Lance-Adams syndrome: a report of two cases

Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterw...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2007-10, Vol.8 (10), p.715-720
Main Authors: Zhang, Yan-xing, Liu, Jian-ren, Jiang, Biao, Liu, Hui-qin, Ding, Mei-ping, Song, Shui-jiang, Zhang, Bao-rong, Zhang, Hong, Xu, Bin, Chen, Huai-hong, Wang, Zhong-jin, Huang, Jian-zheng
Format: Article
Language:English
Subjects:
Biomedicine
Brain
Cardiopulmonary Resuscitation - adverse effects
Cerebellar Ataxia - diagnosis
Cerebellar Ataxia - etiology
Female
Humans
Hypoxia-Ischemia, Brain - diagnosis
Hypoxia-Ischemia, Brain - etiology
Medical imaging
Middle Aged
Myoclonus - diagnosis
Myoclonus - etiology
NMR
Nuclear magnetic resonance
Syndrome
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Summary:Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [(18)F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.2007.B0715