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Angiotensin II induced catabolic effect and muscle atrophy are redox dependent
► Angiotensin II increases NADPH oxidase-derived ROS in skeletal muscle. ► Deletion of p47 phox prevents Ang II-induced skeletal muscle weight loss. ► Ang II-induced proteasome activity in skeletal muscle is prevented in p47 phox−/− mice. Angiotensin II (Ang II) causes skeletal muscle wasting via an...
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| Published in: | Biochemical and biophysical research communications 2011-06, Vol.409 (2), p.217-221 |
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| cites | cdi_FETCH-LOGICAL-c520t-35e68be8e9006b3aabda2717203bd0bc9342b310f31317d0b0fc7a9fadfbde363 |
| container_end_page | 221 |
| container_issue | 2 |
| container_start_page | 217 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 409 |
| creator | Semprun-Prieto, Laura C. Sukhanov, Sergiy Yoshida, Tadashi Rezk, Bashir M. Gonzalez-Villalobos, Romer A. Vaughn, Charlotte Michael Tabony, A. Delafontaine, Patrice |
| description | ► Angiotensin II increases NADPH oxidase-derived ROS in skeletal muscle. ► Deletion of p47
phox prevents Ang II-induced skeletal muscle weight loss. ► Ang II-induced proteasome activity in skeletal muscle is prevented in p47
phox−/− mice.
Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47
phox
−/− mice with vehicle or Ang II for 7
days. Superoxide production was increased 2.4-fold in the skeletal muscle of Ang II infused mice, and this increase was prevented in p47
phox
−/− mice. Apocynin treatment prevented Ang II-induced superoxide production in skeletal muscle, consistent with Ang II increasing NADPH oxidase derived ROS. Ang II induced loss of body and skeletal muscle weight in C57BL/6J mice, whereas the reduction was significantly attenuated in p47
phox
−/− animals. The reduction of skeletal muscle weight caused by Ang II was associated with an increase of proteasome activity, and this increase was completely prevented in the skeletal muscle of p47
phox
−/− mice. In conclusion, Ang II-induced skeletal muscle wasting is in part dependent on NADPH oxidase derived ROS. |
| doi_str_mv | 10.1016/j.bbrc.2011.04.122 |
| format | article |
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phox prevents Ang II-induced skeletal muscle weight loss. ► Ang II-induced proteasome activity in skeletal muscle is prevented in p47
phox−/− mice.
Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47
phox
−/− mice with vehicle or Ang II for 7
days. Superoxide production was increased 2.4-fold in the skeletal muscle of Ang II infused mice, and this increase was prevented in p47
phox
−/− mice. Apocynin treatment prevented Ang II-induced superoxide production in skeletal muscle, consistent with Ang II increasing NADPH oxidase derived ROS. Ang II induced loss of body and skeletal muscle weight in C57BL/6J mice, whereas the reduction was significantly attenuated in p47
phox
−/− animals. The reduction of skeletal muscle weight caused by Ang II was associated with an increase of proteasome activity, and this increase was completely prevented in the skeletal muscle of p47
phox
−/− mice. In conclusion, Ang II-induced skeletal muscle wasting is in part dependent on NADPH oxidase derived ROS.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2011.04.122</identifier><identifier>PMID: 21570954</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Angiotensin II ; Angiotensin II - adverse effects ; Animals ; Atrophy ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscular Atrophy - chemically induced ; Muscular Atrophy - metabolism ; NADPH oxidase ; NADPH Oxidases - genetics ; Oxidation-Reduction ; Oxidative stress ; Proteasome Endopeptidase Complex - metabolism ; Reactive Oxygen Species - metabolism ; Skeletal muscle ; Superoxides - metabolism ; Wasting Syndrome - chemically induced ; Wasting Syndrome - metabolism</subject><ispartof>Biochemical and biophysical research communications, 2011-06, Vol.409 (2), p.217-221</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>2011 Elsevier Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-35e68be8e9006b3aabda2717203bd0bc9342b310f31317d0b0fc7a9fadfbde363</citedby><cites>FETCH-LOGICAL-c520t-35e68be8e9006b3aabda2717203bd0bc9342b310f31317d0b0fc7a9fadfbde363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21570954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Semprun-Prieto, Laura C.</creatorcontrib><creatorcontrib>Sukhanov, Sergiy</creatorcontrib><creatorcontrib>Yoshida, Tadashi</creatorcontrib><creatorcontrib>Rezk, Bashir M.</creatorcontrib><creatorcontrib>Gonzalez-Villalobos, Romer A.</creatorcontrib><creatorcontrib>Vaughn, Charlotte</creatorcontrib><creatorcontrib>Michael Tabony, A.</creatorcontrib><creatorcontrib>Delafontaine, Patrice</creatorcontrib><title>Angiotensin II induced catabolic effect and muscle atrophy are redox dependent</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>► Angiotensin II increases NADPH oxidase-derived ROS in skeletal muscle. ► Deletion of p47
phox prevents Ang II-induced skeletal muscle weight loss. ► Ang II-induced proteasome activity in skeletal muscle is prevented in p47
phox−/− mice.
Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47
phox
−/− mice with vehicle or Ang II for 7
days. Superoxide production was increased 2.4-fold in the skeletal muscle of Ang II infused mice, and this increase was prevented in p47
phox
−/− mice. Apocynin treatment prevented Ang II-induced superoxide production in skeletal muscle, consistent with Ang II increasing NADPH oxidase derived ROS. Ang II induced loss of body and skeletal muscle weight in C57BL/6J mice, whereas the reduction was significantly attenuated in p47
phox
−/− animals. The reduction of skeletal muscle weight caused by Ang II was associated with an increase of proteasome activity, and this increase was completely prevented in the skeletal muscle of p47
phox
−/− mice. In conclusion, Ang II-induced skeletal muscle wasting is in part dependent on NADPH oxidase derived ROS.</description><subject>Angiotensin II</subject><subject>Angiotensin II - adverse effects</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Mutant Strains</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular Atrophy - chemically induced</subject><subject>Muscular Atrophy - metabolism</subject><subject>NADPH oxidase</subject><subject>NADPH Oxidases - genetics</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Proteasome Endopeptidase Complex - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Skeletal muscle</subject><subject>Superoxides - metabolism</subject><subject>Wasting Syndrome - chemically induced</subject><subject>Wasting Syndrome - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMotlZfwIXkBWY8SebSARFK8VIoulFwF3I506a0mZKZFvv2plSLblwFkv__zslHyDWDlAErbhep1sGkHBhLIUsZ5yekz6CChDPITkkfAIqEV-yjRy7adgExmBXVOelxlpdQ5VmfvIz8zDUd-tZ5OplQ5-3GoKVGdUo3S2co1jWajipv6WrTmiVS1YVmPd9RFZAGtM0ntbhGb9F3l-SsVssWr77PAXl_fHgbPyfT16fJeDRNTM6hS0SOxVDjEKu4oRZKaat4yUoOQlvQphIZ14JBLZhgZbyB2pSqqpWttUVRiAG5P3DXG71Ca-LooJZyHdxKhZ1slJN_X7yby1mzlRFaMT6MAH4AmNC0bcD62GUg93blQu7tyr1dCZmMdmPp5vfUY-VHZwzcHQIY_751GGRrHPoo1IUoUdrG_cf_Aum1jak</recordid><startdate>20110603</startdate><enddate>20110603</enddate><creator>Semprun-Prieto, Laura C.</creator><creator>Sukhanov, Sergiy</creator><creator>Yoshida, Tadashi</creator><creator>Rezk, Bashir M.</creator><creator>Gonzalez-Villalobos, Romer A.</creator><creator>Vaughn, Charlotte</creator><creator>Michael Tabony, A.</creator><creator>Delafontaine, Patrice</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110603</creationdate><title>Angiotensin II induced catabolic effect and muscle atrophy are redox dependent</title><author>Semprun-Prieto, Laura C. ; Sukhanov, Sergiy ; Yoshida, Tadashi ; Rezk, Bashir M. ; Gonzalez-Villalobos, Romer A. ; Vaughn, Charlotte ; Michael Tabony, A. ; Delafontaine, Patrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-35e68be8e9006b3aabda2717203bd0bc9342b310f31317d0b0fc7a9fadfbde363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiotensin II</topic><topic>Angiotensin II - adverse effects</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Mutant Strains</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular Atrophy - chemically induced</topic><topic>Muscular Atrophy - metabolism</topic><topic>NADPH oxidase</topic><topic>NADPH Oxidases - genetics</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Proteasome Endopeptidase Complex - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Skeletal muscle</topic><topic>Superoxides - metabolism</topic><topic>Wasting Syndrome - chemically induced</topic><topic>Wasting Syndrome - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Semprun-Prieto, Laura C.</creatorcontrib><creatorcontrib>Sukhanov, Sergiy</creatorcontrib><creatorcontrib>Yoshida, Tadashi</creatorcontrib><creatorcontrib>Rezk, Bashir M.</creatorcontrib><creatorcontrib>Gonzalez-Villalobos, Romer A.</creatorcontrib><creatorcontrib>Vaughn, Charlotte</creatorcontrib><creatorcontrib>Michael Tabony, A.</creatorcontrib><creatorcontrib>Delafontaine, Patrice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Semprun-Prieto, Laura C.</au><au>Sukhanov, Sergiy</au><au>Yoshida, Tadashi</au><au>Rezk, Bashir M.</au><au>Gonzalez-Villalobos, Romer A.</au><au>Vaughn, Charlotte</au><au>Michael Tabony, A.</au><au>Delafontaine, Patrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin II induced catabolic effect and muscle atrophy are redox dependent</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2011-06-03</date><risdate>2011</risdate><volume>409</volume><issue>2</issue><spage>217</spage><epage>221</epage><pages>217-221</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>► Angiotensin II increases NADPH oxidase-derived ROS in skeletal muscle. ► Deletion of p47
phox prevents Ang II-induced skeletal muscle weight loss. ► Ang II-induced proteasome activity in skeletal muscle is prevented in p47
phox−/− mice.
Angiotensin II (Ang II) causes skeletal muscle wasting via an increase in muscle catabolism. To determine whether the wasting effects of Ang II were related to its ability to increase NADPH oxidase-derived reactive oxygen species (ROS) we infused wild-type C57BL/6J or p47
phox
−/− mice with vehicle or Ang II for 7
days. Superoxide production was increased 2.4-fold in the skeletal muscle of Ang II infused mice, and this increase was prevented in p47
phox
−/− mice. Apocynin treatment prevented Ang II-induced superoxide production in skeletal muscle, consistent with Ang II increasing NADPH oxidase derived ROS. Ang II induced loss of body and skeletal muscle weight in C57BL/6J mice, whereas the reduction was significantly attenuated in p47
phox
−/− animals. The reduction of skeletal muscle weight caused by Ang II was associated with an increase of proteasome activity, and this increase was completely prevented in the skeletal muscle of p47
phox
−/− mice. In conclusion, Ang II-induced skeletal muscle wasting is in part dependent on NADPH oxidase derived ROS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21570954</pmid><doi>10.1016/j.bbrc.2011.04.122</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2011-06, Vol.409 (2), p.217-221 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Angiotensin II Angiotensin II - adverse effects Animals Atrophy Male Mice Mice, Inbred C57BL Mice, Mutant Strains Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscular Atrophy - chemically induced Muscular Atrophy - metabolism NADPH oxidase NADPH Oxidases - genetics Oxidation-Reduction Oxidative stress Proteasome Endopeptidase Complex - metabolism Reactive Oxygen Species - metabolism Skeletal muscle Superoxides - metabolism Wasting Syndrome - chemically induced Wasting Syndrome - metabolism |
| title | Angiotensin II induced catabolic effect and muscle atrophy are redox dependent |
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