that a novel recurrent focal amplicon, lq24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic metastasis of the HCC specimens. MPZL1 can significantly enhance the migratory and metastatic potential of the HCC cells. Moreover, we found that one of the mechanisms by which MPZL1 promotes HCC cell migration is by inducing the phosphorylation and activation of the pro-metastatic protein, cortactin. Additionally, we found that Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression. Taken together, these findings suggest that MPZL1 is a novel pro-metastatic gene targeted by a recurrent region of copy number amplification at lq24.1-24.2 in HCC.</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/cr.2013.158</identifier><identifier>PMID: 24296779</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Animals ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; Chromosomes, Human, Pair 1 ; Cortactin - metabolism ; DNA Copy Number Variations ; Down-Regulation ; Hep G2 Cells ; Humans ; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Lung Neoplasms - pathology ; Lung Neoplasms - secondary ; Mice ; Mice, Nude ; Original ; Phosphoproteins - antagonists & inhibitors ; Phosphoproteins - genetics ; Phosphoproteins - metabolism ; Phosphorylation ; Protein Isoforms - antagonists & inhibitors ; Protein Isoforms - genetics ; Protein Isoforms - metabolism ; RNA Interference ; RNA, Small Interfering ; src-Family Kinases - antagonists & inhibitors ; src-Family Kinases - metabolism ; Transplantation, Heterologous ; 介导 ; 化促 ; 皮层 ; 磷酸化 ; 细胞迁移 ; 肝癌细胞 ; 肿瘤细胞 ; 蛋白激酶</subject><ispartof>Cell research, 2014-02, Vol.24 (2), p.204-217</ispartof><rights>Copyright Nature Publishing Group Feb 2014</rights><rights>Copyright © 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-65101f74305fb91567217d5ad85ec860290ab8e56d5c711e54fbc1421b665c3d3</citedby><cites>FETCH-LOGICAL-c436t-65101f74305fb91567217d5ad85ec860290ab8e56d5c711e54fbc1421b665c3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85240X/85240X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915911/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915911/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24296779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Deshui</creatorcontrib><creatorcontrib>Jing, Ying</creatorcontrib><creatorcontrib>Zhang, Zhenfeng</creatorcontrib><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Ding, Jie</creatorcontrib><creatorcontrib>Zhao, Fangyu</creatorcontrib><creatorcontrib>Ge, Chao</creatorcontrib><creatorcontrib>Wang, Qifeng</creatorcontrib><creatorcontrib>Chen, Taoyang</creatorcontrib><creatorcontrib>Yao, Ming</creatorcontrib><creatorcontrib>Li, Jinjun</creatorcontrib><creatorcontrib>Gu, Jianren</creatorcontrib><creatorcontrib>He, Xianghuo</creatorcontrib><title>Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma</title><title>Cell research</title><addtitle>Cell Research</addtitle><description>We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, lq24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic metastasis of the HCC specimens. MPZL1 can significantly enhance the migratory and metastatic potential of the HCC cells. Moreover, we found that one of the mechanisms by which MPZL1 promotes HCC cell migration is by inducing the phosphorylation and activation of the pro-metastatic protein, cortactin. Additionally, we found that Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression. Taken together, these findings suggest that MPZL1 is a novel pro-metastatic gene targeted by a recurrent region of copy number amplification at lq24.1-24.2 in HCC.</description><subject>Animals</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Cortactin - metabolism</subject><subject>DNA Copy Number Variations</subject><subject>Down-Regulation</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Intracellular Signaling Peptides and Proteins - antagonists & inhibitors</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - secondary</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Original</subject><subject>Phosphoproteins - 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metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Cortactin - metabolism</topic><topic>DNA Copy Number Variations</topic><topic>Down-Regulation</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Intracellular Signaling Peptides and Proteins - antagonists & inhibitors</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - secondary</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Original</topic><topic>Phosphoproteins - antagonists & inhibitors</topic><topic>Phosphoproteins - genetics</topic><topic>Phosphoproteins - metabolism</topic><topic>Phosphorylation</topic><topic>Protein Isoforms - antagonists & inhibitors</topic><topic>Protein Isoforms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Deshui</au><au>Jing, Ying</au><au>Zhang, Zhenfeng</au><au>Liu, Li</au><au>Ding, Jie</au><au>Zhao, Fangyu</au><au>Ge, Chao</au><au>Wang, Qifeng</au><au>Chen, Taoyang</au><au>Yao, Ming</au><au>Li, Jinjun</au><au>Gu, Jianren</au><au>He, Xianghuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma</atitle><jtitle>Cell research</jtitle><addtitle>Cell Research</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>24</volume><issue>2</issue><spage>204</spage><epage>217</epage><pages>204-217</pages><issn>1001-0602</issn><eissn>1748-7838</eissn><notes>We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, lq24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic metastasis of the HCC specimens. MPZL1 can significantly enhance the migratory and metastatic potential of the HCC cells. Moreover, we found that one of the mechanisms by which MPZL1 promotes HCC cell migration is by inducing the phosphorylation and activation of the pro-metastatic protein, cortactin. Additionally, we found that Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression. Taken together, these findings suggest that MPZL1 is a novel pro-metastatic gene targeted by a recurrent region of copy number amplification at lq24.1-24.2 in HCC.</notes><notes>copy number alterations; MPZL1; cortactin; migration; hepatocellular carcinoma</notes><notes>31-1568/Q</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, lq24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic metastasis of the HCC specimens. MPZL1 can significantly enhance the migratory and metastatic potential of the HCC cells. Moreover, we found that one of the mechanisms by which MPZL1 promotes HCC cell migration is by inducing the phosphorylation and activation of the pro-metastatic protein, cortactin. Additionally, we found that Src kinase mediates the phosphorylation and activation of cortactin induced by MPZL1 overexpression. Taken together, these findings suggest that MPZL1 is a novel pro-metastatic gene targeted by a recurrent region of copy number amplification at lq24.1-24.2 in HCC.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>24296779</pmid><doi>10.1038/cr.2013.158</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Chromosomes, Human, Pair 1 Cortactin - metabolism DNA Copy Number Variations Down-Regulation Hep G2 Cells Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Liver Neoplasms - metabolism Liver Neoplasms - pathology Lung Neoplasms - pathology Lung Neoplasms - secondary Mice Mice, Nude Original Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - metabolism RNA Interference RNA, Small Interfering src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Transplantation, Heterologous 介导 化促 皮层 磷酸化 细胞迁移 肝癌细胞 肿瘤细胞 蛋白激酶 |
title | Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma |
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