Loading…
Parapharyngeal liposarcoma: a case report
Parapharyngeal liposarcoma is a very rare malignant tumor that often causes nonspecific clinical symptoms, such as progressive dysphagia, globus sensation and/or respiratory disturbances. The combination of radiological imaging techniques and histopathological analysis provides information for diagn...
Saved in:
| Published in: | Diagnostic pathology 2013-03, Vol.8 (1), p.42-42, Article 42 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3 |
| container_end_page | 42 |
| container_issue | 1 |
| container_start_page | 42 |
| container_title | Diagnostic pathology |
| container_volume | 8 |
| creator | Li, Hong Zhou, Xueqin Ran, Qian Wang, Liuqian |
| description | Parapharyngeal liposarcoma is a very rare malignant tumor that often causes nonspecific clinical symptoms, such as progressive dysphagia, globus sensation and/or respiratory disturbances. The combination of radiological imaging techniques and histopathological analysis provides information for diagnosis; however, the pathogenesis is still uncertain.
A 30-year-old male patient presented with a pharyngeal cavity mass, which had been present for 2 years. The clinical syndrome included obstructive sleep apnea symptoms (i.e., respiratory disturbances, excessive daytime somnolence, and headache) and difficulty swallowing. The radiological examination (CT) demonstrated that there was a low-density irregular solid lesion on the posterior wall of the oropharynx and laryngopharynx, which descended to the superior mediastinum and extended to the left parapharyngeal space and sternocleidomastoid muscle. The boundaries of the lesion were clear, and the lesion's density was nonuniform. Several septations inside the lesion were observed. The CT values of the lesion at the epiglottis and the vocal folds were 11 HU and minus 30 HU, respectively. After enhanced scanning, there was no apparent enhancement of the lesion: the surrounding tissue and blood vessels were squeezed and shifted, but the neighboring sclerotin of the cervical vertebrae was not invaded. The mass was removed via a transcervical approach, resulting in a complete amelioration of the patient's symptoms. Interestingly, immunohistochemistry showed that the tumor cells expressed members of the B7 superfamily, including B7-H1, B7-DC and B7-H3. In addition, the expression of TIM-containing molecules, including TIM-3 and TIM-4, was observed.
CT and MRI demonstrated that the mass was a parapharyngeal liposarcoma. Furthermore, carcinoma-associated B7 and TIM-containing molecules were observed in the tissue, indicating that these molecules are most likely active in the pathogenesis of this disease.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1907794973876202. |
| doi_str_mv | 10.1186/1746-1596-8-42 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3599591</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A534705886</galeid><sourcerecordid>A534705886</sourcerecordid><originalsourceid>FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3</originalsourceid><addsrcrecordid>eNp1kk1rGzEQhkVJqRO31x6LIZfksOnqa1fKIWBCviDQHtqzGGklR2Z3tZHsQv99tDh17CRFB2lmHr2aeRFCX3F5hrGovuOaVQXmsipEwcgHdLhNHOycJ-gopWVZMs5J-QlNCGWyphwfotOfEGF4gPi3X1hoZ60fQoJoQgfnM5gZSHYW7RDi6jP66KBN9svzPkW_r69-Xd4W9z9u7i7n94XmjK4KKYA6ZgmpXVM3jYMKmorIHDjtMNGOcaY1zkEDwJxjRlrJSG0arSvuLJ2ii43usNadbYztVxFaNUTf5S5VAK_2K71_UIvwR1EuJZc4C8w3AtqH_wjsV_KwarRKjVYpoRjJGifPTcTwuLZppTqfjG1b6G1YJ4UprkX2sB7R41foMqxjny0aqQoLXgr-Qi2gtcr3LuSnzSiq5pyyuuRCVJk6e4fKq7GdN6G3zuf8exdMDClF67Zj4lKNH-TtYN923d3i_34EfQKYabZX</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1316185085</pqid></control><display><type>article</type><title>Parapharyngeal liposarcoma: a case report</title><source>PMC (PubMed Central)</source><source>Publicly Available Content (ProQuest)</source><creator>Li, Hong ; Zhou, Xueqin ; Ran, Qian ; Wang, Liuqian</creator><creatorcontrib>Li, Hong ; Zhou, Xueqin ; Ran, Qian ; Wang, Liuqian</creatorcontrib><description>Parapharyngeal liposarcoma is a very rare malignant tumor that often causes nonspecific clinical symptoms, such as progressive dysphagia, globus sensation and/or respiratory disturbances. The combination of radiological imaging techniques and histopathological analysis provides information for diagnosis; however, the pathogenesis is still uncertain.
A 30-year-old male patient presented with a pharyngeal cavity mass, which had been present for 2 years. The clinical syndrome included obstructive sleep apnea symptoms (i.e., respiratory disturbances, excessive daytime somnolence, and headache) and difficulty swallowing. The radiological examination (CT) demonstrated that there was a low-density irregular solid lesion on the posterior wall of the oropharynx and laryngopharynx, which descended to the superior mediastinum and extended to the left parapharyngeal space and sternocleidomastoid muscle. The boundaries of the lesion were clear, and the lesion's density was nonuniform. Several septations inside the lesion were observed. The CT values of the lesion at the epiglottis and the vocal folds were 11 HU and minus 30 HU, respectively. After enhanced scanning, there was no apparent enhancement of the lesion: the surrounding tissue and blood vessels were squeezed and shifted, but the neighboring sclerotin of the cervical vertebrae was not invaded. The mass was removed via a transcervical approach, resulting in a complete amelioration of the patient's symptoms. Interestingly, immunohistochemistry showed that the tumor cells expressed members of the B7 superfamily, including B7-H1, B7-DC and B7-H3. In addition, the expression of TIM-containing molecules, including TIM-3 and TIM-4, was observed.
CT and MRI demonstrated that the mass was a parapharyngeal liposarcoma. Furthermore, carcinoma-associated B7 and TIM-containing molecules were observed in the tissue, indicating that these molecules are most likely active in the pathogenesis of this disease.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1907794973876202.</description><identifier>ISSN: 1746-1596</identifier><identifier>EISSN: 1746-1596</identifier><identifier>DOI: 10.1186/1746-1596-8-42</identifier><identifier>PMID: 23497351</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Biomarkers, Tumor - analysis ; Consent ; Debate ; Diagnosis ; Dysphagia ; Hospitals ; Humans ; Immunohistochemistry ; Liposarcoma - chemistry ; Liposarcoma - diagnostic imaging ; Liposarcoma - pathology ; Liposarcoma - surgery ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Otolaryngology ; Pathogenesis ; Pharyngeal Neoplasms - chemistry ; Pharyngeal Neoplasms - diagnostic imaging ; Pharyngeal Neoplasms - pathology ; Pharyngeal Neoplasms - surgery ; Predictive Value of Tests ; Sleep apnea ; Sleep apnea syndromes ; Sleep disorders ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Diagnostic pathology, 2013-03, Vol.8 (1), p.42-42, Article 42</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright ©2013 Li et al; licensee BioMed Central Ltd. 2013 Li et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3</citedby><cites>FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599591/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1316185085?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,25765,27936,27937,37024,37025,44602,53804,53806</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23497351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Zhou, Xueqin</creatorcontrib><creatorcontrib>Ran, Qian</creatorcontrib><creatorcontrib>Wang, Liuqian</creatorcontrib><title>Parapharyngeal liposarcoma: a case report</title><title>Diagnostic pathology</title><addtitle>Diagn Pathol</addtitle><description>Parapharyngeal liposarcoma is a very rare malignant tumor that often causes nonspecific clinical symptoms, such as progressive dysphagia, globus sensation and/or respiratory disturbances. The combination of radiological imaging techniques and histopathological analysis provides information for diagnosis; however, the pathogenesis is still uncertain.
A 30-year-old male patient presented with a pharyngeal cavity mass, which had been present for 2 years. The clinical syndrome included obstructive sleep apnea symptoms (i.e., respiratory disturbances, excessive daytime somnolence, and headache) and difficulty swallowing. The radiological examination (CT) demonstrated that there was a low-density irregular solid lesion on the posterior wall of the oropharynx and laryngopharynx, which descended to the superior mediastinum and extended to the left parapharyngeal space and sternocleidomastoid muscle. The boundaries of the lesion were clear, and the lesion's density was nonuniform. Several septations inside the lesion were observed. The CT values of the lesion at the epiglottis and the vocal folds were 11 HU and minus 30 HU, respectively. After enhanced scanning, there was no apparent enhancement of the lesion: the surrounding tissue and blood vessels were squeezed and shifted, but the neighboring sclerotin of the cervical vertebrae was not invaded. The mass was removed via a transcervical approach, resulting in a complete amelioration of the patient's symptoms. Interestingly, immunohistochemistry showed that the tumor cells expressed members of the B7 superfamily, including B7-H1, B7-DC and B7-H3. In addition, the expression of TIM-containing molecules, including TIM-3 and TIM-4, was observed.
CT and MRI demonstrated that the mass was a parapharyngeal liposarcoma. Furthermore, carcinoma-associated B7 and TIM-containing molecules were observed in the tissue, indicating that these molecules are most likely active in the pathogenesis of this disease.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1907794973876202.</description><subject>Adult</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Consent</subject><subject>Debate</subject><subject>Diagnosis</subject><subject>Dysphagia</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liposarcoma - chemistry</subject><subject>Liposarcoma - diagnostic imaging</subject><subject>Liposarcoma - pathology</subject><subject>Liposarcoma - surgery</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Otolaryngology</subject><subject>Pathogenesis</subject><subject>Pharyngeal Neoplasms - chemistry</subject><subject>Pharyngeal Neoplasms - diagnostic imaging</subject><subject>Pharyngeal Neoplasms - pathology</subject><subject>Pharyngeal Neoplasms - surgery</subject><subject>Predictive Value of Tests</subject><subject>Sleep apnea</subject><subject>Sleep apnea syndromes</subject><subject>Sleep disorders</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>1746-1596</issn><issn>1746-1596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kk1rGzEQhkVJqRO31x6LIZfksOnqa1fKIWBCviDQHtqzGGklR2Z3tZHsQv99tDh17CRFB2lmHr2aeRFCX3F5hrGovuOaVQXmsipEwcgHdLhNHOycJ-gopWVZMs5J-QlNCGWyphwfotOfEGF4gPi3X1hoZ60fQoJoQgfnM5gZSHYW7RDi6jP66KBN9svzPkW_r69-Xd4W9z9u7i7n94XmjK4KKYA6ZgmpXVM3jYMKmorIHDjtMNGOcaY1zkEDwJxjRlrJSG0arSvuLJ2ii43usNadbYztVxFaNUTf5S5VAK_2K71_UIvwR1EuJZc4C8w3AtqH_wjsV_KwarRKjVYpoRjJGifPTcTwuLZppTqfjG1b6G1YJ4UprkX2sB7R41foMqxjny0aqQoLXgr-Qi2gtcr3LuSnzSiq5pyyuuRCVJk6e4fKq7GdN6G3zuf8exdMDClF67Zj4lKNH-TtYN923d3i_34EfQKYabZX</recordid><startdate>20130307</startdate><enddate>20130307</enddate><creator>Li, Hong</creator><creator>Zhou, Xueqin</creator><creator>Ran, Qian</creator><creator>Wang, Liuqian</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130307</creationdate><title>Parapharyngeal liposarcoma: a case report</title><author>Li, Hong ; Zhou, Xueqin ; Ran, Qian ; Wang, Liuqian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Consent</topic><topic>Debate</topic><topic>Diagnosis</topic><topic>Dysphagia</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liposarcoma - chemistry</topic><topic>Liposarcoma - diagnostic imaging</topic><topic>Liposarcoma - pathology</topic><topic>Liposarcoma - surgery</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Otolaryngology</topic><topic>Pathogenesis</topic><topic>Pharyngeal Neoplasms - chemistry</topic><topic>Pharyngeal Neoplasms - diagnostic imaging</topic><topic>Pharyngeal Neoplasms - pathology</topic><topic>Pharyngeal Neoplasms - surgery</topic><topic>Predictive Value of Tests</topic><topic>Sleep apnea</topic><topic>Sleep apnea syndromes</topic><topic>Sleep disorders</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Hong</creatorcontrib><creatorcontrib>Zhou, Xueqin</creatorcontrib><creatorcontrib>Ran, Qian</creatorcontrib><creatorcontrib>Wang, Liuqian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hong</au><au>Zhou, Xueqin</au><au>Ran, Qian</au><au>Wang, Liuqian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parapharyngeal liposarcoma: a case report</atitle><jtitle>Diagnostic pathology</jtitle><addtitle>Diagn Pathol</addtitle><date>2013-03-07</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>42</spage><epage>42</epage><pages>42-42</pages><artnum>42</artnum><issn>1746-1596</issn><eissn>1746-1596</eissn><abstract>Parapharyngeal liposarcoma is a very rare malignant tumor that often causes nonspecific clinical symptoms, such as progressive dysphagia, globus sensation and/or respiratory disturbances. The combination of radiological imaging techniques and histopathological analysis provides information for diagnosis; however, the pathogenesis is still uncertain.
A 30-year-old male patient presented with a pharyngeal cavity mass, which had been present for 2 years. The clinical syndrome included obstructive sleep apnea symptoms (i.e., respiratory disturbances, excessive daytime somnolence, and headache) and difficulty swallowing. The radiological examination (CT) demonstrated that there was a low-density irregular solid lesion on the posterior wall of the oropharynx and laryngopharynx, which descended to the superior mediastinum and extended to the left parapharyngeal space and sternocleidomastoid muscle. The boundaries of the lesion were clear, and the lesion's density was nonuniform. Several septations inside the lesion were observed. The CT values of the lesion at the epiglottis and the vocal folds were 11 HU and minus 30 HU, respectively. After enhanced scanning, there was no apparent enhancement of the lesion: the surrounding tissue and blood vessels were squeezed and shifted, but the neighboring sclerotin of the cervical vertebrae was not invaded. The mass was removed via a transcervical approach, resulting in a complete amelioration of the patient's symptoms. Interestingly, immunohistochemistry showed that the tumor cells expressed members of the B7 superfamily, including B7-H1, B7-DC and B7-H3. In addition, the expression of TIM-containing molecules, including TIM-3 and TIM-4, was observed.
CT and MRI demonstrated that the mass was a parapharyngeal liposarcoma. Furthermore, carcinoma-associated B7 and TIM-containing molecules were observed in the tissue, indicating that these molecules are most likely active in the pathogenesis of this disease.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1907794973876202.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>23497351</pmid><doi>10.1186/1746-1596-8-42</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1746-1596 |
| ispartof | Diagnostic pathology, 2013-03, Vol.8 (1), p.42-42, Article 42 |
| issn | 1746-1596 1746-1596 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3599591 |
| source | PMC (PubMed Central); Publicly Available Content (ProQuest) |
| subjects | Adult Biomarkers, Tumor - analysis Consent Debate Diagnosis Dysphagia Hospitals Humans Immunohistochemistry Liposarcoma - chemistry Liposarcoma - diagnostic imaging Liposarcoma - pathology Liposarcoma - surgery Magnetic Resonance Imaging Male Medical imaging Otolaryngology Pathogenesis Pharyngeal Neoplasms - chemistry Pharyngeal Neoplasms - diagnostic imaging Pharyngeal Neoplasms - pathology Pharyngeal Neoplasms - surgery Predictive Value of Tests Sleep apnea Sleep apnea syndromes Sleep disorders Tomography, X-Ray Computed Treatment Outcome |
| title | Parapharyngeal liposarcoma: a case report |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-14T09%3A07%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parapharyngeal%20liposarcoma:%20a%20case%20report&rft.jtitle=Diagnostic%20pathology&rft.au=Li,%20Hong&rft.date=2013-03-07&rft.volume=8&rft.issue=1&rft.spage=42&rft.epage=42&rft.pages=42-42&rft.artnum=42&rft.issn=1746-1596&rft.eissn=1746-1596&rft_id=info:doi/10.1186/1746-1596-8-42&rft_dat=%3Cgale_pubme%3EA534705886%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b543t-98a3f4e227fd7ddfa6ad629fd7fbf12bf454bb1fbfdaa4ff4c9e9427cdbb65fe3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1316185085&rft_id=info:pmid/23497351&rft_galeid=A534705886&rfr_iscdi=true |