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Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression
Objectives The absence of pathophysiologically relevant diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. Methods We employed a three-wa...
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| Published in: | Biological psychiatry (1969) 2010-09, Vol.68 (6), p.560-567 |
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| container_title | Biological psychiatry (1969) |
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| creator | Versace, Amelia Almeida, Jorge R.C Quevedo, Karina Thompson, Wesley K Terwilliger, Robert A Hassel, Stefanie Kupfer, David J Phillips, Mary L |
| description | Objectives The absence of pathophysiologically relevant diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. Methods We employed a three-way analysis of covariance, covarying for age, to examine whole brain fractional anisotropy (FA), and corresponding longitudinal and radial diffusivity, in currently depressed adults: 15 with BD-type I (mean age 36.3 years, SD 12.0 years), 16 with recurrent UD (mean age 32.3 years, SD 10.0 years), and 24 healthy control adults (HC) (mean age 29.5 years, SD 9.43 years). Depressed groups did not differ in depression severity, age of illness onset, and illness duration. Results There was a main effect of group in left superior and inferior longitudinal fasciculi (SLF and ILF) (all F ≥ 9.8; p ≤ .05, corrected). Whole brain post hoc analyses (all t ≥ 4.2; p ≤ .05, corrected) revealed decreased FA in left SLF in BD, versus UD adults in inferior temporal cortex and, versus HC, in primary sensory cortex (associated with increased radial and decreased longitudinal diffusivity, respectively); and decreased FA in left ILF in UD adults versus HC. A main effect of group in right uncinate fasciculus (in orbitofrontal cortex) just failed to meet significance in all participants but was present in women. Post hoc analyses revealed decreased right uncinate fasciculus FA in all and in women, BD versus HC. Conclusions White matter FA in left occipitotemporal and primary sensory regions supporting visuospatial and sensory processing differentiates BD from UD depression. Abnormally reduced FA in right fronto-temporal regions supporting mood regulation, might underlie predisposition to depression in BD. These measures might help differentiate pathophysiologic processes of BD versus UD depression. |
| doi_str_mv | 10.1016/j.biopsych.2010.04.036 |
| format | article |
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We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. Methods We employed a three-way analysis of covariance, covarying for age, to examine whole brain fractional anisotropy (FA), and corresponding longitudinal and radial diffusivity, in currently depressed adults: 15 with BD-type I (mean age 36.3 years, SD 12.0 years), 16 with recurrent UD (mean age 32.3 years, SD 10.0 years), and 24 healthy control adults (HC) (mean age 29.5 years, SD 9.43 years). Depressed groups did not differ in depression severity, age of illness onset, and illness duration. Results There was a main effect of group in left superior and inferior longitudinal fasciculi (SLF and ILF) (all F ≥ 9.8; p ≤ .05, corrected). Whole brain post hoc analyses (all t ≥ 4.2; p ≤ .05, corrected) revealed decreased FA in left SLF in BD, versus UD adults in inferior temporal cortex and, versus HC, in primary sensory cortex (associated with increased radial and decreased longitudinal diffusivity, respectively); and decreased FA in left ILF in UD adults versus HC. A main effect of group in right uncinate fasciculus (in orbitofrontal cortex) just failed to meet significance in all participants but was present in women. Post hoc analyses revealed decreased right uncinate fasciculus FA in all and in women, BD versus HC. Conclusions White matter FA in left occipitotemporal and primary sensory regions supporting visuospatial and sensory processing differentiates BD from UD depression. Abnormally reduced FA in right fronto-temporal regions supporting mood regulation, might underlie predisposition to depression in BD. These measures might help differentiate pathophysiologic processes of BD versus UD depression.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2010.04.036</identifier><identifier>PMID: 20598288</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Anisotropy ; Biological and medical sciences ; Bipolar Disorder - diagnosis ; Bipolar Disorder - pathology ; Bipolar disorders ; Brain - pathology ; Depression ; Depressive Disorder - diagnosis ; Depressive Disorder - pathology ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging - methods ; diffusion tensor imaging ; Female ; Humans ; inferior longitudinal fasciculus ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Nerve Fibers, Myelinated - pathology ; Neural Pathways - pathology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; superior longitudinal fasciculus ; uncinate fasciculus</subject><ispartof>Biological psychiatry (1969), 2010-09, Vol.68 (6), p.560-567</ispartof><rights>Society of Biological Psychiatry</rights><rights>2010 Society of Biological Psychiatry</rights><rights>2015 INIST-CNRS</rights><rights>2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>2010 Society of Biological Psychiatry 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-c197d5a08b6f1863c6258ae14a65c8f57cd2cd982897b2ada0641861b13265fb3</citedby><cites>FETCH-LOGICAL-c621t-c197d5a08b6f1863c6258ae14a65c8f57cd2cd982897b2ada0641861b13265fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23212934$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20598288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Versace, Amelia</creatorcontrib><creatorcontrib>Almeida, Jorge R.C</creatorcontrib><creatorcontrib>Quevedo, Karina</creatorcontrib><creatorcontrib>Thompson, Wesley K</creatorcontrib><creatorcontrib>Terwilliger, Robert A</creatorcontrib><creatorcontrib>Hassel, Stefanie</creatorcontrib><creatorcontrib>Kupfer, David J</creatorcontrib><creatorcontrib>Phillips, Mary L</creatorcontrib><title>Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Objectives The absence of pathophysiologically relevant diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. Methods We employed a three-way analysis of covariance, covarying for age, to examine whole brain fractional anisotropy (FA), and corresponding longitudinal and radial diffusivity, in currently depressed adults: 15 with BD-type I (mean age 36.3 years, SD 12.0 years), 16 with recurrent UD (mean age 32.3 years, SD 10.0 years), and 24 healthy control adults (HC) (mean age 29.5 years, SD 9.43 years). Depressed groups did not differ in depression severity, age of illness onset, and illness duration. Results There was a main effect of group in left superior and inferior longitudinal fasciculi (SLF and ILF) (all F ≥ 9.8; p ≤ .05, corrected). Whole brain post hoc analyses (all t ≥ 4.2; p ≤ .05, corrected) revealed decreased FA in left SLF in BD, versus UD adults in inferior temporal cortex and, versus HC, in primary sensory cortex (associated with increased radial and decreased longitudinal diffusivity, respectively); and decreased FA in left ILF in UD adults versus HC. A main effect of group in right uncinate fasciculus (in orbitofrontal cortex) just failed to meet significance in all participants but was present in women. Post hoc analyses revealed decreased right uncinate fasciculus FA in all and in women, BD versus HC. Conclusions White matter FA in left occipitotemporal and primary sensory regions supporting visuospatial and sensory processing differentiates BD from UD depression. Abnormally reduced FA in right fronto-temporal regions supporting mood regulation, might underlie predisposition to depression in BD. These measures might help differentiate pathophysiologic processes of BD versus UD depression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anisotropy</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar disorders</subject><subject>Brain - pathology</subject><subject>Depression</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - pathology</subject><subject>Diagnosis, Differential</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>diffusion tensor imaging</subject><subject>Female</subject><subject>Humans</subject><subject>inferior longitudinal fasciculus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Nerve Fibers, Myelinated - pathology</subject><subject>Neural Pathways - pathology</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>superior longitudinal fasciculus</subject><subject>uncinate fasciculus</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkktvEzEURi0EoqHwF6rZIFYT_JjnpgJSXlJQJaBiaXk8180NE3uwnUjZ8svxNEl5bFjZvj7-5o6PCblgdM4oq16u5x26Mez1as5pKtJiTkX1gMxYU4ucF5Q_JDNKaZULzsUZeRLCOi1rztljcsZp2Ta8aWbk52e8XcXs2ncYnfHORjVkC-cjajfgpkOdKdtnSzDxVNZ3Q8K-rTBC9knFCD5tWgs64g7jPrtCY8CDjagS8QZHNyh_F3Rjj4srGD2EgM4-JY-MGgI8O47n5Obd26-LD_ny-v3HxetlrivOYq5ZW_elok1XGdZUIlXLRgErVFXqxpS17rnup99q646rXtGqSBzrmOBVaTpxTi4PueO220CvU3teDXL0uFF-L51C-feOxZW8dTsp6kJw0aaAF8cA735sIUS5waBhGJQFtw2yLkXb1rwoElkdSO1dCB7M_VcYlZM_uZYnf3LyJ2khk7908OLPHu-PnYQl4PkRUCE5MF5ZjeE3JzjjrZg6eHXgIN3oDsHLoBGshh590iR7h__v5fKfCD2gncx_hz2Etdt6m3xJJgOXVH6ZXtv02FiaFIJS8QvRktU5</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Versace, Amelia</creator><creator>Almeida, Jorge R.C</creator><creator>Quevedo, Karina</creator><creator>Thompson, Wesley K</creator><creator>Terwilliger, Robert A</creator><creator>Hassel, Stefanie</creator><creator>Kupfer, David J</creator><creator>Phillips, Mary L</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100915</creationdate><title>Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression</title><author>Versace, Amelia ; Almeida, Jorge R.C ; Quevedo, Karina ; Thompson, Wesley K ; Terwilliger, Robert A ; Hassel, Stefanie ; Kupfer, David J ; Phillips, Mary L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c621t-c197d5a08b6f1863c6258ae14a65c8f57cd2cd982897b2ada0641861b13265fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anisotropy</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - pathology</topic><topic>Bipolar disorders</topic><topic>Brain - pathology</topic><topic>Depression</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - pathology</topic><topic>Diagnosis, Differential</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>diffusion tensor imaging</topic><topic>Female</topic><topic>Humans</topic><topic>inferior longitudinal fasciculus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Nerve Fibers, Myelinated - pathology</topic><topic>Neural Pathways - pathology</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>superior longitudinal fasciculus</topic><topic>uncinate fasciculus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Versace, Amelia</creatorcontrib><creatorcontrib>Almeida, Jorge R.C</creatorcontrib><creatorcontrib>Quevedo, Karina</creatorcontrib><creatorcontrib>Thompson, Wesley K</creatorcontrib><creatorcontrib>Terwilliger, Robert A</creatorcontrib><creatorcontrib>Hassel, Stefanie</creatorcontrib><creatorcontrib>Kupfer, David J</creatorcontrib><creatorcontrib>Phillips, Mary L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Versace, Amelia</au><au>Almeida, Jorge R.C</au><au>Quevedo, Karina</au><au>Thompson, Wesley K</au><au>Terwilliger, Robert A</au><au>Hassel, Stefanie</au><au>Kupfer, David J</au><au>Phillips, Mary L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2010-09-15</date><risdate>2010</risdate><volume>68</volume><issue>6</issue><spage>560</spage><epage>567</epage><pages>560-567</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objectives The absence of pathophysiologically relevant diagnostic markers of bipolar disorder (BD) leads to its frequent misdiagnosis as unipolar depression (UD). We aimed to determine whether whole brain white matter connectivity differentiated BD from UD depression. Methods We employed a three-way analysis of covariance, covarying for age, to examine whole brain fractional anisotropy (FA), and corresponding longitudinal and radial diffusivity, in currently depressed adults: 15 with BD-type I (mean age 36.3 years, SD 12.0 years), 16 with recurrent UD (mean age 32.3 years, SD 10.0 years), and 24 healthy control adults (HC) (mean age 29.5 years, SD 9.43 years). Depressed groups did not differ in depression severity, age of illness onset, and illness duration. Results There was a main effect of group in left superior and inferior longitudinal fasciculi (SLF and ILF) (all F ≥ 9.8; p ≤ .05, corrected). Whole brain post hoc analyses (all t ≥ 4.2; p ≤ .05, corrected) revealed decreased FA in left SLF in BD, versus UD adults in inferior temporal cortex and, versus HC, in primary sensory cortex (associated with increased radial and decreased longitudinal diffusivity, respectively); and decreased FA in left ILF in UD adults versus HC. A main effect of group in right uncinate fasciculus (in orbitofrontal cortex) just failed to meet significance in all participants but was present in women. Post hoc analyses revealed decreased right uncinate fasciculus FA in all and in women, BD versus HC. Conclusions White matter FA in left occipitotemporal and primary sensory regions supporting visuospatial and sensory processing differentiates BD from UD depression. Abnormally reduced FA in right fronto-temporal regions supporting mood regulation, might underlie predisposition to depression in BD. These measures might help differentiate pathophysiologic processes of BD versus UD depression.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20598288</pmid><doi>10.1016/j.biopsych.2010.04.036</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Anisotropy Biological and medical sciences Bipolar Disorder - diagnosis Bipolar Disorder - pathology Bipolar disorders Brain - pathology Depression Depressive Disorder - diagnosis Depressive Disorder - pathology Diagnosis, Differential Diffusion Magnetic Resonance Imaging - methods diffusion tensor imaging Female Humans inferior longitudinal fasciculus Male Medical sciences Middle Aged Mood disorders Nerve Fibers, Myelinated - pathology Neural Pathways - pathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry superior longitudinal fasciculus uncinate fasciculus |
| title | Right Orbitofrontal Corticolimbic and Left Corticocortical White Matter Connectivity Differentiate Bipolar and Unipolar Depression |
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