Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health’s Collaborative Center for Genomic Studies

A number of studies have suggested DNA sequence variability in the serotonin transporter gene ( SLC6A4 ) between European-American (EA) and African-American (AA) populations, which could be clinically important, given the central role SLC6A4 has in serotonin transmission. However, these studies have...

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Bibliographic Details
Published in:Translational psychiatry 2013-09, Vol.3 (9), p.e307-e307
Main Authors: Odgerel, Z, Talati, A, Hamilton, S P, Levinson, D F, Weissman, M M
Format: Article
Language:English
Subjects:
631/208/457/649
631/92/577
692/699/476/1414
African Americans - genetics
Behavioral Sciences
Biological Psychology
European Continental Ancestry Group - genetics
Gene Frequency
Genotype
Humans
Medicine
Medicine & Public Health
National Institute of Mental Health (U.S.)
Neurosciences
Original
original-article
Pharmacotherapy
Polymorphism, Single Nucleotide
Psychiatry
Serotonin Plasma Membrane Transport Proteins - genetics
United States
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Summary:A number of studies have suggested DNA sequence variability in the serotonin transporter gene ( SLC6A4 ) between European-American (EA) and African-American (AA) populations, which could be clinically important, given the central role SLC6A4 has in serotonin transmission. However, these studies have had relatively small samples, used self-reported measures of race, and have only tested the promoter-linked polymorphism 5-HTTLPR. Here we genotype 5-HTTLPR and rs25531, a neighboring functional polymorphism, in 954 AA and 2622EA subjects from a National Institute of Mental Health repository sample. Genotyping was performed using fragment analysis by capillary electrophoresis. AA, as compared with EA, groups had lower frequencies of the S allele (0.25 vs 0.43) and SS genotype (0.06 vs 0.19) at 5-HTTLPR, and higher rates of the G allele at rs25531 (0.21 vs 0.075). A rare xL variant at 5-HTTLPR was also more common among AAs (0.017 vs 0.008). When the polymorphisms were redefined into a high- and low-transcription haplotypes, the AA group showed significantly fewer low-transcription variants ( χ 2 =4.8, P =0.03). No genotypes were associated with major depression, any anxiety disorder, or neuroticism in either EA or AA populations. This is the largest study to show SLC6A4 genotype differences between EA and AA populations, and the first to include rs25531. Lack of associations with clinical outcomes may reflect untested moderating environmental influences.
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2013.80