Midbrain-Driven Emotion and Reward Processing in Alcoholism

Alcohol dependence is associated with impaired control over emotionally motivated actions, possibly associated with abnormalities in the frontoparietal executive control network and midbrain nodes of the reward network associated with automatic attention. To identify differences in the neural respon...

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Published in:Neuropsychopharmacology (New York, N.Y.) N.Y.), 2013-09, Vol.38 (10), p.1844-1853
Main Authors: MÜLLER-OEHRING, E. M, JUNG, Y.-C, SULLIVAN, E. V, HAWKES, W. C, PFEFFERBAUM, A, SCHULTE, T
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Aged
Alcoholism
Alcoholism - physiopathology
Alcoholism - psychology
Alcoholism and acute alcohol poisoning
Behavior, Addictive - physiopathology
Behavioral sciences
Biological and medical sciences
Brain Mapping
Case-Control Studies
Color Perception - physiology
Emotions
Female
Humans
Male
Medical sciences
Mesencephalon - physiology
Middle Aged
Neural Inhibition - physiology
Neural networks
Original
Photic Stimulation
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reward
Stroop Test
Toxicology
Visual Perception - physiology
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description Alcohol dependence is associated with impaired control over emotionally motivated actions, possibly associated with abnormalities in the frontoparietal executive control network and midbrain nodes of the reward network associated with automatic attention. To identify differences in the neural response to alcohol-related word stimuli, 26 chronic alcoholics (ALC) and 26 healthy controls (CTL) performed an alcohol-emotion Stroop Match-to-Sample task during functional MR imaging. Stroop contrasts were modeled for color-word incongruency (eg, word RED printed in green) and for alcohol (eg, BEER), positive (eg, HAPPY) and negative (eg, MAD) emotional word content relative to congruent word conditions (eg, word RED printed in red). During color-Stroop processing, ALC and CTL showed similar left dorsolateral prefrontal activation, and CTL, but not ALC, deactivated posterior cingulate cortex/cuneus. An interaction revealed a dissociation between alcohol-word and color-word Stroop processing: ALC activated midbrain and parahippocampal regions more than CTL when processing alcohol-word relative to color-word conditions. In ALC, the midbrain region was also invoked by negative emotional Stroop words thereby showing significant overlap of this midbrain activation for alcohol-related and negative emotional processing. Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to automatic bias to alcohol-related stimuli.
doi_str_mv 10.1038/npp.2013.102
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subjects Addictive behaviors
Adult
Adult and adolescent clinical studies
Aged
Alcoholism
Alcoholism - physiopathology
Alcoholism - psychology
Alcoholism and acute alcohol poisoning
Behavior, Addictive - physiopathology
Behavioral sciences
Biological and medical sciences
Brain Mapping
Case-Control Studies
Color Perception - physiology
Emotions
Female
Humans
Male
Medical sciences
Mesencephalon - physiology
Middle Aged
Neural Inhibition - physiology
Neural networks
Original
Photic Stimulation
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reward
Stroop Test
Toxicology
Visual Perception - physiology
title Midbrain-Driven Emotion and Reward Processing in Alcoholism
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