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Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET i...
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| Published in: | Translational psychiatry 2013-02, Vol.3 (2), p.e233-e233 |
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| container_title | Translational psychiatry |
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| creator | Frost, S Kanagasingam, Y Sohrabi, H Vignarajan, J Bourgeat, P Salvado, O Villemagne, V Rowe, C C Macaulay, S Lance Szoeke, C Ellis, K A Ames, D Masters, C L Rainey-Smith, S Martins, R N AIBL Research Group |
| description | The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P = 0.01 and P = 0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments. |
| doi_str_mv | 10.1038/tp.2012.150 |
| format | article |
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Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P = 0.01 and P = 0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/tp.2012.150</identifier><identifier>PMID: 23443359</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Aged ; Alzheimer Disease - complications ; Alzheimer Disease - diagnosis ; Analysis of Variance ; Australia ; Biomarkers ; Brain - diagnostic imaging ; Cohort Studies ; Disease Progression ; Early Diagnosis ; Female ; Humans ; Male ; Original ; Photography - methods ; Plaque, Amyloid - diagnostic imaging ; Positron-Emission Tomography - methods ; Reproducibility of Results ; Retinal Artery ; Retinal Diseases - complications ; Retinal Diseases - diagnosis ; Retinal Vein</subject><ispartof>Translational psychiatry, 2013-02, Vol.3 (2), p.e233-e233</ispartof><rights>Copyright Nature Publishing Group Feb 2013</rights><rights>Copyright © 2013 Macmillan Publishers Limited 2013 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-222abfce775aa65754ec0ada55da1abfbaa76f86cba3275247b30a7180eb67dd3</citedby><cites>FETCH-LOGICAL-c409t-222abfce775aa65754ec0ada55da1abfbaa76f86cba3275247b30a7180eb67dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1791393205/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1791393205?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23443359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frost, S</creatorcontrib><creatorcontrib>Kanagasingam, Y</creatorcontrib><creatorcontrib>Sohrabi, H</creatorcontrib><creatorcontrib>Vignarajan, J</creatorcontrib><creatorcontrib>Bourgeat, P</creatorcontrib><creatorcontrib>Salvado, O</creatorcontrib><creatorcontrib>Villemagne, V</creatorcontrib><creatorcontrib>Rowe, C C</creatorcontrib><creatorcontrib>Macaulay, S Lance</creatorcontrib><creatorcontrib>Szoeke, C</creatorcontrib><creatorcontrib>Ellis, K A</creatorcontrib><creatorcontrib>Ames, D</creatorcontrib><creatorcontrib>Masters, C L</creatorcontrib><creatorcontrib>Rainey-Smith, S</creatorcontrib><creatorcontrib>Martins, R N</creatorcontrib><creatorcontrib>AIBL Research Group</creatorcontrib><creatorcontrib>the AIBL Research Group</creatorcontrib><title>Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><description>The earliest detectable change in Alzheimer's disease (AD) is the buildup of amyloid plaque in the brain. Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P = 0.01 and P = 0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments.</description><subject>Aged</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Analysis of Variance</subject><subject>Australia</subject><subject>Biomarkers</subject><subject>Brain - diagnostic imaging</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Original</subject><subject>Photography - methods</subject><subject>Plaque, Amyloid - diagnostic imaging</subject><subject>Positron-Emission Tomography - methods</subject><subject>Reproducibility of Results</subject><subject>Retinal Artery</subject><subject>Retinal Diseases - complications</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Vein</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc1LxDAQxYMoKurJuwQ8KMiu-Wia7kUQ8QsEQfQcpulUo22zJqmgf71ZXEWdywzMj8e8eYTscjblTFbHaT4VjIspV2yFbAquqonkVbX6a94gOzE-s1yqqLjm62RDyKKQUs02ycMdJjdAR98g2rGDQGvnewgvGCJtfaAIoXunDSa0yfmBwtDQ3g8u-eCGR-pbetp9PKHrMRxE2riIEHGbrLXQRdxZ9i3ycHF-f3Y1ubm9vD47vZnYgs3SRAgBdWtRawVQKq0KtAwaUKoBnjc1gC7bqrQ1SKGVKHQtGWheMaxL3TRyi5x86c7HusfG4pACdGYeXLbwbjw483czuCfz6N9M9s4ZE1ngcCkQ_OuIMZneRYtdBwP6MRouuSw4UyXL6P4_9NmPIb8uU3rG5UwKpjJ19EXZ4GMM2P4cw5lZJGbS3CwSMzmxTO_9vv-H_c5HfgKlpZLA</recordid><startdate>20130226</startdate><enddate>20130226</enddate><creator>Frost, S</creator><creator>Kanagasingam, Y</creator><creator>Sohrabi, H</creator><creator>Vignarajan, J</creator><creator>Bourgeat, P</creator><creator>Salvado, O</creator><creator>Villemagne, V</creator><creator>Rowe, C C</creator><creator>Macaulay, S Lance</creator><creator>Szoeke, C</creator><creator>Ellis, K A</creator><creator>Ames, D</creator><creator>Masters, C L</creator><creator>Rainey-Smith, S</creator><creator>Martins, R N</creator><creator>AIBL Research Group</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130226</creationdate><title>Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease</title><author>Frost, S ; 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Early detection of AD, prior to irreversible neurological damage, is important for the efficacy of current interventions as well as for the development of new treatments. Although PiB-PET imaging and CSF amyloid are the gold standards for early AD diagnosis, there are practical limitations for population screening. AD-related pathology occurs primarily in the brain, but some of the hallmarks of the disease have also been shown to occur in other tissues, including the retina, which is more accessible for imaging. Retinal vascular changes and degeneration have previously been reported in AD using optical coherence tomography and laser Doppler techniques. This report presents results from analysis of retinal photographs from AD and healthy control participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. This is the first study to investigate retinal blood vessel changes with respect to amyloid plaque burden in the brain. We demonstrate relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD. A number of RVPs were found to be different in AD. Two of these RVPs, venular branching asymmetry factor and arteriolar length-to-diameter ratio, were also higher in healthy individuals with high plaque burden (P = 0.01 and P = 0.02 respectively, after false discovery rate adjustment). Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>23443359</pmid><doi>10.1038/tp.2012.150</doi><oa>free_for_read</oa></addata></record> |
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| source | Nature Open Access; Publicly Available Content Database; PubMed Central |
| subjects | Aged Alzheimer Disease - complications Alzheimer Disease - diagnosis Analysis of Variance Australia Biomarkers Brain - diagnostic imaging Cohort Studies Disease Progression Early Diagnosis Female Humans Male Original Photography - methods Plaque, Amyloid - diagnostic imaging Positron-Emission Tomography - methods Reproducibility of Results Retinal Artery Retinal Diseases - complications Retinal Diseases - diagnosis Retinal Vein |
| title | Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease |
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