Loading…
The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
Three proteins identified by quite different criteria in three different systems, the Drosophila segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity. These findings raise questions...
Saved in:
| Published in: | The Journal of cell biology 1992-08, Vol.118 (3), p.681-691 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c453t-2f8ba95fe1e55d0aa76d8af9bc8331e414eb89bcf847a9ed3b095b054a4694743 |
|---|---|
| cites | |
| container_end_page | 691 |
| container_issue | 3 |
| container_start_page | 681 |
| container_title | The Journal of cell biology |
| container_volume | 118 |
| creator | Peifer, M. (University of North Carolina, Chapel Hill, NC) McCrea, P.D Green, K.J Wieschaus, E Gumbiner, B.M |
| description | Three proteins identified by quite different criteria in three different systems, the Drosophila segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity. These findings raise questions about the relationship among the three molecules and their roles in different cell-cell adhesive junctions. We have found that antibodies against the Drosophila segment polarity gene armadillo cross react with a conserved vertebrate protein. This protein is membrane associated, probably via its interaction with a cadherin-like molecule. This cross-reacting protein is the cadherin-associated protein beta-catenin. Using anti-armadillo and antiplakoglobin antibodies, it was shown that beta-catenin and plakoglobin are distinct molecules, which can coexist in the same cell type. Plakoglobin interacts with the desmosomal glycoprotein desmoglein I, and weakly with E-cadherin. Although beta-catenin interacts tightly with E-cadherin, it does not seem to be associated with either desmoglein I or with isolated desmosomes. Anti-armadillo antibodies have been further used to determine the intracellular localization of beta-catenin, and to examine its tissue distribution. The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed |
| doi_str_mv | 10.1083/jcb.118.3.681 |
| format | article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2289544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1615288</jstor_id><sourcerecordid>1615288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-2f8ba95fe1e55d0aa76d8af9bc8331e414eb89bcf847a9ed3b095b054a4694743</originalsourceid><addsrcrecordid>eNqNkstu1DAUhiMEKkNhyQaB5BUblMGOncTeIFUD5aJKLGjX1klyMuMhiYPtTDWPxFvikFEpK1jZ1v-dq_8kec7omlHJ3-7ras2YXPN1IdmDZMVyQVPJBH2YrCjNWKryLH-cPPF-TykVpeBnyRkruJI5WyU_r3dIDugCVg4CEmh26M0ByX4a6mDsQEZnA5rBkwoDpHWEBjMQGBoydvDdbjtbnd4hpnrvrLfjznRAPG57HAIZbQfOhCPZ4hALuB4a03WWtNb1BEg_dcH8llroTXcktybsiDfxDm6uPsbuDPqnyaMWOo_PTud5cnP54XrzKb36-vHz5uIqrUXOQ5q1sgKVt8gwzxsKUBaNhFZVteScoWACKxlfrRQlKGx4RVVe0VyAKNS8nfPk3ZJ3nKoemzqO4KDTozM9uKO2YPTfymB2emsPOsukysWc4PUpgbM_JvRB98bX2HUwoJ28LjmVUgn1T5AVZZEpVkYwXcA6btc7bO-6YVTPJtDRBDqaQHMdTRD5V_dH-EMvvx51uei3WNnW1waHGu-oC6ZU9uVSUhH9wuTGBJiNsLHTEGLom_8PjfTLhd77YN29PlieyVl-scgtWA1bZ7y--aY4LXhW8F8tM-ap</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16762917</pqid></control><display><type>article</type><title>The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties</title><source>Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Open Access: PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Peifer, M. (University of North Carolina, Chapel Hill, NC) ; McCrea, P.D ; Green, K.J ; Wieschaus, E ; Gumbiner, B.M</creator><creatorcontrib>Peifer, M. (University of North Carolina, Chapel Hill, NC) ; McCrea, P.D ; Green, K.J ; Wieschaus, E ; Gumbiner, B.M</creatorcontrib><description>Three proteins identified by quite different criteria in three different systems, the Drosophila segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity. These findings raise questions about the relationship among the three molecules and their roles in different cell-cell adhesive junctions. We have found that antibodies against the Drosophila segment polarity gene armadillo cross react with a conserved vertebrate protein. This protein is membrane associated, probably via its interaction with a cadherin-like molecule. This cross-reacting protein is the cadherin-associated protein beta-catenin. Using anti-armadillo and antiplakoglobin antibodies, it was shown that beta-catenin and plakoglobin are distinct molecules, which can coexist in the same cell type. Plakoglobin interacts with the desmosomal glycoprotein desmoglein I, and weakly with E-cadherin. Although beta-catenin interacts tightly with E-cadherin, it does not seem to be associated with either desmoglein I or with isolated desmosomes. Anti-armadillo antibodies have been further used to determine the intracellular localization of beta-catenin, and to examine its tissue distribution. The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.118.3.681</identifier><identifier>PMID: 1639851</identifier><language>eng</language><publisher>NEW YORK: Rockefeller University Press</publisher><subject>Amino Acid Sequence ; AMPHIBIEN ; ANFIBIOS ; Animals ; Antibodies ; ANTICORPS ; ANTICUERPOS ; Armadillo Domain Proteins ; Armadillos ; beta Catenin ; Cadherins ; Cadherins - genetics ; Cadherins - metabolism ; Cell adhesion ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - immunology ; Cell Adhesion Molecules - metabolism ; Cell Biology ; Cell Line ; Cell lines ; Cell membranes ; Cells ; CHIMIE ; Cross Reactions ; Cytoskeletal Proteins - genetics ; Cytoskeletal Proteins - immunology ; Cytoskeletal Proteins - metabolism ; Desmoglein 1 ; Desmogleins ; Desmoplakins ; Desmosomes ; Diptera ; DROSOPHILA ; Drosophila - genetics ; Drosophila Proteins ; Drosophilidae ; Electrophoresis, Polyacrylamide Gel ; Epithelial cells ; Fluorescent Antibody Technique ; gamma Catenin ; GENERO HUMANO ; GENRE HUMAIN ; Humans ; IMMUNOLOGIE ; INMUNOLOGIA ; Intercellular Junctions - metabolism ; Life Sciences & Biomedicine ; MEMBRANAS CELULARES ; MEMBRANE CELLULAIRE ; Mice ; Molecular Sequence Data ; Molecules ; Multigene Family ; PROPIEDADES MECANICAS ; PROPRIETE MECANIQUE ; PROTEINAS ; PROTEINE ; Proteins - genetics ; Proteins - immunology ; Proteins - metabolism ; QUIMICA ; REACCION ANTIGENO-ANTICUERPO ; REACTION ANTIGENE ANTICORPS ; Science & Technology ; Sequence Homology, Nucleic Acid ; Trans-Activators ; Transcription Factors</subject><ispartof>The Journal of cell biology, 1992-08, Vol.118 (3), p.681-691</ispartof><rights>Copyright 1992 The Rockefeller University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>355</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992JF80400018</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c453t-2f8ba95fe1e55d0aa76d8af9bc8331e414eb89bcf847a9ed3b095b054a4694743</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289544/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289544/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27225,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1639851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peifer, M. (University of North Carolina, Chapel Hill, NC)</creatorcontrib><creatorcontrib>McCrea, P.D</creatorcontrib><creatorcontrib>Green, K.J</creatorcontrib><creatorcontrib>Wieschaus, E</creatorcontrib><creatorcontrib>Gumbiner, B.M</creatorcontrib><title>The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties</title><title>The Journal of cell biology</title><addtitle>J CELL BIOL</addtitle><addtitle>J Cell Biol</addtitle><description>Three proteins identified by quite different criteria in three different systems, the Drosophila segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity. These findings raise questions about the relationship among the three molecules and their roles in different cell-cell adhesive junctions. We have found that antibodies against the Drosophila segment polarity gene armadillo cross react with a conserved vertebrate protein. This protein is membrane associated, probably via its interaction with a cadherin-like molecule. This cross-reacting protein is the cadherin-associated protein beta-catenin. Using anti-armadillo and antiplakoglobin antibodies, it was shown that beta-catenin and plakoglobin are distinct molecules, which can coexist in the same cell type. Plakoglobin interacts with the desmosomal glycoprotein desmoglein I, and weakly with E-cadherin. Although beta-catenin interacts tightly with E-cadherin, it does not seem to be associated with either desmoglein I or with isolated desmosomes. Anti-armadillo antibodies have been further used to determine the intracellular localization of beta-catenin, and to examine its tissue distribution. The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed</description><subject>Amino Acid Sequence</subject><subject>AMPHIBIEN</subject><subject>ANFIBIOS</subject><subject>Animals</subject><subject>Antibodies</subject><subject>ANTICORPS</subject><subject>ANTICUERPOS</subject><subject>Armadillo Domain Proteins</subject><subject>Armadillos</subject><subject>beta Catenin</subject><subject>Cadherins</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Cell adhesion</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Biology</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Cell membranes</subject><subject>Cells</subject><subject>CHIMIE</subject><subject>Cross Reactions</subject><subject>Cytoskeletal Proteins - genetics</subject><subject>Cytoskeletal Proteins - immunology</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Desmoglein 1</subject><subject>Desmogleins</subject><subject>Desmoplakins</subject><subject>Desmosomes</subject><subject>Diptera</subject><subject>DROSOPHILA</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Drosophilidae</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Epithelial cells</subject><subject>Fluorescent Antibody Technique</subject><subject>gamma Catenin</subject><subject>GENERO HUMANO</subject><subject>GENRE HUMAIN</subject><subject>Humans</subject><subject>IMMUNOLOGIE</subject><subject>INMUNOLOGIA</subject><subject>Intercellular Junctions - metabolism</subject><subject>Life Sciences & Biomedicine</subject><subject>MEMBRANAS CELULARES</subject><subject>MEMBRANE CELLULAIRE</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Molecules</subject><subject>Multigene Family</subject><subject>PROPIEDADES MECANICAS</subject><subject>PROPRIETE MECANIQUE</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>Proteins - genetics</subject><subject>Proteins - immunology</subject><subject>Proteins - metabolism</subject><subject>QUIMICA</subject><subject>REACCION ANTIGENO-ANTICUERPO</subject><subject>REACTION ANTIGENE ANTICORPS</subject><subject>Science & Technology</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Trans-Activators</subject><subject>Transcription Factors</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><recordid>eNqNkstu1DAUhiMEKkNhyQaB5BUblMGOncTeIFUD5aJKLGjX1klyMuMhiYPtTDWPxFvikFEpK1jZ1v-dq_8kec7omlHJ3-7ras2YXPN1IdmDZMVyQVPJBH2YrCjNWKryLH-cPPF-TykVpeBnyRkruJI5WyU_r3dIDugCVg4CEmh26M0ByX4a6mDsQEZnA5rBkwoDpHWEBjMQGBoydvDdbjtbnd4hpnrvrLfjznRAPG57HAIZbQfOhCPZ4hALuB4a03WWtNb1BEg_dcH8llroTXcktybsiDfxDm6uPsbuDPqnyaMWOo_PTud5cnP54XrzKb36-vHz5uIqrUXOQ5q1sgKVt8gwzxsKUBaNhFZVteScoWACKxlfrRQlKGx4RVVe0VyAKNS8nfPk3ZJ3nKoemzqO4KDTozM9uKO2YPTfymB2emsPOsukysWc4PUpgbM_JvRB98bX2HUwoJ28LjmVUgn1T5AVZZEpVkYwXcA6btc7bO-6YVTPJtDRBDqaQHMdTRD5V_dH-EMvvx51uei3WNnW1waHGu-oC6ZU9uVSUhH9wuTGBJiNsLHTEGLom_8PjfTLhd77YN29PlieyVl-scgtWA1bZ7y--aY4LXhW8F8tM-ap</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Peifer, M. (University of North Carolina, Chapel Hill, NC)</creator><creator>McCrea, P.D</creator><creator>Green, K.J</creator><creator>Wieschaus, E</creator><creator>Gumbiner, B.M</creator><general>Rockefeller University Press</general><general>Rockefeller Univ Press</general><general>The Rockefeller University Press</general><scope>FBQ</scope><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19920801</creationdate><title>The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties</title><author>Peifer, M. (University of North Carolina, Chapel Hill, NC) ; McCrea, P.D ; Green, K.J ; Wieschaus, E ; Gumbiner, B.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-2f8ba95fe1e55d0aa76d8af9bc8331e414eb89bcf847a9ed3b095b054a4694743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>AMPHIBIEN</topic><topic>ANFIBIOS</topic><topic>Animals</topic><topic>Antibodies</topic><topic>ANTICORPS</topic><topic>ANTICUERPOS</topic><topic>Armadillo Domain Proteins</topic><topic>Armadillos</topic><topic>beta Catenin</topic><topic>Cadherins</topic><topic>Cadherins - genetics</topic><topic>Cadherins - metabolism</topic><topic>Cell adhesion</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - immunology</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Biology</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Cell membranes</topic><topic>Cells</topic><topic>CHIMIE</topic><topic>Cross Reactions</topic><topic>Cytoskeletal Proteins - genetics</topic><topic>Cytoskeletal Proteins - immunology</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Desmoglein 1</topic><topic>Desmogleins</topic><topic>Desmoplakins</topic><topic>Desmosomes</topic><topic>Diptera</topic><topic>DROSOPHILA</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Drosophilidae</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Epithelial cells</topic><topic>Fluorescent Antibody Technique</topic><topic>gamma Catenin</topic><topic>GENERO HUMANO</topic><topic>GENRE HUMAIN</topic><topic>Humans</topic><topic>IMMUNOLOGIE</topic><topic>INMUNOLOGIA</topic><topic>Intercellular Junctions - metabolism</topic><topic>Life Sciences & Biomedicine</topic><topic>MEMBRANAS CELULARES</topic><topic>MEMBRANE CELLULAIRE</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Molecules</topic><topic>Multigene Family</topic><topic>PROPIEDADES MECANICAS</topic><topic>PROPRIETE MECANIQUE</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>Proteins - genetics</topic><topic>Proteins - immunology</topic><topic>Proteins - metabolism</topic><topic>QUIMICA</topic><topic>REACCION ANTIGENO-ANTICUERPO</topic><topic>REACTION ANTIGENE ANTICORPS</topic><topic>Science & Technology</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Trans-Activators</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peifer, M. (University of North Carolina, Chapel Hill, NC)</creatorcontrib><creatorcontrib>McCrea, P.D</creatorcontrib><creatorcontrib>Green, K.J</creatorcontrib><creatorcontrib>Wieschaus, E</creatorcontrib><creatorcontrib>Gumbiner, B.M</creatorcontrib><collection>AGRIS</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peifer, M. (University of North Carolina, Chapel Hill, NC)</au><au>McCrea, P.D</au><au>Green, K.J</au><au>Wieschaus, E</au><au>Gumbiner, B.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties</atitle><jtitle>The Journal of cell biology</jtitle><stitle>J CELL BIOL</stitle><addtitle>J Cell Biol</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>118</volume><issue>3</issue><spage>681</spage><epage>691</epage><pages>681-691</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><notes>L50</notes><notes>9306326</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Three proteins identified by quite different criteria in three different systems, the Drosophila segment polarity gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity. These findings raise questions about the relationship among the three molecules and their roles in different cell-cell adhesive junctions. We have found that antibodies against the Drosophila segment polarity gene armadillo cross react with a conserved vertebrate protein. This protein is membrane associated, probably via its interaction with a cadherin-like molecule. This cross-reacting protein is the cadherin-associated protein beta-catenin. Using anti-armadillo and antiplakoglobin antibodies, it was shown that beta-catenin and plakoglobin are distinct molecules, which can coexist in the same cell type. Plakoglobin interacts with the desmosomal glycoprotein desmoglein I, and weakly with E-cadherin. Although beta-catenin interacts tightly with E-cadherin, it does not seem to be associated with either desmoglein I or with isolated desmosomes. Anti-armadillo antibodies have been further used to determine the intracellular localization of beta-catenin, and to examine its tissue distribution. The implications of these results for the structure and function of different cell-cell adhesive junctions are discussed</abstract><cop>NEW YORK</cop><pub>Rockefeller University Press</pub><pmid>1639851</pmid><doi>10.1083/jcb.118.3.681</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9525 |
| ispartof | The Journal of cell biology, 1992-08, Vol.118 (3), p.681-691 |
| issn | 0021-9525 1540-8140 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2289544 |
| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Open Access: PubMed Central; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence AMPHIBIEN ANFIBIOS Animals Antibodies ANTICORPS ANTICUERPOS Armadillo Domain Proteins Armadillos beta Catenin Cadherins Cadherins - genetics Cadherins - metabolism Cell adhesion Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Cell Biology Cell Line Cell lines Cell membranes Cells CHIMIE Cross Reactions Cytoskeletal Proteins - genetics Cytoskeletal Proteins - immunology Cytoskeletal Proteins - metabolism Desmoglein 1 Desmogleins Desmoplakins Desmosomes Diptera DROSOPHILA Drosophila - genetics Drosophila Proteins Drosophilidae Electrophoresis, Polyacrylamide Gel Epithelial cells Fluorescent Antibody Technique gamma Catenin GENERO HUMANO GENRE HUMAIN Humans IMMUNOLOGIE INMUNOLOGIA Intercellular Junctions - metabolism Life Sciences & Biomedicine MEMBRANAS CELULARES MEMBRANE CELLULAIRE Mice Molecular Sequence Data Molecules Multigene Family PROPIEDADES MECANICAS PROPRIETE MECANIQUE PROTEINAS PROTEINE Proteins - genetics Proteins - immunology Proteins - metabolism QUIMICA REACCION ANTIGENO-ANTICUERPO REACTION ANTIGENE ANTICORPS Science & Technology Sequence Homology, Nucleic Acid Trans-Activators Transcription Factors |
| title | The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T06%3A20%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20vertebrate%20adhesive%20junction%20proteins%20beta-catenin%20and%20plakoglobin%20and%20the%20Drosophila%20segment%20polarity%20gene%20armadillo%20form%20a%20multigene%20family%20with%20similar%20properties&rft.jtitle=The%20Journal%20of%20cell%20biology&rft.au=Peifer,%20M.%20(University%20of%20North%20Carolina,%20Chapel%20Hill,%20NC)&rft.date=1992-08-01&rft.volume=118&rft.issue=3&rft.spage=681&rft.epage=691&rft.pages=681-691&rft.issn=0021-9525&rft.eissn=1540-8140&rft_id=info:doi/10.1083/jcb.118.3.681&rft_dat=%3Cjstor_pubme%3E1615288%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c453t-2f8ba95fe1e55d0aa76d8af9bc8331e414eb89bcf847a9ed3b095b054a4694743%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16762917&rft_id=info:pmid/1639851&rft_jstor_id=1615288&rfr_iscdi=true |