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Magnetic relaxometry with an atomic magnetometer and SQUID sensors on targeted cancer cells
Magnetic relaxometry methods have been shown to be very sensitive in detecting cancer cells and other targeted diseases. Superconducting quantum interference device (SQUID) sensors are one of the primary sensor systems used in this methodology because of their high sensitivity with demonstrated capa...
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| Published in: | Journal of magnetism and magnetic materials 2012-08, Vol.324 (17), p.2613-2619 |
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| Main Authors: | , , , , , , |
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| container_end_page | 2619 |
| container_issue | 17 |
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| container_title | Journal of magnetism and magnetic materials |
| container_volume | 324 |
| creator | Johnson, Cort Adolphi, Natalie L. Butler, Kimberly L. Lovato, Debbie M. Larson, Richard Schwindt, Peter D.D. Flynn, Edward R. |
| description | Magnetic relaxometry methods have been shown to be very sensitive in detecting cancer cells and other targeted diseases. Superconducting quantum interference device (SQUID) sensors are one of the primary sensor systems used in this methodology because of their high sensitivity with demonstrated capabilities of detecting fewer than 100,000 magnetically-labeled cancer cells. The emerging technology of atomic magnetometers (AMs) represents a new detection method for magnetic relaxometry with high sensitivity and without the requirement for cryogens. We report here on a study of magnetic relaxometry using both AM and SQUID sensors to detect cancer cells that are coated with superparamagnetic nanoparticles through antibody targeting. The AM studies conform closely to SQUID sensor results in the measurement of the magnetic decay characteristics following a magnetization pulse. The AM and SQUID sensor data are well described theoretically for superparamagnetic particles bound to cells and the results can be used to determine the number of cells in a cell culture or tumor. The observed fields and magnetic moments of cancer cells are linear with the number of cells over a very large range. The AM sensor demonstrates very high sensitivity for detecting magnetically labeled cells, does not require cryogenic cooling and is relatively inexpensive.
► Magnetic relaxometry is used to study antibody targeted nanoparticles and cells. ► Atomic magnetometer and SQUID sensor performances are compared. ► High sensitivity of magnetic relaxometry for cancer cell detection is demonstrated. ► Magnetic relaxometry decay curves from cancer cells are fit by a log function. |
| doi_str_mv | 10.1016/j.jmmm.2012.03.015 |
| format | article |
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► Magnetic relaxometry is used to study antibody targeted nanoparticles and cells. ► Atomic magnetometer and SQUID sensor performances are compared. ► High sensitivity of magnetic relaxometry for cancer cell detection is demonstrated. ► Magnetic relaxometry decay curves from cancer cells are fit by a log function.</description><identifier>ISSN: 0304-8853</identifier><identifier>DOI: 10.1016/j.jmmm.2012.03.015</identifier><identifier>PMID: 22773885</identifier><identifier>CODEN: JMMMDC</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Atomic magnetometer ; Biological and medical sciences ; Cancer ; Culture ; Decay ; Magnetic nanoparticle ; Magnetic relaxometry ; Magnetization ; Medical sciences ; Nanoparticles ; Sensors ; SQUID ; SQUIDs ; Superconducting quantum interference devices ; Treatment with physical agents ; Treatment. General aspects ; Tumors</subject><ispartof>Journal of magnetism and magnetic materials, 2012-08, Vol.324 (17), p.2613-2619</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>2012 Elsevier B.V. All rights reserved 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-1290788c745e0a6d059d8956e961ac2249d6c2fee8cbcab4f8838ef58391045b3</citedby><cites>FETCH-LOGICAL-c551t-1290788c745e0a6d059d8956e961ac2249d6c2fee8cbcab4f8838ef58391045b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25876853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22773885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Cort</creatorcontrib><creatorcontrib>Adolphi, Natalie L.</creatorcontrib><creatorcontrib>Butler, Kimberly L.</creatorcontrib><creatorcontrib>Lovato, Debbie M.</creatorcontrib><creatorcontrib>Larson, Richard</creatorcontrib><creatorcontrib>Schwindt, Peter D.D.</creatorcontrib><creatorcontrib>Flynn, Edward R.</creatorcontrib><title>Magnetic relaxometry with an atomic magnetometer and SQUID sensors on targeted cancer cells</title><title>Journal of magnetism and magnetic materials</title><addtitle>J Magn Magn Mater</addtitle><description>Magnetic relaxometry methods have been shown to be very sensitive in detecting cancer cells and other targeted diseases. Superconducting quantum interference device (SQUID) sensors are one of the primary sensor systems used in this methodology because of their high sensitivity with demonstrated capabilities of detecting fewer than 100,000 magnetically-labeled cancer cells. The emerging technology of atomic magnetometers (AMs) represents a new detection method for magnetic relaxometry with high sensitivity and without the requirement for cryogens. We report here on a study of magnetic relaxometry using both AM and SQUID sensors to detect cancer cells that are coated with superparamagnetic nanoparticles through antibody targeting. The AM studies conform closely to SQUID sensor results in the measurement of the magnetic decay characteristics following a magnetization pulse. The AM and SQUID sensor data are well described theoretically for superparamagnetic particles bound to cells and the results can be used to determine the number of cells in a cell culture or tumor. The observed fields and magnetic moments of cancer cells are linear with the number of cells over a very large range. The AM sensor demonstrates very high sensitivity for detecting magnetically labeled cells, does not require cryogenic cooling and is relatively inexpensive.
► Magnetic relaxometry is used to study antibody targeted nanoparticles and cells. ► Atomic magnetometer and SQUID sensor performances are compared. ► High sensitivity of magnetic relaxometry for cancer cell detection is demonstrated. ► Magnetic relaxometry decay curves from cancer cells are fit by a log function.</description><subject>Atomic magnetometer</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Culture</subject><subject>Decay</subject><subject>Magnetic nanoparticle</subject><subject>Magnetic relaxometry</subject><subject>Magnetization</subject><subject>Medical sciences</subject><subject>Nanoparticles</subject><subject>Sensors</subject><subject>SQUID</subject><subject>SQUIDs</subject><subject>Superconducting quantum interference devices</subject><subject>Treatment with physical agents</subject><subject>Treatment. General aspects</subject><subject>Tumors</subject><issn>0304-8853</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhnMAtaXlD3BAviBx2XRsx18SQkIt0EqtEIKeOFheZ7L1KomLnS303-Ow2wIXerLk95lXM3qq6gWFmgKVx-t6PQxDzYCyGngNVDypDoBDs9Ba8P3qWc5rAKCNlnvVPmNK8RIcVN8u3WrEKXiSsHc_44BTuiM_wnRN3EjcFIcSDb-ZOcNUvlvy5fPV-SnJOOaYMokjmVxalbQl3o2-QB77Ph9VTzvXZ3y-ew-rqw_vv56cLS4-fTw_eXex8ELQaUGZAaW1V41AcLIFYVpthEQjqfOMNaaVnnWI2i-9Wzad1lxjJzQ3FBqx5IfV223vzWY5YOtxnJLr7U0Kg0t3Nrpg_03GcG1X8dZyro3SqhS83hWk-H2DebJDyPMJbsS4yZZqJoUwqoHHUWkYV1xw_jgKjGnRNGZuZVvUp5hzwu5heQp29mvXdvZrZ78WuC1-y9DLv89-GLmXW4BXO8Bl7_ouFTch_-GEVrJghXuz5bBIug2YbPYBi8c2JPSTbWP43x6_AABgxjY</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Johnson, Cort</creator><creator>Adolphi, Natalie L.</creator><creator>Butler, Kimberly L.</creator><creator>Lovato, Debbie M.</creator><creator>Larson, Richard</creator><creator>Schwindt, Peter D.D.</creator><creator>Flynn, Edward R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7SR</scope><scope>8BQ</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120801</creationdate><title>Magnetic relaxometry with an atomic magnetometer and SQUID sensors on targeted cancer cells</title><author>Johnson, Cort ; Adolphi, Natalie L. ; Butler, Kimberly L. ; Lovato, Debbie M. ; Larson, Richard ; Schwindt, Peter D.D. ; Flynn, Edward R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-1290788c745e0a6d059d8956e961ac2249d6c2fee8cbcab4f8838ef58391045b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Atomic magnetometer</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Culture</topic><topic>Decay</topic><topic>Magnetic nanoparticle</topic><topic>Magnetic relaxometry</topic><topic>Magnetization</topic><topic>Medical sciences</topic><topic>Nanoparticles</topic><topic>Sensors</topic><topic>SQUID</topic><topic>SQUIDs</topic><topic>Superconducting quantum interference devices</topic><topic>Treatment with physical agents</topic><topic>Treatment. 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Superconducting quantum interference device (SQUID) sensors are one of the primary sensor systems used in this methodology because of their high sensitivity with demonstrated capabilities of detecting fewer than 100,000 magnetically-labeled cancer cells. The emerging technology of atomic magnetometers (AMs) represents a new detection method for magnetic relaxometry with high sensitivity and without the requirement for cryogens. We report here on a study of magnetic relaxometry using both AM and SQUID sensors to detect cancer cells that are coated with superparamagnetic nanoparticles through antibody targeting. The AM studies conform closely to SQUID sensor results in the measurement of the magnetic decay characteristics following a magnetization pulse. The AM and SQUID sensor data are well described theoretically for superparamagnetic particles bound to cells and the results can be used to determine the number of cells in a cell culture or tumor. The observed fields and magnetic moments of cancer cells are linear with the number of cells over a very large range. The AM sensor demonstrates very high sensitivity for detecting magnetically labeled cells, does not require cryogenic cooling and is relatively inexpensive.
► Magnetic relaxometry is used to study antibody targeted nanoparticles and cells. ► Atomic magnetometer and SQUID sensor performances are compared. ► High sensitivity of magnetic relaxometry for cancer cell detection is demonstrated. ► Magnetic relaxometry decay curves from cancer cells are fit by a log function.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22773885</pmid><doi>10.1016/j.jmmm.2012.03.015</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetism and magnetic materials, 2012-08, Vol.324 (17), p.2613-2619 |
| issn | 0304-8853 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3389787 |
| source | ScienceDirect Journals |
| subjects | Atomic magnetometer Biological and medical sciences Cancer Culture Decay Magnetic nanoparticle Magnetic relaxometry Magnetization Medical sciences Nanoparticles Sensors SQUID SQUIDs Superconducting quantum interference devices Treatment with physical agents Treatment. General aspects Tumors |
| title | Magnetic relaxometry with an atomic magnetometer and SQUID sensors on targeted cancer cells |
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