Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans

The contrast provided by diffusion‐sensitive magnetic resonance offers the promise of improved tumor localization in organ‐confined human prostate cancer (PCa). Diffusion tensor imaging (DTI) measurements of PCa were performed in vivo, in patients undergoing radical prostatectomy, and later, ex vivo...

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Published in:Magnetic resonance in medicine 2009-04, Vol.61 (4), p.842-850
Main Authors: Xu, Junqian, Humphrey, Peter A., Kibel, Adam S., Snyder, Abraham Z., Narra, Vamsidhar R., Ackerman, Joseph J.H., Song, Sheng-Kwei
Format: Article
Language:English
Subjects:
Aged
Algorithms
apparent diffusion coefficient (ADC)
Diffusion Magnetic Resonance Imaging - methods
diffusion tensor imaging (DTI)
fractional anisotropy (FA)
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Male
Middle Aged
prostate carcinoma (PCa)
Prostatic Neoplasms - pathology
Reproducibility of Results
Sensitivity and Specificity
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cited_by cdi_FETCH-LOGICAL-c5486-4d055700ff0081d13d289751dcf29e4cd1050cb50f69737ccaa7f76acde75df83
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container_issue 4
container_start_page 842
container_title Magnetic resonance in medicine
container_volume 61
creator Xu, Junqian
Humphrey, Peter A.
Kibel, Adam S.
Snyder, Abraham Z.
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Ackerman, Joseph J.H.
Song, Sheng-Kwei
description The contrast provided by diffusion‐sensitive magnetic resonance offers the promise of improved tumor localization in organ‐confined human prostate cancer (PCa). Diffusion tensor imaging (DTI) measurements of PCa were performed in vivo, in patients undergoing radical prostatectomy, and later, ex vivo, in the same patients' prostatectomy specimens. The imaging data were coregistered to histological sections of the prostatectomy specimens, thereby enabling unambiguous characterization of diffusion parameters in cancerous and benign tissues. Increased cellularity, and hence decreased luminal spaces, in peripheral zone PCa led to approximately 40% and 50% apparent diffusion policy (ADC) decrease compared with benign peripheral zone tissues in vivo and ex vivo, respectively. In contrast, no significant diffusion anisotropy differences were observed between the cancerous and noncancerous peripheral zone tissues. However, the dense fibromuscular tissues in prostate, such as stromal tissues in benign prostatic hyperplasia in central gland, exhibited high diffusion anisotropy. A tissue classification method is proposed to combine DTI and T2‐weighted image contrasts that may provide improved specificity of PCa detection over T2‐weighted imaging alone. PCa identified in volume rendered MR images qualitatively correlates well with histologically determined PCa foci. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
doi_str_mv 10.1002/mrm.21896
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Reson. Med</addtitle><date>2009-04</date><risdate>2009</risdate><volume>61</volume><issue>4</issue><spage>842</spage><epage>850</epage><pages>842-850</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><notes>Preliminary reports of this work may be found in the Proceedings of the 12-15th Annual Meetings of International Society for Magnetic Resonance in Medicine. 2004. p. 2508, 2005. p. 2125, 2006. p. 174, and 2007. p. 3666.</notes><notes>istex:9A6D65BEE0EF665F725578BAFD7BD580B3D6C7D6</notes><notes>U.S. Army DOD Prostate Cancer Program Pre-doctoral Fellowship - No. PC050667</notes><notes>Washington University Small Animal Imaging Resource - a NCI funded Small Animal Imaging Resource Program facility - No. R24 CA83060</notes><notes>Midwest Stone Institute</notes><notes>Small Animal Imaging Core of the Alvin J. Siteman Cancer Center - a NCI Comprehensive Cancer Center - No. P30 CA91842</notes><notes>NINDS center core grant - No. P30 NS048056</notes><notes>ark:/67375/WNG-GTDZCV1J-0</notes><notes>ArticleID:MRM21896</notes><notes>Preliminary reports of this work may be found in the Proceedings of the 12–15th Annual Meetings of International Society for Magnetic Resonance in Medicine. 2004. p. 2508, 2005. p. 2125, 2006. p. 174, and 2007. p. 3666.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The contrast provided by diffusion‐sensitive magnetic resonance offers the promise of improved tumor localization in organ‐confined human prostate cancer (PCa). Diffusion tensor imaging (DTI) measurements of PCa were performed in vivo, in patients undergoing radical prostatectomy, and later, ex vivo, in the same patients' prostatectomy specimens. The imaging data were coregistered to histological sections of the prostatectomy specimens, thereby enabling unambiguous characterization of diffusion parameters in cancerous and benign tissues. Increased cellularity, and hence decreased luminal spaces, in peripheral zone PCa led to approximately 40% and 50% apparent diffusion policy (ADC) decrease compared with benign peripheral zone tissues in vivo and ex vivo, respectively. In contrast, no significant diffusion anisotropy differences were observed between the cancerous and noncancerous peripheral zone tissues. However, the dense fibromuscular tissues in prostate, such as stromal tissues in benign prostatic hyperplasia in central gland, exhibited high diffusion anisotropy. A tissue classification method is proposed to combine DTI and T2‐weighted image contrasts that may provide improved specificity of PCa detection over T2‐weighted imaging alone. PCa identified in volume rendered MR images qualitatively correlates well with histologically determined PCa foci. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19215051</pmid><doi>10.1002/mrm.21896</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Algorithms
apparent diffusion coefficient (ADC)
Diffusion Magnetic Resonance Imaging - methods
diffusion tensor imaging (DTI)
fractional anisotropy (FA)
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Male
Middle Aged
prostate carcinoma (PCa)
Prostatic Neoplasms - pathology
Reproducibility of Results
Sensitivity and Specificity
title Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans
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