Loading…
Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy
Objective To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. Study design Stage of encephalopathy was evaluated at
Saved in:
| Published in: | The Journal of pediatrics 2012-04, Vol.160 (4), p.567-572.e3 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433 |
| container_end_page | 572.e3 |
| container_issue | 4 |
| container_start_page | 567 |
| container_title | The Journal of pediatrics |
| container_volume | 160 |
| creator | Shankaran, Seetha, MD Laptook, Abbot R., MD Tyson, Jon E., MD, MPH Ehrenkranz, Richard A., MD Bann, Carla M., PhD Das, Abhik, PhD Higgins, Rosemary D., MD Bara, Rebecca, RN, BSN Pappas, Athina, MD McDonald, Scott A., BS Goldberg, Ronald N., MD Walsh, Michele C., MD, MS |
| description | Objective To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. Study design Stage of encephalopathy was evaluated at |
| doi_str_mv | 10.1016/j.jpeds.2011.09.018 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3299861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347611009322</els_id><sourcerecordid>929122119</sourcerecordid><originalsourceid>FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEokvhFyBBLohTwtjOlw9UgmqhlSo4lIqj5TiTjUMSp3ayIv8ep7sU6IWTLfmZ16N5JgheEogJkOxdG7cjVi6mQEgMPAZSPAo2BHgeZQVjj4MNAKURS_LsJHjmXAsAPAF4GpxQCikUOdkE9XZvunnSZghNHW4HhWMjOzPKqVnCarZ62IXfG9Nh-NFUS3ixjGZq0PZahrWx4Rc0g5xkd_fwU6vo0qkGe60eRD0PntSyc_jieJ4GN5-2384voquvny_PP1xFKmNsirBgqcx5WmJJkrLiUCkukzoFjhyrVJVppRDyihdZWVAiiSxYWac5yVWS0ISx0-DskDvOZY8eHiYrOzFa3Uu7CCO1-Pdl0I3Ymb1glPtQ4gPeHgOsuZ3RTaLXTmHXyQHN7ASnnFBKCPckO5DKGucs1ve_EBCrINGKO0FiFSSACy_IV736u8H7mt9GPPDmCEinZFdbOSjt_nBpToGnK_f6wNXSCLmznrm59j-l3nKRJ_k6i_cHAv3A9xqtcEqj11Jpi2oSldH_afXsQb3q9KB9Uz9wQdea2Q7epSDCUQHiet22ddkI8XvG_P0XXQHQeg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>929122119</pqid></control><display><type>article</type><title>Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Shankaran, Seetha, MD ; Laptook, Abbot R., MD ; Tyson, Jon E., MD, MPH ; Ehrenkranz, Richard A., MD ; Bann, Carla M., PhD ; Das, Abhik, PhD ; Higgins, Rosemary D., MD ; Bara, Rebecca, RN, BSN ; Pappas, Athina, MD ; McDonald, Scott A., BS ; Goldberg, Ronald N., MD ; Walsh, Michele C., MD, MS</creator><creatorcontrib>Shankaran, Seetha, MD ; Laptook, Abbot R., MD ; Tyson, Jon E., MD, MPH ; Ehrenkranz, Richard A., MD ; Bann, Carla M., PhD ; Das, Abhik, PhD ; Higgins, Rosemary D., MD ; Bara, Rebecca, RN, BSN ; Pappas, Athina, MD ; McDonald, Scott A., BS ; Goldberg, Ronald N., MD ; Walsh, Michele C., MD, MS ; National Institute of Child Health and Human Development Neonatal Research Network ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><description>Objective To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. Study design Stage of encephalopathy was evaluated at <6 hours of age, during study intervention, and at discharge among 204 participants in the National Institute of Child Health and Human Development Neonatal Research Network Trial of whole body hypothermia for HIE. HIE was examined as a predictor of outcome by regression models. Results Moderate and severe HIE occurred at <6 hours of age among 68% and 32% of 101 hypothermia group infants and 60% and 40% of 103 control group infants, respectively. At 24 and 48 hours of study intervention, infants in the hypothermia group had less severe HIE than infants in the control group. Persistence of severe HIE at 72 hours increased the risk of death or disability after controlling for treatment group. The discharge exam improved the predictive value of stage of HIE at <6 hours for death/disability. Conclusions On serial neurologic examinations, improvement in stage of HIE was associated with cooling. Persistence of severe HIE at 72 hours and an abnormal neurologic exam at discharge were associated with a greater risk of death or disability.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2011.09.018</identifier><identifier>PMID: 22050871</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Mosby, Inc</publisher><subject>Biological and medical sciences ; children ; cooling ; death ; Developmental Disabilities - epidemiology ; Developmental Disabilities - etiology ; encephalopathy ; General aspects ; human development ; human health ; Humans ; hypothermia ; Hypothermia, Induced - methods ; Hypoxia-Ischemia, Brain - complications ; Hypoxia-Ischemia, Brain - mortality ; Hypoxia-Ischemia, Brain - therapy ; Infant, Newborn ; Medical sciences ; neonatal development ; neonates ; Pediatrics ; Prognosis ; Regression Analysis ; risk ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>The Journal of pediatrics, 2012-04, Vol.160 (4), p.567-572.e3</ispartof><rights>Mosby, Inc.</rights><rights>2012 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Mosby, Inc. All rights reserved.</rights><rights>2011 Mosby, Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433</citedby><cites>FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25720951$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22050871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shankaran, Seetha, MD</creatorcontrib><creatorcontrib>Laptook, Abbot R., MD</creatorcontrib><creatorcontrib>Tyson, Jon E., MD, MPH</creatorcontrib><creatorcontrib>Ehrenkranz, Richard A., MD</creatorcontrib><creatorcontrib>Bann, Carla M., PhD</creatorcontrib><creatorcontrib>Das, Abhik, PhD</creatorcontrib><creatorcontrib>Higgins, Rosemary D., MD</creatorcontrib><creatorcontrib>Bara, Rebecca, RN, BSN</creatorcontrib><creatorcontrib>Pappas, Athina, MD</creatorcontrib><creatorcontrib>McDonald, Scott A., BS</creatorcontrib><creatorcontrib>Goldberg, Ronald N., MD</creatorcontrib><creatorcontrib>Walsh, Michele C., MD, MS</creatorcontrib><creatorcontrib>National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><creatorcontrib>Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><title>Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. Study design Stage of encephalopathy was evaluated at <6 hours of age, during study intervention, and at discharge among 204 participants in the National Institute of Child Health and Human Development Neonatal Research Network Trial of whole body hypothermia for HIE. HIE was examined as a predictor of outcome by regression models. Results Moderate and severe HIE occurred at <6 hours of age among 68% and 32% of 101 hypothermia group infants and 60% and 40% of 103 control group infants, respectively. At 24 and 48 hours of study intervention, infants in the hypothermia group had less severe HIE than infants in the control group. Persistence of severe HIE at 72 hours increased the risk of death or disability after controlling for treatment group. The discharge exam improved the predictive value of stage of HIE at <6 hours for death/disability. Conclusions On serial neurologic examinations, improvement in stage of HIE was associated with cooling. Persistence of severe HIE at 72 hours and an abnormal neurologic exam at discharge were associated with a greater risk of death or disability.</description><subject>Biological and medical sciences</subject><subject>children</subject><subject>cooling</subject><subject>death</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Developmental Disabilities - etiology</subject><subject>encephalopathy</subject><subject>General aspects</subject><subject>human development</subject><subject>human health</subject><subject>Humans</subject><subject>hypothermia</subject><subject>Hypothermia, Induced - methods</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Hypoxia-Ischemia, Brain - mortality</subject><subject>Hypoxia-Ischemia, Brain - therapy</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>neonatal development</subject><subject>neonates</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>risk</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkk1v1DAQhiMEokvhFyBBLohTwtjOlw9UgmqhlSo4lIqj5TiTjUMSp3ayIv8ep7sU6IWTLfmZ16N5JgheEogJkOxdG7cjVi6mQEgMPAZSPAo2BHgeZQVjj4MNAKURS_LsJHjmXAsAPAF4GpxQCikUOdkE9XZvunnSZghNHW4HhWMjOzPKqVnCarZ62IXfG9Nh-NFUS3ixjGZq0PZahrWx4Rc0g5xkd_fwU6vo0qkGe60eRD0PntSyc_jieJ4GN5-2384voquvny_PP1xFKmNsirBgqcx5WmJJkrLiUCkukzoFjhyrVJVppRDyihdZWVAiiSxYWac5yVWS0ISx0-DskDvOZY8eHiYrOzFa3Uu7CCO1-Pdl0I3Ymb1glPtQ4gPeHgOsuZ3RTaLXTmHXyQHN7ASnnFBKCPckO5DKGucs1ve_EBCrINGKO0FiFSSACy_IV736u8H7mt9GPPDmCEinZFdbOSjt_nBpToGnK_f6wNXSCLmznrm59j-l3nKRJ_k6i_cHAv3A9xqtcEqj11Jpi2oSldH_afXsQb3q9KB9Uz9wQdea2Q7epSDCUQHiet22ddkI8XvG_P0XXQHQeg</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Shankaran, Seetha, MD</creator><creator>Laptook, Abbot R., MD</creator><creator>Tyson, Jon E., MD, MPH</creator><creator>Ehrenkranz, Richard A., MD</creator><creator>Bann, Carla M., PhD</creator><creator>Das, Abhik, PhD</creator><creator>Higgins, Rosemary D., MD</creator><creator>Bara, Rebecca, RN, BSN</creator><creator>Pappas, Athina, MD</creator><creator>McDonald, Scott A., BS</creator><creator>Goldberg, Ronald N., MD</creator><creator>Walsh, Michele C., MD, MS</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120401</creationdate><title>Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy</title><author>Shankaran, Seetha, MD ; Laptook, Abbot R., MD ; Tyson, Jon E., MD, MPH ; Ehrenkranz, Richard A., MD ; Bann, Carla M., PhD ; Das, Abhik, PhD ; Higgins, Rosemary D., MD ; Bara, Rebecca, RN, BSN ; Pappas, Athina, MD ; McDonald, Scott A., BS ; Goldberg, Ronald N., MD ; Walsh, Michele C., MD, MS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>children</topic><topic>cooling</topic><topic>death</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Developmental Disabilities - etiology</topic><topic>encephalopathy</topic><topic>General aspects</topic><topic>human development</topic><topic>human health</topic><topic>Humans</topic><topic>hypothermia</topic><topic>Hypothermia, Induced - methods</topic><topic>Hypoxia-Ischemia, Brain - complications</topic><topic>Hypoxia-Ischemia, Brain - mortality</topic><topic>Hypoxia-Ischemia, Brain - therapy</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>neonatal development</topic><topic>neonates</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>risk</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shankaran, Seetha, MD</creatorcontrib><creatorcontrib>Laptook, Abbot R., MD</creatorcontrib><creatorcontrib>Tyson, Jon E., MD, MPH</creatorcontrib><creatorcontrib>Ehrenkranz, Richard A., MD</creatorcontrib><creatorcontrib>Bann, Carla M., PhD</creatorcontrib><creatorcontrib>Das, Abhik, PhD</creatorcontrib><creatorcontrib>Higgins, Rosemary D., MD</creatorcontrib><creatorcontrib>Bara, Rebecca, RN, BSN</creatorcontrib><creatorcontrib>Pappas, Athina, MD</creatorcontrib><creatorcontrib>McDonald, Scott A., BS</creatorcontrib><creatorcontrib>Goldberg, Ronald N., MD</creatorcontrib><creatorcontrib>Walsh, Michele C., MD, MS</creatorcontrib><creatorcontrib>National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><creatorcontrib>Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shankaran, Seetha, MD</au><au>Laptook, Abbot R., MD</au><au>Tyson, Jon E., MD, MPH</au><au>Ehrenkranz, Richard A., MD</au><au>Bann, Carla M., PhD</au><au>Das, Abhik, PhD</au><au>Higgins, Rosemary D., MD</au><au>Bara, Rebecca, RN, BSN</au><au>Pappas, Athina, MD</au><au>McDonald, Scott A., BS</au><au>Goldberg, Ronald N., MD</au><au>Walsh, Michele C., MD, MS</au><aucorp>National Institute of Child Health and Human Development Neonatal Research Network</aucorp><aucorp>Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>160</volume><issue>4</issue><spage>567</spage><epage>572.e3</epage><pages>567-572.e3</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><notes>http://dx.doi.org/10.1016/j.jpeds.2011.09.018</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-2</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>A list of members of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network is available at www.jpeds.com (Appendix 1).</notes><abstract>Objective To examine the predictive ability of stage of hypoxic-ischemic encephalopathy (HIE) for death or moderate/severe disability at 18 months among neonates undergoing hypothermia. Study design Stage of encephalopathy was evaluated at <6 hours of age, during study intervention, and at discharge among 204 participants in the National Institute of Child Health and Human Development Neonatal Research Network Trial of whole body hypothermia for HIE. HIE was examined as a predictor of outcome by regression models. Results Moderate and severe HIE occurred at <6 hours of age among 68% and 32% of 101 hypothermia group infants and 60% and 40% of 103 control group infants, respectively. At 24 and 48 hours of study intervention, infants in the hypothermia group had less severe HIE than infants in the control group. Persistence of severe HIE at 72 hours increased the risk of death or disability after controlling for treatment group. The discharge exam improved the predictive value of stage of HIE at <6 hours for death/disability. Conclusions On serial neurologic examinations, improvement in stage of HIE was associated with cooling. Persistence of severe HIE at 72 hours and an abnormal neurologic exam at discharge were associated with a greater risk of death or disability.</abstract><cop>Maryland Heights, MO</cop><pub>Mosby, Inc</pub><pmid>22050871</pmid><doi>10.1016/j.jpeds.2011.09.018</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 2012-04, Vol.160 (4), p.567-572.e3 |
| issn | 0022-3476 1097-6833 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3299861 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Biological and medical sciences children cooling death Developmental Disabilities - epidemiology Developmental Disabilities - etiology encephalopathy General aspects human development human health Humans hypothermia Hypothermia, Induced - methods Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - mortality Hypoxia-Ischemia, Brain - therapy Infant, Newborn Medical sciences neonatal development neonates Pediatrics Prognosis Regression Analysis risk Severity of Illness Index Treatment Outcome |
| title | Evolution of Encephalopathy during Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T05%3A28%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evolution%20of%20Encephalopathy%20during%20Whole%20Body%20Hypothermia%20for%20Neonatal%20Hypoxic-Ischemic%20Encephalopathy&rft.jtitle=The%20Journal%20of%20pediatrics&rft.au=Shankaran,%20Seetha,%20MD&rft.aucorp=National%20Institute%20of%20Child%20Health%20and%20Human%20Development%20Neonatal%20Research%20Network&rft.date=2012-04-01&rft.volume=160&rft.issue=4&rft.spage=567&rft.epage=572.e3&rft.pages=567-572.e3&rft.issn=0022-3476&rft.eissn=1097-6833&rft.coden=JOPDAB&rft_id=info:doi/10.1016/j.jpeds.2011.09.018&rft_dat=%3Cproquest_pubme%3E929122119%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c633t-e835a795beb14bd90dc9a4f509e9ed5cb5dce07d986b821a1a83bf5717c442433%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=929122119&rft_id=info:pmid/22050871&rfr_iscdi=true |