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Effects of acute alcohol intoxication on saccadic conflict and error processing
Rationale Flexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subser...
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| Published in: | Psychopharmacology 2013-12, Vol.230 (3), p.487-497 |
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| container_end_page | 497 |
| container_issue | 3 |
| container_start_page | 487 |
| container_title | Psychopharmacology |
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| creator | Marinkovic, Ksenija Rickenbacher, Elizabeth Azma, Sheeva Artsy, Elinor Lee, Adrian K. C. |
| description | Rationale
Flexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subserving executive tasks. Neuroimaging studies indicate that the ACC is sensitive to acute intoxication during conflict, but such evidence is limited to tasks using manual responses with arbitrary response contingencies.
Objectives
The present study was designed to examine whether alcohol's effects on top–down cognitive control would generalize to the oculomotor system during inhibition of hardwired saccadic responses.
Methods
Healthy social drinkers (
N
= 22) underwent functional magnetic resonance imaging (fMRI) scanning and eye movement tracking during alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed visually guided prosaccades (PS) towards a target and volitional antisaccades (AS) away from it. To mitigate possible vasoactive effects of alcohol on the BOLD (blood oxygenation level-dependent) signal, resting perfusion was quantified with arterial spin labeling (ASL) and used as a covariate in the BOLD analysis.
Results
Saccadic conflict was subserved by a distributed frontoparietal network. However, alcohol intoxication selectively attenuated activity only in the ACC to volitional AS and erroneous responses.
Conclusions
This study provides converging evidence for the selective ACC vulnerability to alcohol intoxication during conflict across different response modalities and executive tasks, confirming its supramodal, high-level role in cognitive control. Alcohol intoxication may impair top–down regulative functions by attenuating the ACC activity, resulting in behavioral disinhibition and decreased self-control. |
| doi_str_mv | 10.1007/s00213-013-3173-y |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3869380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A352849810</galeid><sourcerecordid>A352849810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-21aff157174525d570bf1b7116fc026a85cff4624b4aeedf6835285d430a6d7f3</originalsourceid><addsrcrecordid>eNp1Ut9vFCEQJkZjr9U_wBdD4osvWxl-LPTFpGmqNWnSF30mHAtXmj04Ydd4_72zuVpbo8CEZOabb5jhI-QNsFNgTH9ojHEQHUMToEW3f0ZWIAXvONP8OVkxJpaIMkfkuLU7hksa-ZIccWGA656vyM1ljMFPjZZInZ-nQN3oy20ZacpT-Zm8m1LJFE9z3rsheepLjmPyE3V5oKHWUumuFh9aS3nziryIbmzh9f19Qr59uvx6cdVd33z-cnF-3Xml2dRxcDGC0qCl4mpA3zrCWgP00TPeO6N8jLLnci1dCEPsjVDcqEEK5vpBR3FCPh54d_N6GwYf8lTdaHc1bV3d2-KSfRrJ6dZuyg8rTH8mDEOC9_cEtXyfQ5vsNjUfxtHlUOZmQWJNgcYR-u4v6F2Za8b2EKUMB9VL-IPauDHYlGPBun4htefL4-WZgaXs6T9QuIewTTjZEBP6nyTAIcHX0loN8aFHYHZRgT2owKIK7KICu8ect4-H85Dx-9sRwA-AhqG8CfVRR_9l_QVNtbxL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1458215641</pqid></control><display><type>article</type><title>Effects of acute alcohol intoxication on saccadic conflict and error processing</title><source>SPORTDiscus</source><source>Springer Link</source><creator>Marinkovic, Ksenija ; Rickenbacher, Elizabeth ; Azma, Sheeva ; Artsy, Elinor ; Lee, Adrian K. C.</creator><creatorcontrib>Marinkovic, Ksenija ; Rickenbacher, Elizabeth ; Azma, Sheeva ; Artsy, Elinor ; Lee, Adrian K. C.</creatorcontrib><description>Rationale
Flexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subserving executive tasks. Neuroimaging studies indicate that the ACC is sensitive to acute intoxication during conflict, but such evidence is limited to tasks using manual responses with arbitrary response contingencies.
Objectives
The present study was designed to examine whether alcohol's effects on top–down cognitive control would generalize to the oculomotor system during inhibition of hardwired saccadic responses.
Methods
Healthy social drinkers (
N
= 22) underwent functional magnetic resonance imaging (fMRI) scanning and eye movement tracking during alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed visually guided prosaccades (PS) towards a target and volitional antisaccades (AS) away from it. To mitigate possible vasoactive effects of alcohol on the BOLD (blood oxygenation level-dependent) signal, resting perfusion was quantified with arterial spin labeling (ASL) and used as a covariate in the BOLD analysis.
Results
Saccadic conflict was subserved by a distributed frontoparietal network. However, alcohol intoxication selectively attenuated activity only in the ACC to volitional AS and erroneous responses.
Conclusions
This study provides converging evidence for the selective ACC vulnerability to alcohol intoxication during conflict across different response modalities and executive tasks, confirming its supramodal, high-level role in cognitive control. Alcohol intoxication may impair top–down regulative functions by attenuating the ACC activity, resulting in behavioral disinhibition and decreased self-control.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-013-3173-y</identifier><identifier>PMID: 23812762</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acute intoxication ; Adult ; Alcoholic Intoxication - physiopathology ; Alcoholism ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cognition & reasoning ; Cognition - drug effects ; Conflict (Psychology) ; Drunkenness ; Eye movements ; Female ; Gyrus Cinguli - drug effects ; Gyrus Cinguli - metabolism ; Humans ; Inhibition (Psychology) ; Magnetic Resonance Imaging ; Male ; Nervous system ; Neuroimaging ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Original Investigation ; Pharmacology/Toxicology ; Physiological aspects ; Prefrontal cortex ; Psychiatry ; Saccades - drug effects ; Self control ; Spin Labels ; Young Adult</subject><ispartof>Psychopharmacology, 2013-12, Vol.230 (3), p.487-497</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2013 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-21aff157174525d570bf1b7116fc026a85cff4624b4aeedf6835285d430a6d7f3</citedby><cites>FETCH-LOGICAL-c570t-21aff157174525d570bf1b7116fc026a85cff4624b4aeedf6835285d430a6d7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23812762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marinkovic, Ksenija</creatorcontrib><creatorcontrib>Rickenbacher, Elizabeth</creatorcontrib><creatorcontrib>Azma, Sheeva</creatorcontrib><creatorcontrib>Artsy, Elinor</creatorcontrib><creatorcontrib>Lee, Adrian K. C.</creatorcontrib><title>Effects of acute alcohol intoxication on saccadic conflict and error processing</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Flexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subserving executive tasks. Neuroimaging studies indicate that the ACC is sensitive to acute intoxication during conflict, but such evidence is limited to tasks using manual responses with arbitrary response contingencies.
Objectives
The present study was designed to examine whether alcohol's effects on top–down cognitive control would generalize to the oculomotor system during inhibition of hardwired saccadic responses.
Methods
Healthy social drinkers (
N
= 22) underwent functional magnetic resonance imaging (fMRI) scanning and eye movement tracking during alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed visually guided prosaccades (PS) towards a target and volitional antisaccades (AS) away from it. To mitigate possible vasoactive effects of alcohol on the BOLD (blood oxygenation level-dependent) signal, resting perfusion was quantified with arterial spin labeling (ASL) and used as a covariate in the BOLD analysis.
Results
Saccadic conflict was subserved by a distributed frontoparietal network. However, alcohol intoxication selectively attenuated activity only in the ACC to volitional AS and erroneous responses.
Conclusions
This study provides converging evidence for the selective ACC vulnerability to alcohol intoxication during conflict across different response modalities and executive tasks, confirming its supramodal, high-level role in cognitive control. Alcohol intoxication may impair top–down regulative functions by attenuating the ACC activity, resulting in behavioral disinhibition and decreased self-control.</description><subject>Acute intoxication</subject><subject>Adult</subject><subject>Alcoholic Intoxication - physiopathology</subject><subject>Alcoholism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cognition & reasoning</subject><subject>Cognition - drug effects</subject><subject>Conflict (Psychology)</subject><subject>Drunkenness</subject><subject>Eye movements</subject><subject>Female</subject><subject>Gyrus Cinguli - drug effects</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Humans</subject><subject>Inhibition (Psychology)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Nervous system</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Investigation</subject><subject>Pharmacology/Toxicology</subject><subject>Physiological aspects</subject><subject>Prefrontal cortex</subject><subject>Psychiatry</subject><subject>Saccades - drug effects</subject><subject>Self control</subject><subject>Spin Labels</subject><subject>Young Adult</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1Ut9vFCEQJkZjr9U_wBdD4osvWxl-LPTFpGmqNWnSF30mHAtXmj04Ydd4_72zuVpbo8CEZOabb5jhI-QNsFNgTH9ojHEQHUMToEW3f0ZWIAXvONP8OVkxJpaIMkfkuLU7hksa-ZIccWGA656vyM1ljMFPjZZInZ-nQN3oy20ZacpT-Zm8m1LJFE9z3rsheepLjmPyE3V5oKHWUumuFh9aS3nziryIbmzh9f19Qr59uvx6cdVd33z-cnF-3Xml2dRxcDGC0qCl4mpA3zrCWgP00TPeO6N8jLLnci1dCEPsjVDcqEEK5vpBR3FCPh54d_N6GwYf8lTdaHc1bV3d2-KSfRrJ6dZuyg8rTH8mDEOC9_cEtXyfQ5vsNjUfxtHlUOZmQWJNgcYR-u4v6F2Za8b2EKUMB9VL-IPauDHYlGPBun4htefL4-WZgaXs6T9QuIewTTjZEBP6nyTAIcHX0loN8aFHYHZRgT2owKIK7KICu8ect4-H85Dx-9sRwA-AhqG8CfVRR_9l_QVNtbxL</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Marinkovic, Ksenija</creator><creator>Rickenbacher, Elizabeth</creator><creator>Azma, Sheeva</creator><creator>Artsy, Elinor</creator><creator>Lee, Adrian K. C.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>Effects of acute alcohol intoxication on saccadic conflict and error processing</title><author>Marinkovic, Ksenija ; Rickenbacher, Elizabeth ; Azma, Sheeva ; Artsy, Elinor ; Lee, Adrian K. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-21aff157174525d570bf1b7116fc026a85cff4624b4aeedf6835285d430a6d7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute intoxication</topic><topic>Adult</topic><topic>Alcoholic Intoxication - physiopathology</topic><topic>Alcoholism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cognition & reasoning</topic><topic>Cognition - drug effects</topic><topic>Conflict (Psychology)</topic><topic>Drunkenness</topic><topic>Eye movements</topic><topic>Female</topic><topic>Gyrus Cinguli - drug effects</topic><topic>Gyrus Cinguli - metabolism</topic><topic>Humans</topic><topic>Inhibition (Psychology)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Nervous system</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Original Investigation</topic><topic>Pharmacology/Toxicology</topic><topic>Physiological aspects</topic><topic>Prefrontal cortex</topic><topic>Psychiatry</topic><topic>Saccades - drug effects</topic><topic>Self control</topic><topic>Spin Labels</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marinkovic, Ksenija</creatorcontrib><creatorcontrib>Rickenbacher, Elizabeth</creatorcontrib><creatorcontrib>Azma, Sheeva</creatorcontrib><creatorcontrib>Artsy, Elinor</creatorcontrib><creatorcontrib>Lee, Adrian K. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marinkovic, Ksenija</au><au>Rickenbacher, Elizabeth</au><au>Azma, Sheeva</au><au>Artsy, Elinor</au><au>Lee, Adrian K. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acute alcohol intoxication on saccadic conflict and error processing</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>230</volume><issue>3</issue><spage>487</spage><epage>497</epage><pages>487-497</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>Rationale
Flexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subserving executive tasks. Neuroimaging studies indicate that the ACC is sensitive to acute intoxication during conflict, but such evidence is limited to tasks using manual responses with arbitrary response contingencies.
Objectives
The present study was designed to examine whether alcohol's effects on top–down cognitive control would generalize to the oculomotor system during inhibition of hardwired saccadic responses.
Methods
Healthy social drinkers (
N
= 22) underwent functional magnetic resonance imaging (fMRI) scanning and eye movement tracking during alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed visually guided prosaccades (PS) towards a target and volitional antisaccades (AS) away from it. To mitigate possible vasoactive effects of alcohol on the BOLD (blood oxygenation level-dependent) signal, resting perfusion was quantified with arterial spin labeling (ASL) and used as a covariate in the BOLD analysis.
Results
Saccadic conflict was subserved by a distributed frontoparietal network. However, alcohol intoxication selectively attenuated activity only in the ACC to volitional AS and erroneous responses.
Conclusions
This study provides converging evidence for the selective ACC vulnerability to alcohol intoxication during conflict across different response modalities and executive tasks, confirming its supramodal, high-level role in cognitive control. Alcohol intoxication may impair top–down regulative functions by attenuating the ACC activity, resulting in behavioral disinhibition and decreased self-control.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23812762</pmid><doi>10.1007/s00213-013-3173-y</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Psychopharmacology, 2013-12, Vol.230 (3), p.487-497 |
| issn | 0033-3158 1432-2072 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3869380 |
| source | SPORTDiscus; Springer Link |
| subjects | Acute intoxication Adult Alcoholic Intoxication - physiopathology Alcoholism Biomedical and Life Sciences Biomedicine Brain Cognition & reasoning Cognition - drug effects Conflict (Psychology) Drunkenness Eye movements Female Gyrus Cinguli - drug effects Gyrus Cinguli - metabolism Humans Inhibition (Psychology) Magnetic Resonance Imaging Male Nervous system Neuroimaging Neurosciences NMR Nuclear magnetic resonance Original Investigation Pharmacology/Toxicology Physiological aspects Prefrontal cortex Psychiatry Saccades - drug effects Self control Spin Labels Young Adult |
| title | Effects of acute alcohol intoxication on saccadic conflict and error processing |
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