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Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor
Flavonoids are synthesized through an important metabolic pathway that leads to the production of diverse secondary metabolites, including anthocyanins, flavonols, flavones, and proanthocyanidins. Anthocyanins and flavonols are derived from Phe and share common precursors, dihydroflavonols, which ar...
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| Published in: | The Plant cell 2011-04, Vol.23 (4), p.1512-1522 |
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| container_end_page | 1522 |
| container_issue | 4 |
| container_start_page | 1512 |
| container_title | The Plant cell |
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| creator | Gou, Jin-Ying Felippes, Felipe F. Liu, Chang-Jun Weigel, Detlef Wang, Jia-Wei |
| description | Flavonoids are synthesized through an important metabolic pathway that leads to the production of diverse secondary metabolites, including anthocyanins, flavonols, flavones, and proanthocyanidins. Anthocyanins and flavonols are derived from Phe and share common precursors, dihydroflavonols, which are substrates for both flavonol synthase and dihydrof lavonol 4-reductase. In the stems of Arabidopsis thaliana, anthocyanins accumulate in an acropetal manner, with the highest level at the junction between rosette and stem. We show here that this accumulation pattern is under the regulation of miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE {SPL) genes, which are deeply conserved and known to have important roles in regulating phase change and flowering. Increased miR156 activity promotes accumulation of anthocyanins, whereas reduced miR156 activity results in high levels of flavonols. We further provide evidence that at least one of the miR156 targets, SPL9, negatively regulates anthocyanin accumulation by directly preventing expression of anthocyanin biosynthetic genes through destabilization of a MYB-bHLH-WD40 transcriptional activation complex. Our results reveal a direct link between the transition to flowering and secondary metabolism and provide a potential target for manipulation of anthocyanin and flavonol content in plants. |
| doi_str_mv | 10.1105/tpc.111.084525 |
| format | article |
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Anthocyanins and flavonols are derived from Phe and share common precursors, dihydroflavonols, which are substrates for both flavonol synthase and dihydrof lavonol 4-reductase. In the stems of Arabidopsis thaliana, anthocyanins accumulate in an acropetal manner, with the highest level at the junction between rosette and stem. We show here that this accumulation pattern is under the regulation of miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE {SPL) genes, which are deeply conserved and known to have important roles in regulating phase change and flowering. Increased miR156 activity promotes accumulation of anthocyanins, whereas reduced miR156 activity results in high levels of flavonols. We further provide evidence that at least one of the miR156 targets, SPL9, negatively regulates anthocyanin accumulation by directly preventing expression of anthocyanin biosynthetic genes through destabilization of a MYB-bHLH-WD40 transcriptional activation complex. Our results reveal a direct link between the transition to flowering and secondary metabolism and provide a potential target for manipulation of anthocyanin and flavonol content in plants.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.111.084525</identifier><identifier>PMID: 21487097</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Alcohol Oxidoreductases - genetics ; Alcohol Oxidoreductases - metabolism ; Anthocyanins - biosynthesis ; Anthocyanins - chemistry ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Biosynthesis ; Chromatography, Liquid ; Flavonoids ; Flavonols ; Gene expression regulation ; Gene Expression Regulation, Plant ; Genes ; Genes, Plant - genetics ; Mass Spectrometry ; MicroRNA ; MicroRNAs - metabolism ; Models, Biological ; Multiprotein Complexes - metabolism ; Plant cells ; Plants ; Plants, Genetically Modified ; Promoter Regions, Genetic - genetics ; Protein Binding ; Seedlings ; Stems ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>The Plant cell, 2011-04, Vol.23 (4), p.1512-1522</ispartof><rights>2011 American Society of Plant Biologists</rights><rights>Copyright American Society of Plant Biologists Apr 2011</rights><rights>2011 American Society of Plant Biologists 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-105f32711b57cca817ec4bd1e1e0e32ccacb32f486b29d19c34032dbed0d98df3</citedby><cites>FETCH-LOGICAL-c537t-105f32711b57cca817ec4bd1e1e0e32ccacb32f486b29d19c34032dbed0d98df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41433406$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41433406$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,58593,58826</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21487097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gou, Jin-Ying</creatorcontrib><creatorcontrib>Felippes, Felipe F.</creatorcontrib><creatorcontrib>Liu, Chang-Jun</creatorcontrib><creatorcontrib>Weigel, Detlef</creatorcontrib><creatorcontrib>Wang, Jia-Wei</creatorcontrib><title>Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>Flavonoids are synthesized through an important metabolic pathway that leads to the production of diverse secondary metabolites, including anthocyanins, flavonols, flavones, and proanthocyanidins. 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Our results reveal a direct link between the transition to flowering and secondary metabolism and provide a potential target for manipulation of anthocyanin and flavonol content in plants.</description><subject>Alcohol Oxidoreductases - genetics</subject><subject>Alcohol Oxidoreductases - metabolism</subject><subject>Anthocyanins - biosynthesis</subject><subject>Anthocyanins - chemistry</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Biosynthesis</subject><subject>Chromatography, Liquid</subject><subject>Flavonoids</subject><subject>Flavonols</subject><subject>Gene expression regulation</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genes</subject><subject>Genes, Plant - genetics</subject><subject>Mass Spectrometry</subject><subject>MicroRNA</subject><subject>MicroRNAs - metabolism</subject><subject>Models, Biological</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Plant cells</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protein Binding</subject><subject>Seedlings</subject><subject>Stems</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kc2P0zAQxSMEYpeFKzdQxAUuKR5_JPYFqaxYQKoALUXiZjm203WVxsFOVup_z5QuFXDg5Deen58884riKZAFABGvp9GigAWRXFBxrzgHwWhFlfx-HzXhpOK1gLPiUc5bQgg0oB4WZxS4bIhqzov-k9-YKdz68tpv5h5lHMrYlcthuol2b4YwlG9DzHusfQ65xHqZTBtcHA9luy9NuQvXIOpqbdLGT96VX7-synUyQ7YpjL8cr4ydYnpcPOhMn_2Tu_Oi-Hb1bn35oVp9fv_xcrmqrGDNVOFcHaMNQCsaa42ExlveOvDgiWcUr2zLaMdl3VLlQFnGCaOu9Y44JV3HLoo3R99xbnfeWT9MyfR6TGFn0l5HE_TfnSHc6E281QwI7k-hwcs7gxR_zD5Pehey9X1vBh_nrGWtcJmMcyRf_ZcEXkvGlJIU0Rf_oNs4pwEXcfBrmBQcEFocIZtizsl3p18D0YfENSaOAvQxcXzw_M9ZT_jviBF4dgS2GSM49Tlwhnur2U-NNrHz</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Gou, Jin-Ying</creator><creator>Felippes, Felipe F.</creator><creator>Liu, Chang-Jun</creator><creator>Weigel, Detlef</creator><creator>Wang, Jia-Wei</creator><general>American Society of Plant Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor</title><author>Gou, Jin-Ying ; Felippes, Felipe F. ; Liu, Chang-Jun ; Weigel, Detlef ; Wang, Jia-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-105f32711b57cca817ec4bd1e1e0e32ccacb32f486b29d19c34032dbed0d98df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alcohol Oxidoreductases - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gou, Jin-Ying</au><au>Felippes, Felipe F.</au><au>Liu, Chang-Jun</au><au>Weigel, Detlef</au><au>Wang, Jia-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>23</volume><issue>4</issue><spage>1512</spage><epage>1522</epage><pages>1512-1522</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><notes>Online version contains Web-only data.</notes><notes>www.plantcell.org/cgi/doi/10.1105/tpc.111.084525</notes><notes>The authors responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantcell.org) are: Detlef Weigel (weigel@weigelworld.org) and Jia-Wei Wang (jia-wei.wang@tuebingen.mpg.de).</notes><notes>Open Access articles can be viewed online without a subscription.</notes><abstract>Flavonoids are synthesized through an important metabolic pathway that leads to the production of diverse secondary metabolites, including anthocyanins, flavonols, flavones, and proanthocyanidins. Anthocyanins and flavonols are derived from Phe and share common precursors, dihydroflavonols, which are substrates for both flavonol synthase and dihydrof lavonol 4-reductase. In the stems of Arabidopsis thaliana, anthocyanins accumulate in an acropetal manner, with the highest level at the junction between rosette and stem. We show here that this accumulation pattern is under the regulation of miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE {SPL) genes, which are deeply conserved and known to have important roles in regulating phase change and flowering. Increased miR156 activity promotes accumulation of anthocyanins, whereas reduced miR156 activity results in high levels of flavonols. We further provide evidence that at least one of the miR156 targets, SPL9, negatively regulates anthocyanin accumulation by directly preventing expression of anthocyanin biosynthetic genes through destabilization of a MYB-bHLH-WD40 transcriptional activation complex. Our results reveal a direct link between the transition to flowering and secondary metabolism and provide a potential target for manipulation of anthocyanin and flavonol content in plants.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>21487097</pmid><doi>10.1105/tpc.111.084525</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Plant cell, 2011-04, Vol.23 (4), p.1512-1522 |
| issn | 1040-4651 1532-298X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3101539 |
| source | Oxford University Press Journals All Titles (1996-Current); JSTOR Archival Journals and Primary Sources Collection |
| subjects | Alcohol Oxidoreductases - genetics Alcohol Oxidoreductases - metabolism Anthocyanins - biosynthesis Anthocyanins - chemistry Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Biosynthesis Chromatography, Liquid Flavonoids Flavonols Gene expression regulation Gene Expression Regulation, Plant Genes Genes, Plant - genetics Mass Spectrometry MicroRNA MicroRNAs - metabolism Models, Biological Multiprotein Complexes - metabolism Plant cells Plants Plants, Genetically Modified Promoter Regions, Genetic - genetics Protein Binding Seedlings Stems Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor |
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