Lance-Adams syndrome: a report of two cases

Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterw...

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Published in:Journal of Zhejiang University. B. Science 2007-10, Vol.8 (10), p.715-720
Main Authors: Zhang, Yan-xing, Liu, Jian-ren, Jiang, Biao, Liu, Hui-qin, Ding, Mei-ping, Song, Shui-jiang, Zhang, Bao-rong, Zhang, Hong, Xu, Bin, Chen, Huai-hong, Wang, Zhong-jin, Huang, Jian-zheng
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Language:English
Subjects:
Biomedicine
Brain
Cardiopulmonary Resuscitation - adverse effects
Cerebellar Ataxia - diagnosis
Cerebellar Ataxia - etiology
Female
Humans
Hypoxia-Ischemia, Brain - diagnosis
Hypoxia-Ischemia, Brain - etiology
Medical imaging
Middle Aged
Myoclonus - diagnosis
Myoclonus - etiology
NMR
Nuclear magnetic resonance
Syndrome
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Xu, Bin
Chen, Huai-hong
Wang, Zhong-jin
Huang, Jian-zheng
description Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [(18)F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.
doi_str_mv 10.1631/jzus.2007.B0715
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B. Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yan-xing</au><au>Liu, Jian-ren</au><au>Jiang, Biao</au><au>Liu, Hui-qin</au><au>Ding, Mei-ping</au><au>Song, Shui-jiang</au><au>Zhang, Bao-rong</au><au>Zhang, Hong</au><au>Xu, Bin</au><au>Chen, Huai-hong</au><au>Wang, Zhong-jin</au><au>Huang, Jian-zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lance-Adams syndrome: a report of two cases</atitle><jtitle>Journal of Zhejiang University. B. Science</jtitle><addtitle>J Zhejiang Univ Sci B</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>8</volume><issue>10</issue><spage>715</spage><epage>720</epage><pages>715-720</pages><issn>1673-1581</issn><eissn>1862-1783</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Case Study-3</notes><notes>ObjectType-Review-1</notes><notes>ObjectType-Feature-5</notes><notes>ObjectType-Report-2</notes><notes>ObjectType-Article-4</notes><notes>Corresponding Author</notes><notes>The two authors contributed equally to this work</notes><abstract>Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [(18)F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. 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subjects Biomedicine
Brain
Cardiopulmonary Resuscitation - adverse effects
Cerebellar Ataxia - diagnosis
Cerebellar Ataxia - etiology
Female
Humans
Hypoxia-Ischemia, Brain - diagnosis
Hypoxia-Ischemia, Brain - etiology
Medical imaging
Middle Aged
Myoclonus - diagnosis
Myoclonus - etiology
NMR
Nuclear magnetic resonance
Syndrome
title Lance-Adams syndrome: a report of two cases
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