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Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction
Abstract Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of u...
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| Published in: | Neuroscience 2011-02, Vol.174, p.115-131 |
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| creator | Wilber, A.A Walker, A.G Southwood, C.J Farrell, M.R Lin, G.L Rebec, G.V Wellman, C.L |
| description | Abstract Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed rats during fear conditioning and extinction. After implantation of microwire bundles into infralimbic or prelimbic cortex, rats were either unstressed or stressed via placement in a plastic restrainer (3 h/day for 1 week). Rats then underwent fear conditioning and extinction while activity of neurons in infralimbic or prelimbic cortex was recorded. Percent freezing and neural activity were assessed during all phases of training. Chronic stress enhanced freezing during acquisition of conditioned fear, and altered both prelimbic and infralimbic activity during this phase. Stress did not alter initial extinction or conditioned stimulus (CS)-related activity during this phase. However, stress impaired retrieval of extinction assessed 24 h later, and this was accompanied by alterations in neuronal activity in both prelimbic and infralimbic cortex. In prelimbic cortex, unstressed rats showed decreased activity in response to CS presentation, whereas stressed rats showed no change. In infralimbic cortex, neurons in unstressed rats exhibited increased firing in response to the CS, whereas stressed rats showed no increase in infralimbic firing during the tone. Finally, CS-related firing in infralimbic but not prelimbic cortex was correlated with extinction retrieval. Thus, the stress-induced alteration of neuronal activity in infralimbic cortex may be responsible for the stress-induced deficit in retrieval of extinction. |
| doi_str_mv | 10.1016/j.neuroscience.2010.10.070 |
| format | article |
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To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed rats during fear conditioning and extinction. After implantation of microwire bundles into infralimbic or prelimbic cortex, rats were either unstressed or stressed via placement in a plastic restrainer (3 h/day for 1 week). Rats then underwent fear conditioning and extinction while activity of neurons in infralimbic or prelimbic cortex was recorded. Percent freezing and neural activity were assessed during all phases of training. Chronic stress enhanced freezing during acquisition of conditioned fear, and altered both prelimbic and infralimbic activity during this phase. Stress did not alter initial extinction or conditioned stimulus (CS)-related activity during this phase. However, stress impaired retrieval of extinction assessed 24 h later, and this was accompanied by alterations in neuronal activity in both prelimbic and infralimbic cortex. In prelimbic cortex, unstressed rats showed decreased activity in response to CS presentation, whereas stressed rats showed no change. In infralimbic cortex, neurons in unstressed rats exhibited increased firing in response to the CS, whereas stressed rats showed no increase in infralimbic firing during the tone. Finally, CS-related firing in infralimbic but not prelimbic cortex was correlated with extinction retrieval. Thus, the stress-induced alteration of neuronal activity in infralimbic cortex may be responsible for the stress-induced deficit in retrieval of extinction.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2010.10.070</identifier><identifier>PMID: 21044660</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Action Potentials ; Animals ; Biological and medical sciences ; Conditioning, Operant ; extinction retrieval ; Extinction, Psychological ; extracellular recording ; Fear ; Fundamental and applied biological sciences. Psychology ; infralimbic cortex ; Male ; medial prefrontal cortex ; Neurology ; Neurons - physiology ; Prefrontal Cortex - physiopathology ; prelimbic cortex ; Rats ; Rats, Sprague-Dawley ; Restraint, Physical ; stress ; Stress, Psychological - physiopathology ; Stress, Psychological - psychology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2011-02, Vol.174, p.115-131</ispartof><rights>IBRO</rights><rights>2011 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><rights>2010 IBRO. Published by Elsevier Ltd. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-e601085c0f8de84bd884774cd58a2fc199b4afde32393496cab0169a21812c1c3</citedby><cites>FETCH-LOGICAL-c669t-e601085c0f8de84bd884774cd58a2fc199b4afde32393496cab0169a21812c1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23795464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21044660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilber, A.A</creatorcontrib><creatorcontrib>Walker, A.G</creatorcontrib><creatorcontrib>Southwood, C.J</creatorcontrib><creatorcontrib>Farrell, M.R</creatorcontrib><creatorcontrib>Lin, G.L</creatorcontrib><creatorcontrib>Rebec, G.V</creatorcontrib><creatorcontrib>Wellman, C.L</creatorcontrib><title>Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed rats during fear conditioning and extinction. After implantation of microwire bundles into infralimbic or prelimbic cortex, rats were either unstressed or stressed via placement in a plastic restrainer (3 h/day for 1 week). Rats then underwent fear conditioning and extinction while activity of neurons in infralimbic or prelimbic cortex was recorded. Percent freezing and neural activity were assessed during all phases of training. Chronic stress enhanced freezing during acquisition of conditioned fear, and altered both prelimbic and infralimbic activity during this phase. Stress did not alter initial extinction or conditioned stimulus (CS)-related activity during this phase. However, stress impaired retrieval of extinction assessed 24 h later, and this was accompanied by alterations in neuronal activity in both prelimbic and infralimbic cortex. In prelimbic cortex, unstressed rats showed decreased activity in response to CS presentation, whereas stressed rats showed no change. In infralimbic cortex, neurons in unstressed rats exhibited increased firing in response to the CS, whereas stressed rats showed no increase in infralimbic firing during the tone. Finally, CS-related firing in infralimbic but not prelimbic cortex was correlated with extinction retrieval. Thus, the stress-induced alteration of neuronal activity in infralimbic cortex may be responsible for the stress-induced deficit in retrieval of extinction.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Operant</subject><subject>extinction retrieval</subject><subject>Extinction, Psychological</subject><subject>extracellular recording</subject><subject>Fear</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>infralimbic cortex</subject><subject>Male</subject><subject>medial prefrontal cortex</subject><subject>Neurology</subject><subject>Neurons - physiology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>prelimbic cortex</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Restraint, Physical</subject><subject>stress</subject><subject>Stress, Psychological - physiopathology</subject><subject>Stress, Psychological - psychology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNUstuEzEUHSEQTQu_gEZIiFWCX2N7WFRCoTykSiyAtXE8d1qHiR1sT9T8PXeaUAob8MaW7znnPs6tqueULCih8tV6EWBMMTsPwcGCkdvAgijyoJpRrfhcNUI8rGaEEzkXDWMn1WnOa4KnEfxxdcIoEUJKMqu-La9TDN7VuSTIubZDgZTrKYEdauuK3_myr32oN9B5_Nom6JFR8OliKnBTd2Py4apOUJKHHf7Hvoab4gOSY3hSPertkOHp8T6rvr67-LL8ML_89P7j8s3l3EnZljlI7EI3jvS6Ay1WndZCKeG6RlvWO9q2K2H7DjjjLRetdHaFo2gto5oyRx0_q84PuttxhaU6CAU7MNvkNzbtTbTe_BkJ_tpcxZ3hhBEmBQq8PAqk-GOEXMzGZwfDYAPEMRvdSKWlYvzfSN4qNIopRL4-IB3alXFyd_VQYiYvzdrc99JMXk4x9BLJz-53dEf9ZR4CXhwBNjs79MkG5_NvHFdtI247e3vAAc5_5yGZY7rOJ3DFdNH_Xz3nf8m4wePq2OE77CGv45gCOmyoycwQ83navmn5KCFUsKblPwFOBNt4</recordid><startdate>20110203</startdate><enddate>20110203</enddate><creator>Wilber, A.A</creator><creator>Walker, A.G</creator><creator>Southwood, C.J</creator><creator>Farrell, M.R</creator><creator>Lin, G.L</creator><creator>Rebec, G.V</creator><creator>Wellman, C.L</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20110203</creationdate><title>Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction</title><author>Wilber, A.A ; Walker, A.G ; Southwood, C.J ; Farrell, M.R ; Lin, G.L ; Rebec, G.V ; Wellman, C.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-e601085c0f8de84bd884774cd58a2fc199b4afde32393496cab0169a21812c1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Operant</topic><topic>extinction retrieval</topic><topic>Extinction, Psychological</topic><topic>extracellular recording</topic><topic>Fear</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>infralimbic cortex</topic><topic>Male</topic><topic>medial prefrontal cortex</topic><topic>Neurology</topic><topic>Neurons - physiology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>prelimbic cortex</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Restraint, Physical</topic><topic>stress</topic><topic>Stress, Psychological - physiopathology</topic><topic>Stress, Psychological - psychology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilber, A.A</creatorcontrib><creatorcontrib>Walker, A.G</creatorcontrib><creatorcontrib>Southwood, C.J</creatorcontrib><creatorcontrib>Farrell, M.R</creatorcontrib><creatorcontrib>Lin, G.L</creatorcontrib><creatorcontrib>Rebec, G.V</creatorcontrib><creatorcontrib>Wellman, C.L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilber, A.A</au><au>Walker, A.G</au><au>Southwood, C.J</au><au>Farrell, M.R</au><au>Lin, G.L</au><au>Rebec, G.V</au><au>Wellman, C.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2011-02-03</date><risdate>2011</risdate><volume>174</volume><spage>115</spage><epage>131</epage><pages>115-131</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>Abstract Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed rats during fear conditioning and extinction. After implantation of microwire bundles into infralimbic or prelimbic cortex, rats were either unstressed or stressed via placement in a plastic restrainer (3 h/day for 1 week). Rats then underwent fear conditioning and extinction while activity of neurons in infralimbic or prelimbic cortex was recorded. Percent freezing and neural activity were assessed during all phases of training. Chronic stress enhanced freezing during acquisition of conditioned fear, and altered both prelimbic and infralimbic activity during this phase. Stress did not alter initial extinction or conditioned stimulus (CS)-related activity during this phase. However, stress impaired retrieval of extinction assessed 24 h later, and this was accompanied by alterations in neuronal activity in both prelimbic and infralimbic cortex. In prelimbic cortex, unstressed rats showed decreased activity in response to CS presentation, whereas stressed rats showed no change. In infralimbic cortex, neurons in unstressed rats exhibited increased firing in response to the CS, whereas stressed rats showed no increase in infralimbic firing during the tone. Finally, CS-related firing in infralimbic but not prelimbic cortex was correlated with extinction retrieval. Thus, the stress-induced alteration of neuronal activity in infralimbic cortex may be responsible for the stress-induced deficit in retrieval of extinction.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>21044660</pmid><doi>10.1016/j.neuroscience.2010.10.070</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Action Potentials Animals Biological and medical sciences Conditioning, Operant extinction retrieval Extinction, Psychological extracellular recording Fear Fundamental and applied biological sciences. Psychology infralimbic cortex Male medial prefrontal cortex Neurology Neurons - physiology Prefrontal Cortex - physiopathology prelimbic cortex Rats Rats, Sprague-Dawley Restraint, Physical stress Stress, Psychological - physiopathology Stress, Psychological - psychology Vertebrates: nervous system and sense organs |
| title | Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction |
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