A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave pr...

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Bibliographic Details
Published in:Review of scientific instruments 2012-03, Vol.83 (3), p.033108-033108-8
Main Authors: Flexman, M. L., Kim, H. K., Stoll, R., Khalil, M. A., Fong, C. J., Hielscher, A. H.
Format: Article
Language:English
Subjects:
Image Processing, Computer-Assisted
Molecular Imaging - instrumentation
Optical Phenomena
Optics
Atoms and Molecules
Spectroscopy
Photon Detectors
Phantoms, Imaging
Time Factors
Wireless Technology
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Summary:We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid ® , ink, and dye.
ISSN:0034-6748
1089-7623
DOI:10.1063/1.3694494