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FAK overexpression and p53 mutations are highly correlated in human breast cancer
Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression,...
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| Published in: | International journal of cancer 2009-10, Vol.125 (7), p.1735-1738 |
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| container_end_page | 1738 |
| container_issue | 7 |
| container_start_page | 1735 |
| container_title | International journal of cancer |
| container_volume | 125 |
| creator | Golubovskaya, Vita M. Conway‐Dorsey, Kathleen Edmiston, Sharon N. Tse, Chiu‐Kit Lark, Amy A. Livasy, Chad A. Moore, Dominic Millikan, Robert C. Cance, William G. |
| description | Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression, p53 expression and mutation status in a population‐based series of invasive breast cancer tumors from the Carolina Breast Cancer Study. Immunohistochemical analyses of 622 breast cancer tumors revealed that expression of FAK and p53 were highly correlated (p = 0.0002) and FAK positive tumors were 1.8 times more likely to be p53 positive compared to FAK negative tumors [odds ratio (OR) = 1.8; 95% Confidence Interval (CI) 1.2–2.8, adjusted for age, race and stage at diagnosis]. Tumors positive for p53 expression showed higher intensity of FAK staining (p < 0.0001) and higher percent of FAK positive staining (p < 0.0005). From the same study, we evaluated 596 breast tumors for mutations in the p53 gene, using single strand conformational polymorphism and sequencing. Statistical analyses were performed to determine the correlation between p53 mutation status and FAK expression in these tumors. We found that FAK expression and p53 mutation were positively correlated (p < 0.0001) and FAK positive tumors were 2.5 times more likely to be p53 mutation positive compared to FAK negative tumors [adjusted OR = 2.5, 95% CI 1.6–3.9]. This is the first analysis demonstrating a high correlation between FAK expression and p53 mutations in a population‐based series of breast tumors. © 2009 UICC |
| doi_str_mv | 10.1002/ijc.24486 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2773794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67556282</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5416-592771e6848554aac4f1a9eda031c1daf0e66405b880d2aa75cd997b408787d73</originalsourceid><addsrcrecordid>eNp90U1vEzEQBmALgWhaOPAHkC9Q9bCt7fXnBamK2lKohJDgbE28s42r_Qj2biH_voZEBQ5wsuR5NDOal5BXnJ1yxsRZvAunQkqrn5AFZ85UTHD1lCxKjVWG1_qAHOZ8xxjnisnn5IA7JbizakE-X55_pOM9JvyxSZhzHAcKQ0M3qqb9PMFUPjKFhHQdb9fdloYxJexgwobGga7nHga6Sgh5ogGGgOkFedZCl_Hl_j0iXy8vvizfVzefrq6X5zdVUJLrSjlhDEdtpVVKAgTZcnDYAKt54A20DLWWTK2sZY0AMCo0zpmVZNZY05j6iLzb9d3Mqx6bgMOUoPObFHtIWz9C9H9Xhrj2t-O9L3Nr42RpcLxvkMZvM-bJ9zEH7DoYcJyzN1JpKZRwRb79r9RGKS2sKPBkB0Mac07YPq7Dmf8ZlS9R-V9RFfv6z_1_y302BbzZA8gBujaV88b86AS3wnHNizvbue-xw-2_J_rrD8vd6AcuPKqS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67556282</pqid></control><display><type>article</type><title>FAK overexpression and p53 mutations are highly correlated in human breast cancer</title><source>Wiley-Blackwell Journals</source><creator>Golubovskaya, Vita M. ; Conway‐Dorsey, Kathleen ; Edmiston, Sharon N. ; Tse, Chiu‐Kit ; Lark, Amy A. ; Livasy, Chad A. ; Moore, Dominic ; Millikan, Robert C. ; Cance, William G.</creator><creatorcontrib>Golubovskaya, Vita M. ; Conway‐Dorsey, Kathleen ; Edmiston, Sharon N. ; Tse, Chiu‐Kit ; Lark, Amy A. ; Livasy, Chad A. ; Moore, Dominic ; Millikan, Robert C. ; Cance, William G.</creatorcontrib><description>Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression, p53 expression and mutation status in a population‐based series of invasive breast cancer tumors from the Carolina Breast Cancer Study. Immunohistochemical analyses of 622 breast cancer tumors revealed that expression of FAK and p53 were highly correlated (p = 0.0002) and FAK positive tumors were 1.8 times more likely to be p53 positive compared to FAK negative tumors [odds ratio (OR) = 1.8; 95% Confidence Interval (CI) 1.2–2.8, adjusted for age, race and stage at diagnosis]. Tumors positive for p53 expression showed higher intensity of FAK staining (p < 0.0001) and higher percent of FAK positive staining (p < 0.0005). From the same study, we evaluated 596 breast tumors for mutations in the p53 gene, using single strand conformational polymorphism and sequencing. Statistical analyses were performed to determine the correlation between p53 mutation status and FAK expression in these tumors. We found that FAK expression and p53 mutation were positively correlated (p < 0.0001) and FAK positive tumors were 2.5 times more likely to be p53 mutation positive compared to FAK negative tumors [adjusted OR = 2.5, 95% CI 1.6–3.9]. This is the first analysis demonstrating a high correlation between FAK expression and p53 mutations in a population‐based series of breast tumors. © 2009 UICC</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.24486</identifier><identifier>PMID: 19521985</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Black or African American - genetics ; breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Case-Control Studies ; Female ; focal adhesion kinase ; Focal Adhesion Kinase 1 - metabolism ; Gene Expression Regulation, Neoplastic ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Mutation ; North Carolina ; p53 ; Registries ; tumor ; Tumor Suppressor Protein p53 - genetics ; Tumors ; Up-Regulation ; White People - genetics</subject><ispartof>International journal of cancer, 2009-10, Vol.125 (7), p.1735-1738</ispartof><rights>Copyright © 2009 UICC</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5416-592771e6848554aac4f1a9eda031c1daf0e66405b880d2aa75cd997b408787d73</citedby><cites>FETCH-LOGICAL-c5416-592771e6848554aac4f1a9eda031c1daf0e66405b880d2aa75cd997b408787d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.24486$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.24486$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,786,790,891,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21829161$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19521985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Golubovskaya, Vita M.</creatorcontrib><creatorcontrib>Conway‐Dorsey, Kathleen</creatorcontrib><creatorcontrib>Edmiston, Sharon N.</creatorcontrib><creatorcontrib>Tse, Chiu‐Kit</creatorcontrib><creatorcontrib>Lark, Amy A.</creatorcontrib><creatorcontrib>Livasy, Chad A.</creatorcontrib><creatorcontrib>Moore, Dominic</creatorcontrib><creatorcontrib>Millikan, Robert C.</creatorcontrib><creatorcontrib>Cance, William G.</creatorcontrib><title>FAK overexpression and p53 mutations are highly correlated in human breast cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression, p53 expression and mutation status in a population‐based series of invasive breast cancer tumors from the Carolina Breast Cancer Study. Immunohistochemical analyses of 622 breast cancer tumors revealed that expression of FAK and p53 were highly correlated (p = 0.0002) and FAK positive tumors were 1.8 times more likely to be p53 positive compared to FAK negative tumors [odds ratio (OR) = 1.8; 95% Confidence Interval (CI) 1.2–2.8, adjusted for age, race and stage at diagnosis]. Tumors positive for p53 expression showed higher intensity of FAK staining (p < 0.0001) and higher percent of FAK positive staining (p < 0.0005). From the same study, we evaluated 596 breast tumors for mutations in the p53 gene, using single strand conformational polymorphism and sequencing. Statistical analyses were performed to determine the correlation between p53 mutation status and FAK expression in these tumors. We found that FAK expression and p53 mutation were positively correlated (p < 0.0001) and FAK positive tumors were 2.5 times more likely to be p53 mutation positive compared to FAK negative tumors [adjusted OR = 2.5, 95% CI 1.6–3.9]. This is the first analysis demonstrating a high correlation between FAK expression and p53 mutations in a population‐based series of breast tumors. © 2009 UICC</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Black or African American - genetics</subject><subject>breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>focal adhesion kinase</subject><subject>Focal Adhesion Kinase 1 - metabolism</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>North Carolina</subject><subject>p53</subject><subject>Registries</subject><subject>tumor</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumors</subject><subject>Up-Regulation</subject><subject>White People - genetics</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp90U1vEzEQBmALgWhaOPAHkC9Q9bCt7fXnBamK2lKohJDgbE28s42r_Qj2biH_voZEBQ5wsuR5NDOal5BXnJ1yxsRZvAunQkqrn5AFZ85UTHD1lCxKjVWG1_qAHOZ8xxjnisnn5IA7JbizakE-X55_pOM9JvyxSZhzHAcKQ0M3qqb9PMFUPjKFhHQdb9fdloYxJexgwobGga7nHga6Sgh5ogGGgOkFedZCl_Hl_j0iXy8vvizfVzefrq6X5zdVUJLrSjlhDEdtpVVKAgTZcnDYAKt54A20DLWWTK2sZY0AMCo0zpmVZNZY05j6iLzb9d3Mqx6bgMOUoPObFHtIWz9C9H9Xhrj2t-O9L3Nr42RpcLxvkMZvM-bJ9zEH7DoYcJyzN1JpKZRwRb79r9RGKS2sKPBkB0Mac07YPq7Dmf8ZlS9R-V9RFfv6z_1_y302BbzZA8gBujaV88b86AS3wnHNizvbue-xw-2_J_rrD8vd6AcuPKqS</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Golubovskaya, Vita M.</creator><creator>Conway‐Dorsey, Kathleen</creator><creator>Edmiston, Sharon N.</creator><creator>Tse, Chiu‐Kit</creator><creator>Lark, Amy A.</creator><creator>Livasy, Chad A.</creator><creator>Moore, Dominic</creator><creator>Millikan, Robert C.</creator><creator>Cance, William G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20091001</creationdate><title>FAK overexpression and p53 mutations are highly correlated in human breast cancer</title><author>Golubovskaya, Vita M. ; Conway‐Dorsey, Kathleen ; Edmiston, Sharon N. ; Tse, Chiu‐Kit ; Lark, Amy A. ; Livasy, Chad A. ; Moore, Dominic ; Millikan, Robert C. ; Cance, William G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5416-592771e6848554aac4f1a9eda031c1daf0e66405b880d2aa75cd997b408787d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Black or African American - genetics</topic><topic>breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>focal adhesion kinase</topic><topic>Focal Adhesion Kinase 1 - metabolism</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>North Carolina</topic><topic>p53</topic><topic>Registries</topic><topic>tumor</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumors</topic><topic>Up-Regulation</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Golubovskaya, Vita M.</creatorcontrib><creatorcontrib>Conway‐Dorsey, Kathleen</creatorcontrib><creatorcontrib>Edmiston, Sharon N.</creatorcontrib><creatorcontrib>Tse, Chiu‐Kit</creatorcontrib><creatorcontrib>Lark, Amy A.</creatorcontrib><creatorcontrib>Livasy, Chad A.</creatorcontrib><creatorcontrib>Moore, Dominic</creatorcontrib><creatorcontrib>Millikan, Robert C.</creatorcontrib><creatorcontrib>Cance, William G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Golubovskaya, Vita M.</au><au>Conway‐Dorsey, Kathleen</au><au>Edmiston, Sharon N.</au><au>Tse, Chiu‐Kit</au><au>Lark, Amy A.</au><au>Livasy, Chad A.</au><au>Moore, Dominic</au><au>Millikan, Robert C.</au><au>Cance, William G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FAK overexpression and p53 mutations are highly correlated in human breast cancer</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>125</volume><issue>7</issue><spage>1735</spage><epage>1738</epage><pages>1735-1738</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><notes>Fax : +716‐845‐8204 or +716‐845‐3944.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression, p53 expression and mutation status in a population‐based series of invasive breast cancer tumors from the Carolina Breast Cancer Study. Immunohistochemical analyses of 622 breast cancer tumors revealed that expression of FAK and p53 were highly correlated (p = 0.0002) and FAK positive tumors were 1.8 times more likely to be p53 positive compared to FAK negative tumors [odds ratio (OR) = 1.8; 95% Confidence Interval (CI) 1.2–2.8, adjusted for age, race and stage at diagnosis]. Tumors positive for p53 expression showed higher intensity of FAK staining (p < 0.0001) and higher percent of FAK positive staining (p < 0.0005). From the same study, we evaluated 596 breast tumors for mutations in the p53 gene, using single strand conformational polymorphism and sequencing. Statistical analyses were performed to determine the correlation between p53 mutation status and FAK expression in these tumors. We found that FAK expression and p53 mutation were positively correlated (p < 0.0001) and FAK positive tumors were 2.5 times more likely to be p53 mutation positive compared to FAK negative tumors [adjusted OR = 2.5, 95% CI 1.6–3.9]. This is the first analysis demonstrating a high correlation between FAK expression and p53 mutations in a population‐based series of breast tumors. © 2009 UICC</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19521985</pmid><doi>10.1002/ijc.24486</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of cancer, 2009-10, Vol.125 (7), p.1735-1738 |
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| subjects | Adult Aged Biological and medical sciences Black or African American - genetics breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Case-Control Studies Female focal adhesion kinase Focal Adhesion Kinase 1 - metabolism Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Mammary gland diseases Medical sciences Middle Aged Mutation North Carolina p53 Registries tumor Tumor Suppressor Protein p53 - genetics Tumors Up-Regulation White People - genetics |
| title | FAK overexpression and p53 mutations are highly correlated in human breast cancer |
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