Four-dimensional ultrasound current source density imaging of a dipole field

Ultrasound current source density imaging (UCSDI) potentially transforms conventional electrical mapping of excitable organs, such as the brain and heart. For this study, we demonstrate volume imaging of a time-varying current field by scanning a focused ultrasound beam and detecting the acoustoelec...

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Bibliographic Details
Published in:Applied physics letters 2011-09, Vol.99 (11), p.113701-113701-3
Main Authors: Wang, Z. H., Olafsson, R., Ingram, P., Li, Q., Qin, Y., Witte, R. S.
Format: Article
Language:English
Subjects:
Biophysics and Bio-Inspired Systems
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Summary:Ultrasound current source density imaging (UCSDI) potentially transforms conventional electrical mapping of excitable organs, such as the brain and heart. For this study, we demonstrate volume imaging of a time-varying current field by scanning a focused ultrasound beam and detecting the acoustoelectric (AE) interaction signal. A pair of electrodes produced an alternating current distribution in a special imaging chamber filled with a 0.9% NaCl solution. A pulsed 1 MHz ultrasound beam was scanned near the source and sink, while the AE signal was detected on remote recording electrodes, resulting in time-lapsed volume movies of the alternating current distribution.
ISSN:0003-6951
1077-3118
0003-6951
DOI:10.1063/1.3632034