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Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery
Objective: This study was designed to determine how gastric bypass affects the sympathetically‐mediated component of resting energy expenditure (REE) and muscle sympathetic nerve activity (MSNA). Design and Methods: We measured REE before and after beta‐blockade in seventeen female subjects approxim...
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| Published in: | Obesity (Silver Spring, Md.) Md.), 2013-03, Vol.21 (3), p.480-485 |
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| Main Authors: | , , , , , , |
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| container_end_page | 485 |
| container_issue | 3 |
| container_start_page | 480 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 21 |
| creator | Curry, Timothy B. Somaraju, Madhuri Hines, Casey N. Groenewald, Cornelius B. Miles, John M. Joyner, Michael J. Charkoudian, Nisha |
| description | Objective:
This study was designed to determine how gastric bypass affects the sympathetically‐mediated component of resting energy expenditure (REE) and muscle sympathetic nerve activity (MSNA).
Design and Methods:
We measured REE before and after beta‐blockade in seventeen female subjects approximately three years post‐gastric bypass surgery and in nineteen female obese individuals for comparison. We also measured MSNA in a subset of these subjects.
Results:
The gastric bypass subjects had no change in REE after systemic beta‐blockade, reflecting a lack of sympathetic support of REE, in contrast to obese subjects where REE was reduced by beta‐blockade by approximately 5% (P < 0.05). The gastric bypass subjects, while still overweight (BMI = 29.3 vs 38.0 kg·m−2 for obese subjects, P < 0.05), also had significantly lower MSNA compared to obese subjects (10.9 ± 2.3 vs. 21.9 ± 4.1 bursts·min−1, P < 0.05). The reasons for low MSNA and a lack of sympathetically mediated support of REE after gastric bypass are likely multifactorial and may be related to changes in insulin sensitivity, body composition, and leptin, among other factors.
Conclusions:
These findings may have important consequences for the maintenance of weight loss after gastric bypass. Longitudinal studies are needed to further explore the changes in sympathetic support of REE and if changes in MSNA or tissue responsiveness are related to the sympathetic support of REE. |
| doi_str_mv | 10.1002/oby.20106 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3630471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3661841481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5096-bc59a4c384391452919b7c034ba589ab28140f82f5ecfe5223d925c8ce49df7b3</originalsourceid><addsrcrecordid>eNp10U9LHDEYBvBQWqpde_ALSKCXeljN35nJpWDFqiB40EJ7CpnMO2tkZjJNMqvz7Zt2dbEFTwnJj4f35UFon5IjSgg79vV8xAglxRu0SxUny5KrH2-394ruoA8x3hMiCiLpe7TDuFSskMUuGm7mfjTpDpKzOE7j6EPCvsUwQFjNGB5HGBqXpgDYDA2OL3QWaz_F_BYT9NjY5NYuzdi0CQJemZhCVvU8mpjRFFYQ5j30rjVdhI9P5wJ9_3Z2e3qxvLo-vzw9uVpaSVSxrK1URlheCa6okExRVZeWcFEbWSlTs4oK0laslWBbkIzxRjFpKwtCNW1Z8wX6sskdp7qHxsKQgun0GFxvwqy9cfrfn8Hd6ZVfa15wIkqaAz4_BQT_a4KYdO-iha4zA-SlNeWskkKSgmf66T9676cw5PU0LUqRuxB5jwU63CgbfIwB2u0wlOg_Lercov7bYrYHL6ffyufaMjjegAfXwfx6kr7--nMT-Ru0MaoM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1674739484</pqid></control><display><type>article</type><title>Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery</title><source>Wiley-Blackwell Journals</source><creator>Curry, Timothy B. ; Somaraju, Madhuri ; Hines, Casey N. ; Groenewald, Cornelius B. ; Miles, John M. ; Joyner, Michael J. ; Charkoudian, Nisha</creator><creatorcontrib>Curry, Timothy B. ; Somaraju, Madhuri ; Hines, Casey N. ; Groenewald, Cornelius B. ; Miles, John M. ; Joyner, Michael J. ; Charkoudian, Nisha</creatorcontrib><description>Objective:
This study was designed to determine how gastric bypass affects the sympathetically‐mediated component of resting energy expenditure (REE) and muscle sympathetic nerve activity (MSNA).
Design and Methods:
We measured REE before and after beta‐blockade in seventeen female subjects approximately three years post‐gastric bypass surgery and in nineteen female obese individuals for comparison. We also measured MSNA in a subset of these subjects.
Results:
The gastric bypass subjects had no change in REE after systemic beta‐blockade, reflecting a lack of sympathetic support of REE, in contrast to obese subjects where REE was reduced by beta‐blockade by approximately 5% (P < 0.05). The gastric bypass subjects, while still overweight (BMI = 29.3 vs 38.0 kg·m−2 for obese subjects, P < 0.05), also had significantly lower MSNA compared to obese subjects (10.9 ± 2.3 vs. 21.9 ± 4.1 bursts·min−1, P < 0.05). The reasons for low MSNA and a lack of sympathetically mediated support of REE after gastric bypass are likely multifactorial and may be related to changes in insulin sensitivity, body composition, and leptin, among other factors.
Conclusions:
These findings may have important consequences for the maintenance of weight loss after gastric bypass. Longitudinal studies are needed to further explore the changes in sympathetic support of REE and if changes in MSNA or tissue responsiveness are related to the sympathetic support of REE.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20106</identifier><identifier>PMID: 23592656</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Abdomen ; Adolescent ; Adult ; Age ; Aldosterone - blood ; Basal Metabolism - physiology ; Behavior ; Blood Glucose - analysis ; Body Composition ; Body Mass Index ; Catheters ; Cholesterol - blood ; Energy Metabolism - physiology ; Epinephrine - blood ; Fasting ; Female ; Gastric Bypass - methods ; Gastrointestinal surgery ; Heart surgery ; Humans ; Insulin Resistance ; Leptin - blood ; Linear Models ; Metabolism ; Muscle, Skeletal - metabolism ; Nervous system ; Norepinephrine - blood ; Obesity ; Obesity - surgery ; Overweight - surgery ; Studies ; Sympathetic Nervous System - physiology ; Triglycerides - blood ; Weight control ; Weight Loss ; Young Adult</subject><ispartof>Obesity (Silver Spring, Md.), 2013-03, Vol.21 (3), p.480-485</ispartof><rights>Copyright © 2013 The Obesity Society</rights><rights>Copyright © 2013 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Mar 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5096-bc59a4c384391452919b7c034ba589ab28140f82f5ecfe5223d925c8ce49df7b3</citedby><cites>FETCH-LOGICAL-c5096-bc59a4c384391452919b7c034ba589ab28140f82f5ecfe5223d925c8ce49df7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20106$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20106$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23592656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Curry, Timothy B.</creatorcontrib><creatorcontrib>Somaraju, Madhuri</creatorcontrib><creatorcontrib>Hines, Casey N.</creatorcontrib><creatorcontrib>Groenewald, Cornelius B.</creatorcontrib><creatorcontrib>Miles, John M.</creatorcontrib><creatorcontrib>Joyner, Michael J.</creatorcontrib><creatorcontrib>Charkoudian, Nisha</creatorcontrib><title>Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective:
This study was designed to determine how gastric bypass affects the sympathetically‐mediated component of resting energy expenditure (REE) and muscle sympathetic nerve activity (MSNA).
Design and Methods:
We measured REE before and after beta‐blockade in seventeen female subjects approximately three years post‐gastric bypass surgery and in nineteen female obese individuals for comparison. We also measured MSNA in a subset of these subjects.
Results:
The gastric bypass subjects had no change in REE after systemic beta‐blockade, reflecting a lack of sympathetic support of REE, in contrast to obese subjects where REE was reduced by beta‐blockade by approximately 5% (P < 0.05). The gastric bypass subjects, while still overweight (BMI = 29.3 vs 38.0 kg·m−2 for obese subjects, P < 0.05), also had significantly lower MSNA compared to obese subjects (10.9 ± 2.3 vs. 21.9 ± 4.1 bursts·min−1, P < 0.05). The reasons for low MSNA and a lack of sympathetically mediated support of REE after gastric bypass are likely multifactorial and may be related to changes in insulin sensitivity, body composition, and leptin, among other factors.
Conclusions:
These findings may have important consequences for the maintenance of weight loss after gastric bypass. Longitudinal studies are needed to further explore the changes in sympathetic support of REE and if changes in MSNA or tissue responsiveness are related to the sympathetic support of REE.</description><subject>Abdomen</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aldosterone - blood</subject><subject>Basal Metabolism - physiology</subject><subject>Behavior</subject><subject>Blood Glucose - analysis</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Catheters</subject><subject>Cholesterol - blood</subject><subject>Energy Metabolism - physiology</subject><subject>Epinephrine - blood</subject><subject>Fasting</subject><subject>Female</subject><subject>Gastric Bypass - methods</subject><subject>Gastrointestinal surgery</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Leptin - blood</subject><subject>Linear Models</subject><subject>Metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Nervous system</subject><subject>Norepinephrine - blood</subject><subject>Obesity</subject><subject>Obesity - surgery</subject><subject>Overweight - surgery</subject><subject>Studies</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Triglycerides - blood</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Young Adult</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp10U9LHDEYBvBQWqpde_ALSKCXeljN35nJpWDFqiB40EJ7CpnMO2tkZjJNMqvz7Zt2dbEFTwnJj4f35UFon5IjSgg79vV8xAglxRu0SxUny5KrH2-394ruoA8x3hMiCiLpe7TDuFSskMUuGm7mfjTpDpKzOE7j6EPCvsUwQFjNGB5HGBqXpgDYDA2OL3QWaz_F_BYT9NjY5NYuzdi0CQJemZhCVvU8mpjRFFYQ5j30rjVdhI9P5wJ9_3Z2e3qxvLo-vzw9uVpaSVSxrK1URlheCa6okExRVZeWcFEbWSlTs4oK0laslWBbkIzxRjFpKwtCNW1Z8wX6sskdp7qHxsKQgun0GFxvwqy9cfrfn8Hd6ZVfa15wIkqaAz4_BQT_a4KYdO-iha4zA-SlNeWskkKSgmf66T9676cw5PU0LUqRuxB5jwU63CgbfIwB2u0wlOg_Lercov7bYrYHL6ffyufaMjjegAfXwfx6kr7--nMT-Ru0MaoM</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Curry, Timothy B.</creator><creator>Somaraju, Madhuri</creator><creator>Hines, Casey N.</creator><creator>Groenewald, Cornelius B.</creator><creator>Miles, John M.</creator><creator>Joyner, Michael J.</creator><creator>Charkoudian, Nisha</creator><general>John Wiley & Sons, Inc</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201303</creationdate><title>Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery</title><author>Curry, Timothy B. ; Somaraju, Madhuri ; Hines, Casey N. ; Groenewald, Cornelius B. ; Miles, John M. ; Joyner, Michael J. ; Charkoudian, Nisha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5096-bc59a4c384391452919b7c034ba589ab28140f82f5ecfe5223d925c8ce49df7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdomen</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aldosterone - blood</topic><topic>Basal Metabolism - physiology</topic><topic>Behavior</topic><topic>Blood Glucose - analysis</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Catheters</topic><topic>Cholesterol - blood</topic><topic>Energy Metabolism - physiology</topic><topic>Epinephrine - blood</topic><topic>Fasting</topic><topic>Female</topic><topic>Gastric Bypass - methods</topic><topic>Gastrointestinal surgery</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Leptin - blood</topic><topic>Linear Models</topic><topic>Metabolism</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Nervous system</topic><topic>Norepinephrine - blood</topic><topic>Obesity</topic><topic>Obesity - surgery</topic><topic>Overweight - surgery</topic><topic>Studies</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Triglycerides - blood</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Curry, Timothy B.</creatorcontrib><creatorcontrib>Somaraju, Madhuri</creatorcontrib><creatorcontrib>Hines, Casey N.</creatorcontrib><creatorcontrib>Groenewald, Cornelius B.</creatorcontrib><creatorcontrib>Miles, John M.</creatorcontrib><creatorcontrib>Joyner, Michael J.</creatorcontrib><creatorcontrib>Charkoudian, Nisha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Curry, Timothy B.</au><au>Somaraju, Madhuri</au><au>Hines, Casey N.</au><au>Groenewald, Cornelius B.</au><au>Miles, John M.</au><au>Joyner, Michael J.</au><au>Charkoudian, Nisha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2013-03</date><risdate>2013</risdate><volume>21</volume><issue>3</issue><spage>480</spage><epage>485</epage><pages>480-485</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><notes>Funding agencies: The project described was supported by the Mayo Foundation for Medical Education and Research and NIH Grant Numbers K23 DK82424, R01 HL67933, R01 HL083947, and UL1 RR024150.</notes><notes>Disclosure: The authors declared no conflict of interest.</notes><notes>Current address for author Dr. Nisha Charkoudian: Thermal & Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Bldg 42, Natick, MA 01760‐5007.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Current address for author Dr. Nisha Charkoudian: Thermal & Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Bldg 42, Natick, MA 01760-5007</notes><abstract>Objective:
This study was designed to determine how gastric bypass affects the sympathetically‐mediated component of resting energy expenditure (REE) and muscle sympathetic nerve activity (MSNA).
Design and Methods:
We measured REE before and after beta‐blockade in seventeen female subjects approximately three years post‐gastric bypass surgery and in nineteen female obese individuals for comparison. We also measured MSNA in a subset of these subjects.
Results:
The gastric bypass subjects had no change in REE after systemic beta‐blockade, reflecting a lack of sympathetic support of REE, in contrast to obese subjects where REE was reduced by beta‐blockade by approximately 5% (P < 0.05). The gastric bypass subjects, while still overweight (BMI = 29.3 vs 38.0 kg·m−2 for obese subjects, P < 0.05), also had significantly lower MSNA compared to obese subjects (10.9 ± 2.3 vs. 21.9 ± 4.1 bursts·min−1, P < 0.05). The reasons for low MSNA and a lack of sympathetically mediated support of REE after gastric bypass are likely multifactorial and may be related to changes in insulin sensitivity, body composition, and leptin, among other factors.
Conclusions:
These findings may have important consequences for the maintenance of weight loss after gastric bypass. Longitudinal studies are needed to further explore the changes in sympathetic support of REE and if changes in MSNA or tissue responsiveness are related to the sympathetic support of REE.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>23592656</pmid><doi>10.1002/oby.20106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2013-03, Vol.21 (3), p.480-485 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3630471 |
| source | Wiley-Blackwell Journals |
| subjects | Abdomen Adolescent Adult Age Aldosterone - blood Basal Metabolism - physiology Behavior Blood Glucose - analysis Body Composition Body Mass Index Catheters Cholesterol - blood Energy Metabolism - physiology Epinephrine - blood Fasting Female Gastric Bypass - methods Gastrointestinal surgery Heart surgery Humans Insulin Resistance Leptin - blood Linear Models Metabolism Muscle, Skeletal - metabolism Nervous system Norepinephrine - blood Obesity Obesity - surgery Overweight - surgery Studies Sympathetic Nervous System - physiology Triglycerides - blood Weight control Weight Loss Young Adult |
| title | Sympathetic support of energy expenditure and sympathetic nervous system activity after gastric bypass surgery |
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