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Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis
Objective To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles. Design Individual patient data meta-analysis. Setting Assisted reproduction centers. Patient(s) Infertile patients undergoing ND mature oocyte cryopreservation. Intervention(s) Pu...
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| Published in: | Fertility and sterility 2013-08, Vol.100 (2), p.492-499.e3 |
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| container_end_page | 499.e3 |
| container_issue | 2 |
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| container_title | Fertility and sterility |
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| creator | Cil, Aylin Pelin, M.D Bang, Heejung, Ph.D Oktay, Kutluk, M.D., F.A.C.O.G |
| description | Objective To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles. Design Individual patient data meta-analysis. Setting Assisted reproduction centers. Patient(s) Infertile patients undergoing ND mature oocyte cryopreservation. Intervention(s) PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen–thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data. Main Outcome Measure(s) Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Result(s) Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen. Conclusion(s) The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility. |
| doi_str_mv | 10.1016/j.fertnstert.2013.04.023 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3888550</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028213005190</els_id><sourcerecordid>1417535196</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-b1e128a2f89854f2470973a16810ac31cf9026e45f84c9ac9eda4281e85414ec3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhL4CPXLKM7ThxOFQqFV9SJQ6lZ8vrTLazJHGwvYvy7_FqS_k4cRlL9jvvjOeZomAc1hx4_Wa37jGkKaYc1wK4XEO1BiEfFSuuVF2qWsnHxQqAqxKEFmfFsxh3AFDzRjwtzoRsoJayXRXj5RbLOKOjnhybg9_YDQ2UFuZ7NtAB2YZCumM_KAfv3ZKQubD4OWDEcLCJ_PSW2YnR1NGBur0d2JxvcUqss8myEZMt7WSHJVJ8Xjzp7RDxxf15Xtx-eP_16lN5_eXj56vL69IppVO54ciFtqLXrVZVL6oG2kZaXmsO1knu-hZEjZXqdeVa61rsbCU0x6zmFTp5XlycfOf9ZsTO5W6CHcwcaLRhMd6S-ftlojuz9QcjtdZKQTZ4fW8Q_Pc9xmRGig6HwU7o99HwijdKKt7WWapPUhd8jAH7hzIczJGW2ZnftMyRloHKZFo59eWfbT4k_sKTBa9Ogt56Y7eBorm9yQ4qkxUt1CIr3p0UmMd5IAwmujx8hx0FdMl0nv6nj4t_TNxAEzk7fMMF487vQwaYf22iMGBujnt1XCsuAfIMQP4EvE3MkA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1417535196</pqid></control><display><type>article</type><title>Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis</title><source>ScienceDirect (Online service)</source><creator>Cil, Aylin Pelin, M.D ; Bang, Heejung, Ph.D ; Oktay, Kutluk, M.D., F.A.C.O.G</creator><creatorcontrib>Cil, Aylin Pelin, M.D ; Bang, Heejung, Ph.D ; Oktay, Kutluk, M.D., F.A.C.O.G</creatorcontrib><description>Objective To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles. Design Individual patient data meta-analysis. Setting Assisted reproduction centers. Patient(s) Infertile patients undergoing ND mature oocyte cryopreservation. Intervention(s) PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen–thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data. Main Outcome Measure(s) Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Result(s) Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen. Conclusion(s) The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2013.04.023</identifier><identifier>PMID: 23706339</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age Factors ; assisted reproductive technologies ; clinical trials ; counseling ; Cryopreservation ; eggs ; Female ; freezing ; Humans ; individual patient data ; Individuality ; Infant, Newborn ; Infertility, Female - diagnosis ; Infertility, Female - epidemiology ; Infertility, Female - therapy ; Internal Medicine ; issues and policy ; Live Birth - epidemiology ; Maternal Age ; meta-analysis ; Obstetrics and Gynecology ; Oocyte cryopreservation ; Oocytes ; patients ; Pregnancy ; pregnancy outcome ; Pregnancy Rate ; Probability ; Prognosis ; Reproductive Techniques, Assisted - statistics & numerical data ; slow freezing ; vitrification ; women</subject><ispartof>Fertility and sterility, 2013-08, Vol.100 (2), p.492-499.e3</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2013 American Society for Reproductive Medicine</rights><rights>Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><rights>2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-b1e128a2f89854f2470973a16810ac31cf9026e45f84c9ac9eda4281e85414ec3</citedby><cites>FETCH-LOGICAL-c558t-b1e128a2f89854f2470973a16810ac31cf9026e45f84c9ac9eda4281e85414ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028213005190$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,786,790,891,3568,27957,27958,45815</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23706339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cil, Aylin Pelin, M.D</creatorcontrib><creatorcontrib>Bang, Heejung, Ph.D</creatorcontrib><creatorcontrib>Oktay, Kutluk, M.D., F.A.C.O.G</creatorcontrib><title>Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles. Design Individual patient data meta-analysis. Setting Assisted reproduction centers. Patient(s) Infertile patients undergoing ND mature oocyte cryopreservation. Intervention(s) PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen–thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data. Main Outcome Measure(s) Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Result(s) Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen. Conclusion(s) The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.</description><subject>Adult</subject><subject>Age Factors</subject><subject>assisted reproductive technologies</subject><subject>clinical trials</subject><subject>counseling</subject><subject>Cryopreservation</subject><subject>eggs</subject><subject>Female</subject><subject>freezing</subject><subject>Humans</subject><subject>individual patient data</subject><subject>Individuality</subject><subject>Infant, Newborn</subject><subject>Infertility, Female - diagnosis</subject><subject>Infertility, Female - epidemiology</subject><subject>Infertility, Female - therapy</subject><subject>Internal Medicine</subject><subject>issues and policy</subject><subject>Live Birth - epidemiology</subject><subject>Maternal Age</subject><subject>meta-analysis</subject><subject>Obstetrics and Gynecology</subject><subject>Oocyte cryopreservation</subject><subject>Oocytes</subject><subject>patients</subject><subject>Pregnancy</subject><subject>pregnancy outcome</subject><subject>Pregnancy Rate</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Reproductive Techniques, Assisted - statistics & numerical data</subject><subject>slow freezing</subject><subject>vitrification</subject><subject>women</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkk1v1DAQhiMEokvhL4CPXLKM7ThxOFQqFV9SJQ6lZ8vrTLazJHGwvYvy7_FqS_k4cRlL9jvvjOeZomAc1hx4_Wa37jGkKaYc1wK4XEO1BiEfFSuuVF2qWsnHxQqAqxKEFmfFsxh3AFDzRjwtzoRsoJayXRXj5RbLOKOjnhybg9_YDQ2UFuZ7NtAB2YZCumM_KAfv3ZKQubD4OWDEcLCJ_PSW2YnR1NGBur0d2JxvcUqss8myEZMt7WSHJVJ8Xjzp7RDxxf15Xtx-eP_16lN5_eXj56vL69IppVO54ciFtqLXrVZVL6oG2kZaXmsO1knu-hZEjZXqdeVa61rsbCU0x6zmFTp5XlycfOf9ZsTO5W6CHcwcaLRhMd6S-ftlojuz9QcjtdZKQTZ4fW8Q_Pc9xmRGig6HwU7o99HwijdKKt7WWapPUhd8jAH7hzIczJGW2ZnftMyRloHKZFo59eWfbT4k_sKTBa9Ogt56Y7eBorm9yQ4qkxUt1CIr3p0UmMd5IAwmujx8hx0FdMl0nv6nj4t_TNxAEzk7fMMF487vQwaYf22iMGBujnt1XCsuAfIMQP4EvE3MkA</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Cil, Aylin Pelin, M.D</creator><creator>Bang, Heejung, Ph.D</creator><creator>Oktay, Kutluk, M.D., F.A.C.O.G</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis</title><author>Cil, Aylin Pelin, M.D ; Bang, Heejung, Ph.D ; Oktay, Kutluk, M.D., F.A.C.O.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-b1e128a2f89854f2470973a16810ac31cf9026e45f84c9ac9eda4281e85414ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>assisted reproductive technologies</topic><topic>clinical trials</topic><topic>counseling</topic><topic>Cryopreservation</topic><topic>eggs</topic><topic>Female</topic><topic>freezing</topic><topic>Humans</topic><topic>individual patient data</topic><topic>Individuality</topic><topic>Infant, Newborn</topic><topic>Infertility, Female - diagnosis</topic><topic>Infertility, Female - epidemiology</topic><topic>Infertility, Female - therapy</topic><topic>Internal Medicine</topic><topic>issues and policy</topic><topic>Live Birth - epidemiology</topic><topic>Maternal Age</topic><topic>meta-analysis</topic><topic>Obstetrics and Gynecology</topic><topic>Oocyte cryopreservation</topic><topic>Oocytes</topic><topic>patients</topic><topic>Pregnancy</topic><topic>pregnancy outcome</topic><topic>Pregnancy Rate</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Reproductive Techniques, Assisted - statistics & numerical data</topic><topic>slow freezing</topic><topic>vitrification</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cil, Aylin Pelin, M.D</creatorcontrib><creatorcontrib>Bang, Heejung, Ph.D</creatorcontrib><creatorcontrib>Oktay, Kutluk, M.D., F.A.C.O.G</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cil, Aylin Pelin, M.D</au><au>Bang, Heejung, Ph.D</au><au>Oktay, Kutluk, M.D., F.A.C.O.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>100</volume><issue>2</issue><spage>492</spage><epage>499.e3</epage><pages>492-499.e3</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><notes>http://dx.doi.org/10.1016/j.fertnstert.2013.04.023</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>Objective To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles. Design Individual patient data meta-analysis. Setting Assisted reproduction centers. Patient(s) Infertile patients undergoing ND mature oocyte cryopreservation. Intervention(s) PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen–thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data. Main Outcome Measure(s) Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Result(s) Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen. Conclusion(s) The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23706339</pmid><doi>10.1016/j.fertnstert.2013.04.023</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2013-08, Vol.100 (2), p.492-499.e3 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | ScienceDirect (Online service) |
| subjects | Adult Age Factors assisted reproductive technologies clinical trials counseling Cryopreservation eggs Female freezing Humans individual patient data Individuality Infant, Newborn Infertility, Female - diagnosis Infertility, Female - epidemiology Infertility, Female - therapy Internal Medicine issues and policy Live Birth - epidemiology Maternal Age meta-analysis Obstetrics and Gynecology Oocyte cryopreservation Oocytes patients Pregnancy pregnancy outcome Pregnancy Rate Probability Prognosis Reproductive Techniques, Assisted - statistics & numerical data slow freezing vitrification women |
| title | Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis |
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