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Persistence in herpes simplex virus infections
Diseases of man caused by the virus of herpes simplex fall into two broad categories. The primary disease occurs only once in any individual's life and is caused by transmission of virus from an already infected human. Thereafter, the individual may be subject to recurrent herpetic disease, the...
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Published in: | Postgraduate Medical Journal 1978-09, Vol.54 (635), p.603-612 |
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description | Diseases of man caused by the virus of herpes simplex fall into two broad categories. The primary disease occurs only once in any individual's life and is caused by transmission of virus from an already infected human. Thereafter, the individual may be subject to recurrent herpetic disease, the manifestations of which are different from the primary disease. Recurrent disease varies in severity from trivial, to incapacitating and frankly lethal (as in diseases resulting from the virus's neurotropic and oncogenic properties). The source of the virus in recurrent herpetic disease has never been conclusively resolved, but is almost certainly endogenous to the patient. Theories, case reports and experiments exist to show that endogenous virus may, in periods of clinical quiescence, be latent (or persistent) at the site of the recurrent lesions itself, or more remotely in nerve tissues related to the site of recurrence. |
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Theories, case reports and experiments exist to show that endogenous virus may, in periods of clinical quiescence, be latent (or persistent) at the site of the recurrent lesions itself, or more remotely in nerve tissues related to the site of recurrence.</description><identifier>ISSN: 0032-5473</identifier><identifier>EISSN: 1469-0756</identifier><identifier>DOI: 10.1136/pgmj.54.635.603</identifier><identifier>PMID: 214773</identifier><language>eng</language><publisher>England: The Fellowship of Postgraduate Medicine</publisher><subject>Animals ; Herpes Simplex - microbiology ; Herpes Simplex - physiopathology ; Humans ; Nerve Tissue - microbiology ; Recurrence ; Simplexvirus - isolation & purification ; Time Factors</subject><ispartof>Postgraduate Medical Journal, 1978-09, Vol.54 (635), p.603-612</ispartof><rights>Copyright BMJ Publishing Group LTD Sep 1978</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b488t-44a3aa6e2e31166df1fc5b69cd031b3f0d529b3e37c492d3b9c3a51f10b0106c3</citedby><cites>FETCH-LOGICAL-b488t-44a3aa6e2e31166df1fc5b69cd031b3f0d529b3e37c492d3b9c3a51f10b0106c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425224/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425224/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,315,733,786,790,798,891,27955,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/214773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Longson, M.</creatorcontrib><title>Persistence in herpes simplex virus infections</title><title>Postgraduate Medical Journal</title><addtitle>Postgrad Med J</addtitle><description>Diseases of man caused by the virus of herpes simplex fall into two broad categories. 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Theories, case reports and experiments exist to show that endogenous virus may, in periods of clinical quiescence, be latent (or persistent) at the site of the recurrent lesions itself, or more remotely in nerve tissues related to the site of recurrence.</description><subject>Animals</subject><subject>Herpes Simplex - microbiology</subject><subject>Herpes Simplex - physiopathology</subject><subject>Humans</subject><subject>Nerve Tissue - microbiology</subject><subject>Recurrence</subject><subject>Simplexvirus - isolation & purification</subject><subject>Time Factors</subject><issn>0032-5473</issn><issn>1469-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNqFkctr3DAQxkXpa5v03EsPC4EeCnY0Gj3sS6EsSRMIbQ5tchSyLCfa-hXJDsl_Xy0OS9pLTwPz_fSNZj5CPgDNAVAejzfdNhc8lyhySfEFWQGXZUaVkC_JilJkmeAK35J3MW4pBVQc3pDXDLhSuCL5pQvRx8n11q19v751YXRxHX03tu5hfe_DHFO_cXbyQx8PyavGtNG9f6oH5Nfpyc_NWXbx49v55utFVvGimDLODRojHXMIIGXdQGNFJUtbU4QKG1oLVlboUFleshqr0qIR0ACtKFBp8YB8WXzHuepcbV0_BdPqMfjOhEc9GK__Vnp_q2-Ge804E4zxZPDpySAMd7OLk-58tK5tTe-GOWrFmRQFiAQe_QNuhzn0aTkNStECaHJL1PFC2TDEGFyz_wpQvctB73LQguuUg045pBcfn2-w55fDJzlb5N3tH_aqCb-1VKiE_n610RtRXJbXeK1PE_954as05n-z_wAstaCR</recordid><startdate>19780901</startdate><enddate>19780901</enddate><creator>Longson, M.</creator><general>The Fellowship of Postgraduate Medicine</general><general>Oxford University Press</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19780901</creationdate><title>Persistence in herpes simplex virus infections</title><author>Longson, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b488t-44a3aa6e2e31166df1fc5b69cd031b3f0d529b3e37c492d3b9c3a51f10b0106c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Herpes Simplex - 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subjects | Animals Herpes Simplex - microbiology Herpes Simplex - physiopathology Humans Nerve Tissue - microbiology Recurrence Simplexvirus - isolation & purification Time Factors |
title | Persistence in herpes simplex virus infections |
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