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The reticulons: a family of proteins with diverse functions
The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon homology domain that consists of two hydrophobic regions flanking a hydrophilic loop of 60-70 amino acids, but reticulon...
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Published in: | Genome biology 2007-01, Vol.8 (12), p.234-234 |
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creator | Yang, Yvonne S Strittmatter, Stephen M |
description | The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon homology domain that consists of two hydrophobic regions flanking a hydrophilic loop of 60-70 amino acids, but reticulon amino-terminal domains display little or no similarity to each other. Reticulons principally localize to the endoplasmic reticulum, and there is evidence that they influence endoplasmic reticulum-Golgi trafficking, vesicle formation and membrane morphogenesis. However, mammalian reticulons have also been found on the cell surface and mammalian reticulon 4 expressed on the surface of oligodendrocytes is an inhibitor of axon growth both in culture and in vivo. There is also growing evidence that reticulons may be important in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. The diversity of structure, topology, localization and expression patterns of reticulons is reflected in their multiple, diverse functions in the cell. |
doi_str_mv | 10.1186/gb-2007-8-12-234 |
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The diversity of structure, topology, localization and expression patterns of reticulons is reflected in their multiple, diverse functions in the cell.</description><identifier>ISSN: 1465-6906</identifier><identifier>EISSN: 1474-760X</identifier><identifier>EISSN: 1465-6914</identifier><identifier>DOI: 10.1186/gb-2007-8-12-234</identifier><identifier>PMID: 18177508</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Animals ; Humans ; Membrane Proteins - chemistry ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Nerve Tissue Proteins - chemistry ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Protein Family Review</subject><ispartof>Genome biology, 2007-01, Vol.8 (12), p.234-234</ispartof><rights>Copyright © 2007 BioMed Central Ltd 2007 BioMed Central Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-cb52970b68a0ae7324f4ca1791d79039201187c8f08090b3b1ca2b87fc0124503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246256/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246256/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18177508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yvonne S</creatorcontrib><creatorcontrib>Strittmatter, Stephen M</creatorcontrib><title>The reticulons: a family of proteins with diverse functions</title><title>Genome biology</title><addtitle>Genome Biol</addtitle><description>The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. 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The diversity of structure, topology, localization and expression patterns of reticulons is reflected in their multiple, diverse functions in the cell.</description><subject>Animals</subject><subject>Humans</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Nerve Tissue Proteins - chemistry</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Protein Family Review</subject><issn>1465-6906</issn><issn>1474-760X</issn><issn>1465-6914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkc1LxDAQxYMorq7ePUlP3qKTaZoPBUHELxC8KHgLaTbdjXTbNWlX9r-3i4sfJ08zMO895vEj5IjBKWNKnE1LigCSKsqQYs63yB7jklMp4HV7vYuCCg1iRPZTegNgmqPYJSOmmJQFqD1y8TzzWfRdcH3dNuk8s1ll56FeZW2VLWLb-dCk7CN0s2wSlj4mn1V947owiA_ITmXr5A83c0xebm-er-_p49Pdw_XVI3Vc5x11ZYFaQimUBetljrzizjKp2URqyDXC0EU6VYECDWVeMmexVLJywJAXkI_J5Vfuoi_nfuJ800Vbm0UMcxtXprXB_L00YWam7dIgcoGFGAJONgGxfe996sw8JOfr2ja-7ZORAFqjkv8KEVAXLMdBCF9CF9uUoq--v2Fg1mjMtDRrNEYZhmZAM1iOf7f4MWxY5J8C-4ni</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Yang, Yvonne S</creator><creator>Strittmatter, Stephen M</creator><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070101</creationdate><title>The reticulons: a family of proteins with diverse functions</title><author>Yang, Yvonne S ; Strittmatter, Stephen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-cb52970b68a0ae7324f4ca1791d79039201187c8f08090b3b1ca2b87fc0124503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Membrane Proteins - chemistry</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Nerve Tissue Proteins - chemistry</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Protein Family Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yvonne S</creatorcontrib><creatorcontrib>Strittmatter, Stephen M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genome biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yvonne S</au><au>Strittmatter, Stephen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The reticulons: a family of proteins with diverse functions</atitle><jtitle>Genome biology</jtitle><addtitle>Genome Biol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>8</volume><issue>12</issue><spage>234</spage><epage>234</epage><pages>234-234</pages><issn>1465-6906</issn><eissn>1474-760X</eissn><eissn>1465-6914</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-3</notes><notes>ObjectType-Review-1</notes><abstract>The reticulon family is a large and diverse group of membrane-associated proteins found throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon homology domain that consists of two hydrophobic regions flanking a hydrophilic loop of 60-70 amino acids, but reticulon amino-terminal domains display little or no similarity to each other. Reticulons principally localize to the endoplasmic reticulum, and there is evidence that they influence endoplasmic reticulum-Golgi trafficking, vesicle formation and membrane morphogenesis. However, mammalian reticulons have also been found on the cell surface and mammalian reticulon 4 expressed on the surface of oligodendrocytes is an inhibitor of axon growth both in culture and in vivo. There is also growing evidence that reticulons may be important in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. The diversity of structure, topology, localization and expression patterns of reticulons is reflected in their multiple, diverse functions in the cell.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>18177508</pmid><doi>10.1186/gb-2007-8-12-234</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Humans Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Protein Family Review |
title | The reticulons: a family of proteins with diverse functions |
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