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Biological basis of suicide and suicidal behavior
Objective Suicide is a major public health concern as each year 30000 people die by suicide in the USA alone. In the teenage population, it is the second leading cause of death. There have been extensive studies of psychosocial factors associated with suicide and suicidal behavior. However, very lit...
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| Published in: | Bipolar disorders 2013-08, Vol.15 (5), p.524-541 |
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| container_title | Bipolar disorders |
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| creator | Pandey, Ghanshyam N |
| description | Objective
Suicide is a major public health concern as each year 30000 people die by suicide in the USA alone. In the teenage population, it is the second leading cause of death. There have been extensive studies of psychosocial factors associated with suicide and suicidal behavior. However, very little is known about the neurobiology of suicide. Recent research has provided some understanding of the neurobiology of suicide, which is the topic of this review.
Methods
Neurobiology of suicide has been studied using peripheral tissues such as platelets, lymphocytes, and cerebrospinal fluid obtained from suicidal patients or from the postmortem brains of suicide victims.
Results
These studies have provided encouraging information with regard to the neurobiology of suicide. They show an abnormality of the serotonergic mechanism, such as increased serotonin receptor subtypes and decreased serotonin metabolites (e.g. 5‐hydroxyindoleacetic acid). These studies also suggest abnormalities of receptor‐linked signaling mechanisms such as phosphoinositide and adenylyl cyclase. Other biological systems that appear to be dysregulated in suicide involve the hypothalamic–pituitary–adrenal axis, and neurotrophins and neurotrophin receptors. More recently, several studies have also indicated abnormalities of neuroimmune functions in suicide.
Conclusions
Some encouraging information emerged from the present review, primarily related to some of the neurobiological mechanisms mentioned above. It is hoped that neurobiological studies may eventually result in the identification of appropriate biomarkers for suicidal behavior as well as appropriate therapeutic targets for its treatment. |
| doi_str_mv | 10.1111/bdi.12089 |
| format | article |
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Suicide is a major public health concern as each year 30000 people die by suicide in the USA alone. In the teenage population, it is the second leading cause of death. There have been extensive studies of psychosocial factors associated with suicide and suicidal behavior. However, very little is known about the neurobiology of suicide. Recent research has provided some understanding of the neurobiology of suicide, which is the topic of this review.
Methods
Neurobiology of suicide has been studied using peripheral tissues such as platelets, lymphocytes, and cerebrospinal fluid obtained from suicidal patients or from the postmortem brains of suicide victims.
Results
These studies have provided encouraging information with regard to the neurobiology of suicide. They show an abnormality of the serotonergic mechanism, such as increased serotonin receptor subtypes and decreased serotonin metabolites (e.g. 5‐hydroxyindoleacetic acid). These studies also suggest abnormalities of receptor‐linked signaling mechanisms such as phosphoinositide and adenylyl cyclase. Other biological systems that appear to be dysregulated in suicide involve the hypothalamic–pituitary–adrenal axis, and neurotrophins and neurotrophin receptors. More recently, several studies have also indicated abnormalities of neuroimmune functions in suicide.
Conclusions
Some encouraging information emerged from the present review, primarily related to some of the neurobiological mechanisms mentioned above. It is hoped that neurobiological studies may eventually result in the identification of appropriate biomarkers for suicidal behavior as well as appropriate therapeutic targets for its treatment.</description><identifier>ISSN: 1398-5647</identifier><identifier>EISSN: 1399-5618</identifier><identifier>DOI: 10.1111/bdi.12089</identifier><identifier>PMID: 23773657</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Animals ; Brain - metabolism ; brain-derived neurotrophic factor ; cAMP response element-binding protein ; cytokines ; Humans ; hypothalamic-pituitary-adrenal axis ; Hypothalamo-Hypophyseal System - metabolism ; Neurobiology ; norepinephrine ; Norepinephrine - metabolism ; Pituitary-Adrenal System - metabolism ; protein kinase A ; protein kinase C ; serotonin ; Serotonin - metabolism ; serotonin receptors ; Signal Transduction - physiology ; suicide ; Suicide - psychology</subject><ispartof>Bipolar disorders, 2013-08, Vol.15 (5), p.524-541</ispartof><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6229-de62f1f6de66a94f3f54289859e5018a5eaeb6ac0ddc8248a93b70d76f9199913</citedby><cites>FETCH-LOGICAL-c6229-de62f1f6de66a94f3f54289859e5018a5eaeb6ac0ddc8248a93b70d76f9199913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbdi.12089$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbdi.12089$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23773657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pandey, Ghanshyam N</creatorcontrib><title>Biological basis of suicide and suicidal behavior</title><title>Bipolar disorders</title><addtitle>Bipolar Disord</addtitle><description>Objective
Suicide is a major public health concern as each year 30000 people die by suicide in the USA alone. In the teenage population, it is the second leading cause of death. There have been extensive studies of psychosocial factors associated with suicide and suicidal behavior. However, very little is known about the neurobiology of suicide. Recent research has provided some understanding of the neurobiology of suicide, which is the topic of this review.
Methods
Neurobiology of suicide has been studied using peripheral tissues such as platelets, lymphocytes, and cerebrospinal fluid obtained from suicidal patients or from the postmortem brains of suicide victims.
Results
These studies have provided encouraging information with regard to the neurobiology of suicide. They show an abnormality of the serotonergic mechanism, such as increased serotonin receptor subtypes and decreased serotonin metabolites (e.g. 5‐hydroxyindoleacetic acid). These studies also suggest abnormalities of receptor‐linked signaling mechanisms such as phosphoinositide and adenylyl cyclase. Other biological systems that appear to be dysregulated in suicide involve the hypothalamic–pituitary–adrenal axis, and neurotrophins and neurotrophin receptors. More recently, several studies have also indicated abnormalities of neuroimmune functions in suicide.
Conclusions
Some encouraging information emerged from the present review, primarily related to some of the neurobiological mechanisms mentioned above. It is hoped that neurobiological studies may eventually result in the identification of appropriate biomarkers for suicidal behavior as well as appropriate therapeutic targets for its treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Brain - metabolism</subject><subject>brain-derived neurotrophic factor</subject><subject>cAMP response element-binding protein</subject><subject>cytokines</subject><subject>Humans</subject><subject>hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Neurobiology</subject><subject>norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>protein kinase A</subject><subject>protein kinase C</subject><subject>serotonin</subject><subject>Serotonin - metabolism</subject><subject>serotonin receptors</subject><subject>Signal Transduction - physiology</subject><subject>suicide</subject><subject>Suicide - psychology</subject><issn>1398-5647</issn><issn>1399-5618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkUtPAjEUhRujEUQX_gEzS10M9DF9bUwEBUmIbhCXTWemA9WB4pRB-fcOz-jCxLu5J7nfPWnvAeASwSaqqhWntokwFPII1BGRMqQMieONFpWOeA2cef8GIWIY0lNQw4RzwiivA9S2Lndjm-g8iLW3PnBZ4Eub2NQEepbu9HpqJnppXXEOTjKde3Ox6w3w0n0Ydh7DwXOv37kbhAnDWIapYThDGas60zLKSEYjLKSg0lCIhKZGm5jpBKZpInAktCQxhylnmURSSkQa4HbrOy_jqUkTM1sUOlfzwk51sVJOW_V7MrMTNXZLRXgkBeGVwfXOoHAfpfELNbU-MXmuZ8aVXqEIc4iIiNA_UCRYRLHEFXqzRZPCeV-Y7PAiBNU6DVWloTZpVOzVzy8cyP35K6C1BT5tblZ_O6n2fX9vGW43rF-Yr8OGLt4V44RT9frUU3iEh90RhEqSb9bDohQ</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Pandey, Ghanshyam N</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201308</creationdate><title>Biological basis of suicide and suicidal behavior</title><author>Pandey, Ghanshyam N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6229-de62f1f6de66a94f3f54289859e5018a5eaeb6ac0ddc8248a93b70d76f9199913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Brain - metabolism</topic><topic>brain-derived neurotrophic factor</topic><topic>cAMP response element-binding protein</topic><topic>cytokines</topic><topic>Humans</topic><topic>hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Neurobiology</topic><topic>norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>protein kinase A</topic><topic>protein kinase C</topic><topic>serotonin</topic><topic>Serotonin - metabolism</topic><topic>serotonin receptors</topic><topic>Signal Transduction - physiology</topic><topic>suicide</topic><topic>Suicide - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Ghanshyam N</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bipolar disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Ghanshyam N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological basis of suicide and suicidal behavior</atitle><jtitle>Bipolar disorders</jtitle><addtitle>Bipolar Disord</addtitle><date>2013-08</date><risdate>2013</risdate><volume>15</volume><issue>5</issue><spage>524</spage><epage>541</epage><pages>524-541</pages><issn>1398-5647</issn><eissn>1399-5618</eissn><notes>ArticleID:BDI12089</notes><notes>National Institute of Mental Health</notes><notes>ark:/67375/WNG-2V2TFV00-9</notes><notes>istex:795D44FEE255CFB4ABE6EBB2542DA1CD46561585</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-2</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Objective
Suicide is a major public health concern as each year 30000 people die by suicide in the USA alone. In the teenage population, it is the second leading cause of death. There have been extensive studies of psychosocial factors associated with suicide and suicidal behavior. However, very little is known about the neurobiology of suicide. Recent research has provided some understanding of the neurobiology of suicide, which is the topic of this review.
Methods
Neurobiology of suicide has been studied using peripheral tissues such as platelets, lymphocytes, and cerebrospinal fluid obtained from suicidal patients or from the postmortem brains of suicide victims.
Results
These studies have provided encouraging information with regard to the neurobiology of suicide. They show an abnormality of the serotonergic mechanism, such as increased serotonin receptor subtypes and decreased serotonin metabolites (e.g. 5‐hydroxyindoleacetic acid). These studies also suggest abnormalities of receptor‐linked signaling mechanisms such as phosphoinositide and adenylyl cyclase. Other biological systems that appear to be dysregulated in suicide involve the hypothalamic–pituitary–adrenal axis, and neurotrophins and neurotrophin receptors. More recently, several studies have also indicated abnormalities of neuroimmune functions in suicide.
Conclusions
Some encouraging information emerged from the present review, primarily related to some of the neurobiological mechanisms mentioned above. It is hoped that neurobiological studies may eventually result in the identification of appropriate biomarkers for suicidal behavior as well as appropriate therapeutic targets for its treatment.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>23773657</pmid><doi>10.1111/bdi.12089</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bipolar disorders, 2013-08, Vol.15 (5), p.524-541 |
| issn | 1398-5647 1399-5618 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3749837 |
| source | Wiley |
| subjects | Adolescent Adult Animals Brain - metabolism brain-derived neurotrophic factor cAMP response element-binding protein cytokines Humans hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - metabolism Neurobiology norepinephrine Norepinephrine - metabolism Pituitary-Adrenal System - metabolism protein kinase A protein kinase C serotonin Serotonin - metabolism serotonin receptors Signal Transduction - physiology suicide Suicide - psychology |
| title | Biological basis of suicide and suicidal behavior |
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