Loading…
CD134 is a cellular receptor specific for human herpesvirus-6B entry
Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection ca...
Saved in:
| Published in: | Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (22), p.9096-9099 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3 |
| container_end_page | 9099 |
| container_issue | 22 |
| container_start_page | 9096 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 110 |
| creator | Tang, Huamin Serada, Satoshi Kawabata, Akiko Ota, Megumi Hayashi, Emi Naka, Tetsuji Yamanishi, Koichi Mori, Yasuko |
| description | Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B–infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis. |
| doi_str_mv | 10.1073/pnas.1305187110 |
| format | article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3670305</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>42657219</jstor_id><sourcerecordid>42657219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3</originalsourceid><addsrcrecordid>eNpdkc1P3DAQxS1UVLa0Z04tkXrpJTDjz_hSqV3Kh4TEoeVsOV6H9SqbBHuDxH9fR7tdoCfLmt-8mTePkBOEMwTFzofOpjNkILBSiHBAZggaS8k1vCMzAKrKilN-RD6ktAIALSp4T44ok4pLhTNyMb9AxouQCls437Zja2MRvfPDpo9FGrwLTXBFkz_LcW27Yunj4NNTiGMq5c_Cd5v4_JEcNrZN_tPuPSb3l7_-zK_L27urm_mP29IJoTYlihrrhadeaSsVqFo0mjNaOS4b4JUUtPaaYQUeqwUwwQUov3BiWtpZ37Bj8n2rO4z1Olem4bY1QwxrG59Nb4N5W-nC0jz0TybbhXykLPBtJxD7x9GnjVmHNNm2ne_HZJAJqYVCqjP69T901Y-xy_YyJbkElTfO1PmWcrFPKfpmvwyCmRIyU0LmJaHc8eW1hz3_L5IMnO6AqXMvl_UoNRr0NPTzllilHNIe4VQKRVG_KDS2N_YhhmTuf1NACYBMSU7ZX2kVp8s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1364607486</pqid></control><display><type>article</type><title>CD134 is a cellular receptor specific for human herpesvirus-6B entry</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>PubMed Central</source><creator>Tang, Huamin ; Serada, Satoshi ; Kawabata, Akiko ; Ota, Megumi ; Hayashi, Emi ; Naka, Tetsuji ; Yamanishi, Koichi ; Mori, Yasuko</creator><creatorcontrib>Tang, Huamin ; Serada, Satoshi ; Kawabata, Akiko ; Ota, Megumi ; Hayashi, Emi ; Naka, Tetsuji ; Yamanishi, Koichi ; Mori, Yasuko</creatorcontrib><description>Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B–infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1305187110</identifier><identifier>PMID: 23674671</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Antibodies ; Biological Sciences ; Cell lines ; Cellular receptors ; Flow Cytometry ; Gene expression ; Glycoproteins ; HEK293 Cells ; Herpes viruses ; Herpesviridae ; Herpesvirus 6, Human - metabolism ; Herpesvirus 6, Human - physiology ; Human herpesvirus 6 ; Humans ; Infections ; Pathogenesis ; Plasmids ; Plasmids - genetics ; Receptors ; Receptors, OX40 - metabolism ; T cell receptors ; T lymphocytes ; T-Lymphocytes - metabolism ; T-Lymphocytes - virology ; Viral Fusion Proteins - metabolism ; Virus Internalization ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.9096-9099</ispartof><rights>copyright © 1993-2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences May 28, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3</citedby><cites>FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/110/22.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42657219$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42657219$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829,58593,58826</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23674671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Huamin</creatorcontrib><creatorcontrib>Serada, Satoshi</creatorcontrib><creatorcontrib>Kawabata, Akiko</creatorcontrib><creatorcontrib>Ota, Megumi</creatorcontrib><creatorcontrib>Hayashi, Emi</creatorcontrib><creatorcontrib>Naka, Tetsuji</creatorcontrib><creatorcontrib>Yamanishi, Koichi</creatorcontrib><creatorcontrib>Mori, Yasuko</creatorcontrib><title>CD134 is a cellular receptor specific for human herpesvirus-6B entry</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B–infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis.</description><subject>Antibodies</subject><subject>Biological Sciences</subject><subject>Cell lines</subject><subject>Cellular receptors</subject><subject>Flow Cytometry</subject><subject>Gene expression</subject><subject>Glycoproteins</subject><subject>HEK293 Cells</subject><subject>Herpes viruses</subject><subject>Herpesviridae</subject><subject>Herpesvirus 6, Human - metabolism</subject><subject>Herpesvirus 6, Human - physiology</subject><subject>Human herpesvirus 6</subject><subject>Humans</subject><subject>Infections</subject><subject>Pathogenesis</subject><subject>Plasmids</subject><subject>Plasmids - genetics</subject><subject>Receptors</subject><subject>Receptors, OX40 - metabolism</subject><subject>T cell receptors</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - metabolism</subject><subject>T-Lymphocytes - virology</subject><subject>Viral Fusion Proteins - metabolism</subject><subject>Virus Internalization</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpdkc1P3DAQxS1UVLa0Z04tkXrpJTDjz_hSqV3Kh4TEoeVsOV6H9SqbBHuDxH9fR7tdoCfLmt-8mTePkBOEMwTFzofOpjNkILBSiHBAZggaS8k1vCMzAKrKilN-RD6ktAIALSp4T44ok4pLhTNyMb9AxouQCls437Zja2MRvfPDpo9FGrwLTXBFkz_LcW27Yunj4NNTiGMq5c_Cd5v4_JEcNrZN_tPuPSb3l7_-zK_L27urm_mP29IJoTYlihrrhadeaSsVqFo0mjNaOS4b4JUUtPaaYQUeqwUwwQUov3BiWtpZ37Bj8n2rO4z1Olem4bY1QwxrG59Nb4N5W-nC0jz0TybbhXykLPBtJxD7x9GnjVmHNNm2ne_HZJAJqYVCqjP69T901Y-xy_YyJbkElTfO1PmWcrFPKfpmvwyCmRIyU0LmJaHc8eW1hz3_L5IMnO6AqXMvl_UoNRr0NPTzllilHNIe4VQKRVG_KDS2N_YhhmTuf1NACYBMSU7ZX2kVp8s</recordid><startdate>20130528</startdate><enddate>20130528</enddate><creator>Tang, Huamin</creator><creator>Serada, Satoshi</creator><creator>Kawabata, Akiko</creator><creator>Ota, Megumi</creator><creator>Hayashi, Emi</creator><creator>Naka, Tetsuji</creator><creator>Yamanishi, Koichi</creator><creator>Mori, Yasuko</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130528</creationdate><title>CD134 is a cellular receptor specific for human herpesvirus-6B entry</title><author>Tang, Huamin ; Serada, Satoshi ; Kawabata, Akiko ; Ota, Megumi ; Hayashi, Emi ; Naka, Tetsuji ; Yamanishi, Koichi ; Mori, Yasuko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antibodies</topic><topic>Biological Sciences</topic><topic>Cell lines</topic><topic>Cellular receptors</topic><topic>Flow Cytometry</topic><topic>Gene expression</topic><topic>Glycoproteins</topic><topic>HEK293 Cells</topic><topic>Herpes viruses</topic><topic>Herpesviridae</topic><topic>Herpesvirus 6, Human - metabolism</topic><topic>Herpesvirus 6, Human - physiology</topic><topic>Human herpesvirus 6</topic><topic>Humans</topic><topic>Infections</topic><topic>Pathogenesis</topic><topic>Plasmids</topic><topic>Plasmids - genetics</topic><topic>Receptors</topic><topic>Receptors, OX40 - metabolism</topic><topic>T cell receptors</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - metabolism</topic><topic>T-Lymphocytes - virology</topic><topic>Viral Fusion Proteins - metabolism</topic><topic>Virus Internalization</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Huamin</creatorcontrib><creatorcontrib>Serada, Satoshi</creatorcontrib><creatorcontrib>Kawabata, Akiko</creatorcontrib><creatorcontrib>Ota, Megumi</creatorcontrib><creatorcontrib>Hayashi, Emi</creatorcontrib><creatorcontrib>Naka, Tetsuji</creatorcontrib><creatorcontrib>Yamanishi, Koichi</creatorcontrib><creatorcontrib>Mori, Yasuko</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Huamin</au><au>Serada, Satoshi</au><au>Kawabata, Akiko</au><au>Ota, Megumi</au><au>Hayashi, Emi</au><au>Naka, Tetsuji</au><au>Yamanishi, Koichi</au><au>Mori, Yasuko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD134 is a cellular receptor specific for human herpesvirus-6B entry</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2013-05-28</date><risdate>2013</risdate><volume>110</volume><issue>22</issue><spage>9096</spage><epage>9099</epage><pages>9096-9099</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><notes>http://dx.doi.org/10.1073/pnas.1305187110</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Author contributions: H.T. and Y.M. designed research; H.T., S.S., A.K., M.O., E.H., T.N., and Y.M. performed research; H.T., K.Y., and Y.M. analyzed data; and H.T. and Y.M. wrote the paper.</notes><notes>Edited* by Bernard Roizman, University of Chicago, Chicago, IL, and approved April 24, 2013 (received for review March 20, 2013)</notes><abstract>Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B–infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>23674671</pmid><doi>10.1073/pnas.1305187110</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.9096-9099 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3670305 |
| source | JSTOR Archival Journals and Primary Sources Collection; PubMed Central |
| subjects | Antibodies Biological Sciences Cell lines Cellular receptors Flow Cytometry Gene expression Glycoproteins HEK293 Cells Herpes viruses Herpesviridae Herpesvirus 6, Human - metabolism Herpesvirus 6, Human - physiology Human herpesvirus 6 Humans Infections Pathogenesis Plasmids Plasmids - genetics Receptors Receptors, OX40 - metabolism T cell receptors T lymphocytes T-Lymphocytes - metabolism T-Lymphocytes - virology Viral Fusion Proteins - metabolism Virus Internalization Viruses |
| title | CD134 is a cellular receptor specific for human herpesvirus-6B entry |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A40%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD134%20is%20a%20cellular%20receptor%20specific%20for%20human%20herpesvirus-6B%20entry&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Tang,%20Huamin&rft.date=2013-05-28&rft.volume=110&rft.issue=22&rft.spage=9096&rft.epage=9099&rft.pages=9096-9099&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1305187110&rft_dat=%3Cjstor_pubme%3E42657219%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c557t-15b1bde2e79a6707b5f94328c46f048652be93180e18d0354507edc59580caef3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1364607486&rft_id=info:pmid/23674671&rft_jstor_id=42657219&rfr_iscdi=true |