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Bacterial small RNA regulators: versatile roles and rapidly evolving variations

Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to play critical regulatory roles in many processes. The major families of sRNAs include true antisense RNAs, synthesized from the strand complementary to the mRNA they regulate, sRNAs that also act by pairing bu...

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Published in:	Cold Spring Harbor perspectives in biology 2011-12, Vol.3 (12), p.a003798-a003798
Main Authors:	Gottesman, Susan, Storz, Gisela
Format:	Article
Language:	English
Subjects:	Bacteria Bacteria - genetics Base Pairing Concept Evolution, Molecular RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - physiology RNA, Small Untranslated - chemistry RNA, Small Untranslated - genetics RNA, Small Untranslated - physiology
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container_title	Cold Spring Harbor perspectives in biology
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creator	Gottesman, Susan Storz, Gisela
description	Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to play critical regulatory roles in many processes. The major families of sRNAs include true antisense RNAs, synthesized from the strand complementary to the mRNA they regulate, sRNAs that also act by pairing but have limited complementarity with their targets, and sRNAs that regulate proteins by binding to and affecting protein activity. The sRNAs with limited complementarity are akin to eukaryotic microRNAs in their ability to modulate the activity and stability of multiple mRNAs. In many bacterial species, the RNA chaperone Hfq is required to promote pairing between these sRNAs and their target mRNAs. Understanding the evolution of regulatory sRNAs remains a challenge; sRNA genes show evidence of duplication and horizontal transfer but also could be evolved from tRNAs, mRNAs or random transcription.
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subjects	Bacteria Bacteria - genetics Base Pairing Concept Evolution, Molecular RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - physiology RNA, Small Untranslated - chemistry RNA, Small Untranslated - genetics RNA, Small Untranslated - physiology
title	Bacterial small RNA regulators: versatile roles and rapidly evolving variations
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