Loading…
Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats
Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg−1 d−1), Ag...
Saved in:
Published in: | Journal of Clinical Biochemistry and Nutrition 2011, Vol.48(3), pp.194-202 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253 |
---|---|
cites | cdi_FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253 |
container_end_page | 202 |
container_issue | 3 |
container_start_page | 194 |
container_title | Journal of Clinical Biochemistry and Nutrition |
container_volume | 48 |
creator | Niwa, Atsuko Tajiri, Takashi Higashino, Hideaki |
description | Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg−1 d−1), Agaricus blazei (1 g kg−1 d−1) or Smallanthus sonchifolius (4 g kg−1 d−1) for 2 months. Treatments with Ipomoea batatas or Agaricus blazei, but not Smallanthus sonchifolius, significantly suppressed the increases of fasting plasma glucose and hemoglobin A1c levels, and restored body weight loss during diabetes. Serum insulin levels after oral glucose administration tests increased along the treatments of Ipomoea batatas or Agaricus blazei. Moreover, Ipomoea batatas and Agaricus blazei reduced superoxide production from leukocytes and vascular homogenates, serum 8-oxo-2'-deoxyguanosine, and vascular nitrotyrosine formation of diabetic rats to comparable levels of normal control animals. Stress- and inflammation-related p38 mitogen-activated protein kinase activity and tumor necrosis factor-α production of diabetic rats were significantly depressed by Ipomoea batatas administration. Histological examination also exhibited improvement of pancreatic β-cells mass after treatments with Ipomoea batatas or Agaricus blazei. These results suggest that hypoglycemic effects of Ipomoea batatas or Agaricus blazei result from their suppression of oxidative stress and proinflammatory cytokine production followed by improvement of pancreatic β-cells mass. |
doi_str_mv | 10.3164/jcbn.10-78 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3082073</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3099851801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253</originalsourceid><addsrcrecordid>eNpdkdtu1DAQhiMEokvhhgdAlrhAQkoZx46T3CCqikOlStzAtTWxZ3e9ysbBdgrtS_SVcdiyHGTJM6P59M9vT1E853AmuJJvdqYfzziUTfugWPG2hbKGVj0sVtDxqgSA7qR4EuMOQKpaycfFScVrVSnRroq7y8nvPSHrMeUTGY6WnW8wOBNZP-AtOYZ7GpwPmIhZhz0lZ3ISfbAUIvvu0palLQWcaF5aOCbnfzibI5t8olziwNzIYgo0JX_rkzduLN1oZ0P2j2aeEJ8Wj9Y4RHp2H0-Lrx_ef7n4VF59_nh5cX5VGgm8LVXHDdYNYtegIMEtiA4BSRGCFY1Vtua9NY2teiFlVVdy3Yk1AUohOVS1OC3eHnSnud-TNdllwEFPwe0x3GiPTv_bGd1Wb_y1FtBW0Igs8OpeIPhvM8Wk9y4aGgYcyc9Rt0rVQjRyGfXyP3Ln5zDm12mevVUAXHWZen2gTPAxBlofvXDQy5r1sualaNoMv_jb_RH9vdcMvDsAu5hwQ0cAQ_7ogQ5astViuX5pHltmi0HTKH4CWX-_Jg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1442200169</pqid></control><display><type>article</type><title>Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats</title><source>J-STAGE (Japan Science & Tech Info) Free</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Niwa, Atsuko ; Tajiri, Takashi ; Higashino, Hideaki</creator><creatorcontrib>Niwa, Atsuko ; Tajiri, Takashi ; Higashino, Hideaki</creatorcontrib><description>Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg−1 d−1), Agaricus blazei (1 g kg−1 d−1) or Smallanthus sonchifolius (4 g kg−1 d−1) for 2 months. Treatments with Ipomoea batatas or Agaricus blazei, but not Smallanthus sonchifolius, significantly suppressed the increases of fasting plasma glucose and hemoglobin A1c levels, and restored body weight loss during diabetes. Serum insulin levels after oral glucose administration tests increased along the treatments of Ipomoea batatas or Agaricus blazei. Moreover, Ipomoea batatas and Agaricus blazei reduced superoxide production from leukocytes and vascular homogenates, serum 8-oxo-2'-deoxyguanosine, and vascular nitrotyrosine formation of diabetic rats to comparable levels of normal control animals. Stress- and inflammation-related p38 mitogen-activated protein kinase activity and tumor necrosis factor-α production of diabetic rats were significantly depressed by Ipomoea batatas administration. Histological examination also exhibited improvement of pancreatic β-cells mass after treatments with Ipomoea batatas or Agaricus blazei. These results suggest that hypoglycemic effects of Ipomoea batatas or Agaricus blazei result from their suppression of oxidative stress and proinflammatory cytokine production followed by improvement of pancreatic β-cells mass.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.10-78</identifier><identifier>PMID: 21562638</identifier><language>eng</language><publisher>Japan: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>Agaricus blazei (Agaricus) ; hypoglycemic effect ; Ipomoea batatas (Caiapo) ; Original ; oxidative stress ; pancreatic islet β-cells</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2011, Vol.48(3), pp.194-202</ispartof><rights>2011 by The Editorial Secretariat of JCBN</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><rights>Copyright © 2011 JCBN 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253</citedby><cites>FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082073/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082073/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,1894,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21562638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niwa, Atsuko</creatorcontrib><creatorcontrib>Tajiri, Takashi</creatorcontrib><creatorcontrib>Higashino, Hideaki</creatorcontrib><title>Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats</title><title>Journal of Clinical Biochemistry and Nutrition</title><addtitle>J. Clin. Biochem. Nutr.</addtitle><description>Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg−1 d−1), Agaricus blazei (1 g kg−1 d−1) or Smallanthus sonchifolius (4 g kg−1 d−1) for 2 months. Treatments with Ipomoea batatas or Agaricus blazei, but not Smallanthus sonchifolius, significantly suppressed the increases of fasting plasma glucose and hemoglobin A1c levels, and restored body weight loss during diabetes. Serum insulin levels after oral glucose administration tests increased along the treatments of Ipomoea batatas or Agaricus blazei. Moreover, Ipomoea batatas and Agaricus blazei reduced superoxide production from leukocytes and vascular homogenates, serum 8-oxo-2'-deoxyguanosine, and vascular nitrotyrosine formation of diabetic rats to comparable levels of normal control animals. Stress- and inflammation-related p38 mitogen-activated protein kinase activity and tumor necrosis factor-α production of diabetic rats were significantly depressed by Ipomoea batatas administration. Histological examination also exhibited improvement of pancreatic β-cells mass after treatments with Ipomoea batatas or Agaricus blazei. These results suggest that hypoglycemic effects of Ipomoea batatas or Agaricus blazei result from their suppression of oxidative stress and proinflammatory cytokine production followed by improvement of pancreatic β-cells mass.</description><subject>Agaricus blazei (Agaricus)</subject><subject>hypoglycemic effect</subject><subject>Ipomoea batatas (Caiapo)</subject><subject>Original</subject><subject>oxidative stress</subject><subject>pancreatic islet β-cells</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpdkdtu1DAQhiMEokvhhgdAlrhAQkoZx46T3CCqikOlStzAtTWxZ3e9ysbBdgrtS_SVcdiyHGTJM6P59M9vT1E853AmuJJvdqYfzziUTfugWPG2hbKGVj0sVtDxqgSA7qR4EuMOQKpaycfFScVrVSnRroq7y8nvPSHrMeUTGY6WnW8wOBNZP-AtOYZ7GpwPmIhZhz0lZ3ISfbAUIvvu0palLQWcaF5aOCbnfzibI5t8olziwNzIYgo0JX_rkzduLN1oZ0P2j2aeEJ8Wj9Y4RHp2H0-Lrx_ef7n4VF59_nh5cX5VGgm8LVXHDdYNYtegIMEtiA4BSRGCFY1Vtua9NY2teiFlVVdy3Yk1AUohOVS1OC3eHnSnud-TNdllwEFPwe0x3GiPTv_bGd1Wb_y1FtBW0Igs8OpeIPhvM8Wk9y4aGgYcyc9Rt0rVQjRyGfXyP3Ln5zDm12mevVUAXHWZen2gTPAxBlofvXDQy5r1sualaNoMv_jb_RH9vdcMvDsAu5hwQ0cAQ_7ogQ5astViuX5pHltmi0HTKH4CWX-_Jg</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Niwa, Atsuko</creator><creator>Tajiri, Takashi</creator><creator>Higashino, Hideaki</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201105</creationdate><title>Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats</title><author>Niwa, Atsuko ; Tajiri, Takashi ; Higashino, Hideaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Agaricus blazei (Agaricus)</topic><topic>hypoglycemic effect</topic><topic>Ipomoea batatas (Caiapo)</topic><topic>Original</topic><topic>oxidative stress</topic><topic>pancreatic islet β-cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niwa, Atsuko</creatorcontrib><creatorcontrib>Tajiri, Takashi</creatorcontrib><creatorcontrib>Higashino, Hideaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niwa, Atsuko</au><au>Tajiri, Takashi</au><au>Higashino, Hideaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2011-05</date><risdate>2011</risdate><volume>48</volume><issue>3</issue><spage>194</spage><epage>202</epage><pages>194-202</pages><issn>0912-0009</issn><eissn>1880-5086</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Ipomoea batatas, Agaricus blazei and Smallanthus sonchifolius are known to favorably influence diabetes mellitus. To clarify their antidiabetic efficacy and hypoglycemic mechanisms, we treated streptozotocin-induced diabetic rats with daily oral feeding of powdered Ipomoea batatas (5 g kg−1 d−1), Agaricus blazei (1 g kg−1 d−1) or Smallanthus sonchifolius (4 g kg−1 d−1) for 2 months. Treatments with Ipomoea batatas or Agaricus blazei, but not Smallanthus sonchifolius, significantly suppressed the increases of fasting plasma glucose and hemoglobin A1c levels, and restored body weight loss during diabetes. Serum insulin levels after oral glucose administration tests increased along the treatments of Ipomoea batatas or Agaricus blazei. Moreover, Ipomoea batatas and Agaricus blazei reduced superoxide production from leukocytes and vascular homogenates, serum 8-oxo-2'-deoxyguanosine, and vascular nitrotyrosine formation of diabetic rats to comparable levels of normal control animals. Stress- and inflammation-related p38 mitogen-activated protein kinase activity and tumor necrosis factor-α production of diabetic rats were significantly depressed by Ipomoea batatas administration. Histological examination also exhibited improvement of pancreatic β-cells mass after treatments with Ipomoea batatas or Agaricus blazei. These results suggest that hypoglycemic effects of Ipomoea batatas or Agaricus blazei result from their suppression of oxidative stress and proinflammatory cytokine production followed by improvement of pancreatic β-cells mass.</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>21562638</pmid><doi>10.3164/jcbn.10-78</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0912-0009 |
ispartof | Journal of Clinical Biochemistry and Nutrition, 2011, Vol.48(3), pp.194-202 |
issn | 0912-0009 1880-5086 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3082073 |
source | J-STAGE (Japan Science & Tech Info) Free; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Agaricus blazei (Agaricus) hypoglycemic effect Ipomoea batatas (Caiapo) Original oxidative stress pancreatic islet β-cells |
title | Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T03%3A14%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ipomoea%20batatas%20and%20Agarics%20blazei%20ameliorate%20diabetic%20disorders%20with%20therapeutic%20antioxidant%20potential%20in%20streptozotocin-induced%20diabetic%20rats&rft.jtitle=Journal%20of%20Clinical%20Biochemistry%20and%20Nutrition&rft.au=Niwa,%20Atsuko&rft.date=2011-05&rft.volume=48&rft.issue=3&rft.spage=194&rft.epage=202&rft.pages=194-202&rft.issn=0912-0009&rft.eissn=1880-5086&rft_id=info:doi/10.3164/jcbn.10-78&rft_dat=%3Cproquest_pubme%3E3099851801%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4018-691ca57aa97a3e31d039a0ae6ea0d37d6d51bdc7d2b3442524f93fe0a43410253%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1442200169&rft_id=info:pmid/21562638&rfr_iscdi=true |